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| 1 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 2 | The Immune System and the Role of Inflammation in Perinatal Depression显示文摘Major depression during pregnancy is a common psychiatric disorder that arises from a complex and multifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic–pituitary–adrenal axis hyperactivity. Dysregulation of this intricate neuroimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neuropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during pregnancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Th1/Th2 bias towards a predominant Th1/Th17 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy. | Philippe Leff-Gelman Ismael Mancilla-Herrera Monica Flores-Ramos Carlos Cruz-Fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio | 2016 | Neuroscience Bulletin2016，32，4： | 17 |
| 3 | Perioperative visual loss after spine surgery显示文摘Perioperative visual loss(POVL) is an uncommon, but devastating complication that remains primarily associated with spine and cardiac surgery. The incidence and mechanisms of visual loss after surgery remain difficult to determine. According to the American Society of Anesthesiologists Postoperative Visual Loss Registry, the most common causes of POVL in spine procedures are the two different forms of ischemic optic neuropathy: anterior ischemic optic neuropathy and posterior ischemic optic neuropathy, accounting for 89% of the cases. Retinal ischemia, cortical blindness, and posterior reversible encephalopathy are also observed, but in a small minority of cases. A recent multicenter case control study has identified risk factors associated with ischemic optic neuropathy for patients undergoing prone spinal fusion surgery. These include obesity, male sex, Wilson frame use, longer anesthetic duration, greater estimated blood loss, and decreased percent colloid administration. These risk factors are thought to contribute to the elevation of venous pressure and interstitial edema, resulting in damage to the optic nerve by compression of the vessels that feed the optic nerve, venous infarction or direct mechanical compression. This review will expand on these findings as well as the recently updated American Society of Anesthesiologists practice advisory on POVL. There are no effectivetreatment options for POVL and the diagnosis is often irreversible, so efforts must focus on prevention and risk factor modification. The role of crystalloids versus colloids and the use of α-2 agonists to decrease intraocular pressure during prone spine surgery will also be discussed as a potential preventative strategy. | Travis J Nickels Mariel R Manlapaz Ehab Farag | 2014 | World Journal of Orthopedics2014，5，2： | 7 |
| 4 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 6 |
| 5 | Cancer stem cell impact on clinical oncology显示文摘Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo-and radio-resistance. Several mechanisms have been studied to explain chemo-and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes. Interestingly, the presence of cancer stem cells(CSCs), which are a subset of cells within the tumors, has been related to therapy resistance. In this review, we focus on evaluating the presence of CSCs in different tumors such as breast cancer, gastric cancer, lung cancer, and hematological neoplasias, highlighting studies where CSCs were identified in patient samples. It is evident that there has been a great drive to identify the cell surface phenotypes of CSCs so that they can be used as a tool for anti-tumor therapy treatment design. We also review the potential effect of nanoparticles, drugs, natural compounds, aldehyde dehydrogenase inhibitors, cell signaling inhibitors, and antibodies to treat CSCs from specific tumors. Taken together, we present an overview of the role of CSCs in tumorigenesis and how research is advancing to target these highly tumorigenic cells to improve oncology patient outcomes. | Mariel E Toledo-Guzmán Gabriele D Bigoni-Ordonez Miguel Ibanez Hernandez Elizabeth Ortiz-Sánchez | 2018 | World Journal of Stem Cells2018，10，12： | 4 |
| 6 | Atrial Fibrillation and Heart Failure: Treatment Considerations for a Dual Epidemic显示文摘 | Elad Anter Mariell Jessup David J. Callans | 2009 | Circulation2009，，18： | 2 |
| 7 | 2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Clyde W. Yancy Mariell Jessup Biykem Bozkurt Javed Butler Donald E. Casey Mark H. Drazner Gregg C. Fonarow Stephen A. Geraci Tamara Horwich James L. Januzzi Maryl R. Johnson Edward K. Kasper Wayne C. Levy Frederick A. Masoudi Patrick E. McBride John J.V. | 2013 | Circulation2013，，16： | 2 |
| 8 | Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats显示文摘 | Leobardo Gaona-Gaona Eduardo Molina-Jijón Edilia Tapia Cecilia Zazueta Rogelio Hernández-Pando Mariel Calderón-Oliver Guillermo Zarco-Márquez Enrique Pinzón José Pedraza-Chaverri | 2011 | Toxicology2011，，1： | 2 |
| 9 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 2 |
| 10 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | 2011 (9785)2011，，9785： | 2 |
| 11 | Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure显示文摘 | Maria Rosa Costanzo Maya E. Guglin Mitchell T. Saltzberg Mariell L. Jessup Bradley A. Bart John R. Teerlink Brian E. Jaski James C. Fang Erika D. Feller Garrie J. Haas Allen S. Anderson Michael P. Schollmeyer Paul A. Sobotka | 2007 | Journal of the American College of Cardiology2007，，6： | 2 |
| 12 | Advances in managing hepatocellular carcinoma显示文摘为 hepatocellular 癌的治疗的多重形式是可得到的,取决于肿瘤尺寸和数字。外科的切除术仍然是标准答案,只要剩余肝功能储备是足够的。在有先进肝硬化的病人,肝移植是比较喜欢的选择,当这些病人不能在切除术以后有足够的肝的保守。抢救肝移植也为精选很少成为了一种选择在外科的切除术以后复发的病人。夺格的技术被用于减轻以及完全破坏肿瘤到也,充当附属物到切除术,或向舞台前方满足米兰标准以便一个病人可以是肝移植的一个候选人的肿瘤。Radiofrequency 脱离,微波脱离, chemoembolization, radioembolization,和不可逆的 electroporation 都在这个能力被使用了。当前, sorafenib 是唯一的美国食物和药同意管理为 hepatocellular 化学疗法癌。sorafenib 的功效在有另外的代理人的联合, transarterial chemoembolization,和外科的切除术当前正在被调查。Sunitinib 和 brivanib,酷氨酸 kinase 禁止者,为化疗作为潜在的首要或第二线的选择失败了。在有 erlotinib 的联合的 Bevacizumab 当前也正在被学习。为 ramucirumab 和 axitinib 的最后的分析是未解决的。Tivantinib,一个选择间充质上皮的转变因素(相遇) 禁止者,也在遇见高度肿瘤为功效正在经历临床的试用。这评论服务强调出现在 hepatocellular 癌的治疗的当前、新的技术。 | Marielle Reataza David K. Imagawa | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 13 | Prevalence of and risk factors for malaria,filariasis,and intestinal parasites as single infections or co-infections in different settlements of Gabon,Central Africa显示文摘Background:Malaria,filariasis,and intestinal parasitic infections(IPIs)are common and frequently overlap in developing countries.The prevalence and predictors of these infections were investigated in three different settlements(rural,semi-urban,and urban)of Gabon.Methods:During cross-sectional surveys performed from September 2013 to June 2014,451 individuals were interviewed.In addition,blood and stool samples were analysed for the presence of Plasmodium,filarial roundworm,intestinal protozoan,and helminth infections.Results:Intestinal parasitic infections(61.1%),including intestinal protozoa(56.7%)and soil-transmitted helminths(STHs)(22.2%),predominated,whereas Plasmodium falciparum(18.8%),Loa loa(4.7%),and Mansonella perstans(1.1%)were less prevalent.Filariasis and STHs were mainly found in rural settlements,whereas a higher plasmodial infection prevalence rate was observed in the periurban area.The most common IPI was blastocystosis(48.6%),followed by ascaridiasis(13.7%),trichuriasis(11.8%),amoebiasis(9.3%),giardiasis(4.8%),and strongyloidiasis(3.7%).Hookworm was detected in one adult from rural Dienga.Adults had a higher prevalence of Blastocystis hominis and STHs,whereas Giardia duodenalis was more frequently observed among children aged below 5 years(P<0.01).The polyparasitism rate was 41.5%,with 7.0%Plasmodium-IPIs and 1.8%Plasmodium-STH co-infections.The multivariate analysis showed that living in a suburban area,belonging to the age group of 5-15 years,having none or a secondary education,or having an open body water close to home were significant risk factors for malaria(P≤0.01).For STH infections,identified risk factors were drinking untreated water and living in a rural area(P≤0.04).No significant predictors were identified for IPIs and malaria-IPI co-infection.Conclusions:This study reports a high prevalence of IPIs and intestinal protozoa,but a low rate of malaria-IPI co-infections in the study sites.Improvements in the living conditions of the population such as adequate water supply and proper health education and sanitation should be integrated into control strategies for malaria,STHs,and IPIs. | Noe Patrick M’bondoukwe Eric Kendjo Denise Patricia Mawili-Mboumba Jeanne Vanessa Koumba Lengongo Christelle Offouga Mbouoronde Dieudonne Nkoghe Fousseyni Toure Marielle Karine Bouyou-AkotetAuthor details | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 14 | Protective effect of sulforaphane against oxidative stress: Recent advances显示文摘 | Carlos Enrique Guerrero-Beltrán Mariel Calderón-Oliver José Pedraza-Chaverri Yolanda Irasema Chirino | 2010 | Experimental and Toxicologic Pathology2010，，5： | 2 |
| 15 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，14： | 2 |
| 16 | NMDA receptor involvement in spatial delayed alternation in developing rats显示文摘 | Deborah J Watson Mariel R | 2009 | Behav Neurosci2009，123，1： | 1 |
| 17 | The white spot syndrome virus envelope protein VP28 is involved in the irlfection of shrimp显示文摘 | Marielle C W van Hulten Jeroen Witteveldt Marjolein Snippe M Vlak | 2001 | Virology2001，285，： | 1 |
| 18 | Reduced levels of specific autobiographical memories in schizophrenia显示文摘 | Marielle Riutort Christine Cuervo Jean-Marie Danion Charles Siegfried Peretti Pierre Salamé | 2002 | Psychiatry Research2002，，1： | 1 |
| 19 | A model of optimal advertising expenditures in a dynamic duopoly显示文摘 | Espinosa MP Mariel P | 2001 | Atlantic Economic Journal2001，29，2： | 1 |
| 20 | 2009 Focused Update Incorporated Into the ACc/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults 显示文摘 | Mariell Jessup William T Abraham Donald E Casey | 2009 | Circulation2009，119，14： | 1 |
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