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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | Role of microRNAs in the immune system,inflammation and cancer显示文摘MicroRNAs,a key class of gene expression regulators,have emerged as crucial players in various biological processes such as cellular proliferation and differentiation,development and apoptosis.In addition,microRNAs are coming to light as crucial regulators of innate and adaptive immune responses,and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders,such as inflammatory bowel disease,and cancers.In this review,we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. | Jennifer Raisch Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2013 | World Journal of Gastroenterology2013，19，20： | 17 |
| 3 | 线性自抗扰控制在全桥DC–DC变换器中的应用显示文摘针对DC–DC变换器在实际应用中会受到多种输入扰动、负载扰动及电磁扰动影响的问题,本文结合全桥DC–DC变换器的系统模型特点,对传统线性自抗扰控制器进行了改进.设计了基于降阶扩张状态观测器和以比例控制作为误差反馈律的自抗扰控制器用于实际系统,在确保系统性能的前提下优化了参数整定过程.仿真和实验结果表明,该控制系统具有比传统PI控制系统更优的快速性、鲁棒性和适应性,且大大简化了传统自抗扰控制器设计过程中参数过多、取值困难的问题,具有良好的发展前景. | 王孝洪 吴丰 HOANG Thi Thu Giang 潘志锋 曾健华 | 2018 | 控制理论与应用2018，35，11： | 11 |
| 4 | 金华市义乌江沉积物磁性特征与重金属污染显示文摘对浙江省金华市义乌江采集的边滩沉积物柱样,进行了系统的环境磁学、粒度、地球化学分析,以探讨环境磁学方法诊断河流沉积物重金属污染的可行性.结果表明,柱样磁性特征由亚铁磁性矿物主导,其垂向变化受到粒度和早期成岩作用的一定影响.柱样中重金属Cr、Ni、Cu、Zn、Cd、Pb含量及其富集因子除底部外,自下而上呈增加趋势,指示了柱样上部存在人为来源的重金属污染.柱样沉积物磁性特征与重金属含量及其富集因子的垂向变化存在相似性,其中磁化率(χ)、频率磁化率(χfd%)和硬剩磁(HIRM)与Cr、Cu、Zn、Cd、Pb的含量具有显著的正相关关系,反映了磁性矿物与重金属具有相同的来源,或者细颗粒磁性矿物对重金属的吸附作用.上述结果表明,磁学方法可用于指示义乌江的重金属污染.但由于义乌江属于开放性的河流环境系统,磁性特征变化受多重因素影响,增加了利用磁学手段定量诊断重金属污染的复杂性. | 李文 胡忠行 吉茹 Nguyen Thi Thu Hien 刘晋嫣 白雪莘 葛灿 张曼 张卫国 | 2016 | 环境科学学报2016，36，1： | 8 |
| 5 | Sucrose transporter2 contributes to maize growth,development,and crop yield显示文摘During daylight, plants produce excess photosynthates, including sucrose, which is temporarily stored in the vacuole. At night, plants remobilize sucrose to sustain metabolism and growth. Based on homology to other sucrose transporter(SUT) proteins, we hypothesized the maize(Zea mays) SUCROSE TRANSPORTER2(ZmSUT2)protein functions as a sucrose/Htsymporter on the vacuolar membrane to export transiently stored sucrose.To understand the biological role of ZmSut2, we examined its spatial and temporal gene expression, determined the protein subcellular localization, and characterized loss-offunction mutations. ZmSut2 mRNA was ubiquitously expressed and exhibited diurnal cycling in transcript abundance. Expressing a translational fusion of ZmSUT2 fused to a red fluorescent protein in maize mesophyll cell protoplasts revealed that the protein localized to the tonoplast. Under field conditions, zmsut2 mutant plants grew slower, possessed smaller tassels and ears, and produced fewer kernels when compared to wild-type siblings. zmsut2 mutants also accumulated two-fold more sucrose, glucose, and fructose as well as starch in source leaves compared to wild type. These findings suggest(i) ZmSUT2 functions to remobilize sucrose out of the vacuole for subsequent use in growing tissues; and(ii) its function provides an important contribution to maize development and agronomic yield. | Kristen A.Leach Thu M.Tran Thomas L.Slewinski Robert B.Meeley David M.Braun | 2017 | Journal of Integrative Plant Biology2017，59，6： | 8 |
| 6 | Activated carbon derived from rice husk by NaOH activation and its application in supercapacitor显示文摘Four activated carbon(AC) samples prepared from rice husk under different activation temperatures have been characterized by N2adsorption–desorption isotherms, thermogravimetric analysis(TGA–DTA), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy(SEM). The specific surface area of AC sample reached 2681 m2 g 1under activation temperature of 800 1C. The AC samples were then tested as electrode material; the specific capacitance of the as-prepared activated carbon electrode was found to be 172.3 F g 1using cyclic voltammetry at a scan rate of 5 mV s 1and 198.4 F g 1at current density 1000 mA g 1in the charge/discharge mode.& 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved. | Khu Le Van Thu Thuy Luong Thi | 2014 | Progress in Natural Science:Materials International2014，24，3： | 7 |
| 7 | Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies显示文摘Eurycoma longifolia(EL) has been well recognized as a booster of male sexual health. Over the past few decades, numerous in vivo animal studies and human clinical trials have been conducted across the globe to explore the promising role of EL in managing various male sexual disorders, which include erectile dysfunction, male infertility, low libido, and downregulated testosterone levels. The aim of the present review is to analyze and summarize the literature on human clinical trials which revealed the clinical significance and therapeutic feasibility of EL in improving male sexual health. This systematic review is focused on the following databases: Medline, Wiley Online Library, Bio Med Central, Hindawi, Web of Knowledge, Pub Med Central and Google Scholar, using search terms such as 'Eurycoma longifolia', 'EL', 'Tongkat Ali', 'male sexual health', 'sexual infertility', 'erectile dysfunction', 'male libido', and 'testosterone levels'. Notably, only human clinical studies published between 2000 and 2014 were selected and thoroughly reviewed for relevant citations. Out of 150 articles, 11 met the inclusion criteria. The majority of articles included were randomized placebo-controlled trials, multiple cohort studies, or pilot trials. All these studies demonstrated considerable effects of EL on male sexual health disorders. Among them, 7 studies revealed remarkable association between the use of EL and the efficacy in the treatment of male sexual disorders, and remaining 4 studies failed to demonstrate sufficient effects on male sexual health. In summary, there is convincing evidence for the prominence of EL in improving the male sexual health. The review also substantiates the use of current methodology in the development of novel and more rationale natural herbal medicines for the management of male sexual disorders. | Hnin Ei Thu Isa Naina Mohamed Zahid Hussain Putri Ayu Jayusman Ahmad Nazrun Shuid | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 7 |
| 8 | Sodium cantharidinate,a novel anti-pancreatic cancer agent that activates functional p53显示文摘Despite the use of many types of chemotherapies for pancreatic cancer, optimal efficacy has not been obtained so far. Pancreatic cancer shows a high incidence of TP53 mutations, inactivating its tumor suppressor activity. In this study, we identified sodium cantharidinate as a novel, potential anti-pancreatic cancer agent that activates p53 function. Sodium cantharidinate reduced the viability of pancreatic cancer cells, including the human primary pancreatic cancer cells, PANC-1, As PC-1, SW1990 and BXPC-3, in a dose-dependent manner. Sodium cantharidinate induced apoptosis and DNA damage of pancreatic cancer cells. Furthermore, proteome-wide sequencing analysis detected a marked perturbation in p53 signaling pathway on PANC-1 cells upon sodium cantharidinate. Consistent with the previous results, sodium cantharidinate treatment decreased Bcl-2 and mitochondrial cytochrome-c protein expression, as well as phosphorylation of MDM2;meanwhile, it increased the levels of cleaved-caspase-3,cleaved-caspase-9, cleaved-PARP, Bax, and phosphorylated p53, thus inducing the apoptosis of pancreatic cancer cells. The p53-activating effect of sodium cantharidinate was strongly abrogated by treatment with TP53-targeting sh RNA. Moreover, sodium cantharidinate inhibited neoplasm growth via the JAK2-STAT3 pathway, which was inhibited by sh RNA-TP53 and triggered by combination with gemcitabine. Combination therapy indicated that sodium cantharidinate and gemcitabine synergistically reduced ex vivo and in vivo growth of pancreatic neoplasm. Further docking studies revealed the different binding fates of sodium cantharidinate to activate wild-type p53 function. Thus, sodium cantharidinate could be a potential agent with promising anti-pancreatic cancer efficacy. | Xiaoxiao Liu Li Zhang Pyone Myat Thu Wenjian Min Peng Yang Ji Li Ping Li Xiaojun Xu | 2021 | Science China(Life Sciences)2021，64，8： | 5 |
| 9 | Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells显示文摘Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer cells.These nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to infrared.In this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical application.After synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic acid.Folic acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via endocytosis.The sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 nm.Phase structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal system.The photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were measured.These nanophosphors emit in red color with the strongest band at 650 nm under 980 nm excitation.This result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine. | Ha Thi Phuong Tran Thu Huong Le Thi Vinh Hoang Thi Khuyen Do Thi Thao Nguyen Thanh Huong Pham Thi Lien Le Quoc Minh | 2019 | Journal of Rare Earths2019，37，11： | 5 |
| 10 | 永磁同步风力发电系统的分数阶比例积分控制算法研究显示文摘将分数阶比例积分(PIλ)控制器应用于直驱型永磁同步风力发电系统,来达到实现系统高性能控制的目的。重点研究了永磁同步风力发电系统的分数阶PIλ控制器参数设计方法。通过分数阶PIλ控制器系统的仿真研究与试验分析,结果表明:采用分数阶PIλ控制器的系统具有较快的响应速度和较高的功率输出性能,具有一定的发展潜力和实用价值。 | 周小壮 王孝洪 HOANG THI THU GIANG | 2017 | 电机与控制应用2017，44，7： | 4 |
| 11 | Infectious etiopathogenesis of Crohn's disease显示文摘Important advances during the last decade have been made in understanding the complex etiopathogenesis of Crohn’s disease(CD).While many gaps in our knowledge still exist,it has been suggested that the etiology of CD is multifactorial including genetic,environmental and infectious factors.The most widely accepted theory states that CD is caused by an aggressive immune response to infectious agents in genetically predisposed individuals.The rise of genome-wide association studies allowed the identification of loci and genetic variants in several components of host innate and adaptive immune responses to microorganisms in the gut,highlighting an implication of intestinal microbiota in CD etiology.Moreover,numerous independent studies reported a dysbiosis,i.e.,a modification of intestinal microbiota composition,with an imbalance between the abundance of beneficial and harmful bacteria.Although microorganisms including viruses,yeasts,fungi and bacteria have been postulated as potential CD pathogens,based on epidemiological,clinicopathological,genetic and experimental evidence,their precise role in this disease is not clearly defined.This review summarizes the current knowledge of the infectious agents associated with an increased risk of developing CD.Therapeutic approaches to modulate the intestinal dysbiosis and to target the putative CD-associated pathogens,as well as their potential mechanisms of action are also discussed. | Jessica Carriere Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2014 | World Journal of Gastroenterology2014，20，34： | 4 |
| 12 | Sequence Information on Simple Sequence Repeats and Single Nucleotide Polymorphisms through Transcriptome Analysis of Mungbean显示文摘Mungbean(Vigna radiata(L.) Wilczek) is a unique species in its ability to fix atmospheric nitrogen,with early maturity,and relatively good drought resistance.We used 454 sequencing technology for transcriptome sequencing.A total of 150 159 and 142 993 reads produced 5 254 and 6 374 large contigs(≥500 bp) with an average length of 833 and 853 for Sunhwa and Jangan,respectively.Functional annotation to known sequences yielded 41.34% and 41.74% unigenes for Jangan and Sunhwa.A higher number of simple sequence repeat(SSR) motifs was identified in Jangan(1 630) compared with that of Sunhwa(1 334).A similar SSR distribution pattern was observed in both varieties.A total of 8 249 single nucleotide polymorphisms(SNPs) and indels with 2 098 high-confidence candidates were identified in the two mungbean varieties.The average distance between individual SNPs was ~860 bp.Our report demonstrates the utility of transcriptomic data for implementing a functional annotation and development of genetic markers.We also provide large resource sequence data for mungbean improvement programs. | Kyaw Thu Moe Jong-Wook Chung Young-Il Cho Jung-Kyung Moon Ja-Hwan Ku Jin-Kyo Jung Jungran Lee Yong-Jin Park | 2011 | Journal of Integrative Plant Biology2011，53，1： | 4 |
| 13 | Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation显示文摘Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis. | Syed Nasir Abbas Bukhari Fahad Hussain Hnin Ei Thu Zahid Hussain | 2019 | Journal of Integrative Medicine2019，17，1： | 4 |
| 14 | 拔牙后不同类型骨缺损行位点保存术骨量恢复的CBCT比较研究显示文摘目的:探讨拔牙位点保存术在恢复骨缺损中的作用以及对不同类型骨缺损可能存在的骨增量差异。方法:选取广西医科大学附属口腔医院种植科就诊的患者80例,分为实验组和对照组,每组40例。实验组在行拔牙术的同时行拔牙位点保存术,对照组拔牙术后不填充骨替代材料;两组再根据拔牙窝牙槽骨缺损的类型分为4个亚组:拔牙窝为一壁骨缺损(A组)、二壁骨缺损(B组)、三壁骨缺损(C组)、四壁骨缺损(D组)。实验组无膜拔牙后采用脱矿的牛骨混合10%骨胶原(Bio-Oss Collagen?)保存牙槽骨,所有研究对象拔牙术前行锥形束计算机断层扫描(CBCT),6个月后随访。结果:实验组平均骨高度较术前增加,牙槽骨平均宽度较估计原始骨轮廓恢复72.79%~88.08%,对照组牙槽骨平均宽度较估计原始骨轮廓恢复57.20%~84.91%。结论:拔牙位点保存术对牙槽骨的恢复具有明显效果,可以有效减少拔牙后牙槽骨骨吸收。 | Ye Myat Thu 李晓 蒋延波 Aung Than Oo 唐礼 | 2020 | 广西医科大学学报2020，37，1： | 4 |
| 15 | Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice显示文摘Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis(S. baicalensis) against lipopolysaccharide(LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and m RNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. C yclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS signifi cantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver mice.Conclusions: Our study showed that S. baicalensis is potentially protective against LPS-induced liver injury in mice. | Hai Nguyen Thanh Hue Pham Thi Minh Tuan Anh Le Huong Duong Thi Ly Tung Nguyen Huu Loi Vu Duc Thu Dang Kim Tung Bui Thanh | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，9： | 3 |
| 16 | 乳化鱼油对冻藏期间狭鳕鱼糜热凝胶持水性和冰结晶形成的影响(英文)显示文摘评估乳化鱼油对冻藏期间狭鳕鱼糜热凝胶持水性和冰结晶形成的影响。鱼糜经盐擂后,加入5%鱼油经乳化制得乳化鱼糜热凝胶。随后用快速冻结和慢速冻结2种方式冻结样品并评估其在冻藏期间热凝胶品质的变化。研究结果表明:与对照相比,乳化热凝胶在冻藏期间的解冻损失和压榨损失均有降低。显微观察结果显示经3个月冻藏后乳化热凝胶内的冰结晶平均粒径与其对照相比均有减小,其中快速冻结乳化样品为7.2μm,对照样品为13.1μm,慢速冻结乳化样品为13.7μm,对照样品为31.2μm。以上结果表明乳化鱼油可能对冻藏期间的热凝胶的冰结晶形成和其分布的影响而导致其持水性不同。 | 牛丽琼 HUYNH Thi Thu Huong 贾茹 高元沛 中澤奈穂 大迫一史 岡﨑惠美子 | 2016 | 食品科学2016，37，20： | 3 |
| 17 | Enhancing soil water holding capacity and provision of a potassium source via optimization of the pyrolysis of bamboo biochar显示文摘Rapid expansion of cultivated bamboo negatively impacts on biodiversity and soil microbial community.As such,it is important to properly manage and use bamboo to prevent and control such issues.This study focuses on optimizing pyrolysis conditions to produce bamboo biochar for agricultural soil amendment,particularly soil potassium(K)and water holding capacity.Bamboo chips were pyrolyzed under nitrogen gas at 400,600,and 800℃ for 1 and 2 h of retention.A total of six biochar products were created:400-1(i.e.,400℃ in 1 h),400-2,600-1,600-2,800-1,and 800-2.The 600℃ bamboo biochar products were observed to have the greatest potential in increasing soil K and water holding capacity.The 600-1 product had the highest potassium content(4.87%),with a water holding capacity of 3.73 g g^(−1),while the 600-2 product had the second-highest potassium content(4.13%)and the highest water holding capacity(4.21 g g^(−1))and cation exchange capacity.The K release in 600℃ products was larger and slower than that of the 400℃ and 800℃ products,respectively.The results also indicated that the physicochemical characteristics of bamboo biochar,such as yield,pH,surface area,water holding capacity,and K content,were significantly impacted by temperature,retention time,or a combination of these parameters.The outcomes from this study are a valuable reference for bamboo biochar production targeting agricultural soil amendment,particularly when it is directed at increasing soil K and water holding capacity. | Tran Thi Thu Hien Toshiki Tsubota Tomoyuki Taniguchi Yoshiyuki Shinogi | 2021 | Biochar2021，3，1： | 3 |
| 18 | Crohn’s Disease–Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy显示文摘 | Hang Thi Thu Nguyen Guillaume Dalmasso Stefan Müller Jessica Carrière Frank Seibold Arlette Darfeuille–Michaud | 2014 | Gastroenterology2014，，2： | 3 |
| 19 | Establishing the Basic Indicator for the Calculation of the Flood Vulnerability Index for River Basins in Vietnam显示文摘 | Can Thu Van Nguyen Thanh Son Phan Vu Hoang Phuong | 2016 | Journal of Environmental Science and Engineering(B)2016，5，8： | 3 |
| 20 | Natural products and food components with anti-Helicobacter pylori activities显示文摘The bacterial pathogen Helicobacter pylori(H. pylori) colonizes in over half of the world's population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Triple therapy which consists of a proton pump inhibitor and combinations of two antibiotics(amoxicillin, clarithromycin or amoxicillin, metronidazol) is commonly used for H. pylori eradication. Recently, the occurrence of drug-resistant H. pylori and the adverse effect of antibiotics have severely weakened eradication therapy. Generally antibiotics induce the disturbance of human gastrointestinal microflora. Furthermore, there are inappropriate cases of triple therapy such as allergy to antibiotics, severe complications(liver and/or kidney dysfunction), the aged and people who reject the triple therapy. These prompt us to seek alterative agents instead of antibiotics and to develop more effective and safe therapy with these agents. The combination of these agents actually may result in lower a dose of antibiotics. There are many reports world-wide that non-antibiotic substances from natural products potentially have an anti-H. pylori agent. We briefly review the constituents derived from nature that fight against H. pylori in the literature with our studies. | Hiroaki Takeuchi Vu Thu Trang Norihito Morimoto Yoshie Nishida Yoshihisa Matsumura Tetsuro Sugiura | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
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