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| 1 | Polo-like kinase 1,a new therapeutic target in hepatocellular carcinoma显示文摘AIM:To investigate the role of polo-like kinase 1 (PLK1) as a therapeutic target for hepatocellular carcinoma (HCC).METHODS:PLK1 gene expression was evaluated in HCC tissue and HCC cell lines.Gene knockdown with short-interfering RNA (siRNA) was used to study PLK1 gene and protein expression using real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting,and cell proliferation using 3-(4,5-dim ethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2(4-sulf ophenyl)-2H-tetrazolium (MTS) and bromodeoxyuridine (BrdU) assays.Apoptosis was evaluated using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay,and caspase-inhibition assay.Huh-7 cells were transplanted into nude mice and co-cultured with PLK1 siRNA or control siRNA,and tumor progression was compared with controls.RESULTS:RT-PCR showed that PLK1 was overexpressed 12-fold in tumor samples compared with controls,and also was overexpressed in Huh-7 cells.siRNA against PLK1 showed a reduction in PLK1 gene and protein expression of up to 96% in Huh-7 cells,and a reduction in cell proliferation by 68% and 92% in MTS and BrdU cell proliferation assays,respectively.There was a 3-fold increase in apoptosis events,and TUNEL staining and caspase-3 assays suggested that this was caspase-independent.The pan-caspase inhibitor Z-VAD-FMK was unable to rescue the apoptotic cells.Immnofluorescence co-localized endonuclease-G to fragmented chromosomes,implicating it in apoptosis.Huh-7 cells transplanted subcutaneously into nude mice showed tumor regression in siPLK1-treated mice,but not in controls.CONCLUSION:Knockdown of PLK1 overexpression in HCC was shown to be a potential therapeutic target,leading to apoptosis through the endonuclease-G pathway. | Wei Chuen Mok Shanthi Wasser Theresa Tan Seng Gee Lim | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 2 | Ameliorating effect of Semecarpus anacardium Linn.nut milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats显示文摘Objective:To explore the protective effect of the drug Semecarpus anacardium(S.anacardium) on altered glucose metabolism in diabetic rats.Methods:Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ)(35 mg/kg b.w.).Seven days after STZ induction,diabetic rats received nut milk extract of S.anacardium Linn.nut milk extract orally at a dosage of 200 mg/kg daily for 4 weeks.The effect of nut milk extract of S.anacardium on blood glucose,plasma insulin,glucose metabolising enzymes and GSK were studied.Results:Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA-βand decrease in HOMA -IR.The drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic enzymes.The drug also effectively ameliorated the alterations in GSK-3 mRNA expression.Conclusions:Overall,the present study demonstrates the possible mechanism of glucose regulation of S.anacardium suggestive of its therapeutic potential for the management of diabetes mellitus. | Haseena Banu Hedayathullah Khan Kaladevi Siddhi Vinayagam Shanthi Palanivelu Sachdanandam Panchanadham | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 3 |
| 3 | Two-Dimensional Photonic Crystal Based Sensor for Pressure Sensing显示文摘在这份报纸,二维的 photonic 晶体(2DPC ) 基于压力传感器被建议并且设计,并且象敏感那样的察觉到的特征和动态范围从 0 GPa 在压力的范围上被分析到 7 GPa。传感器与坐飞机包围的硅杆的方形的数组基于 2DPC。传感器由二 photonic 水晶伪波导和 L3 缺点组成。L3 缺点被放在二波导之间并且被修改三 Si 杆的半径形成。当增加应用压力水平时,通过模拟,传感器的反响的波长向更高的波长区域线性地被转移,这被注意当增加应用压力水平时。完成的敏感和传感器的动态范围分别地是 2 nm/GPa 和 7 Gpa。 | Krishnan VIJAYA SHANTHI Savarimuthu ROBINSON | 2014 | Photonic Sensors2014，4，3： | 3 |
| 4 | Attribute driven inverse materials design using deep learning Bayesian framework显示文摘Much of computational materials science has focused on fast and accurate forward predictions of materials properties,for example,given a molecular structure predict its electronic properties.This is achieved with first principles calculations and more recently through machine learning approaches,since the former is computation-intensive and not practical for high-throughput screening.Searching for the right material for any given application,though follows an inverse path—the desired properties are given and the task is to find the right materials.Here we present a deep learning inverse prediction framework,Structure Learning for Attributedriven Materials Design Using Novel Conditional Sampling(SLAMDUNCS),for efficient and accurate prediction of molecules exhibiting target properties.We apply this framework to the computational design of organic molecules for three applications,organic semiconductors for thin-film transistors,small organic acceptors for solar cells and electrolyte additives with high redox stability.Our method is general enough to be extended to inorganic compounds and represents an important step in deep learning based completely automated materials discovery. | Piyush M.Tagade Shashishekar P.Adiga Shanthi Pandian Min Sik Park Krishnan S.Hariharan Subramanya Mayya Kolake | 2019 | npj Computational Materials2019，，1： | 2 |
| 5 | Women with Preeclampsia Have Increased Serum Levels of Pregnancy‐Associated Plasma Protein A (PAPP‐A), Inhibin A, Activin A and Soluble E‐selectin显示文摘 | Nick A. Bersinger Alexander K. Smárason Shanthi Muttukrishna Nigel P. Groome Christopher W. Redman | 2003 | Hypertension in Pregnancy2003，，1： | 2 |
| 6 | Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model显示文摘 | Hamed Laroui Guillaume Dalmasso Hang Thi Thu Nguyen Yutao Yan Shanthi V. Sitaraman Didier Merlin | 2010 | Gastroenterology2010，，3： | 2 |
| 7 | Outstanding performance of activated graphene based supercapacitors in ionic liquid electrolyte from ?50 to 80<ce:hsp sp='0.25'/>°C显示文摘 | Wan-Yu Tsai Rongying Lin Shanthi Murali Li Li Zhang John K. McDonough Rodney S. Ruoff Pierre-Louis Taberna Yury Gogotsi Patrice Simon | 2013 | Nano Energy2013，，3： | 2 |
| 8 | P 53 and PCNA in Non Hodgkin's lymphoma-an immunohistochemical evaluation显示文摘 | Shanthi P Krishnan KB | 2000 | Indian J Pathol Microbiol2000，43，1： | 1 |
| 9 | Comparison of intralesionaI verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids显示文摘 | Margaret Shanthi FX Ernest K Dhanraj P | 2008 | Indian J Dermatol Venereol Leprol2008，74，4： | 1 |
| 10 | Electrical and optical properties of tin oxide films doped with F and (Sb plus F)显示文摘 | SHANTHI E BANERIEE A DUTTA V | 1982 | J of Applied Physics1982，53，3： | 1 |
| 11 | A reexamination of product and process innovations using a knowledge-based view显示文摘 | Shanthi Gopalakrishnan | | 0，，： | 1 |
| 12 | Carbon-based supercapcitors produced by activation of grapheme显示文摘 | ZHU Y W SHANTHI M STOLLER M D | 2011 | Science2011，332，： | 1 |
| 13 | EUS for detection of the hepatocellular carcinoma: results of a prospective study显示文摘 | Pankaj Singh Richard A. Erickson Phalguni Mukhopadhyay Shanthi Gopal Alex Kiss Ahmed Khan T. Ulf Westblom | 2007 | Gastrointestinal Endoscopy2007，，2： | 1 |
| 14 | Silver nano particle incorporated Ti metal prepared by chemical treatment for antibacterial and corrosion resistance study 显示文摘 | RAJENDRAN A VINOTH G SHANTHI V BARIK RPATTANAYAK D | 2014 | Materials Technology: Advanced Biomaterials B2014，29，： | 1 |
| 15 | Elrctrical and optical properties of undoped and antimony-doped tin oxide films显示文摘 | SHANTHI E DUTTA V BANERJEE A | 1980 | J Appl Phys1980，51，12： | 1 |
| 16 | Growth and characterization of antimony doped tin oxide thin films显示文摘 | Shanthi S Subramanian C Ramasamy P | 1999 | Journal of Crystal Growth1999，197，4： | 1 |
| 17 | Electronic structure of electron doped SrTiO3 : SrTiO3-δ and Sr1-x LaxTiO3 显示文摘 | Shanthi N and Sarma D D | 1998 | Phys Rev B1998，57，： | 1 |
| 18 | World Health Organization (WHO) and International Society of Hypertension (ISH) risk prediction charts: assessment of cardiovascular risk for prevention and control of cardiovascular disease in low and middle-income countries显示文摘 | Shanthi M Lars H L Giuseppe M | 2007 | Journal of hypertension2007，25，8： | 1 |
| 19 | Synthesis and characterization of nano-hydroxyapatite at ambient temperature using cationic surfactant显示文摘 | Shanthi P M S Ashok M Balasubramanian T | 2009 | Materials Letters2009，63，2425： | 1 |
| 20 | Dielectric and piezoelectric properties of and -poled relaxor ferroelectric PZN-PT and PMN-PT single crystals显示文摘 | RAJAN K K SHANTHI M CHANG W S | 2007 | Sensors and Actuators a-Physical2007，133，1： | 1 |
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