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| 1 | Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors显示文摘AIM:To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease(GERD) patients with persistent symptoms who are non-responsive to medical therapy.METHODS:Sixty-five patients(40 male,25 female;mean age,50 ± 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor(PPI) therapy,as well as 18 patients with Barrett's esophagus,were studied.All patients filled out symptom questionnaires and underwent endoscopy,manometry and combined pH-metry and bilimetry.RESULTS:There were 4 groups of patients:22(26.5%) without esophagitis,24(28.9%) grade A-B esophagitis,19(22.8%) grade C-D and 18(21.6%) Barrett's esophagus.Heartburn was present in 71 patients(85.5%) and regurgitation in 55(66.2%),with 44(53%) reporting simultaneous heartburn and regurgitation.The prevalence of pathologic acid reflux in the groups without esophagitis and with grades A-B and C-D esophagitis was 45.4%,66.6% and 73.6%,respectively.The prevalence of pathologic bilirubin exposure in these 3 groups was 53.3%,75% and 78.9%,respectively.The overall prevalence of bile reflux in non-responsive patients was 68.7%.Pathologic acid and bile reflux was observed in 22.7% and 58.1% of non-esophagitic patients and esophagitic patients,respectively.CONCLUSION:The high percentage of patients poorly responsive to PPI therapy may result from poor control of duodenogastroesophageal reflux.Many patients without esophagitis have simultaneous acid and bile reflux,which increases with increasing esophagitis grade. | Luigi Monaco Antonio Brillantino Francesco Torelli Michele Schettino Giuseppe Izzo Angelo Cosenza Natale Di Martino | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Adenocarcinoma of gastric cardia in the elderly: Surgical problems and prognostic factors显示文摘AIM: To analyze retrospectively, our results about patients who underwent surgical treatment for adenocarcinoma of the cardia in relation to age, in order to evaluate surgical problems and prognostic factors.METHODS: From January 1987 to March 2003, 140 patients with adenocarcinoma of the cardia underwent resection in the authors' institution. They were divided into three groups with regard to age. Patients <70 and >60 year old (31) were excluded; we also excluded 18 out of 109 patients with poor general status or systemic metastases. So, we compared 51 elderly (≥ 70 year old)and 58 younger patients (≤ 60 year old). The treatment was esophagectomy for type Ⅰ tumors, and extended gastrectomy and distal esophagectomy for type Ⅱ and Ⅲ lesions.RESULTS: Laparotomy was carried out in 91 patients (83.4%), 38 in the elderly (74.5%) and 53 in younger patients (91.3%, P<0.05). Primary resection was performed in 811 cases (89%) without significant differences between the two groups. Postoperative death was higher in the elderly (12.1%) than the other group (4.1%, P<0.05), while morbidity was similar in both groups. A curative resection (R0) was performed in 59 patients (72.8%), 69.6% in the elderly and 75% in the younger group (P>0.05). The overall 3- and 5-year survival rates were 26.7% and 117.8% respectively for the elderly and 40.7% and 35.1% respectively for younger patients (P = 0.1544). Survival rates were significantly associated with R0 resection,pathological node-positive category and tumor differentiation in both groups.CONCLUSION: As the age of the general population increases, more elderly patients with gastric cardia cancer will be candidates for surgical resection. Age alone should not preclude surgical treatment in elderly patients with gastric cardia cancer and a tumor resection can be carried out safely. Certainly, we should take care in defining the surgical treatment in elderly patients, particularly as regarding the surgical approach; although the surgical approach does not influence the survival rate, the transhiatal way still remains the best one due, to the lower incidence of respiratory morbidity and thoracic pain. | Natale Di Martino Giuseppe Izzo Angelo Cosenza Guido Cerullo Francesco Torelli Antonio Brillantino Alberto del Genio | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 3 | Headache, anxiety and depressive disorders: the HADAS study显示文摘 | Ettore Beghi Gennaro Bussone Domenico D’Amico Pietro Cortelli Sabina Cevoli Gian Camillo Manzoni Paola Torelli Maria Clara Tonini Giovanni Allais Roberto Simone Florindo D’Onofrio Sergio Genco Franca Moschiano Massimiliano Beghi Sara Salvi | 2010 | The Journal of Headache and Pain2010，，2： | 3 |
| 4 | Laparoscopic splenectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES)显示文摘 | B. Habermalz S. Sauerland G. Decker B. Delaitre J.-F. Gigot E. Leandros K. Lechner M. Rhodes G. Silecchia A. Szold E. Targarona P. Torelli E. Neugebauer | 2008 | Surgical Endoscopy2008，，4： | 3 |
| 5 | Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori : A Clinical Trial显示文摘 | Giovanni Cammarota Giovanna Branca Fausta Ardito Maurizio Sanguinetti Gianluca Ianiro Rossella Cianci Riccardo Torelli Giovanna Masala Antonio Gasbarrini Giovanni Fadda Raffaele Landolfi Giovanni Gasbarrini | 2010 | Clinical Gastroenterology and Hepatology2010，，9： | 3 |
| 6 | Rapid maxillary expansion in the deciduous and mixed dentition evaluated through posteroanterior cephalometric analysis显示文摘 | Da Silva Filho O G Montes I A Torelly I F | 1995 | Am J Orthod Dentofacial Or-thop1995，107，3： | 1 |
| 7 | Headache classification:criticism and suggestions显示文摘 | Manzoni GC Torelli P | 2004 | Neurol Sci2004，25，3： | 1 |
| 8 | A high-quality sine-wave oscillator for analog built-in self-testing显示文摘 | DOMINGUEZ M A AUSIN J L DUQUECARILLO J F TORELLI G | 2006 | IEEE Circuits and Systems2006，，5： | 1 |
| 9 | Electronic nose predicts high and low fumonisin contamination in maize cul- tures 显示文摘 | Gobbi E Falasconi M Torelli E | 2011 | Food Research International2011，44，4： | 1 |
| 10 | Headache classification : criticism and suggestions显示文摘 | Manzoni GC Torelli P | 2004 | Neurol Sci2004，25，3： | 1 |
| 11 | Defective expression of the Tcell receptor-CD3 zeta chain in T-cell acute lymphoblastic leukaemia 显示文摘 | TORELLI G F PAOLINI R TATARELLI C | 2003 | Br J Haematol2003，120，2： | 1 |
| 12 | Cognitive profile and brain morphological changes in obstructive sleep apnea 显示文摘 | Torelli F Moscufo N Garreffa G | 2011 | Neuroimage2011，54，： | 1 |
| 13 | Contribution of CgPDRI - regulated genes in enhanced virulence of azole - resistant Candida glabrata 显示文摘 | Ferrari S Sanguinetti M Torelli R | 2011 | PLoS One2011，6，17： | 1 |
| 14 | 2D Euclidean distance transform algorithms:A comparative survey显示文摘 | FABBRI R COSTA L D F TORELLI J C | | 0，，01： | 1 |
| 15 | Headache classification:criticism and suggestions显示文摘 | Manzoni GC Torelli P | 2004 | Neurol Sci2004，25，3： | 1 |
| 16 | Assessment of a new mathematical model for the computation of numerical parameters related to renal cortical blood flow and fractional blood volume by contrast- enhanced uhrasound显示文摘 | Quaia E Nocentini A Torelli L | 2009 | Ultrasound Med Biol2009，35，： | 1 |
| 17 | Input/Output Rail-to-Rail CMOS Operational Amplifier with Shaped Common-Mode Response显示文摘 | J. F. Duque-Carrillo J. M. Carrillo J. L. Ausín G. Torelli | 2003 | Analog Integrated Circuits and Signal Processing2003，，3： | 1 |
| 18 | Cognitive profile and brain morphological changes in obstructive sleep apnea显示文摘 | Torelli F Moscufo N Garreffa G | 2011 | Neuroimage2011，54，： | 1 |
| 19 | Human acute stem cell leukemia with muhilineage differentiation potential via cascade activation of growth factor receptors 显示文摘 | TESTA U TORELLI GF RICCIONI R | 2002 | Blood2002，99，12： | 1 |
| 20 | A coherency recognition based on structural decomposition procedure显示文摘 | Enrico De Tuglie Silvio Marcello Iannone Francesco Torelli | 2008 | IEEE Transactions on Power Systems2008，23，2： | 1 |
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