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| 1 | Mitochondrial metabolism and cancer显示文摘Glycolysis 长在癌症房间为精力生产和 anabolism 的生长被看作了主要新陈代谢的过程。尽管如此的一个看法为仍然在诊所被使用的强大的成像工具的发展是有帮助的,线粒体在 oncogenesis 起一个关键作用,现在是清楚的。除施加中央 bioenergetic 函数以外,线粒体确实为肿瘤同化提供积木,控制氧化还原作用和钙动态平衡,参予 transcriptional 规定,并且管理房间死亡。因此,线粒体为新奇 anticancer 代理人的发展组成有希望的目标。然而,肿瘤产生,进行,并且回答功能依靠未经触动的 mitochondrial 新陈代谢到在有主人免疫系统,和许多免疫学的亲密串音的上下文的治疗。这里,我们考察房间内在的癌症和线粒体影响都 oncogenesis 通过走的房间外来的机制,与指向为癌症治疗的 mitochondrial 新陈代谢的治疗学的潜力的一个焦点。 | Paolo Ettore Porporato Nicoletta Filigheddu José Manuel Bravo-San Pedro, Guido Kroemer, Lorenzo Galluzzi José Manuel Bravo-San Pedro, Guido Kroemer José Manuel Bravo-San Pedro, Guido Kroemer José Manuel Bravo-San Pedro, Guido Kroemer José Manuel Bravo-San Pedro, Guido Kroemer Guido Kroemer Guido Kroemer Lorenzo Galluzzi Lorenzo Galluzzi | 2018 | Cell Research2018，28，3： | 33 |
| 2 | 基于自加强学习算法的发电商报价策略研究显示文摘电力市场中发电商的决策过程和多发电商的相互作用过程是个复杂动态问题,很难用传统的解析方法进行分析计算,这在考虑中长时间段交易时尤为突出,且多代理作用机制是个很好的补充。文中提出了一个能够模拟发电商在市场中进行策略性报价的中长期交易时间段决策过程模型,对多发电商交互作用导致的市场行为进行了仿真试验。该模型基于自加强Watkins’sQ(λ)学习算法并包含了可能对电力市场运行产生重要影响的网络阻塞因素。该模型可以形成发电商的最优策略以最大化中长期生产效益和可以找到中长期市场平衡点并据此评估市场中长期运行情况。通过在标准IEEE-14节点系统中进行仿真计算表明该模型的有效性和新颖性。 | 马豫超 蒋传文 候志俭 Ettore Bompard 王承民 | 2006 | 中国电机工程学报2006，26，17： | 17 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Surgical treatment of ulcerative colitis in the biologic therapy era显示文摘Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field. | Alberto Biondi Marco Zoccali Stefano Costa Albert Troci Ettore Contessini-Avesani Alessandro Fichera | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 5 | emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer显示文摘Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic or epigenetic alterations affecting almost 90%of Wnt/β-catenin gene members.A major challenge is thus learning how the corrupted coordination of this pathway is tied to other signalings to enhance cell growth.Peroxisome proliferator activated receptorγ(PPARγ)is emerging as a growth-limiting and differentiation-promoting factor.In tumorigenesis it exerts a tumor suppressor role and is potentially linked with the Wnt/β-catenin pathway.Based on these results,the identification of new selective PPARγmodulators with inhibitory effects on the Wnt/β-catenin pathway is becoming an interesting perspective.Should,in fact,these molecules display such properties,new research avenues would be opened aimed at developing new molecular targeted drugs.Herein,we review the basic principles and present new hypotheses underlying the crosstalk between Wnt/β-catenin and PPARγsignaling.Furthermore,we discuss the advances in our understanding as to how their altered regulation can culminate in colon cancer and the efforts aimed at designing novel PPARγagonists endowed with Wnt/β-catenin inhibitory effects to be used as therapeutic and/or preventive agents. | Lina Sabatino Massimo Pancione Carolina Votino Tommaso Colangelo Angelo Lupo Ettore Novellino Antonio Lavecchia Vittorio Colantuoni | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 6 | Regression of liver metastases of occult carcinoid tumor with slow release Lanreotide therapy显示文摘Few clinical studies have demonstrated an anti-proliferative activity of somatostatin (SST) analogs in carcinoids. We report the case of a woman with liver metastases of neuroendocrine tumor and no evidence of the primary tumor. The liver metastases were characterized by high proliferation indes, immunoreactiviy for somatostatin receptor (SSTR) -1,2,3 and 5and positive octreoscan. Urinary 5-hydrozyindolacetic acid, serum serotonin and chromogranin A were elevated. Slow release lanretoide (SR-LAN) therapy for 3 mo controlled clinical and biochemical signs of carcinoid tumor and caused a clear-cut reduction in the diameter of two liver metastases and disappearance of another lesion, with further reduction after 6 and 18 mo. We demonstrated a Clear-cut long-lasting antioccult carcinoid with high proliferation index and immunoreactivity for SSTR-1,2,3, and 5. Immunohistochemistry for SSTRs could be a suitable method for the selection of patients with metasatic carcinoid that may benefit from SST analog therapy. | Marta Bondanelli Maria Rosaria Ambrosio Maria Chiara Zatelli Luigi Cavazzini Laura Al Jandali Rifa'y Ettore C.degli Uberti | 2005 | World Journal of Gastroenterology2005，11，13： | 7 |
| 7 | Corrective osteotomies of the radius:Grafting or not?显示文摘AIM:To review the current literature regarding corrective osteotomies to provide the best evidence of the rule of bone grafting.METHODS:Our MEDLINE literature search included 280 studies using the following key words 'Malunited distal radius fracture' and 150 studies using key words 'Corrective osteotomy of the distal radius'.Inclusion criteria were:Malunited distal radial,extra articular fracture,volar locking plate,use of iliac bone graft(cancellous or corticocancellous),non-use of bone graft.Twelve studies met the inclusion criteria.RESULTS:Seven of the 12 studies considered,described the use of a graft;the remaining five studies didn't use any graft.Type of malunion was dorsal in most of the studies.The healing time was comparable using the graft or not(mean 12.5 wk),ranging from 7.5 to 16 wk.The mean disabilities of the arm,shoulder and hand score improvement was 23 points both in the studies that used the graft and in those not using the graft.CONCLUSION:This review demonstrated that corrective osteotomy of extra-articular malunited fractures of the distal radius treated by volar locking plate does not necessarily require bone graft. | Raffaele Mugnai Luigi Tarallo Enrico Lancellotti Francesco Zambianchi Ettore Di Giovine Fabio Catani Roberto Adani | 2016 | World Journal of Orthopedics2016，7，2： | 5 |
| 8 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 9 | Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma显示文摘AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. | Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini | 2011 | World Journal of Hepatology2011，3，11： | 4 |
| 10 | How to approach the pediatric flatfoot显示文摘The most difficult aspect regarding treatment of the pediatric flatfoot is understanding who needs surgery,when it is necessary, and what procedure to be done.A thorough history, clinical examination, and imaging should be performed to guide the surgeon through an often complex treatment path. Surgical technique can be divided in three categories: Soft tissue, bony,and arthroereisis. This paper will describe the jointpreserving techniques and their application to treat the pediatric flatfoot deformity. | Ettore Vulcano Camilla Maccario Mark S Myerson | 2016 | World Journal of Orthopedics2016，7，1： | 4 |
| 11 | 基于猜测供给函数的需求弹性对电力市场运行的影响显示文摘影响市场运行的一个重要因素是需求弹性。低需求弹性将导致市场出清价格高,市场运行效率低,经济效益分配不合理。由于电力商品的特殊性,目前电力市场本质上具有寡头竞争的特点。相对较完全的竞争市场,发电商的策略竟标行为将导致市场运行在低效率水平下,这一消极因素在低需求弹性下尤为突出。为此提出了一个能评估需求弹性对发电商策略竞标行为影响的模型。该模型将发电商的博弈行为模拟成猜测供给函数(conjiecture supply function,CSF)竞争,同时将交易市场中的用户需求弹性包含在数学模型中。通过对意大利电力市场的单时段交易的模拟,运用一系列指标来量化评估需求弹性对具有寡头竞争性质的市场运行的影响。 | 马豫超 蒋传文 候志俭 王承民 Ettore Bompard | 2006 | 中国电机工程学报2006，26，13： | 4 |
| 12 | Recent developments in Boolean networks control显示文摘The aim of this survey paper is to provide the state of the art of the research on control and optimal control of Boolean control networks,under the assumption that all the state variables are accessible and hence available for feedback.Necessary and sufficient conditions for stabilisability to a limit cycle or to an equilibrium point are given.Additionally,it is shown that when such conditions are satisfied,stabilisation can always be achieved by means of state feedback.Analogous results are obtained for the safe control problem that is investigated for the first time in this survey.Finite and infinite horizon optimal control are subsequently considered,and solution algorithms are provided,based on suitable adaptations of theRiccati difference and algebraic equations.Finally,an appropriate definition of the cost function allows to restate and to solve both stabilisation and safe control as infinite horizon optimal control problems. | Ettore Fornasini Maria Elena Valcher | 2016 | Journal of Control and Decision2016，3，1： | 3 |
| 13 | Pseudoaneurysm of the Common Hepatic Artery: Treatment with a Stent-Graft显示文摘 | Enrico Paci Ettore Antico Roberto Candelari Salvatore Alborino Cristina Marmorale Eduardo Landi | 2000 | CardioVascular and Interventional Radiology2000，，6： | 3 |
| 14 | Headache, anxiety and depressive disorders: the HADAS study显示文摘 | Ettore Beghi Gennaro Bussone Domenico D’Amico Pietro Cortelli Sabina Cevoli Gian Camillo Manzoni Paola Torelli Maria Clara Tonini Giovanni Allais Roberto Simone Florindo D’Onofrio Sergio Genco Franca Moschiano Massimiliano Beghi Sara Salvi | 2010 | The Journal of Headache and Pain2010，，2： | 3 |
| 15 | Targeting of acute myeloid leukaemia by cytokine‐induced killer cells redirected with a novel CD 123‐specific chimeric antigen receptor显示文摘 | Sarah Tettamanti Virna Marin Irene Pizzitola Chiara F. Magnani Greta M. P. Giordano Attianese Elisabetta Cribioli Francesca Maltese Stefania Galimberti Angel F. Lopez Andrea Biondi Dominique Bonnet Ettore Biagi | 2013 | Br J Haematol2013，，3： | 3 |
| 16 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 17 | Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study显示文摘 | Mario Pirisi Claudio Avellini Carlo Fabris Cathryn Scott Paola Bardus Giorgio Soardo Carlo A. Beltrami Ettore Bartoli | 1998 | Journal of Cancer Research and Clinical Oncology1998，，： | 2 |
| 18 | Identification of the pharmaceuticals for human use contaminating the Italian aquatic environment显示文摘 | Ettore Zuccato Sara Castiglioni Roberto Fanelli | 2005 | Journal of Hazardous Materials2005，，3： | 2 |
| 19 | Analysis of structural vulnerabilities in power transmission grids显示文摘 | Ettore Bompard Roberto Napoli Fei Xue | 2009 | International Journal of Critical Infrastructure Protection2009，，1： | 2 |
| 20 | Wip1 Phosphatase Regulates p53-Dependent Apoptosis of Stem Cells and Tumorigenesis in the Mouse Intestine显示文摘 | Oleg N. Demidov Oleg Timofeev Hnin N.Y. Lwin Calvina Kek Ettore Appella Dmitry V. Bulavin | 2007 | Cell Stem Cell2007，，2： | 2 |
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