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| 1 | 发酵条件对红茶菌发酵品质及风味的影响显示文摘探究发酵条件对红茶菌发酵品质及发酵液风味的影响。以发酵产酸率、感官评分为指标,考察红茶品种、茶叶浸提方式、糖添加量、茶叶添加量及红茶菌膜接种量的影响;同时,对发酵过程中风味物质的变化进行分析。结果表明:将水煮沸后,加0.5%醇香红茶浸提15 min,加入7%糖,冷却后加8%红茶菌膜于30℃条件下发酵10 d,得到的产品感官品质好,发酵液呈清澈淡黄色,酸甜适中,微酸,口味纯;茶汤经发酵后风味物质显著改变,共检测到19种风味成分,其中醇类7种、酯类6种、酸类4种、酚类1种、烷烃类1种,即风味物质多为醇类、酯类和酸类。醇类的含量为25.09%,其中乙醇含量为21.51%;酸类的含量为46.40%,其中正辛酸含量为19.41%;酯类的含量为15.91%,其中乙酸乙酯含量为9.47%。 | 袁磊 张国华 Faizan Ahmed SADIQ 何国庆 | 2017 | 食品科学2017，38，2： | 23 |
| 2 | Vascular endothelial growth factor trap-eye(Aflibercept) for the management of diabetic macular edema显示文摘Diabetic retinopathy(DR)is the most common cause of visual loss among working age individuals.Diabetic macular edema(DME)is an important complication of DR that affects around one third of the patients with DR.Several treatments have been approved for DME ranging from blood pressure and glycemic control to photocoagulation and more recently the use of vascular endothelial growth factor(VEGF)antagonists.The index review discusses aflibercept(EYLEA-Regeneron Pharmaceuticals,Inc.,Tarrytown,New York,NY,and Bayer Healthcare Pharmaceuticals,Berlin,Germany)in the context of other VEGF antagonists currently available for the treatment of DME.A systematic search of literature was conducted on PubMed,Scopus,and Google Scholar with no limitation on language or year of publication.Pre-clinical studies of aflibercept have shown a higher affinity of this molecule for vascular endothelial growth factor A(VEGF-A)along with a longer duration of action as compared to other VEGF antagonists.Recent clinical trials have shown visual outcome results for aflibercept to be similarly favorable as compared to other available agents with the added benefit of fewer required injections and less frequent monitoring.Aflibercept presents a potential exciting new addition to the armamentarium of current VEGF antagonists available for the treatment of DME and other retinal vascular diseases.However,further studies are indicated to confirm the role,safety,and efficacy of aflibercept for DME. | Ahmadreza Moradi Yasir Jamal Sepah Mohammad Ali Sadiq Humzah Nasir Salima Kherani Raafay Sophie Diana V Do Quan Dong Nguyen | 2013 | World Journal of Diabetes2013，4，6： | 8 |
| 3 | 一种优化关系型溯源信息存储的新方法显示文摘现代数据管理必须处理来源不同、质量各异的数据,因此从系统层面支持数据溯源,让用户了解数据的来源及派生过程成为当前至关重要的一个研究课题.基于标注的方法是支持数据溯源的基本方法之一.这种方法的主要问题是存储空间开销,因为溯源信息可能会超过实际数据的大小.在该文中,作者提出了一个用与查询结构匹配的溯源树来表达和存储溯源信息从而避免数据派生过程中冗余存储的基本框架.基于这个框架,作者提出了一系列针对关系型查询的存储优化方法,选择查询树部分节点来存储溯源信息.这些优化算法对于查询大小是多项式时间,对于溯源信息大小是线性时间,在溯源信息的跟踪和优化方面均不会产生巨大的开销.这一框架是数据溯源研究的一个新思路,有着广泛的应用前景. | 王黎维 鲍芝峰 KOEHLER Henning 周晓方 SADIQ Shazia | 2011 | 计算机学报2011，34，10： | 6 |
| 4 | Comparative transcriptome analysis of different nitrogen responses in low-nitrogen sensitive and tolerant maize genotypes显示文摘Although previous researches have greatly increased our general knowledge on plant responses to nitrogen(N)stress,a comprehensive understanding of the different responses in crop genotypes is still needed.This study evaluated 304 maize accessions for low-N tolerance under field conditions,and selected the low-N sensitive Ye478 and low-N tolerant Qi319 for further investigations.After a 5-day low-N treatment,the typical N-deficient phenotype with yellowing older leaves was observed in Ye478 but not in Qi319.After the 5-day low-N stress,16 RNA libraries from leaf and root of Ye478 and Qi319 were generated.The differentially expressed genes(DEGs)in the root of Qi319 up-regulated by special N deficiency were mainly enriched in energy-related metabolic pathways,including tricarboxylic acid metabolic process and nicotinamide metabolic process.Consistent with yellowing older leaves only observed in Ye478,the special N deficiency-responsive DEGs related to thylakoid,chloroplast,photosynthetic membrane,and chloroplast stroma pathways were repressed by low-N stress in Ye478.A total of 216 transcription factors(TFs),including ZmNLP5,were identified as special N deficiencyresponsive TFs between Qi319 and Ye478,indicating the importance of transcriptional regulation of N stress-responsive pathway in different tolerance to low-N stress between crop genotypes.In addition,15 miRNAs were identified as DEGs between Qi319 and Ye478.Taken together,this study contributes to the understanding of the genetic variations and molecular basis of low-N tolerance in maize. | DU Qing-guo YANG Juan Shah Syed Muhammad Sadiq YANG Rong-xin YU Jing-juan LI Wen-xue | 2021 | Journal of Integrative Agriculture2021，20，8： | 5 |
| 5 | Low-velocity simultaneous bilateral femoral neck fracture following long-term antiepileptic therapy:A case report显示文摘BACKGROUND Simultaneous bilateral femoral neck fractures are relatively rare injuries.They are usually associated with underlying metabolic bone disorders or systemic diseases.Long-term use of narcotics and bisphosphonates can also result in similar fracture patterns;however,association of this fracture type with longterm use of antiepileptic drugs is not very common.Only one such case has been reported in the literature.This article describes the second.CASE REPORT We report a case of simultaneous displaced bilateral femoral neck fractures in a 50-year-old epileptic patient,who had taken phenytoin for the past 3 years.The fractures were a result of low-velocity injury following a fall from the bed.The fractures were managed with a bilateral hemi-replacement arthroplasty.Oral bisphosphonates were given to improve the bone quality in the post-operative period.The patient had a good post-operative outcome,that was sustained throughout the entire follow-up period of 1 year.CONCLUSION Antiepileptic drugs should be supplemented with bisphosphonates and vitamin D to improve bone quality and prevent fractures in epileptic patients. | Mohammed Sadiq Vikrant Kulkarni Syed Azher Hussain Mohammed Ismail Mayur Nayak | 2019 | World Journal of Orthopedics2019，10，10： | 5 |
| 6 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 4 |
| 7 | Macrophages are the primary effector cells in IL-7-induced arthritis显示文摘Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages.The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ induction.Hence, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity. | Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien Van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi David A.Fox Nadera Sweiss Shiva Shahrara | 2020 | Cellular & Molecular Immunology2020，17，7： | 4 |
| 8 | 乳酸菌协同小麦胚芽油发酵对黑曲霉生长活性的影响显示文摘本文通过初筛和复筛考察不同乳酸菌的抗真菌活性,并将小麦胚芽油添加入乳酸菌培养液中进行发酵,旨在明确乳酸菌协同小麦胚芽油发酵对抗黑曲霉活性的影响。研究表明,小麦胚芽油不具有抑制黑曲霉生长的能力,而乳杆菌LF5发酵液抑菌率随着小麦胚芽油浓度的升高明显提升,且该现象具有菌株特异性。通过加热、中和pH、添加蛋白酶及过氧化氢酶发现,乳酸菌协同发酵上清液中的抗真菌活性物质主要由有机酸以及部分具有良好热稳定性的非蛋白类组分组成。此外,采用乳杆菌LF5协同小麦胚芽油发酵制备面包,在第5 d发现肉眼可见霉菌,与空白组(第2~3 d)相较具有显著抑制黑曲霉生长活性的作用,为乳酸菌在发酵米面食品中的应用提供了新的方向。 | 史梦洁 闫博文 Faizan Ahmed Sadiq 范大明 连惠章 田丰伟 赵建新 张灏 陈卫 | 2020 | 食品工业科技2020，41，19： | 3 |
| 9 | Congenital diarrhea in a newborn infant: A case report显示文摘BACKGROUND Microvillus inclusion disease(MVID)is a rare autosomal recessive cause of severe congenital diarrhea with significant morbidity and mortality.Definitive treatment involves bowel transplant.The diagnosis of this condition can be challenging and a few genetic panels are available for the identification of the most common mutations.We present the case of an infant with MVID due to a mutation not reported in the literature before.CASE SUMMARY We report the case of an infant transferred to our institution with severe diarrhea of unknown etiology,failure to thrive,and significant metabolic derangements.An extensive work-up including stool studies for common gastrointestinal pathogens,abdominal ultrasound,esophagogastroduodenoscopy with duodenal biopsy and flexible sigmoidoscopy failed to reveal a diagnosis.Multiple dietary and formula regimens were introduced but all resulted in voluminous diarrhea.She remained on total parenteral nutrition(TPN)for the duration of her hospital stay.Genetic testing was done and she was subsequently found to have a novel mutation in the MYO5B gene[homozygous mutation for MYO5B c.1462del,p.(Ile488Leufs*93)]giving us the diagnosis of MVID.She remains on TPN while awaiting bowel transplant at the time of the compilation of this case report.CONCLUSION We report a novel mutation involved in MVID and highlight the importance of considering this disease when faced with a newborn presenting with life threatening diarrhea.At the time of this publication,232 allelic variations of this gene(MIM#606540)exist in National Center for Biotechnology Information’s database.Our patient’s mutation has not been reported in literature as a cause of MVID. | Mehrin Sadiq Omer Choudry Arun K Kashyap Danitza M Velazquez | 2019 | World Journal of Clinical Pediatrics2019，8，3： | 3 |
| 10 | 经验模态分解(EMD)法及其在流噪声实验研究中的应用显示文摘经验模态分解(EMD)法是近年来发展起来的一种新的信号分析方法,其创新之处在于通过对信号的分解可以得到一个个与一定物理意义相对应的本征模态函数(IMF),对每一个IMF作Hilbert变化后,可以得到其时-频关系曲线,该分析方法不仅可以分析线性稳态信号,还可用于非线性非稳态信号.该文将其用于有自由液面的陷落式圆腔流噪声实验研究中,采用对比研究的实验方法,判别出与腔体产生的流噪声相对应的本征模态函数(IMF),从而得到了所需的流噪声结果。该方法使用的成功为流噪声的研究提供了一个新的实验研究方法. | 姚熊亮 康庄 戴伟 SADIQ Salman | 2007 | 哈尔滨工程大学学报2007，28，1： | 3 |
| 11 | Hydrometallurgical leaching and kinetic modeling of low-grade manganese ore with banana peel in sulfuric acid显示文摘Manganese was leached from a low-grade manganese ore(LGMO)using banana peel as the reductant in a dilute sulfuric acid medium.The effects of banana peel amount,H2SO4 concentration,reaction temperature,and time on Mn leaching from the complex LGMO were studied.A leaching efficiency of~98%was achieved at a leaching time of 2 h,banana peel amount of 4 g,leaching temperature of 120°C,manganese ore amount of 5 g,and sulfuric acid concentration of 15vol%.The phase,microstructural,and chemical analyses of LGMO samples before and after the leaching process confirmed the successful leaching of manganese.Furthermore,the leaching process followed the shrinking core model and the leaching rate was controlled by a surface chemical reaction(1−(1−x)^1/3=kt)mechanism with an apparent activation energy of 40.19 kJ·mol^−1. | Sajjad Ali Yaseen Iqbal Inamullah Khan Ansar Ullah Muhammad Sadiq Muhammad Fahad Khizar Hussain Shah | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，2： | 3 |
| 12 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 2 |
| 13 | Evaluation of five medicinal plants used in diarrhoea treatment in Nigeria显示文摘 | Abdulkarim Agunu Sadiq Yusuf Gabriel Onyiloyi Andrew Abdulkadir Umar Zezi Ezzeldin Mukhtar Abdurahman | 2005 | Journal of Ethnopharmacology2005，，1： | 2 |
| 14 | ZrO2催化无溶剂条件下醇的液相氧化反应显示文摘采用一种环境友好的方法,以分子氧为氧化剂,以ZrO2为催化剂,在无溶剂的条件下实现了醇的选择性氧化.苯甲醛、环己酮和辛醛等是相应醇的主要氧化产物.考察了不同反应条件(搅拌速度、反应时间和温度)、催化剂制备参数(焙烧温度和负载量)及氧分压等的影响.结果发现,对于醇氧化生成相应羰基化合物,1 223 K焙烧的ZrO2比723 K焙烧的ZrO2显示出更高的催化活性.催化剂在反应混合物中不溶解,可以通过简单的过滤使其分离并重复使用.当搅拌速度大于900 r/min时,对醇的转化速率无明显的影响. | Mohammad ILYAS Mohammad SADIQ Imdad KHAN | 2007 | 催化学报2007，28，5： | 2 |
| 15 | Surgical strategies in patients with gallbladder cancer: Nihilism to optimism显示文摘 | Sadiq S.Sikora Rajneesh K.Singh | 2006 | Oncol2006，，8： | 2 |
| 16 | Synthesis of BaWOq/NRGO-g-C3N4 nanocomposites with excellent multifunctional catalytic performance via microwave approach显示文摘 | M. Mohamed Jaffer SADIQ U. Sandhya SHENOY D. Krishna BHAT | 2018 | Frontiers of Materials Science2018，12，3： | 2 |
| 17 | Optimization study of a PEM fuel cell performance using 3D multi-phase computational fluid dynamics model显示文摘An optimization study using a comprehensive 3D, multi-phase, non-isothermal model of a PEM (proton exchange membrane) fuel cell that incorporates significant physical processes and key parameters affecting fuel cell performance is pre-sented and discussed in detail. The model accounts for both gas and liquid phase in the same computational domain, and thus allows for the implementation of phase change inside the gas diffusion layers. The model includes the transport of gaseous species, liquid water, protons, energy, and water dissolved in the ion-conducting polymer. Water is assumed to be exchanged among three phases: liquid, vapour, and dissolved, with equilibrium among these phases being assumed. This model also takes into account convection and diffusion of different species in the channels as well as in the porous gas diffusion layer, heat transfer in the solids as well as in the gases, and electrochemical reactions. The results showed that the present multi-phase model is capable of iden-tifying important parameters for the wetting behaviour of the gas diffusion layers and can be used to identify conditions that might lead to the onset of pore plugging, which has a detrimental effect on the fuel cell performance. This model is used to study the effects of several operating, design, and material parameters on fuel cell performance. Detailed analyses of the fuel cell per-formance under various operating conditions have been conducted and examined. | AL-BAGHDADI Maher A.R. Sadiq AL-JANABI Haroun A.K.Shahad | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，2： | 2 |
| 18 | Fuzzy synthetic evaluation of disinfection by-products-a risk-based indexing system 显示文摘 | Sadiq R Rodriguez M J | 2004 | J Environ Manage2004，73，1： | 1 |
| 19 | Xylanases and their applications in baking industry显示文摘 | MASOOD SADIQ BUTT MUHAMMAD TAHIR-NADEEM | 2008 | Food Technol2008，46，1： | 1 |
| 20 | Spatial variations of human health risk associated with exposure to chlorination by-products occurring in drinking water显示文摘 | LEGAY C RODRIGUEZ M J SADIQ R | 2011 | Journal of Environmental Management2011，92，3： | 1 |
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