|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Domb, Biodegradable Injectable in Situ Depot - forming Drug Delivery Systems 显示文摘 | Deepak Chitkara Ariella Shikanov Neeraj Kumar | 2006 | Macromol Biosci2006，6，： | 1 |
| 2 | Biodegradable Injectable in situ Depot -forming Drug Delivery Systems- Macromo显示文摘 | Deepak Chitkara Ariella Shikanov Neeraj Kumar Abraham J Domb | 2006 | Biosc2006，6，： | 1 |
| 3 | HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilie polymer matrix 显示文摘 | Anupama Mittal Deepak Chitkara Neeraj Kumar | 2007 | Journal of Chromatography B2007，855，： | 1 |
| 4 | Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers显示文摘The benefcial or deleterious effects of nanomedicines emerge from their complex interactions with intracellular pathways and their subcellular fate.Moreover,the dynamic nature of plasma membrane accounts for the movement of these nanocarriers within the cell towards different organelles thereby not only infuencing their pharmacokinetic and pharmacodynamic properties but also bioavailability,therapeutic effcacy and toxicity.Therefore,an in-depth understanding of underlying parameters controlling nanocarrier endocytosis and intracellular fate is essential.In order to direct nanoparticles towards specifc sub-cellular organelles the physicochemical attributes of nanocarriers can be manipulated.These include particle size,shape and surface charge/chemistry.Restricting the particle size of nanocarriers below 200 nm contributes to internalization via clathrin and caveolae mediated pathways.Similarly,a moderate negative surface potential confers endolysosomal escape and targeting towards mitochondria,endoplasmic reticulum(ER)and Golgi.This review aims to provide an insight into these physicochemical attributes of nanocarriers fabricated using amphiphilic graft copolymers affecting cellular internalization.Fundamental principles understood from experimental studies have been extrapolated to draw a general conclusion for the designing of optimized nanoparticulate drug delivery systems and enhanced intracellular uptake via specifc endocytic pathway. | Samrat Mazumdar Deepak Chitkara Anupama Mittal | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 1 |
| 5 | Use of a digital infrared pupillometer to assess patient suitability for refractive surgery显示文摘 | Emanuel S Rosen Christa L Gore Daniel Taylor Deepak Chitkara Frank Howes Elizabeth Kowalewski | 2002 | Journal of Cataract & Refractive Surgery2002，，8： | 1 |
| 6 | Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer显示文摘 | Anupama Mittal Deepak Chitkara Stephan W. Behrman Ram I. Mahato | 2014 | Biomaterials2014，，25： | 1 |
| 7 | miRNA profiling in pancreatic cancer and restoration of chemosensitivity显示文摘 | Saurabh Singh Deepak Chitkara Virender Kumar Stephen W. Behrman Ram I. Mahato | 2013 | Cancer Letters2013，，2： | 1 |
| 8 | Delivery strategies for CRISPR/Cas genome editing tool for retinal dystrophies:challenges and opportunities显示文摘CRISPR/Cas,an adaptive immune system in bacteria,has been adopted as an efficient and precise tool for site-specific gene editing with potential therapeutic opportunities.It has been explored for a variety of applications,including gene modulation,epigenome editing,diagnosis,mRNA editing,etc.It has found applications in retinal dystrophic conditions including progressive cone and cone-rod dystrophies,congenital stationary night blindness,X-linked juvenile retinoschisis,retinitis pigmentosa,age-related macular degeneration,leber’s congenital amaurosis,etc.Most of the therapies for retinal dystrophic conditions work by regressing symptoms instead of reversing the genemutations.CRISPR/Cas9 through indel could impart beneficial effects in the reversal of gene mutations in dystrophic conditions.Recent research has also consolidated on the approaches of using CRISPR systems for retinal dystrophies but their delivery to the posterior part of the eye is a major concern due to high molecular weight,negative charge,and in vivo stability of CRISPR components.Recently,non-viral vectors have gained interest due to their potential in tissue-specific nucleic acid(miRNA/siRNA/CRISPR)delivery.This review highlights the opportunities of retinal dystrophies management using CRISPR/Cas nanomedicine. | Aayushi Lohia Deepak Kumar Sahel Mohd Salman Vivek Singh Indumathi Mariappan Anupama Mittal Deepak Chitkara | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员