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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 3 | En bloc resection for locally advanced cancer of the pancreas: Is it worthwhile?显示文摘 | Aaron R. Sasson M.D. John P. Hoffman M.D. Eric A. Ross Ph.D. Steven A. Kagan James F. Pingpank M.D. Burton L. Eisenberg M.D | 2002 | Journal of Gastrointestinal Surgery2002，，2： | 4 |
| 4 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 5 | Characterization of Hepatitis C Virus Resistance from a Multiple-Dose Clinical Trial of the Novel NS5A Inhibitor GS-5885显示文摘 | Kelly A. Wong Angela Worth Ross Martin Evguenia Svarovskaia Diana M. Brainard Eric Lawitz Michael D. Miller Hongmei Mo | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 2 |
| 6 | Dynamics of protein expression during pollen germination in canola (Brassica napus)显示文摘 | Inder S. Sheoran Eric J. Pedersen Andrew R. S. Ross Vipen K. Sawhney | 2009 | Planta2009，，4： | 1 |
| 7 | Dietary Selenium (Se) and Copper (Cu) Interact to Affect Homocysteine Metabolism in Rats显示文摘 | Eric O. Uthus Sharon Ross | 2009 | Biological Trace Element Research2009，，1： | 1 |
| 8 | Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives显示文摘 | Ya-Hui Chuang Zhe-Xiong Lian Chun-Mei Cheng Ruth Y. Lan Guo-Xiang Yang Yuki Moritoki Bor-Luen Chiang Aftab A. Ansari Koichi Tsuneyama Ross L. Coppel M. Eric Gershwin | 2005 | Journal of Autoimmunity2005，，2： | 1 |
| 9 | The interaction of BMXD and its copper ( Ⅱ ) complexes with glycine, aspartic acid, and histidine显示文摘 | Eric Ross Ramunas J Motekaitis Arthur E Martel | 1999 | Inorg Chim Acta1999，286，1： | 1 |
| 10 | Lung cancer and cyclooxygenase-2显示文摘 | J.Esteban Castelao Robert D Bart Costanzo A DiPerna Eric M Sievers Ross M Bremner | 2003 | The Annals of Thoracic Surgery2003，，4： | 1 |
| 11 | Paclitaxel (Taxol) 显示文摘 | Eric K Rowinsky MD Ross C | 1995 | N Engl J Med1995，332，15： | 1 |
| 12 | Performance and Behavior of (Oncorhynchus Clarki) Reared in or Demand Fed Cutthroat Trout Covered Raceways显示文摘 | Eric J W David A Ross D R | | 0，，： | 1 |
| 13 | Hepatic IL-17 responses in human and murine primary biliary cirrhosis显示文摘 | Ruth Y.Z. Lan Thucydides L. Salunga Koichi Tsuneyama Zhe-Xiong Lian Guo-Xiang Yang Willy Hsu Yuki Moritoki Aftab A. Ansari Claudia Kemper Jeff Price John P. Atkinson Ross L. Coppel M. Eric Gershwin | 2008 | Journal of Autoimmunity2008，，1： | 1 |
| 14 | Paclitaxel(Taxol) 显示文摘 | ERIC K ROWINSKY M D ROSS C | 1995 | The New England Journal of Medicin1995，13，4： | 1 |
| 15 | SmedGD: the Schmidtea mediterranea genome database显示文摘 | Sofia M C Robb Eric Ross Alejandro Sclnchez Alvarado | 2008 | Nucleic Acids Res2008，36，： | 1 |
| 16 | An assessment of the necessity of transfusion during pancreatoduodenectomy显示文摘 | Amelia Ross Somala Mohammed George VanBuren Eric J. Silberfein Avo Artinyan Sally E. Hodges William E. Fisher | 2013 | Surgery2013，，3： | 1 |
| 17 | Intraventricular Thrombolysis Speeds Blood Clot Resolution: Results of a Pilot, Prospective, Randomized, Double-blind, Controlled Trial显示文摘 | Neal J. Naff Daniel F. Hanley Penelope M. Keyl Stanley Tuhrim Michael Kraut Joshua Bederson Ross Bullock Stephan A. Mayer Eric Schmutzhard | 2004 | Neurosurgery2004，，3： | 1 |
| 18 | Primary biliary cirrhosis显示文摘 | Carlo Selmi Christopher L Bowlus M Eric Gershwin Ross L Coppel | 2011 | 2011 (9777)2011，，9777： | 1 |
| 19 | Quantitative genetics and heritability of growth- related traits in hybrid striped bass(Morone chrysops ♀× Morone saxatilis ♂) 显示文摘 | WANG X X ROSS K E ERIC SAILLANT E | 2006 | Aquaculture2006，261，2： | 1 |
| 20 | A prospective study of continuous intravenous milrinone therapy for status IB patients awaiting heart transplant at home显示文摘 | Susan C. Brozena Carol Twomey Lee R. Goldberg Shashank S. Desai Brian Drachman Andrew Kao Eric Popjes Ross Zimmer Mariell Jessup | 2004 | Journal of Heart and Lung Transplantation2004，，： | 1 |
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