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| 1 | Targeting inflammation in diabetes: Newer therapeutic options显示文摘Inflammation has been recognised to both decrease beta cell insulin secretion and increase insulin resis-tance. Circulating cytokines can affect beta cell function directly leading to secretory dysfunction and increased apoptosis. These cytokines can also indirectly affect beta cell function by increasing adipocyte inflamma-tion.The resulting glucotoxicity and lipotoxicity further enhance the inflammatory process resulting in a vicious cycle. Weight reduction and drugs such as metformin have been shown to decrease the levels of C-Reactive Protein by 31% and 13%, respectively. Pioglitazone, insulin and statins have anti-inflammatory effects. In-terleukin 1 and tumor necrosis factor-α antagonists are in trials and NSAIDs such as salsalate have shown an improvement in insulin sensitivity. Inhibition of 12-lipo-oxygenase, histone de-acetylases, and activation of sirtuin-1 are upcoming molecular targets to reduce in-flammation. These therapies have also been shown to decrease the conversion of pre-diabetes state to diabe-tes. Drugs like glicazide, troglitazone, N-acetylcysteine and selective COX-2 inhibitors have shown benefit in diabetic neuropathy by decreasing inflammatory mark-ers. Retinopathy drugs are used to target vascular en-dothelial growth factor, angiopoietin-2, various protein-ases and chemokines. Drugs targeting the proteinases and various chemokines are pentoxifylline, inhibitors of nuclear factor-kappa B and mammalian target of rapa-mycin and are in clinical trials for diabetic nephropathy. Commonly used drugs such as insulin, metformin, per-oxisome proliferator-activated receptors, glucagon like peptide-1 agonists and dipeptidyl peptidase-4 inhibitors also decrease inflammation. Anti-inflammatory thera-pies represent a potential approach for the therapy of diabetes and its complications. | Neeraj Kumar Agrawal Saket Kant | 2014 | World Journal of Diabetes2014，5，5： | 41 |
| 2 | Cryptanalysis and improvement of a certificateless signcryption scheme without bilinear pairing显示文摘 | Wenbo SHI Neeraj KUMAR Peng GONG Zezhong ZHANG | 2014 | Frontiers of Computer Science2014，8，4： | 11 |
| 3 | Antioxidant activity and identification of bioactive compounds from leaves of Anthocephalus cadamba by ultra-performance liquid chromatography/electrospray ionization quadrupole time of flight mass spectrometry显示文摘Objective:To evaluate the antioxidant potential of different extract/fractions of Anthocephalus cadamba(A.cadamba)(Roxb.) Miq.(Rubiaceae) and study the tentative identification of their active constituents.Methods:The extract/fractions were screened for antioxidant activity using various in vitro assays viz.DPPH assay,ABTS assay,superoxide anion radical scavenging assay, reducing power assay and plasmid DNA nicking assay.Total phenolic content of extract/fractions was determined by colorimetric method.An ultra-performance LC-electrospray-quadrupoletime of flight mass spectrometry method was used to analyse the active constituents of extract/ fractions of A.cadamba.Results:The ethyl acetate fraction was found to be most active fraction in all the assays as compared to other extract/fractions.The IC50 value of ethyl acetate fraction (ETAC fraction) was 21.24μg/mL,1.12μg/mL,9.68μg/mL and S7.81μg/mL in DPPH assay, ABTS assay,reducing power assay and superoxide scavenging assay respectively.All the extract/ fractions also showed the potential to protect the plasmid DNA(pBR322) against the attack of hydroxyl radicals generated by Fenton’s reagent.The bioactive compounds were identified by UPLC-ESI-QTOF-MS,by comparing the mass andλmax with literature values.Conclusions:The potential of the extract/fractions to scavenge different free radicals in different systems indicated that they may be useful therapeutic agents for treating radical-related pathologic damage. | Madhu Chandel Upendra Sharma Neeraj Kumar Bikram Singh Satwinderjeet Kaur | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 6 |
| 4 | SecBCS: a secure and privacy-preserving blockchain-based crowdsourcing system显示文摘A robust and scalable crowd management infrastructure is crucial in addressing operational challenges when deploying high-density sensors and actuators in a smart city. While crowdsourcing is widely used in crowd management, conventional solutions, such as Upwork and Amazon Mechanical Turk, generally depend on a trusted third-party platform. There exist several potential security concerns(e.g., sensitive leakage, single point of failure and unfair judgment) in such a centralized paradigm. Hence, a recent trend in crowdsourcing is to leverage blockchain(a decentralized ledger technology) to address some of the existing limitations. A small number of blockchain-based crowdsourcing systems(BCSs) with incentive mechanisms have been proposed in the literature, but they are generally not designed with security in mind. Thus, we study the security and privacy requirements of a secure BCS and propose a concrete solution(i.e., SecBCS)with a prototype implementation based on JUICE. | Chao LIN Debiao HE Sherali ZEADALLY Neeraj KUMAR Kim-Kwang Raymond CHOO | 2020 | Science China(Information Sciences)2020，63，3： | 4 |
| 5 | 利用卫星遥感和GIS技术测定印度切蒂斯格尔地区干旱热带森林的土地利用、生物量和碳贮量(英文)显示文摘2001-2002年间,利用卫星遥感和GIS技术研究印度切蒂斯格尔邦的赖布尔地区干旱热带森林的土地利用、生物量和碳贮量情况。主要森林类型为:柚木森林、混合林、衰退森林和婆罗双树混交林。在这些不同森林类型中,立地的坡度和坡面影响森林植被类型、生物量和碳贮量。不同森林类型中,木材积蓄积量、生物量和碳贮量的变化范围分别为:35.59~64.31 m3·hm-2、45.94~78.31Mg·hm-2和22.97~33.27Mg·hm-2。混合林中每公顷的木材蓄积量、生物量和碳贮量最大,衰退森林中的最低。混合林、柚木森林、衰退森林和婆罗双树混交林的总碳量分别为8170.72 Mg、81656.91 Mg、7833.23 Mg和7470.45 Mg。蒂斯格尔邦地区干旱热带森林处于不成熟的生长阶段,且具有很强的碳回收潜力。图6表7参49。 | Arvind Bijalwan S.L.Swamy Chandra Mohan Sharma Neeraj Kumar Sharma A.K.Tiwari | 2010 | Journal of Forestry Research2010，21，2： | 3 |
| 6 | 建立林业部和非政府组织间的信任——印度参与式森林经营的政策和实践 | Neeraj Kumar Negi 李文英 | 2000 | 林业与社会2000，，5： | 2 |
| 7 | EMD-Att-LSTM: A Data-driven Strategy Combined with Deep Learning for Short-term Load Forecasting显示文摘Electric load forecasting is an efficient tool for system planning, and consequently, building sustainable power systems. However, achieving desirable performance is difficult owing to the irregular, nonstationary, nonlinear, and noisy nature of the observed data. Therefore, a new attention-based encoderdecoder model is proposed, called empirical mode decomposition-attention-long short-term memory(EMD-Att-LSTM).EMD is a data-driven technique used for the decomposition of complex series into subsequent simpler series. It explores the inherent properties of data to obtain the components such as trend and seasonality. Neural network architecture driven by deep learning uses the idea of a fine-grained attention mechanism, that is, considering the hidden state instead of the hidden state vectors, which can help reflect the significance and contributions of each hidden state dimension. In addition, it is useful for locating and concentrating the relevant temporary data,leading to a distinctly interpretable network. To evaluate the proposed model, we use the repository dataset of Australian energy market operator(AEMO). The proposed architecture provides superior empirical results compared with other advanced models. It is explored using the indices of root mean square error(RMSE) and mean absolute percentage error(MAPE). | Neeraj Jimson Mathew Ranjan Kumar Behera | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 2 |
| 8 | Synthesis,isolation,identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC,LC/ESI-MS and NMR显示文摘One unknown impurity(Imp-Ⅱ) during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-(propan-2-ylamino)ethyl]benzene-1,2-diol(Imp-Ⅱ) using the liquid chromatography–mass spectrophotometry(LC–MS) analysis. Imp-Ⅱ was isolated by semi-preparative liquid chromatography from the impurity-enriched reaction crude sample. Its proposed structure was confirmed by nuclear magnetic spectroscopy such as ~1H,^(13)C, DEPT(1D NMR), HSQC(2D NMR)and infrared spectroscopy(IR), and retention time and purity with HPLC followed by the chemical synthesis.Due to less removable nature of Imp-Ⅱ during the purification, the synthetic process was optimized proficiently to control the formation of Imp-Ⅱ below to the limit < 0.12% in the course of reaction. The new chemical route was developed for the preparation of this impurity in required quantity with purity to use as reference standard.The most probable mechanism for the formation of Imp-Ⅱ was discussed in details. | Neeraj Kumar Subba Rao Devineni Prasad Reddy Gajjala Shailendra Kumar Dubey Pramod Kumar | 2017 | Journal of Pharmaceutical Analysis2017，7，6： | 2 |
| 9 | 提高认知能力的印度传统草药土丁桂(英文)显示文摘土丁桂属草药是作用于中枢神经系统的印度传统药物,特别是对促进记忆和改善智力有较好疗效。从印度传统医学和梵语文献中提取的大量信息提示,冠以土丁桂属草药名称的植物类别共4种:旋花科田旋花、旋花科土丁桂、蝶形花科蝴蝶花豆和龙胆科穿心草。这些草药名称均在古代文献中有所记载,可单独使用或与其他药材组合成各种草药处方。本文就现有的科学信息,如土丁桂属不同植物来源物种的生药学特征、化学成分、药理作用、临床前及临床应用等方面进行述评,以期为科学地应用土丁桂提供依据。此外,还可根据不同植物来源土丁桂属草药的不同功效进行鉴别应用。 | Neeraj Kumar SETHIYA Alok NAHATA Sri Hari MISHRA Vinod Kumar DIXIT | 2009 | 中西医结合学报2009，7，11： | 2 |
| 10 | Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics显示文摘Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of cancer.Recently,2 D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of cancer.The high surface area,surface functional groups availability,and excellent electrical conductivity of MXene make it the 2 D material of choice for the fabrication of advanced electrochemical biosensors for disease diagnostics.MXene-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of detection.Additionally,the stability,ease of synthesis,good reproducibility,and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic approach.In this review,the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been discussed.Besides,various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been elucidated.Further,futuristic sensing applications along with challenges will be deliberated herein. | Arpana Parihar Ayushi Singhal Neeraj Kumar Raju Khan MohdAkram Khan Avanish KSrivastava | 2022 | Nano-Micro Letters2022，14，6： | 2 |
| 11 | Progress in bioactive surface coatings on biodegradable Mg alloys:A critical review towards clinical translation显示文摘Mg and its alloys evince strong candidature for biodegradable bone implants,cardiovascular stents,and wound closing devices.However,their rapid degradation rate causes premature implant failure,constraining clinical applications.Bio-functional surface coatings have emerged as the most competent strategy to fulfill the diverse clinical requirements,besides yielding effective corrosion resistance.This article reviews the progress of biodegradable and advanced surface coatings on Mg alloys investigated in recent years,aiming to build up a comprehensive knowledge framework of coating techniques,processing parameters,performance measures in terms of corrosion resistance,adhesion strength,and biocompatibility.Recently developed conversion and deposition type surface coatings are thoroughly discussed by reporting their essential therapeutic responses like osteogenesis,angiogenesis,cytocompatibility,hemocompatibility,anti-bacterial,and controlled drug release towards in-vitro and in-vivo study models.The challenges associated with metallic,ceramic and polymeric coatings along with merits and demerits of various coatings have been illustrated.The use of multilayered hybrid coating comprising a unique combination of organic and inorganic components has been emphasized with future perspectives to obtain diverse bio-functionalities in a facile single coating system for orthopedic implant applications. | Navdeep Singh Uma Batra Kamal Kumar Neeraj Ahuja Anil Mahapatro | 2023 | Bioactive Materials2023，，1： | 2 |
| 12 | Alteration in the expression of microRNA-21 regulated target genes:Role in breast cancer显示文摘Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of cancer.New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis.MicroRNAs(miRNAs),a class of non-coding RNAs,are known to control the biological processes involving transcription,post-transcriptional and covalent modifications,splicing,translation,cell differentiation,proliferation,apoptosis,cancer progression,and invasion.Any dysregulation in miRNA expression,demonstrating their oncogenic and tumor-suppressive functions,contributes to cancer progression.MicroRNA-21(miR-21),an‘onco-miR’in breast cancer,is involved in tumor progression and metastasis by suppressing the activity of the target gene via its interaction with the 3’UTR of the target gene.The upregulation of miR-21 is observed in many instances of breast cancer.Our review aims to summarize the current understanding of miR-21 in the regulation of important cellular functions via regulation of its target genes.We discuss its biosynthesis,oncogenic function in breast cancer,and different methods used for its detection.This will increase the current understanding of the role of miR-21 in breast cancer tumorigenesis,which will offer a perception of using miR-21 as an early detection molecular prognostic and diagnostic biomarker and as a therapeutic target in breast cancer care. | PRIYANKA THAKUR REENA V.SAINI ANIL K.CHHILLAR NEERAJ K.SAINI VIJAY KUMAR THAKUR SAMARJEET SINGH SIWAL ADESH K.SAINI | 2022 | BIOCELL2022，46，2： | 1 |
| 13 | Effect of In- trinsic Stress on the Optical Properties of Nanostrucmred ZnO Thin Films Grown by Rf Magnetron Sputtering 显示文摘 | Kumar Rajesh Khare Neeraj Kumar Vijay | 2008 | Applied Surface Science2008，254，： | 1 |
| 14 | Band gap optimization of p–i–n layers of a-Si:H by computer aided simulation for development of efficient solar cell显示文摘 | Sukhbir Singh Sushil Kumar Neeraj Dwivedi | 2012 | Solar Energy2012，，5： | 1 |
| 15 | Competent Faculty in Engineering Institutions Requirement vs Availability 显示文摘 | NEERAJ KUMAR | 2008 | The Journal of Technical Education2008，31，1： | 1 |
| 16 | Domb, Biodegradable Injectable in Situ Depot - forming Drug Delivery Systems 显示文摘 | Deepak Chitkara Ariella Shikanov Neeraj Kumar | 2006 | Macromol Biosci2006，6，： | 1 |
| 17 | Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration显示文摘 | Neeraj Kumar John B. Gross J. Eric Ahlskog | 2004 | Neurology2004，，1： | 1 |
| 18 | Development of amphotericin B loaded polymersomes based on (PEG) 3 -PLA co-polymers: Factors affecting size and in vitro evaluation显示文摘 | Jay Prakash Jain Neeraj Kumar | 2010 | European Journal of Pharmaceutical Sciences2010，，： | 1 |
| 19 | Biodegradable Injectable in situ Depot -forming Drug Delivery Systems- Macromo显示文摘 | Deepak Chitkara Ariella Shikanov Neeraj Kumar Abraham J Domb | 2006 | Biosc2006，6，： | 1 |
| 20 | Analysis of dichroic dye-doped polymer-dispersed liquid crystal materials for display devices显示文摘 | Kumar P Neeraj Kang S W | 2011 | Thin Solid Films2011，520，1： | 1 |
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