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| 1 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 2 | 花椒毒素在人体皮肤及角质层中的渗透动力学探讨显示文摘目的探讨花椒毒素在人体完整皮肤及其角质层中的渗透动力学特性。方法采用人体离体皮肤及从完整皮肤中分离出的角质层,在Franz-cell扩散池中进行不同浓度的花椒毒素乙醇溶液(0.1,0.5,2.5和5.0 mg.mL-1)的渗透实验,均采用1.4%的人血清溶液作为接收液,用HPLC法测定各接收液的药物量和皮肤中的贮存药物量。结果花椒毒素乙醇溶液单位面积透过完整人皮肤速率随着浓度增加而增加,2.5 mg.mL-1以上的浓度对其速率几乎无影响。在角质层中也存在同样的现象,但其单位面积透皮速率最大值提前了约6 h。而且随着给药浓度的增加,24 h后完整皮肤和角质层的药物贮存量也相应增加,但达到一定浓度后存在饱和现象。且花椒毒素乙醇溶液在完整皮肤中的透皮时滞(0.82 h)明显大于在角质层中的透皮时滞(0.47 h)。结论该结果对开发花椒毒素外用制剂时浓度的选择提供了依据,并对其外用药物后照射长波段紫外光(UVA)的时间提供了参考。 | 王来友 Jelle Millet 黄芳芳 杨得坡 | 2006 | 药学学报2006，41，9： | 10 |
| 3 | 颈部动脉夹层分离及其与颈椎推拿疗法的联系:美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘目的:颈部动脉夹层分离(cervicalarterydissection,CD)是中青年人卒中的最常见病因。本指南旨在对CD诊治的现有证据水平以及其与颈椎推拿疗法(cervical manipulative therapy, CMT)的统计学联系进行回顾。某些类型的CMT是由医疗专业人员对颈椎施加猛烈或轻柔的推力。方法写作组成员由美国心脏协会卒中委员会的科学声明监督委员会以及美国心脏协会的手稿监督委员会任命。各成员负责与其专业领域相关的主题,回顾适当的文献并参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有证据进行总结并指出目前的知识空白。结果CD患者可表现为单侧头痛、后颈部痛或主要由动脉-动脉栓塞导致的脑或视网膜缺血(短暂性缺血或卒中)、CD脑神经麻痹、眼交感神经麻痹或搏动性耳鸣。CD的诊断依赖于完整的病史、体格检查和针对性的辅助检查。尽管轻微创伤的作用存在争议,但机械压力可造成椎动脉和颈内动脉内膜损伤,进而导致CD。CD患者的残疾程度存在差异,一些患者预后良好,但有些患者则会出现严重神经系统后遗症。目前尚无循证指南可用来指导CD的最佳处理策略。抗血小板和抗凝治疗均被用于局部血栓和继发性栓塞的预防。病例对照研究和其他文献提示CD[尤其是椎动脉夹层分离(vertebral artery dissection, VAD)]与CMT之间存在流行病学联系,但尚不清楚这是由于对先前存在的CD认识不足还是CMT导致的创伤。超声、CT血管造影以及磁共振血管造影都有助于CD的诊断。神经影像学随访首选无创性检查措施,但我们认为任何单一的检查方法都不能作为金标准。结论 CD是中青年患者发生缺血性卒中的重要病因。CD最好发于颈椎上段,可累及颈内动脉或椎动脉。尽管目前的生物力学证据不足以证实CMT 可导致CD,但临床报道提示机械压力在相当一部分CD中起着一定的作用,而且大多数基于人群的对照研究在年轻患者中显示CMT与VAD卒中之间存在联系。尽管对于曾经接受过CMT的患者,CMT相关性CD的发生率尚不完全清楚并且很可能较低,但当有临床症状时,医生应考虑到CD的可能性,并且在进行颈椎推拿前告知患者CD与CMT之间的统计学联系。 | José Biller Ralph L. Sacco Felipe C. Albuquerque Bart M. Demaerschalk Pierre Fayad Preston H. Long Lori D. Noorollah Peter D. Panagos Wouter I. Schievink Neil E. Schw artz Ashfaq Shuaib David E. Thaler David L. Tirschw ell 牛牧 陈进 宋艳 吴丹 王玉琴 柯开富 | 2015 | 国际脑血管病杂志2015，23，5： | 8 |
| 4 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 5 | Nickel ferrite spinel as catalyst precursor in the dry reforming of methane:Synthesis,characterization and catalytic properties显示文摘Dry reforming of methane by CO2 using nickel ferrite as precursor of catalysts was investigated.Nickel ferrite crystalline particles were prepared by coprecipitation of nitrates with NaOH or ammonia followed by calcination,or by hydrothermal synthesis without calcination step.The textural and structural properties were determined by a number of analysis methods,including X-ray diffraction (XRD),Raman spectroscopy and X-ray photoelectron spectroscopy (XPS),among which X-ray diffraction (XRD) was at room and variable temperatures.All synthesized oxides showed the presence of micro or nanoparticles of NiFe2O4 inverse spinel,but Fe2O3 (hematite) was also present when ammonia was used for coprecipitation.The reducibility by hydrogen was studied by temperature-programmed reduction (TPR) and in situ XRD,which showed the influence of the preparation method.The surface area (BET),particle size (Rietveld refinement),as well as surface Ni/Fe atomic ratio (XPS) and the behavior upon reduction varied according to the synthesis method.The catalytic reactivity was investigated using isopropanol decomposition to determine the acid/base properties.The catalytic performance of methane reforming with CO2 was measured with and without the pre-treatment of catalysts under H2 in 650-800 C range.The catalytic conversions of methane and CO2 were quite low but they increased when the catalysts were pre-reduced.A significant contribution of reverse water gas shift reaction accounted for the low values of H2 /CO ratio.No coking was observed as shown by the reoxidation step performed after the catalytic reactions.The possible formation of nickel-iron alloy observed during the study of reducibility by hydrogen was invoked to account for the catalytic behavior. | Rafik Benrabaa Hamza Boukhlouf Axel Lfberg Annick Rubbens Rose-Nelle Vannier Elisabeth Bordes-Richard Akila Barama | 2012 | Journal of Natural Gas Chemistry2012，21，5： | 5 |
| 6 | Accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancer显示文摘 | O. Pech E. Günter F. Dusemund J. Origer D. Lorenz C. Ell | 2010 | Endoscopy2010，，06： | 3 |
| 7 | A LED-based smart illumination system for studying plant growth显示文摘 | Olvera-Gonzalez E Alaniz-Lumbreras D Torres-Arg?elles V Gonz?lez-Ram?rez E Villa-Hern?ndez J Araiza-Esquivel M Ivanov-Tsonchev R Olvera-Olvera C Casta?o VM | 2014 | Lighting Research and Technology2014，，2： | 2 |
| 8 | Phakic intraocular lenses显示文摘 | Thomas Kohnen Daniel Kook Merce Morral Jose Luis Güell | 2010 | Journal of Cataract & Refractive Surgery2010，，12： | 2 |
| 9 | Curative endoscopic resection of early esophageal adenocarcinomas (Barrett’s cancer)显示文摘 | Christian Ell Andrea May Oliver Pech Liebwin Gossner Erwin Guenter Angelika Behrens Lars Nachbar Josephus Huijsmans Michael Vieth Manfred Stolte | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 10 | The First Prospective Controlled Trial Comparing Wireless Capsule Endoscopy with Push Enteroscopy in Chronic Gastrointestinal Bleeding显示文摘 | C. Ell S. Remke A. May L. Helou R. Henrich G. Mayer | 2002 | Endoscopy2002，，09： | 2 |
| 11 | Double-balloon enteroscopy (push-and-pull enteroscopy) of the small bowel: feasibility and diagnostic and therapeutic yield in patients with suspected small bowel disease <ce:link locator='fx1'/>显示文摘 | Andrea May Lars Nachbar Christian Ell | 2005 | Gastrointestinal Endoscopy2005，，1： | 2 |
| 12 | A vital sugar code for ricin toxicity显示文摘 | Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger | 2017 | Cell Research2017，27，11： | 2 |
| 13 | Prospective, cross-over, single-center trial comparing oral double-balloon enteroscopy and oral spiral enteroscopy in patients with suspected small-bowel vascular malformations显示文摘 | A. May H. Manner I. Aschmoneit C. Ell | 2011 | Endoscopy2011，，06： | 2 |
| 14 | Early oral feeding after pancreatoduodenectomy enhances recovery without increasing morbidity显示文摘 | Arja Gerritsen Roos A. W. Wennink Marc G. H. Besselink Hjalmar C. Santvoort Dorine S. J. Tseng Elles Steenhagen Inne H. M. Borel Rinkes I. Quintus Molenaar | 2014 | HPB2014，，： | 2 |
| 15 | Water-aided colonoscopy: a systematic review显示文摘 | Felix W. Leung Arnaldo Amato Christian Ell Shai Friedland Judith O. Harker Yu-Hsi Hsieh Joseph W. Leung Surinder K. Mann Silvia Paggi Jürgen Pohl Franco Radaelli Francisco C. Ramirez Rodelei Siao-Salera Vittorio Terruzzi | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 16 | Postoperative complications and weight loss following jejunostomy tube feeding after total gastrectomy for advanced adenocarcinomas显示文摘Objective: Patients undergoing total gastrectomy for cancer are at risk of malnourishment. The aim of this selfcontrolled study was to examine the effect of jejunostomy tube feeding(JTF) and other factors on postoperative weight and the incidence of jejunostomy-related complications in patients undergoing total gastrectomy for cancer.Methods: All consecutive patients who underwent total gastrectomy for gastric cancer with jejunostomy placement were included from a prospective single-center database(2003–2014). Jejunostomy-related complications and postoperative weight changes were evaluated up to 12 months after surgery. Multivariable linear regression analysis was performed to identify factors associated with weight loss 12 months after gastrectomy.Results: Of 113 patients operated in the study period, 65 received JTF after total gastrectomy for a median duration of 18 d [interquartile range(IQR), 10–55 d]. Jejunostomy-related complications occurred in 11(17%)patients, including skin leakage(n=3) and peritoneal leakage(n=2), luxation(n=3), occlusion(n=2), infection(n=1)and torsion(n=1). In 2(3%) patients, a reoperation was needed due to jejunostomy-related complications. The mean preoperative weight of patients was 71.8 kg(100%), and remained stable during JTF(73.9 kg, 103%,P=0.331). After JTF was stopped, the mean weight of patients decreased to 64.9 kg(90%) at 12 months after surgery(P<0.001). A high preoperative body mass index(BMI)(≥25 kg/m^2) was associated with high postoperative weight loss compared to patients with a low BMI(<25 kg/m^2)(16.3% vs. 8.6%, P=0.016).Conclusions: JTF can prevent weight loss in the early postoperative phase. However, this is at the prize of possible complications. As weight loss in the long term is not prevented, routine JTF should be re-evaluated and balanced against the selected use in preoperatively malnourished patients. Special attention should be paid to patients with a high preoperative BMI, who are at risk of more postoperative weight loss. | hylke j.f.brenkman stéphanie v.s.roelen elles steenhagen jelle p.ruurda richard van hillegersberg | 2017 | Chinese Journal of Cancer Research2017，29，4： | 2 |
| 17 | Complications in and performance of double-balloon enteroscopy (DBE): results from a large prospective DBE database in Germany显示文摘 | O. M?schler A. May M. Müller C. Ell | 2011 | Endoscopy2011，，06： | 2 |
| 18 | Comparison of computed virtual chromoendoscopy and conventional chromoendoscopy with acetic acid for detection of neoplasia in Barrett’s esophagus显示文摘 | J. Pohl A. May T. Rabenstein O. Pech M. Nguyen-Tat A. Fissler-Eckhoff C. Ell | 2007 | Endoscopy2007，，： | 2 |
| 19 | The European experience with double-balloon enteroscopy: indications, methodology, safety, and clinical impact显示文摘 | Simona Di Caro Andrea May Dimitri G.N. Heine Lucia Fini Bruno Landi Lucio Petruzziello Christophe Cellier Chris J. Mulder Guido Costamagna Christian Ell Antonio Gasbarrini | 2005 | Gastrointestinal Endoscopy2005，，4： | 2 |
| 20 | Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal显示文摘 | Antonio Ayala Mario F. Mu?oz Sandro Argüelles Kota V. Ramana | 2014 | Oxidative Medicine and Cellular Longevity2014，，： | 2 |
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