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| 1 | Comparative study of the results of compound tibial shaft fractures treated by Ilizarov ring fixators and limb reconstruction system fixators显示文摘Purpose: llizarov ring fixator and limb reconstruction system (LRS) fixators have been used in the management of complex tibial fractures with severe soft tissue injuries, compound tibial fractures, and infected tibial nonunion for which conventional internal fixation cannot be contemplated. Fracture union and distraction osteogenesis can be done simultaneously with these external fixators, allowing early weight bearing. Several previous studies have shown almost equal results of rail and ring fixators for the compound tibial shaft fractures. Thus we performed a prospective study to evaluate the union rate, functional outcome and amount of limb lengthening after the treatment of compound tibial shaft fractures with or without infected nonunion by ring or LRS fixators. Methods: This prospective study was done at Sarojini Naidu Medical College and Hospital, Agra, India and included 32 patients of compound tibial shaft fractures with or without infected nonunion. There were 26 males and 6 females and the average age was 40 years. Patients were randomly divided into two groups (n - 16 for each): one underwent llizarov fixation and the other received LRS fixation. Cases were followed up for 3-24 months, 6 months on average from September 2012 to October 2014. Functional and radiological outcomes were assessed using the Association for the Study and Application of Methods of llizarov (ASAMI) criteria for both rail and ring fixators. Results: Union was achieved in all cases. Radiological outcome was found excellent in 68.75%, good in 18.75% and fair in 12.50% of cases treated by rail fixators whereas it was excellent in 56.25%, good in 18.75%, fair in 12.50% and poor in 12.50% of cases treated by ring fixators. Functional result was satis- factory in 75.00% of cases treated by rail fixator and 68.75% of cases treated by ring fixators whereas the corresponding rate of unsatisfactory was 25.00% vs. 31.25%. Conclusion: In our short-term assessment, LRS fixators show a better result than llizarov fixators in terms of fracture union and functional outcome with soft tissue care and limb length. | Chandra Prakash Pal Harish Kumar Deepak Kumar K.S. Dinkar Vivek Mittal Naveen Kumar Singh | 2015 | Chinese Journal of Traumatology2015，18，6： | 3 |
| 2 | Role of <sup>18</sup> F ‐fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: Experience from tropics显示文摘 | Sampath Santhosh Bhagwant Rai Mittal Deepak Bhasin Radhika Srinivasan Surinder Rana Ashim Das Ritambhra Nada Anish Bhattacharya Rajesh Gupta Rakesh Kapoor | 2013 | J Gastroenterol Hepatol2013，，2： | 2 |
| 3 | HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilie polymer matrix 显示文摘 | Anupama Mittal Deepak Chitkara Neeraj Kumar | 2007 | Journal of Chromatography B2007，855，： | 1 |
| 4 | Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers显示文摘The benefcial or deleterious effects of nanomedicines emerge from their complex interactions with intracellular pathways and their subcellular fate.Moreover,the dynamic nature of plasma membrane accounts for the movement of these nanocarriers within the cell towards different organelles thereby not only infuencing their pharmacokinetic and pharmacodynamic properties but also bioavailability,therapeutic effcacy and toxicity.Therefore,an in-depth understanding of underlying parameters controlling nanocarrier endocytosis and intracellular fate is essential.In order to direct nanoparticles towards specifc sub-cellular organelles the physicochemical attributes of nanocarriers can be manipulated.These include particle size,shape and surface charge/chemistry.Restricting the particle size of nanocarriers below 200 nm contributes to internalization via clathrin and caveolae mediated pathways.Similarly,a moderate negative surface potential confers endolysosomal escape and targeting towards mitochondria,endoplasmic reticulum(ER)and Golgi.This review aims to provide an insight into these physicochemical attributes of nanocarriers fabricated using amphiphilic graft copolymers affecting cellular internalization.Fundamental principles understood from experimental studies have been extrapolated to draw a general conclusion for the designing of optimized nanoparticulate drug delivery systems and enhanced intracellular uptake via specifc endocytic pathway. | Samrat Mazumdar Deepak Chitkara Anupama Mittal | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 1 |
| 5 | Comparative evaluation of scintigraphy and upper gastrointestinal tract endoscopy for detection of duodenogastric reflux显示文摘 | Bhagwant R. Mittal Mohammad Ibrarullah Deepak K. Agarwal Atul Maini Wasif Ali Sadiq S. Sikora Birendra K. Das | 1994 | Annals of Nuclear Medicine1994，，3： | 1 |
| 6 | New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape显示文摘 | Deepak Mittal Matthew M Gubin Robert D Schreiber Mark J Smyth | 2014 | Current Opinion in Immunology2014，，： | 1 |
| 7 | Role of <sup>18</sup> F ‐fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: Experience from tropics显示文摘 | Sampath Santhosh Bhagwant Rai Mittal Deepak Bhasin Radhika Srinivasan Surinder Rana Ashim Das Ritambhra Nada Anish Bhattacharya Rajesh Gupta Rakesh Kapoor | 2013 | J Gastroenterol Hepatol2013，，2： | 1 |
| 8 | Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer显示文摘 | Anupama Mittal Deepak Chitkara Stephan W. Behrman Ram I. Mahato | 2014 | Biomaterials2014，，25： | 1 |
| 9 | Hepatic endogenous defense potential of propolis after mercury intoxication显示文摘Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in serum.Therapy with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the liver.Release of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis treatment.The activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis administration.These observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent. | Monika BHADAURIA Sangeeta SHUKLA Ramesh MATHUR Om PAGRAWAL Sadhana SHRIVASTAVA Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA | 2008 | Integrative Zoology2008，3，4： | 0 |
| 10 | Regulatory framework of cosmetic in the European Union显示文摘Cosmetics that are personal or personalized are now becoming extremely prevalent.While compliance is mandated by European Union(EU)Cosmetics Directive 1223/2009,there seem to be no strict guidelines for maintaining obedience.Cosmetics must meet a number of conditions in order to be sold in the European Single Market;however,the focus of this article is on the Cosmetics Regulation 1223/2009.Regulations are examined for certain elements and several solutions are presented that allow for careful use of individually cloaked cosmetics that are available on the market.Metallic nanoparticles(NMs)have been proposed for usage as active ingredients/excipient in a number of cosmetics products.Due to fast-paced businesses in the cosmetic industry,cosmetology tends to focus on its distinctive characteristics to bring value to a diverse array of products,but due to the small size of nanometers,NMs may not always follow the very same handling guidelines as their conventional material.As a result,a nano-specific framework for regulating the use of nanomaterials&creation of nano-improved cosmetics is becoming increasingly prevalent.Scientific and industrial perspective into the NMs presently used for the m arketplace,with an emphasis on metallic NMs,and also an evaluation of the regulatory requirements and Scientific Commission on Consumer Safety(SCCS)Opinions.Considering the fact that the original Cosmetic products Directive(EU Legislation No 1223/2009)has precise restrictions on NMs,beauty materials containing unlawful NMs have already been supplied in the EU on numerous times.Researchers examine the risk evaluation indicated in Article 16 of the Cosmetology Code acts as a framework for the potential expansion to enhance nano-items,considering the long-term risks of nanomaterials if mistreated.The nation’s attention is on synchronizing efforts to integrate metallic NMs into cosmetic products but to the restricted fusion of metallic NMs with numerous non-metallic n anoparticles.Although Directive 76/768/EEC on the beauty items is an upright division of amendment that requires the European market for every cosmetic product placed to meet its exigencies would be irrational that it is for believings a stand-alone part of regulations is unaffected by other legal texts.In reality,D irective 76/768/EEC takes the form part of complicated legal action that began 40 years ago that ensure the free passage of goods throughout the EU while also European individuals’and their environment’s safety.The ongoing chapter outlines the most important aspects of the Directive Cosmetic Products along with the latest guidelines 2022 prepared by the COS law Team of what happened in the EU cosmetics regulatory framework between January and March,which serves as the book’s foundation.The trend of personal skincare seems to be high among clients. | Preeti Gautam Deepak Ganghas Payal Mittal Vikas Gupta Kanika Dhiman | 2022 | Toxicology Communications2022，4，3： | 0 |
| 11 | Delivery strategies for CRISPR/Cas genome editing tool for retinal dystrophies:challenges and opportunities显示文摘CRISPR/Cas,an adaptive immune system in bacteria,has been adopted as an efficient and precise tool for site-specific gene editing with potential therapeutic opportunities.It has been explored for a variety of applications,including gene modulation,epigenome editing,diagnosis,mRNA editing,etc.It has found applications in retinal dystrophic conditions including progressive cone and cone-rod dystrophies,congenital stationary night blindness,X-linked juvenile retinoschisis,retinitis pigmentosa,age-related macular degeneration,leber’s congenital amaurosis,etc.Most of the therapies for retinal dystrophic conditions work by regressing symptoms instead of reversing the genemutations.CRISPR/Cas9 through indel could impart beneficial effects in the reversal of gene mutations in dystrophic conditions.Recent research has also consolidated on the approaches of using CRISPR systems for retinal dystrophies but their delivery to the posterior part of the eye is a major concern due to high molecular weight,negative charge,and in vivo stability of CRISPR components.Recently,non-viral vectors have gained interest due to their potential in tissue-specific nucleic acid(miRNA/siRNA/CRISPR)delivery.This review highlights the opportunities of retinal dystrophies management using CRISPR/Cas nanomedicine. | Aayushi Lohia Deepak Kumar Sahel Mohd Salman Vivek Singh Indumathi Mariappan Anupama Mittal Deepak Chitkara | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 0 |
| 12 | FDGPET/CT显像对初次分期胰腺癌患者的转移评估优于增强CT显示文摘【摘要】目的评价脱氧葡萄糖(FDG)PET/CT在胰腺癌初次分期中较常规多相增强cT(CECT)的增益作用。方法54例病理证实的胰腺癌患者行FDGPET/CECT显像,计算PET/CT和CECT在淋巴结分期和转移分期中的灵敏度、特异性、阳性NN值(PPV)、阴性预测值(NPV)和准确性。 | 唐军 Sampath Santhosh Bhagwant Rai Mittal Deepak Kumar Bhasin Surinder Singh Rana Rajesh Gupta Ashim Das Ritambhra Nada | 2018 | 中华核医学与分子影像杂志2018，38，4： | 0 |
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