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| 1 | Ultrasonically activated scalpel versus monopolar electrocautery shovel in laparoscopic total mesorectal excision for rectal cancer显示文摘AIM: To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with anal sphincter preservation for rectal cancer in order to reduce the cost of the laparoscopic operation, and to compare ES with the ultrasonically activated scalpel (US). METHODS: Forty patients with rectal cancer, who underwent laparoscopic TME with anal sphincter preservation from June 2005 to June 2007, were randomly divided into ultrasonic scalpel group and monopolar ES group, prospectively. White blood cells (WBC) were measured before and after operation, operative time, blood loss, pelvic volume of drainage, time of anal exhaust, visual analogue scales (VAS) and surgery-related complications were recorded. RESULTS: All the operations were successful; no one was converted to open procedure. No significant differences were observed in terms of preoperative and postoperative d 1 and d 3 WBC counts (P = 0.493, P = 0.375, P = 0.559), operation time (P = 0.235), blood loss (P = 0.296), anal exhaust time (P = 0.431), pelvicdrainage volume and VAS in postoperative d 1 (P = 0.431, P = 0.426) and d 3 (P = 0.844, P = 0.617) between ES group and US group. The occurrence of surgery-related complications such as anastomotic leakage and wound infection was the same in the two groups. CONCLUSION: ES is a safe and feasible tool as same as US used in laparoscopic TME with anal sphincter preservation for rectal cancer on the basis of the skillful laparoscopic technique and the complete understanding of laparoscopic pelvic anatomy. Application of ES can not only reduce the operation costs but also benef it the popularization of laparoscopic operation for rectal cancer patients. | Bao-Jun Zhou, Wei-Qing Song, Qing-Hui Yan, Jian-Hui Cai, Feng-An Wang, Jin Liu, Guo-Jian Zhang, Guo-Qiang Duan, Zhan-Xue Zhang, Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China Author contributions: Zhou BJ, Song WQ, Yan QH, Cai JH, Wang FA, Liu J, Zhang GJ, Duan GQ and Zhang ZX contributed equally to this work Zhou BJ, Song WQ, Yan QH, Cai JH and Wang FA designed the research Zhou BJ, Liu J and Zhang GJ performed the research Duan GQ and Zhang ZX analyzed the data and Zhou BJ, Song WQ and Yan QH wrote the paper. | 2008 | World Journal of Gastroenterology2008，14，25： | 25 |
| 2 | Investigation of recombinant Schistosoma japonicum paramyosin fragments for immunogenicity and vaccine efficacy in mice显示文摘 | Zhang DM Pan WQ Qian L Duke M Shen LH McManus DP | 2006 | 第二军医大学学报2006，27，6： | 6 |
| 3 | Overexpression/amplification of HER-2/neu is uncommon in hepatocellular carcinoma显示文摘 | Xian ZH Zhang SH Cong WM Wu WQ Wu MC | 2005 | 第二军医大学学报2005，26，11： | 6 |
| 4 | FREE VIBRATION OF PIEZOELECTRIC CYLINDRICAL SHELLS显示文摘Three displacement functions are introduced to represent each mechanical displacementaccording to the 3-D theory in this paper,By expanding the displacement functions and the electric po-tential in orthogonal series,the free vibration equation of piezoelectric cylindrical shells satisfying SS3boundary conditions can be obtained.The equation was solved by utilizing Bessel functions with com-plex arguments.Results are presented graphically as well as in table,and compared with those of otherreferences.Some frequencies that were missing in Ref.[9]are discovered. | Ding, HJ Guo, YM Yang, QD Chen, WQ | 1997 | Acta Mechanica Solida Sinica1997，10，1： | 5 |
| 5 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 6 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 7 | Lipopolysaccharide decreasing albumin expression in rat hepatocytes显示文摘The relations of the severity of hypoalbu-minemia to morbidity and mortality of patients with critical illness illustrate the need for better understanding of molecular mechanism of hypoalbuminemia. This study was undertaken to investigate the response of albumin synthesis to lipopolysaccharide(LPS)in rat hepatocytes in vitro in early acute phase of sepsis. METHODS:Hepatocytes were cultured at an initial cell density of 1.5×106 cells/well in 3 ml culture medium. There were two groups of samples which received either normal saline or 1 μg/L LPS randomly. Albumin mRNA in hepatocytes was assessed by reverse transcription-poly-merase chain reaction(RT-PCR) and albumin level in the supernatant was measured by ELISA at 0,2,8,12,24 hours after exposure. Meanwhile, the albumin precursor was evaluated at the same time points by flow cytometry. RESULTS:The quantitative changes of mRNA, albumin precursor and its protein were analogous. All of them tended to decline at 12 hours post-treatment and did not decrease significantly until 24 hours after LPS exposure. Meanwhile, albumin mRNA decreased about 30% and the levels of albumin precursor and albumin reduced approximately 50%. CONCLUSIONS: LPS can inhibit albumin synthesis in rat hepatocytes by prevention of albumin transcription. Moreover, the response of hepatic albumin synthesis to LPS changes with the stage of sepsis process. The results show that albumin metabolism in sepsis is a complicated process and further studies are required to understand the molecular mechanism of LPS-induced hypoalbuminemia in sepsis. | Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, China (Wang XY, Li WQ, Li N and Li JS) and Department of Orthopaedics, Zhongda Hospital, Nanjing 210009, China (Lu J) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 2 |
| 8 | Parallel algorithm for generalized matrix eigen-problem and its application in calculation of crystal electronic structure显示文摘1 Problem and algorithmMANY computing tasks arising from computational physics, chemistry and biology are relatedto solving so-called generalized eigen-decomposition problems. Consider the following general-ized eigen-decomposition problem: | Sun, JC Deng, JX Cao, JW Wang, DS Zhang, WQ Li, J | 1997 | Chinese Science Bulletin1997，42，13： | 2 |
| 9 | Fusion of two malaria vaccine candidate antigens enhances product yield, immunogenieity, and antibody-mediated inhibition of parasite growth in vitro 显示文摘 | Pan WQ Huang DQ Zhang QF | 2004 | J Immunol2004，172，10： | 1 |
| 10 | Notes on Carbonaria species group of genus Fannia Robineau-Desvoidy (Diptera: Fanniidae) from China 显示文摘 | Wang MF Xue WQ Su LX | 2004 | Entomol Sinica2004，11，2： | 1 |
| 11 | The interactions between cigarette smoking and reduced lung function on systemic inflammation 显示文摘 | GAN WQ MAN SF SIN DD | 2005 | Chest2005，127，2： | 1 |
| 12 | Fusion of two malaria vaccine candidates enhances product yield, immunogenieity and antibody-mediated inhibition of parasite growth in vitro显示文摘 | Pan WQ Huang DQ Zhang QF | 2004 | J Immunol2004，172，10： | 1 |
| 13 | Cell biology of IL-7,a key lymphotrophin显示文摘 | Jiang Q Li WQ Aiello FB | 2005 | Cytokine Growth Factor Rev2005，16，45： | 1 |
| 14 | Acquisition of desiccation tolerance in soybeans 显示文摘 | Sun WQ Lepolod AC | 1993 | Physiol Planta1993，87，： | 1 |
| 15 | Calmodulin binds to maize lipid transfer protein and modulates its lipids binding ability 显示文摘 | Li CF Xie WQ Bai WY | 2008 | FEBS J2008，275，21： | 1 |
| 16 | Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization 显示文摘 | SHI J CAI WQ CHEN X | 2001 | Brain Res2001，910，12： | 1 |
| 17 | Association between chronic obstructive pulmonary disease and systemic in flammation:a systematic review and a meta-analysis显示文摘 | Gan WQ Man SFP Senthilselvan A | 2004 | Thorax2004，59，： | 1 |
| 18 | Bonding of chemically treated titanium implants to bone 显示文摘 | Yan WQ Nakamura T Kobavashi M | 1997 | J Biomed Mater Res1997，37，2： | 1 |
| 19 | Tripterygium wilfordii Hook F extract suppresses proinflammatory cytokine - induced expression of matrix metalloproteinase genes in articular chondroeytes by inhibiting activating protein- 1 and nuclear factor- kappaB activities显示文摘 | Sylvester J Liacini A Li WQ | 2001 | Mol Pharmacol2001，59，5： | 1 |
| 20 | Evidence for early oral feeding of patients after e- lective open colorectal surgery : a literature review 显示文摘 | Ng WQ Neill J | 2006 | J Nurs2006，15，6： | 1 |
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