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| 1 | Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) is a chronic relapsing disease in gastrointestinal tract. Conventional medications lack the efficacy to offer complete remission in IBD therapy,and usually associate with serious side effects. Recent studies indicated that nanoparticle-based nanotherapeutics may offer precise and safe alternative to conventional medications via enhanced targeting,sustained drug release,and decreased adverse effects. Here,we reviewed orally cell-specific nanotherapeutics developed in recent years. In addition,the various obstacles for oral drug delivery are also reviewed in this manuscript. Orally administrated cell-specific nanotherapeutics is expected to become a novel therapeutic approach for IBD treatment. | Xiao-Ying Si Didier Merlin Bo Xiao | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | Fab’-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis显示文摘 | Hamed Laroui Emilie Viennois Bo Xiao Brandon S.B. Canup Duke Geem Timothy L. Denning Didier Merlin | 2014 | Journal of Controlled Release2014，，： | 2 |
| 3 | Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model显示文摘 | Hamed Laroui Guillaume Dalmasso Hang Thi Thu Nguyen Yutao Yan Shanthi V. Sitaraman Didier Merlin | 2010 | Gastroenterology2010，，3： | 2 |
| 4 | Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice显示文摘 | Bo Xiao Hamed Laroui Emilie Viennois Saravanan Ayyadurai Moiz A. Charania Yuchen Zhang Zhan Zhang Mark T. Baker Benyue Zhang Andrew T. Gewirtz Didier Merlin | 2014 | Gastroenterology2014，，： | 2 |
| 5 | Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy显示文摘 | Bo Xiao Hamed Laroui Saravanan Ayyadurai Emilie Viennois Moiz A. Charania Yuchen Zhang Didier Merlin | 2013 | Biomaterials2013，，30： | 2 |
| 6 | Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles显示文摘 | Bo Xiao Mingzhen Zhang Emilie Viennois Yuchen Zhang Na Wei Mark T. Baker Yunjin Jung Didier Merlin | 2015 | Biomaterials2015，，： | 1 |
| 7 | Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy显示文摘 | Bo Xiao Xiaoying Si Mingzhen Zhang Didier Merlin | 2015 | Colloids and Surfaces B: Biointerfaces2015，，： | 1 |
| 8 | Tumor necrosis factor-α and interferon-γ increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine显示文摘 | Stephan R. Vavricka Mark W. Musch Mikihiro Fujiya Keri Kles Laura Chang Jyrki J. Eloranta Gerd A. Kullak-Ublick Ken Drabik Didier Merlin Eugene B. Chang | 2006 | Pflügers Archiv - European Journal of Physiology2006，，1： | 1 |
| 9 | Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-Derived MMP显示文摘 | Florencia E. Castaneda Baljit Walia Matam Vijay–Kumar Neal R. Patel Susanne Roser Vasantha L. Kolachala Mauricio Rojas Lixin Wang Gabriela Oprea Pallavi Garg Andrew T. Gewirtz Jesse Roman Didier Merlin Shanthi V. Sitaraman | 2005 | Gastroenterology2005，，6： | 1 |
| 10 | All- trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Krüppel-like factor 5显示文摘 | Sengthong Chanchevalap Mandayam O. Nandan Didier Merlin Vincent W. Yang | 2004 | FEBS Letters2004，，1： | 1 |
| 11 | CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice显示文摘 | Nguyen Hang Thi Thu Dalmasso Guillaume Torkvist Leif Halfvarson Jonas Yan Yutao Laroui Hamed Shmerling Doron Tallone Tiziano D’Amato Mauro Sitaraman Shanthi V Merlin Didier | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 12 | Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon显示文摘 | Hamed Laroui Arianne L. Theiss Yutao Yan Guillaume Dalmasso Hang T.T. Nguyen Shanthi V. Sitaraman Didier Merlin | 2010 | Biomaterials2010，，4： | 1 |
| 13 | PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation显示文摘 | Guillaume Dalmasso Laetitia Charrier–Hisamuddin Hang Thi Thu Nguyen Yutao Yan Shanthi Sitaraman Didier Merlin | 2008 | Gastroenterology2008，，1： | 1 |
| 14 | TGF-β down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2显示文摘 | Baljit Walia Lixin Wang Didier Merlin | 2003 | FASEB J2003，17，14： | 1 |
| 15 | Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice显示文摘 | Arianne L. Theiss Matam Vijay–Kumar Tracy S. Obertone Dean P. Jones Jason M. Hansen Andrew T. Gewirtz Didier Merlin Shanthi V. Sitaraman | 2009 | Gastroenterology2009，，1： | 1 |
| 16 | Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98显示文摘 | Hang Thi Thu Nguyen Didier Merlin | 2012 | Cellular and Molecular Life Sciences2012，，18： | 1 |
| 17 | Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease显示文摘 | Bo Xiao Didier Merlin | 2012 | Expert Opinion on Drug Delivery2012，，11： | 1 |
| 18 | Ste20-related proline/alanine-rich kinase:A novel regulator of intestinal inflammation显示文摘Recently,inflammatory bowel disease (IBD) has been the subject of considerable research,with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis.Ste20-related proline/alanine-rich kinase (SPAK) is involved in regulating barrier function.SPAK is known to interact with inflammation-related kinases (such as p38,JNK,NKCC1,PKCθ,WNK and MLCK),and with transcription factor AP-1,resulting in diverse biological phenomena,including cell differentiation,cell transformation and proliferation,cytoskeleton rearrangement,and regulation of chloride transport.This review examines the involvement of Ste20-like kinases and downstream mitogen-activated protein kinases (MAPKs) pathways in the pathogenesis and control of intestinal inflammation.The primary focus will be on the molecular features of intestinal inflammation,with an emphasis on the interaction between SPAK and other molecules,and the effect of these interactions on homeostatic maintenance,cell volume regulation and increased cell permeability in intestinal inflammation. | Didier Merlin | 2008 | World Journal of Gastroenterology2008，14，40： | 0 |
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