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| 1 | Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury显示文摘To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury. | Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，11： | 1 |
| 2 | Reversal of acetaminophen induced subchronic hepatorenal injury by propolis extract in rats显示文摘 | Monika Bhadauria Satendra Kumar Nirala | 2008 | Environmental Toxicology and Pharmacology2008，，1： | 1 |
| 3 | Attenuation of beryllium induced hepatorenal dysfunction and oxidative stress in rodents by combined effect of gallic acid and piperine显示文摘 | Jun-Quan Zhao Guo-Zhen Du You-Cai Xiong Yi-Fu Wen Monika Bhadauria Satendra Kumar Nirala | 2007 | Archives of Pharmacal Research2007，，12： | 1 |
| 4 | Attenuation of beryllium induced hepatorenal dysfunction and oxidative stress in rodents by combined effect of gallic acid and piperine显示文摘 | Jun-Quan Zhao Guo-Zhen Du You-Cai Xiong Yi-Fu Wen Monika Bhadauria Satendra Kumar Nirala | 2007 | Archives of Pharmacal Research2007，，12： | 1 |
| 5 | Combined effects of gallic acid and propolis on beryllium-induced hepatorenal toxicity显示文摘The combined effect of gallic acid (3,4,5-trihydroxy benzoic acid;GA;50 mg kg^(-1) i.p.) and propolis (200 mg kg^(-1)p.o.)was evaluated against beryllium-induced biochemical and morphological alterations in the liver and kidney. Femalealbino rats were exposed to beryllium nitrate (1 mg kg^(-1)i.p.) daily for 28 days followed by treatment with the abovementioned therapeutic agents either individually or in combination for five consecutive days. Exposure to berylliumincreased its concentration in the serum, liver and kidney and caused significant alterations in cytochrome P450enzymes, microsomal lipid peroxidation and protein contents. Beryllium administration significantly altered theaspartate aminotransaminase, alanine aminotransaminase, lactate dehydrogenase, -glutamyl transpeptidase,bilirubin, creatinine and urea in serum, and the activity of acid phosphatase, alkaline phosphatase, adenosinetriphosphatase, glucose-6-phophatase and succinic dehydrogenase, triglycerides, cholesterol, protein contents,glycogen contents, lipid peroxidation and glutathione level in the liver and kidney. Beryllium exposure inducedsevere alterations in hepatorenal morphology, revealing its toxic consequences at a cellular level. Individual administrationof GA and propolis reduced the effects on the studied parameters to a degree. Interestingly, GA in conjunctionwith propolis reversed the alterations in all of the variables examined, highlighting the beneficial effects ofcombined therapy over monotherapy in the alleviation of beryllium-induced systemic toxicity. | Satendra K.NIRALA Peiqiang LI Monika BHADAURIA Guangqin GUO | 2008 | Integrative Zoology2008，3，3： | 0 |
| 6 | Hepatic endogenous defense potential of propolis after mercury intoxication显示文摘Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in serum.Therapy with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the liver.Release of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis treatment.The activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis administration.These observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent. | Monika BHADAURIA Sangeeta SHUKLA Ramesh MATHUR Om PAGRAWAL Sadhana SHRIVASTAVA Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA | 2008 | Integrative Zoology2008，3，4： | 0 |
| 7 | Ameliorative effect of Pergularia daemia(Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats显示文摘Objective:To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia(P.daemia) against anti-tuberculosis drugs(ATDs) induced liver injury.Methods:Wistar albino rats were divided into seven groups of six animal in each.The ATDs and P.daemia extract(100,200 and 400 mg/kg,p.o.) were conjointly administered for 8 weeks and various biochemical,histoarchitectural,ultrastructural studies were performed.Results:Administration of ATDs significantly increased aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,triglycerides,cholesterol,bilirubin and decreased glucose and albumin level.Increased lipid peroxidation and reduction in glutathione,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure.Administration of P.daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent manner.Histological and ultra-structural observations substantiated biochemical findings.Conclusions:P.daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies. | Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 0 |
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