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| 1 | Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis显示文摘AIM: To compare previously reported randomized controlled studies(RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords 'cold polypectomy'. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients' demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size(less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy. | Mikihiro Fujiya Hiroki Sato Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi Shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari Yutaka Kohgo | 2016 | World Journal of Gastroenterology2016，22，23： | 3 |
| 2 | Efficacy and adverse events of EMR and submucosal dissection for the treatment of colon neoplasms: a meta-analysis of studies comparing EMR and endoscopic submucosal dissection显示文摘 | Mikihiro Fujiya Kazuyuki Tanaka Tatsuya Dokoshi Motoya Tominaga Nobuhiro Ueno Yuhei Inaba Takahiro Ito Kentaro Moriichi Yutaka Kohgo | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 3 | Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report显示文摘BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas.Some previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic resection.CASE SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before ESD.The resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and submucosa.The final diagnosis was submucosa-invasive poorly differentiated gastric adenocarcinoma.Accordingly,additional gastrectomy was recommended to obtain a complete cure.One patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular complications.Both patients remained in remission for more than half a year.EBV positivity was determined by EBV-encoded RNA in situ hybridization.We also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by ESD.CONCLUSION Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is required.Further prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection. | Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 2 |
| 4 | Vanished islets mellitus in an adult显示文摘 | Kimura N Fujiya H Yamaguchi K | 1994 | Arch Pathol Lab Med1994，118，1： | 1 |
| 5 | The Bacillus subtilis quorum-qensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter 显示文摘 | Fujiya M Museh M W Nakagawa Y | 2007 | Cell Host and Microbe2007，1，29： | 1 |
| 6 | Burst fractures with neurologic deficits of the thoracolumbar - lumbar spinc : results of anterior decompression and stabclization with anterior instrumentation 显示文摘 | Kaneda K Fujiya M | 1984 | Spine1984，9，： | 1 |
| 7 | Novel perspectives in probiotic treatment: the efficacy and unveiled mechanisms of the physiological functions 显示文摘 | FUJIYA M KOHGO Y | 2010 | Clin J Gastroentero12010，3，3： | 1 |
| 8 | The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter 显示文摘 | Fujiya M Musch M W Nakagawa Y | 2007 | Cell Host & Microbe2007，1，4： | 1 |
| 9 | Effect of muscle loads and torque applied to the tibia on the strain behavior of the anterior cruciate ligament: An in vitro investigation显示文摘 | Hiroto Fujiya Petteri Kousa Braden C. Fleming David L. Churchill Bruce D. Beynnon | 2011 | Clinical Biomechanics2011，，10： | 1 |
| 10 | Atypical mucosa-associated lymphoid tissue lymphoma in the transverse colon associated with macroglobulinemia显示文摘 | Ikuta K Fujiya M Ueno N | 2010 | Intern Med2010，49，7： | 1 |
| 11 | Banded structure and its distribution in friction stir processing of 316L austenitic stainless steel显示文摘 | Y.C. Chen H. Fujii T. Tsumura Y. Kitagawa K. Nakata K. Ikeuchi K. Matsubayashi Y. Michishita Y. Fujiya J. Katoh | 2011 | Journal of Nuclear Materials2011，，1： | 1 |
| 12 | Tegafur-uracil-induced rapid development of advanced hepatic fibrosis显示文摘Tegafur-uracil has been reported to have only minor adverse effects and is associated with liver injury in 1.79% of Japanese patients. The development of tegafur-uracil-induced hepatic fibrosis with portal hypertension is rare. Here, we report a case of a 74-year-old woman with rapidly developing tegafururacil-induced hepatic fibrosis. The patient had no history of liver disease and had been treated with tegafur-uracil for 8 mo after breast cancer surgery. The patient was admitted to our hospital for abdominal distension and leg edema associated with liver dysfunction. Computed tomography imaging revealed massive ascites and splenomegaly, and a non-invasive assessment of liver fibrosis indicated advanced fibrosis. The histopathological findings revealed periportal fibrosis and bridging fibrosis with septation. The massive ascites resolved after discontinuing tegafururacil. These findings suggest that advanced hepatic fibrosis can develop from a relatively short-term administration of tegafur-uracil and that non-invasive assessment is useful for predicting hepatic fibrosis. | shuya honda koji sawada takumu hasebe shunsuke nakajima mikihiro fujiya toshikatsu okumura | 2017 | World Journal of Gastroenterology2017，23，31： | 1 |
| 13 | Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer显示文摘 | Fujiya M Watari J Ashida T | 2001 | Jpn J Cancer Res2001，92，10： | 1 |
| 14 | Myelopathy caused by chronic epidural hematoma associated with 11 osteoporotic vertebral collapse:a ease report and review of the literature 显示文摘 | Oda I Fujiya M Hasegawa K | 2008 | Open Orthop J2008，2，： | 1 |
| 15 | Cadherin family显示文摘 | Fujiya T Yamanami H Kakukawa Y | 2005 | Nippon Rinsho2005，63，8： | 1 |
| 16 | A Comparison Between the External Taste Sense of Marine and Freshwater Fishes 显示文摘 | Fujiya M Bardach J E | 1966 | Bulletin Japan Society Science Fish1966，32，： | 1 |
| 17 | Small depressed neoplasms of the large bow- el: radiographic visualization and clinical significance显示文摘 | Fujiya M Maruyama M | 1997 | Abdom Imaging1997，22，3： | 1 |
| 18 | Tumor necrosis factor-α and interferon-γ increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine显示文摘 | Stephan R. Vavricka Mark W. Musch Mikihiro Fujiya Keri Kles Laura Chang Jyrki J. Eloranta Gerd A. Kullak-Ublick Ken Drabik Didier Merlin Eugene B. Chang | 2006 | Pflügers Archiv - European Journal of Physiology2006，，1： | 1 |
| 19 | Preparation,clathration ability,and catalysis of a two-dimensional square network material composed of cadmium(Ⅱ) and 4,4'-bipyridine显示文摘 | Fujiya M Kwon Y J Washizu S | 1994 | J Am Chem Soc1994，116，： | 1 |
| 20 | Prediction of recurrence and extratumor spreas of hepatocellular carcinoma following resection显示文摘 | Ouchi K Sugawara T Fujiya T | 2000 | J Surg Oncol2000，75，4： | 1 |
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