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| 1 | 未来收入预期与进城农民工生活满意度——对上海等12个城市调查数据的实证研究显示文摘进城农民工是推动中国经济高速增长的重要引擎,既便在生活和工作条件很艰苦的条件下,进城农民工为何还继续留在城市?利用2005年全国12个城市的大样本调查数据,通过研究进城农民工生活满意度的决定因素发现,对未来收入的预期是进城农民工生活满意度的一个重要决定因素。研究发现,很多进城农民工对未来的收入甚至生活状况都有良好的乐观预期,这对他们当前的生活满意度和幸福感产生了积极影响。这一发现对于中国的经济增长以及社会经济的稳定具有重要含义,因为保持社会经济的稳定对于保持中国高速的经济增长非常重要,而对未来收入的积极预期对于在经济转型时期保持社会经济稳定具有重要意义。 | 高文书 Russell Smyth | 2010 | 云南财经大学学报2010，26，6： | 29 |
| 2 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 3 | Computed tomography scans of paranasal sinuses before functional endoscopic sinus surgery显示文摘This review aims to familiarize the radiologist with the common types of sinus surgery including their indications and techniques.We also illustrate how surgeons interpret 3D sinus anatomy when evaluating computed tomography(CT)studies.Preoperative evaluation by CT is mandatory for all patients undergoing functional endoscopic sinus surgery(FESS).In the past decade in particular,CT of the paranasal sinuses has become a roadmap for FESS.The radiologist's goal is to report on five key points:the extent of sinus opacification,opacification of sinus drainage pathways,anatomical variants,critical variants,and condition of surrounding soft tissues of the neck,brain and orbits.We present a systematic approach to the use of coronal,axial,and sagittal images in CT evaluation before FESS. | Emma C Cashman Peter J MacMahon David Smyth | 2011 | World Journal of Radiology2011，3，8： | 10 |
| 4 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 5 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 6 | Migration and the Right to Social Security:Perceptions of Off-farm Migrants' Rights to Social Insurance in China's Jiangsu Province显示文摘In 2001 China ratified the International Covenant on Economic,Social and Cultural Rights. By so doing the national government became legally bound,'to the maximum of its available resources',to achieve 'progressively' full realization of the rights specified in the Covenant. Included amongst these entitlements is the 'right of everyone to social security,including social insurance'. This paper uses data from Jiangsu to examine the extent to which urbanites agree that previously disenfranchised migrants have the same right to social insurance as the urban population. Many urbanites fear that their existing entitlements to social protection will be diluted if social insurance coverage is extended to include new populations. Accordingly,state agencies and the media have sought to promote acceptance of a more positive view of migrant workers than has traditionally prevailed within towns and cities. We find that younger urban residents,urban residents who already have social insurance and urban residents working in the state-owned sector are more likely to agree that migrants have the same right to social insurance as the urban population. | Ingrid Nielsen Chris Nyland Russell Smyth Minqiong Zhang | 2007 | China & World Economy2007，15，2： | 6 |
| 7 | Role of(~(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies显示文摘The role of whole-body FDG [(~(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two decades.FDG-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging tools.The sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose metabolism.The metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall survival.This may offer a future paradigm ofpersonalized treatment based on the PET response to chemotherapy.FDG-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal disease.Efforts to improve the accuracy of PET include the use of novel radiotrac-ers such as(~(18)F)FLT(3-deoxy-3-fluorothymidine)or 11C-choline,or fusion PET-CT with concurrent high-res-olution computed tomography.This review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma. | Elizabeth C Smyth Manish A Shah | 2011 | World Journal of Gastroenterology2011，17，46： | 6 |
| 8 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 9 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 10 | Emerging molecular targets and therapy for cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients. | Hamzeh Kayhanian Elizabeth C Smyth Chiara Braconi | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 5 |
| 11 | 阿斯匹林预防心血管疾病的剂量系统综述显示文摘背景:为了长期预防心血管疾病,目前美国有5千万以上的成年人定期服用阿斯匹林,所用剂量通常为81mg/d或325mg/d。关于长期服用阿斯匹林的最佳剂量目前仍有争议。
目的:复习阿斯匹林的作用机制,对论述阿斯匹林剂量、效果和安全性相互关系的临床文献进行系统回顾。证据获取:使用MEDLINE和EMBASE(至2007年2月)对相关英文文献进行系统回顾。所用检索词为:阿斯匹林或乙酰水杨酸和剂量。检索限于临床试验,通过审查相关原始资料报告和综述文章的参考文献进一步扩展检索范围。已发表的关于心血管患者使用不同剂量阿斯匹林的前瞻性研究亦纳入分析。
证据综合:尽管药理学数据证实长期服用30mg/d阿斯匹林足以充分抑制血小板血栓烷生成,但是目前批准使用的剂量高达1300mg/d。在美国,最常采用的剂量为81mg/d(60%),其次为325mg/d(35%)。现有证据(主要来自二级预防观察研究)支持下述观点:阿斯匹林剂量大于75至80mg/d并不提高疗效,更大剂量反而增加出血事件发生率,后者主要与胃肠道毒性有关。
结论:对于心血管疾病的预防,现有临床数据并不支持常规、长期使用大于75~81mg/d剂量阿斯匹林。较高剂量的阿斯匹林虽然常用,但是并不能更好地预防心血管事件,而且发生胃肠道出血的危险增加。 | Charles L. Campbell Susan Smyth Gilles Montalescot Steven R. Steinhubl 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，5： | 4 |
| 12 | Economic Openness and Subjective Well-being in China显示文摘用在 2003 年 9 月越过 30 个城市管理的大家庭调查,我们检验在经济坦诚的度之间的关系,在城市的中国作为 GDP,和主观健康的份额作为进出口的和测量了。我们发现与经济坦诚的高水平在城市里住在一起的回答者显著地报导主观健康 ceteris paribus 的底层。我们为这结果提供四解释;也就是,在面临全球化,未实现的期望,政治不满和社会的反常状态时的不适当的社会保护。 | Russell Smyth | 2010 | China & World Economy2010，18，2： | 4 |
| 13 | 澳大利亚国企改革实践及对中国国企改革的启示显示文摘本文介绍了澳大利亚国企改革的私有化、开放市场等的具体进程 ,分析了改革对于效率、价格、社会服务、国有资产流失等方面的影响。尽管澳大利亚与中国有许多不同之处 ,但是两国国企改革中也有许多共同性的问题 ,文中就一些共性的问题 ,分析了澳大利亚国企改革对于中国国企改革的借鉴作用。 | Russell Smyth 翟庆国 | 2001 | 财经问题研究2001，，7： | 3 |
| 14 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 15 | 新型的持续配戴高DK值的角膜接触镜(英文)显示文摘目的 :随着镜片材料和制作工艺的高速发展 ,更加安全地过夜配戴角膜接触镜已逐渐成为可能。方法 :对近年来涉及持续配戴高DK值角膜接触镜的一些研究论文进行综述。结果 :新型的高DK值的硅胶和硅氟化物水凝胶镜片与传统的HEMA镜片相比 ,氧传导性高出 6倍 ,这种新材料的镜片能够从根本上避免任何与组织缺氧有关的并发症。另一个明显的差异在于 :新一代的硅胶镜片有更高的系数。而且在生理反应、匹配以及易操作性方面 ,与传统的低DK值镜片也明显不同。另外 ,尽管与组织缺氧相关的并发症不再存在 ,但是由于镜片覆盖在角巩缘 36 0度范围 ,所以潜在的炎症反应以及机械性的损伤仍然不可避免。因此 ,制造者对涉及角膜生理反应的评估和对配适关系重要性的理解是这些新镜片获得成功过夜配戴的关键。结论 :作为眼保健的从业者 ,视光医师必须了解持续配戴镜片的新进展情况、新材料潜在的副反应和配适特性。 | Jennifer L. Smythe Peter Bergenske Patrick J. Caroline | 2003 | 眼视光学杂志2003，5，4： | 3 |
| 16 | Percutaneous transluminal angioplasty and stenting in patients with proximal vertebral artery stenosis显示文摘 | George A. Antoniou David Murray George S. Georgiadis Stavros A. Antoniou Andrew Schiro Ferdinand Serracino-Inglott J. Vincent Smyth | 2012 | Journal of Vascular Surgery2012，，4： | 2 |
| 17 | The KDD process for extracting useful knowledge from volumes of data显示文摘 | Usama Fayyad Gregory Piatetsky-Shapiro Padhraic Smyth | 1996 | Communications of the ACM1996，，11： | 2 |
| 18 | Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance显示文摘 | Laurence Zitvogel Lorenzo Galluzzi Mark J. Smyth Guido Kroemer | 2013 | Immunity2013，，1： | 2 |
| 19 | Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity显示文摘 | SMYTH S S SCIORRA V A SIGAL Y J | 2003 | J Biol Chem2003，278，43： | 2 |
| 20 | A modified Prony algorithmfor exponential function fitting显示文摘 | Osborne M R Smyth G | 1995 | SIAM J Comput1995，16，： | 2 |
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