|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Somatosensory evoked potentials in patients with primary premature ejaculation显示文摘 | Xin ZC Choi YD Rha KH | 1997 | J Urol1997，158，2： | 1 |
| 3 | Penile sensitivity in patients with primary premature ejaculation显示文摘 | Xin ZC Chung WS Choi YD | 1996 | J Urol1996，156，3： | 1 |
| 4 | Penile sensitivity in patients with primary premature ejaculation 显示文摘 | Xin ZC Chung WS Choi YD | 1996 | J Urol1996，156，3： | 1 |
| 5 | Penile sensitivity in patients with primary premature ejaculation 显示文摘 | Xin ZC Chung WS Choi YD | 1997 | J Urol1997，158，1： | 1 |
| 6 | Disorders of orgasm and ejaculation in men显示文摘 | McMahon CG Abdo C Incrocci L Perelman M Rowland D Waldinger M Xin ZC | 2004 | Sex Med2004，1，1： | 1 |
| 7 | Sensory evoked potential and effect of SS-cream in premature ejaculation显示文摘 | Xin ZC Choi YD Seong DH | 1995 | Yonsei Med J1995，36，5： | 1 |
| 8 | High-flow pria pism:Superselec-tive caverno us artery embolization with mieroeoils显示文摘 | Liu BX Xin ZC Zou YH | 2008 | Urology2008，72，3： | 1 |
| 9 | Studies of sexual funetionin young and middle 2 aged Chinese women with BISF ( Brief Indexof Sexual FunetionforWomen ) 显示文摘 | Xin ZC Tian ZJ Yin XR | 2000 | Int J Impot Res2000，1729，： | 1 |
| 10 | Phosphodiesterases as therapeutic targets显示文摘 | Lin CS Xin ZC Lin G | 2003 | Urology2003，61，4： | 1 |
| 11 | Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation 显示文摘 | Xin ZC Choi YD Lee WH | 2000 | Yonsei Med J2000，41，1： | 1 |
| 12 | Safety and efficacy study with various doses of SS-cream in patients with premature ejaculation ina double-blind, randomized, placebo controlled clinical study显示文摘 | Choi HK Xin ZC Choi YD | 1999 | Int J Impot Res1999，11，5： | 1 |
| 13 | Defining adipose tissue-derived stem cells in tissue and in euhure显示文摘 | Lin CS Xin ZC Deng CH | 2010 | Hi stol Histopathol2010，25，6： | 1 |
| 14 | Penile sensitivity in patients with primary premature ejaculation 显示文摘 | Xin ZC Chung WS Choi YD | 1996 | J Urol1996，156，3： | 1 |
| 15 | Changes of ejaculatory latency and penile vibration threshod with SS-cream in patients with primary premature ejaculation显示文摘 | Choi YD Lee WH | 1999 | J Sex Dysfunction1999，1，： | 1 |
| 16 | Penile sensitivity in patients with primary premature ejaculation显示文摘 | Xin ZC Chung WS Choi YD | 1996 | J Urol1996，156，3： | 1 |
| 17 | Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism显示文摘 | Lin G Xin ZC Lue TF | 2003 | J Urol2003，，： | 1 |
| 18 | Somatosensory evoked potentials in patients with primary premature ejaculation显示文摘 | Choi YD Rha KH | 1997 | J Urol1997，158，2： | 1 |
| 19 | Sensory evoked potential and effect of SS-cream in premature ejaculation显示文摘 | XIN ZC CHIO YD SEONG DH | 1995 | Yonsei Med J1995，36，5： | 1 |
| 20 | Safety and eff1cacy study with various dosrs of SS-cream in patients with premature ejaculation in a double-blind,randomized,placebo controlled clinical study显示文摘 | Xin ZC Choi YD | 1999 | IntJ Impot Res1999，11，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员