|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 2 | Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study显示文摘 | Mario Pirisi Claudio Avellini Carlo Fabris Cathryn Scott Paola Bardus Giorgio Soardo Carlo A. Beltrami Ettore Bartoli | 1998 | Journal of Cancer Research and Clinical Oncology1998，，： | 2 |
| 3 | Increased serum resisitin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance 显示文摘 | Pagano C Soardo G Pilon C | 2005 | J Clin Endocrinol Metab2005，91，： | 1 |
| 4 | Systematic use of recurrent laryngeal nerve neuromonitoring changes the operative strategy in planned bilateral thyroidectomy 显示文摘 | Sadowski SM Soardo P Leuchter I | 2013 | Thyroid2013，23，3： | 1 |
| 5 | Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance 显示文摘 | Pagano C Soardo G Pilon C | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 6 | Systematic use of recurrent laryngeal nerve neuromonitoring changes the operative strategy in planned bilateral thyroidectomy显示文摘 | Sadowksi SM Soardo P Leuchter I | 2012 | Thyroid2012，23，3： | 1 |
| 7 | Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance显示文摘 | Pagano C Soardo G Pilon C | 2006 | J Clin E ndocrinol Metab2006，91，3： | 1 |
| 8 | Dependence of power losses on peak magnetization and magnetization frequency in grain-oriented and non-oriented 3%Si Fe显示文摘 | BERTOTTI G FIORILLO F SOARDO G | 1987 | IEEE Transactions on Magnetics1987，23，5： | 1 |
| 9 | Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance显示文摘 | Pagano C Soardo G Pilon C | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 10 | Plasma adiponectin is decre-ased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soardo G Esposito W etal | 2005 | European journal of en- docrinology / European Federation of Endocrine Societies2005，152，1： | 1 |
| 11 | Circulating and adipose tissue ex-pression of Visfatin in non-alcoholic fatty liver disease显示文摘 | Soardo G Pagano C Donnini D | 2006 | J Hepatol2006，44，2： | 1 |
| 12 | Increased serum resisfin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance 显示文摘 | Pagano C Soardo G Pilon C | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 13 | Plasma adiponectin is decreased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soardo G Esposito W | 2005 | Eur J Endocrinol2005，152，1： | 1 |
| 14 | Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance 显示文摘 | Pagano C Soardo G Pilon C | 2006 | J clin Endocrin Metab2006，91，3： | 1 |
| 15 | Increased serum Visfatin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance 显示文摘 | Pagano C Soardo G PilIon C | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 16 | Plasma adiponectin is decreased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soardo G Esposito W | 2005 | Eurl Endocrinol2005，152，1： | 1 |
| 17 | Dependence of power losses on peak magnetization and magnetization frequency in gain-oriented and non-oriented 3% SiFe显示文摘 | BERTOTYI G FIORILLO F SOARDO G P | 1987 | IEEE Transactions on Magnetics1987，23，5： | 1 |
| 18 | Plasma adiponectin is decreased in nonalcoholic fatty liver disease 显示文摘 | Pagano C Soardo G Esposito W | 2005 | Eur J Endocrinol2005，152，： | 1 |
| 19 | Effects of alcohol with- drawal on blood pressure in hypertensive heavy drinkers显示文摘 | Soardo G Donnini D Varutti R | 2006 | J Hypertens2006，24，8： | 1 |
| 20 | Increased serum resis- tin in nonalcoholic fatty liver disease is related to liver disease severity and not toinsulin resistance显示文摘 | Pagano C Soardo G Pilon C | 2006 | J Clin En- docrinol Metab2006，91，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员