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| 1 | Beta secretase activity in peripheral nerve regeneration显示文摘While the peripheral nervous system has the capacity to regenerate following a nerve injury,it is often at a slow rate and results in unsatisfactory recovery,leaving patients with reduced function.Many regeneration associated genes have been identified over the years,which may shed some insight into how we can manipulate this intrinsic regenerative ability to enhance repair following peripheral nerve injuries.Our lab has identified the membrane bound protease beta-site amyloid precursor protein-cleaving enzyme 1(BACE1),or beta secretase,as a potential negative regulator of peripheral nerve regeneration.When beta secretase activity levels are abolished via a null mutation in mice,peripheral regeneration is enhanced following a sciatic nerve crush injury.Conversely,when activity levels are greatly increased by overexpressing beta secretase in mice,nerve regeneration and functional recovery are impaired after a sciatic nerve crush injury.In addition to our work,many substrates of beta secretase have been found to be involved in regulating neurite outgrowth and some have even been identified as regeneration associated genes.In this review,we set out to discuss BACE1 and its substrates with respect to axonal regeneration and speculate on the possibility of utilizing BACE1 inhibitors to enhance regeneration following acute nerve injury and potential uses in peripheral neuropathies. | Carolyn Tallon Mohamed H.Farah | 2017 | Neural Regeneration Research2017，12，10： | 4 |
| 2 | Long-term ulrasonographic features of the Achiles terdor after rupture 显示文摘 | Bleakney RR Tallon C Wong JK | 2002 | Clin J Sport Med2002，12，5： | 1 |
| 3 | Where pigmented piloma- tricoma and melanoeytie matrieoma eollide显示文摘 | TALLON B CERRONI L | 2010 | Am JDermatopathol2010，32，8： | 1 |
| 4 | Flagellate erythema induced by docetaxel 显示文摘 | Tallon B Lamb S | 2008 | Clin Exp Dermatol2008，33，3： | 1 |
| 5 | Strain-and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds显示文摘 | Tallon R Arias S Bressollier P | 2007 | Journal of Applied Microbiology2007，102，2： | 1 |
| 6 | Synthesis of γ-Al203 anopowders by freeze-drying显示文摘 | Carolina Tallon Rodrigo Moreno M Isabel Nieto | 2006 | Materials Research Bulletin2006，41，： | 1 |
| 7 | No adverse effect of early weight bearing following open repair of acute tears of the Achilles tendon 显示文摘 | MAFFULLI N TALLON C | 2003 | J Sports Med Phys Fitness2003，43，： | 1 |
| 8 | Wave-front reconstruction using a Shack- Hartmann sensor显示文摘 | Lane R G Tallon M | 1992 | ApplOpt1992，31，13： | 1 |
| 9 | Inhibitory killer immunoglobulin- like receptors to self HLA-B and HLA-C ligands contribute differentially to natural killer cell functional potential in HIV infected slow progressors 显示文摘 | amya P Tallon B Melendez-Pena C | 2012 | Clin Immunol2012，143，3： | 1 |
| 10 | Analysis of modes and behavior of a multiconjugate adaptive optics system显示文摘 | Louarn M L Tallon M | 2002 | J Opt Soc Am A2002，19，5： | 1 |
| 11 | The effect of Pipeline location on acoustic measurement of gas solid pipeline flow显示文摘 | Stephen J Tallon Clive E Davies | 2000 | Flow Measurement and Instrumentation2000，，11： | 1 |
| 12 | Strain- and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds 显示文摘 | TALLON R ARIAS S BRESSOLLIER P | 2007 | Journal of Applied Microbiology2007，102，2： | 1 |
| 13 | Isolation and Characterization of Two Exopolysaccharides Produced by Lactobacillus plantarum EP56显示文摘 | TALLON R BRESSOLLIER P URDACI MC | 2003 | Research in Microbiology2003，154，： | 1 |
| 14 | Ambiguity aversion and incompleteness of financialmarkets 显示文摘 | Mukerji S Tallon J | 2001 | The Review of Economic Studies2001，68，4： | 1 |
| 15 | Information lifecycle manage- ment 显示文摘 | Tallon P Scannell R | 2007 | Communications of the ACM2007，50，11： | 1 |
| 16 | Competing perspectives on the link between strategic information technology alignment and organizational agility: insights from a mediation model 显示文摘 | Tallon P P pinsonneauh A | 2011 | Mis Quarterly2011，35，2： | 1 |
| 17 | Understanding the Dynamics of Infor- mationManagement Costs 显示文摘 | Panl P Tallon | 2010 | Communications of the ACM2010，53，5： | 1 |
| 18 | Interaction of circadian clock protein PER2 and CRY with BMAL 1 and CLOCK显示文摘 | Langmesser S Tallone T Bordon A | | 0，，： | 1 |
| 19 | A process-oriented perspective on the alignment of information technology and business strategy 显示文摘 | Tallon P P | 2007 | Journal of Management Information Systems2007，24，3： | 1 |
| 20 | Micro and nano cellular amorphouspolymers(PMMA,PS)in supercritical CO2assisted bynanostructured C02-philic block copolymers-one stepfoaming process显示文摘 | Jose Antonio Reglero Ruiz Matthieu Pedros Jean-Marc Tallon | 2011 | J of Supercritical Fluids2011，，58： | 1 |
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