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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 3 | Transactivation,dimerization,and DNA-binding activity of white spot syndrome virus immediate early protein IE1显示文摘 | Liu WJ Chang YS Wang HC | 2008 | J Virol2008，82，11： | 1 |
| 4 | Inflammation-induced up-regulation of protein kinase Cγ immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing显示文摘 | Liu H Wang AB | 1999 | Neuroscienee1999，88，4： | 1 |
| 5 | Clinicopathological features of breast cancer patients with nipple discharge显示文摘 | Yin WJ Di GH Liu GY | 2010 | Mol Med Report2010，3，5： | 1 |
| 6 | Targeted therapeutic remodeling of the tumor microenvironment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model显示文摘 | Liao D Liu Z Wrasidlo WJ | 2011 | Cancer Res2011，71，17： | 1 |
| 7 | Inhibition of prohferation and induction of apoptosis by genistein in coloncancer HT-29 cells 显示文摘 | Yu ZL Li WJ Liu FY | 2004 | Cancer Lett2004，2，： | 1 |
| 8 | Molecular characteristics of methicillinresistant Staphylococcus aureus isolated from Chinese children 显示文摘 | Liu YC Geng WJ Wu DJ ei al | 2012 | FEMS Immunol Med Microbiol2012，50，1： | 1 |
| 9 | Autophagy activation reduces renal tubular injury induced by urinary proteins显示文摘 | Liu WJ Luo MN Tan J | 2014 | Autophagy2014，10，： | 1 |
| 10 | Nonoperative treatment versus posterior fixation for thoracolumbar junction burst fractures without neurologic deficit显示文摘 | Shen WJ Liu TJ Shen YS | | 0，，09： | 1 |
| 11 | Microarray and RT-PCR screening for white spot syndrome virus immediate-early genes in cycloheximide-treated shrimp显示文摘 | Liu WJ Chang YS Wang CH | 2005 | Virology2005，334，2： | 1 |
| 12 | Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD -MRI显示文摘 | Yin WJ Liu F Li XM | 2012 | Eur J Radio12012，81，： | 1 |
| 13 | Correlations between measures of atherosclerosis change using carotid ultra- sonography and coronary angiography显示文摘 | Mack WJ Labree L Liu C | 2000 | Atherosclero sis2000，150，2： | 1 |
| 14 | Good death study of elderly patients with terminal cancer in Taiwan显示文摘 | SY Cheng WY Hu WJ Liu | 2008 | Palliative Medicine2008，，22： | 1 |
| 15 | Enhanced oral bioavailability of novel mucoadhesive pellets containing valsartan prepared by a dry powder-coating technique显示文摘 | Cao QR Liu Y Xu WJ | 2012 | Int J Pharm2012，434，12： | 1 |
| 16 | Galangin attenuates airway remodelling by inhibiting TGF-betal-mediated ROS gen- eration and MAPK/Akt phosphorylation in asthma显示文摘 | Liu YN Zha WJ Ma Y | 2015 | Sci Rep2015，5，11： | 1 |
| 17 | Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability显示文摘 | Zhou J Liu WJ Peng SW | 1999 | J Virol1999，73，6： | 1 |
| 18 | Common variation in the fatmass and obesity-associated (FTO) gene confers risk of obesity andmodulates BMI in the Chinese population 显示文摘 | CHANG YC LIU PH Lee WJ | 2008 | Diabetes2008，57，8： | 1 |
| 19 | A combined approach of physicochemical and biological methods for the characterization of petroleum hydrocarbon-contaminated soil显示文摘 | Masakorala K Yao J Chandankere R Liu H Liu WJ Cai MM Choi MMF | 2014 | Environmental Science and Pollution Research2014，21，1： | 1 |
| 20 | Nonoperative treatment versus posterior fixation for thoracolumbar junction burst fractures without neurologic deficit显示文摘 | Shen WJ Liu TJ Shen YS | 2001 | Spine2001，26，9： | 1 |
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