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| 1 | Opportunities and Challenges in Deep Mining: A Brief Review显示文摘随着全球生活水平的提高,更多消费者进入了矿物资源市场,使得矿物资源的消耗正在迅速增长。其结果是,在21世纪为了有效应对矿物资源供应危机,地下采矿持续地向更深的水平推进。然而,深部采矿在一个需要有非常规技术以及有挑战性的环境下进行,为了克服这些挑战和实现可观的经济收益需要重大的创新性解决方案、最佳实践以及实施额外的安全标准。这些挑战包括深部采矿工程常常遇到的灾难性事件:岩爆、瓦斯突出、高的原岩和次生应力、大变形、挤压和流变岩体以及高温。本文回顾了全球深部采矿现状,指出了一些与深部采矿的岩石力学和工程地质相关的技术进展及机遇。在这些技术进展中,基于全自动化的采矿和矿物提取过程的无人工作面和无人矿山已成为21世纪的重要领域。 | Pathegama G. Ranjith Jian Zhao Minghe Ju Radhika V. S. De Silva Tharaka D. Rathnaweera Adheesha K. M. S. Bandara | 2017 | Engineering2017，3，4： | 31 |
| 2 | Comparison of visual analogue scale (VAS) and the Nasal Obstruction Symptom Evaluation (NOSE) score in evaluation of post septoplasty patients显示文摘Objective:To compare and correlate the efficacy of the NOSE score&the VAS score in determining the symptomatic benefit in patients undergoing septoplasty.Materials and methods:Eighty patients with deviated nasal septum undergoing septoplasty were included in the study.NOSE score&VAS score(out of 100)was documented before and after surgery.Results were correlated and compared statistically.Results:In the NOSE score,the most bothersome symptom was trouble breathing through the nose(85.83);followed by Nasal obstruction or blockage(82.50).Wilcoxon test showed significant improvement with NOSE score and VAS score in all patients at 1 month and 3 months.Spearman’s coefficient showed a positive correlation between the two,though the score improvement and patient satisfaction rate was significantly high with NOSE score.Conclusions:NOSE score and the VAS score both provide effective framework for evaluating treatment responses after septoplasty.However,the NOSE score showed higher improvement and better patient satisfaction rate when used to measure of nasal obstruction as compared to the VAS score. | Radhika Hiren Shukla Sanjana Vijay Nemade Kiran Jaywant Shinde | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，1： | 28 |
| 3 | Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke显示文摘Nicotinamide adenine dinucleotide phosphate oxidase(NOX) is a multisubunit enzyme complex that utilizes nicotinamide adenine dinucleotide phosphate to produce superoxide anions and other reactive oxygen species. Under normal circumstances, reactive oxygen species mediate a number of important cellular functions, including the facilitation of adaptive immunity. In pathogenic circumstances, however,excess reactive oxygen species generated by NOX promotes apoptotic cell death. In ischemic stroke, in particular, it has been shown that both NOX activation and derangements in glucose metabolism result in increased apoptosis. Moreover, recent studies have established that glucose, as a NOX substrate, plays a vital role in the pathogenesis of reperfusion injury. Thus, NOX inhibition has the potential to mitigate the deleterious impact of hyperglycemia on stroke. In this paper, we provide an overview of this research,coupled with a discussion of its implications for the development of NOX inhibition as a strategy for the treatment of ischemic stroke. Both inhibition using apocynin, as well as the prospect of developing more specific inhibitors based on what is now understood of the biology of NOX assembly and activation, will be highlighted in the course of our discussion. | Jiamei Shen Radhika Rastogi Xiaokun Geng Yuchuan Ding | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 4 | Bioefficacy of Mentha piperita essential oil against dengue fever mosquito Aedes aegypti L显示文摘Objective:To assess the larvicidal and repellent potential of the essential oil extracted from the leaves of peppermint plant,Mentha piperita(M.piperita)against the larval and adult stages of Aedes aegypli(Ae.Aegypti).Methods:The larvicidal potential of peppermint oil was evaluated against early fourth instar larvae of Ae.aegypli using WHO protocol.The mortality counts were made after 24 and 48 h,and LC_(50)and LC_(90)values were calculated.The efficacy of peppermint oil as mosquito repellent was assessed using the human-bait technique.The measured area of one arm of a human volunteer was applied with the oil and the other arm was applied with ethanol.The mosquito bites on both the arms were recorded for 3 rain after every 15 min.The experiment continued for 3 h and the percent protection was calculated.Results:The essential oil extracted from M.piperita possessed excellent larvicidal efficiency against dengue vector.The bioassays showed an LC_(50)and LC_(90)value of 111.9 and 295.18 ppm,respectively after 24 h of exposure.The toxicity of the oil increased 11.8%when the larvae were exposed to the oil for 48h.The remarkable repellent properties of M.piperita essential oil were established against adults Ae.aegypti.The application of oil resulted in 100%protection till 150 min.After next 30 min,only 1-2 bites were recorded as compared with 8-9 bites on the control arm.Conclusions:The peppermint essential oil is proved to be efficient larvicide and repellent against dengue vector.Further studies are needed to identify the possible role of oil as adulticide.oviposition deterrent and ovicidal agent.The isolation of active ingredient from the oil could help in formulating strategies for mosquito control. | Sarita Kumar Naim Wahab Radhika Warikoo | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 5 |
| 5 | Rare earth doped cobalt aluminate blue as an environmentally benign colorant显示文摘Increasing energy cost calls for exterior coatings with high near infra-red reflectance,so as to reduce heat absorption and in turn cost of air-conditioning.While modulations of substrate,use of white metal oxides as pigments or under-layers has been reported in past,reports on metal oxide or doped metal oxide pigments with high NIR reflectance is scarce.We report for the first time a blue colored cobalt aluminate type pigment prepared through doping of cerium,praseodymium or neodymium.CIELAB color measurements and calculation ofDE indicated that the Nd doped sample had crystal size of(36±1)nm,bandgap value of(2.4±0.2)eV and color coordinates similar to that of cobalt aluminate.The molar ratio as estimated by EDX was found to be Al:Cu:Co:Ce:Nd:O=2:0.06:0.06:0.012:0.00012:6.18.The pigment was found to have potential applications as a cool blue colorant,owing to changes in optical properties arising out of crystal chemistry changes.Incorporation of rare earth metal ions was found to enhance the NIR reflectance by 10%,when compared to a conventional cobalt aluminate pigment.The oxide has been well characterized and its performance as a pigment evaluated.We have proposed that changes in crystal lattice when neodymium enters into Ce4+sites enhance the NIR reflectance by about 9%as against the entry of praseodymium. | Sri Parasara RADHIKA Kalarical Janardhanan SREERAM Balachandran Unni NAIR | 2012 | Journal of Advanced Ceramics2012，1，4： | 3 |
| 6 | Advances in cirrhosis: Optimizing the management of hepatic encephalopathy显示文摘Hepatic encephalopathy(HE) is a major complication of cirrhosis resulting in significant socioeconomic burden, morbidity, and mortality. HE can be further subdivided into covert HE(CHE) and overt HE(OHE). CHE is a subclinical, less severe manifestation of HE and requires psychometric testing for diagnosis. Due to the time consuming screening process and lack of standardized diagnostic criteria, CHE is frequently underdiagnosed despite its recognized role as a precursor to OHE. Screening for CHE with the availability of the Stroop test has provided a pragmatic method to promptly diagnose CHE. Management of acute OHE involves institution of lactulose, the preferred first-line therapy. In addition, prompt recognition and treatment of precipitating factors is critical as it may result in complete resolution of acute episodes of OHE. Treatment goals include improvement of daily functioning, evaluation for liver transplantation, and prevention of OHE recurrence. For secondary prophylaxis, intolerance to indefinite lactulose therapy may lead to non-adherence and has been identified as a precipitating factor for recurrent OHE. Rifaximin is an effective add-on therapy to lactulose for treatment and prevention of recurrent OHE. Recent studies have demonstrated comparable efficacy of probiotic therapy to lactulose use in both primary prophylaxis and secondary prophylaxis. | Andy Liu Ryan B Perumpail Radhika Kumari Zobair M Younossi Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 7 | Biochar-mediated regulation of greenhouse gas emission and toxicity reduction in bioremediation of organophosphorus pesticide-contaminated soils显示文摘Organophosphorus pesticides(OPPs) are a set of toxic persistent organic pollutants(POPs) present in the environment. Recently, biochar-mediated bioremediation has exhibited many advantages over conventional methods for the remediation of pesticide-contaminated soil. In the present study, biochar and nitrogen fertilizer(NH_4NO_3)were employed to remediate OPP-contaminated soil and the greenhouse gas(GHG) emission during 90 days of incubation was investigated. After thermal desorption treatment, the content of organophosphorus pesticides reduced from 175.61 μg·kg^(-1) to 62.68 μg·kg^(-1). The addition of NH_4NO_3 in the following bioremediation led to larger reduction(34.35%) of the pesticide concentration than that of biochar(31.90%) for the contaminated soils with thermal desorption treatment, while the simultaneous addition of biochar and NH_4NO_3 led to the largest reduction of pesticide concentration(11.07%) for the soil without thermal desorption treatment. The addition of biochar and NH_4NO_3 only slightly increased the emission rate of GHGs from the soil without thermal treatment,but remarkably increased the emission rate of GHGs from the soil after thermal treatment. In most cases, the addition of NH_4NO_3 is more effective than biochar to promote the degradation of pesticide, but also exhibited higher GHG emission. The microbial community analysis suggests that the enhanced degradation of pesticide is mainly owing to the increased activity of microorganism. | Meinan Zhen Benru Song Xiaomei Liu Radhika Chandankere Jingchun Tang | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 3 |
| 8 | Extracellular matrix-based intracortical microelectrodes:Toward a microfabricated neural interface based on natural materials显示文摘Extracellular matrix(ECM)-based implantable neural electrodes(NEs)were achieved using a microfabrication strategy on naturalsubstrate-based organic materials.The ECM-based design minimized the introduction of non-natural products into the brain.Further,it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions,thereby reducing inflammatory strain fields in the tissue.Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches.In vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs. | Wen Shen Lohitash Karumbaiah Xi Liu Tarun Saxena Shuodan Chen Radhika Patkar Ravi V.Bellamkonda Mark G.Allen | 2015 | Microsystems & Nanoengineering2015，1，1： | 3 |
| 9 | Analysis of functions of the chitin deacetylase gene family in Tribolium castaneum显示文摘 | Yasuyuki Arakane Radhika Dixit Khurshida Begum Yoonseong Park Charles A. Specht Hans Merzendorfer Karl J. Kramer Subbaratnam Muthukrishnan Richard W. Beeman | 2009 | Insect Biochemistry and Molecular Biology2009，，5： | 2 |
| 10 | Larvicidal and irritant activities of hexane leaf extracts of Citrus sinensis against dengue vector Aedes aegypti L.显示文摘Objective:To assess the larvicidal and irritant activities of the hexane extracts of leaves of Citrus sinensis(C.sinensis)against the early fourth instars and female adults of Aedes aegypti(Ae.aegypti).Methods:The larvicidal potential of the prepared leaf extract was evaluated against early fourth instar larvae of Ae.aegypli using WHO protocol.The mortality counts were made after 24 h and LC_(50)and LG_(50)values were calculated.The efficacy of extract as mosquito irritant was assessed by contact irritancy assays.Extract-impregnated paper was placed on a glass plate over which a perspex funnel with a hole on the top was kept inverted.Single female adult,3-day old unfed/blood-fed,was released inside the funnel.After 3 min of acclimatization time,the time taken for the first take-off and total number of flights undertaken during 15 min were scored.Results:The citrus leaf extracts from hexane possessed moderate larvicidal efficiency against dengue vector.The bioassays resulted in an LC_(50)and LC_(90)value of 446.84 and 1370.96 ppm,respectively after 24 h of exposure.However,the extracts were proved to be remarkable irritant against adults Ae.aegypti,more pronounced effects being observed on blood-fed females than unfed females.The extract-impregnated paper was thus proved to be 7-11 times more irritable as compared with the control paper.Conclusions:The hexane extracts from C.sinensis leaves are proved to be reasonably larvicidal But remarkably irritant against dengue vector.Further studies are needed to identify the possible role of extract as adulticide,oviposition deterrent and ovicidal agent.The isolation of active ingredient from the extract could help in formulating strategies for mosquito control. | Radhika Warikoo Ankita Ray Jasdeep Kaur Sandhu Roopa Sanial Naim Wahab Sarita Kumar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 2 |
| 11 | Domain organization and phylogenetic analysis of proteins from the chitin deacetylase gene family of Tribolium castaneum and three other species of insects显示文摘 | Radhika Dixit Yasuyuki Arakane Charles A. Specht Chad Richard Karl J. Kramer Richard W. Beeman Subbaratnam Muthukrishnan | 2007 | Insect Biochemistry and Molecular Biology2007，，4： | 2 |
| 12 | Crop and weed discrimination using Laws’ texture masks显示文摘Computers have become an integral part of human lives.Computers are used in almost every field even in agriculture.Technologies like computer vision-based pattern recognition are being used to detect diseases and pests like weeds affecting the crop.The Weeds are unwanted plants growing among crops competing for nutrients,water,and sunlight.It can significantly reduce the quality and yield of the crops incurring a huge loss to the farmers.This paper investigates the use of texture features extracted from Laws’texture masks for discrimination of Carrot crops and weeds in digital images.Laws’texture method is one of the popular methods used to extract texture features in medical image processing,though not much explored in plant-based images or agricultural images.This experiment was carried out on two categories of benchmark digital image datasets of Carrot crop and Carrot weed respectively,which are publicly available.A total of 70 texture features were extracted.The dimensionality reduction technique was used to get the optimal features.These features were then used to train the Random Forest classifier.The results and observations from the experiment showed that the classifier achieved above 94%accuracy. | Radhika Kamath Mamatha Balachandra Srikanth Prabhu | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 2 |
| 13 | 市售长叶松油和锡兰肉桂油对登革热媒蚊埃及伊蚊的灭幼效果(英文)显示文摘松油和桂皮油由于具有芳香性气味,因而成为良好的成虫驱避剂,但是关于它们对蚊虫的杀幼虫作用研究不多。为揭示市售的长叶松Pinus longifolia油和锡兰肉桂Cinnamomum zeylanicum油对来源于印度德里的埃及伊蚊Aedes aegypti4龄幼虫的毒杀潜力,我们进行了室内研究,以幼虫死亡率及行为改变和形态改变等指标评估其杀幼虫潜力。结果表明:两种油对埃及伊蚊4龄幼虫均具有毒杀作用,且松油的灭幼效果优于桂皮油。松油的LC50和LC70值分别为0.33093mg/L和0.54476mg/L,而桂皮油的LC50和LC70值分别为0.63159mg/L和0.77736。进一步观察发现,LC90剂量下桂皮油的杀幼虫潜力强于松油,其LC90为1.11879mg/L,而松油的LC90为1.04915mg/L。在处理的幼虫中观察到行为改变,如兴奋、坐立不安、颤抖、痉挛然后瘫痪,说明这两种油可能对其神经肌肉系统产生了影响。显微观察处理幼虫的形态改变发现,与对照相比,大多数器官的外观正常,只是肛鳃略为内收缩而引起结构畸形,提示肛腮可能是这两种油的作用位点,腮的功能异常引起了幼虫死亡。这两种油品可开发用作防治蚊虫的新型杀幼虫药剂。 | Radhika WARIKOO Naim WAHAB Sarita KUMAR | 2011 | 昆虫学报2011，54，7： | 2 |
| 14 | Role of <sup>18</sup> F ‐fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: Experience from tropics显示文摘 | Sampath Santhosh Bhagwant Rai Mittal Deepak Bhasin Radhika Srinivasan Surinder Rana Ashim Das Ritambhra Nada Anish Bhattacharya Rajesh Gupta Rakesh Kapoor | 2013 | J Gastroenterol Hepatol2013，，2： | 2 |
| 15 | Awareness, self-management behaviors, health literacy and kidney function relationships in specialty practice显示文摘AIM To determine the relationship between chronic kidney disease(CKD) awareness(CKD-A), self-management behaviors(CKD-SMB) knowledge, performance of CKDSMBs, health literacy(HL) and kidney function. METHODS Participants were eligible patients attending an outpatient nephrology clinic. Participants were administered: Newest Vital Sign to measure HL, CKD self-managementknowledge tool(CKD-SMKT) to assess knowledge, past performance of CKD-SMB, CKD-A. Estimated GFR(e GFR) was determined using the MDRD-4 equation. Duration of clinic participation and CKD cause were extracted from medical charts. RESULTS One-hundred-fifty patients participated in the study. e GFRs ranged from 17-152 m L/min per 1.73 m2. Majority(83%) of respondents had stage 3 or 4 CKD, low HL(63%), and were CKD aware(88%). Approximately 40%(10/25) of patients in stages 1 and 2 and 6.4%(8/125) in stages 3 and 4 were unaware of their CKD. CKD-A differed with stage(P < 0.001) but not by HL level, duration of clinic participation, or CKD cause. Majority of respondents(≥ 90%) correctly answered one or more CKD-SMKT items. Knowledge of one behavior, 'controlling blood pressure' differed significantly by CKD-A. CKD-A was associated with past performance of two CKD-SMBs, 'controlling blood pressure'(P = 0.02), and 'keeping healthy body weight'(P = 0.01). Adjusted multivariate analyses between CKD-A and:(1) HL; and(2) CKD-SMB knowledge were nonsignificant. However, there was a significant relationship between CKD-A and kidney function after controlling for demographics, HL, and CKD-SMB(P < 0.05). CONCLUSION CKD-A is not associated with HL, or better CKD-SMBs. CKD-A is significantly associated with kidney function and substantially lower e GFR, suggesting the need for focused patient education in CKD stages 1. | Radhika Devraj Matthew E Borrego A Mary Vilay Junvie Pailden Bruce Horowitz | 2018 | World Journal of Nephrology2018，7，1： | 2 |
| 16 | 利用MaxEnt研究印度中部秃鹫栖息地适宜性及气候变化的影响显示文摘秃鹫提供了宝贵的生态系统服务,在生态系统平衡中发挥着重要作用,但印度本土秃鹫数量在过去几年有所下降。掌握秃鹫栖息地的分布现状对于管理和防止秃鹫数量继续下降至关重要。可以预见,目前的气候危机可能会进一步导致秃鹫生境适宜性的变化,并影响现存的秃鹫种群。因此,本研究利用物种分布模型,对印度中部一个秃鹫栖息地的短期和长期变化进行预测,并以统计和图形的方式呈现数据。选择MaxEnt软件进行预测,是因为它与其他模型相比具有一定的优势,如只使用现有数据,在数据不完整、样本量小、样本间隙小等情况下表现良好。采用全球气候模式集成学习算法(CCSM4、Had GEM2AO和MIROC5)以获得更好的预测结果。14个稳健模型(AUC 0.864–0.892)是利用7个秃鹫种群(长喙、白臀、红头、银灰色、埃及秃鹫、喜马拉雅和欧亚狮鹫)在两个季节共1000多个地点的数据建立的。选定的气候(温度和降水)和环境变量(NDVI、海拔和土地利用/土地覆盖)被用于预测当前栖息地,未来的预测只基于气候变量。影响秃鹫栖息地分布的最重要变量是降水量(bio 15,bio 18,bio19)和温度(bio 3,bio 5)。在目前的预测中,森林和水体是影响土地利用的主要因素。在较小尺度上,随着时间的推移,极端适宜的栖息地面积减少,高度适宜的栖息地面积增加,总适宜栖息地面积在2050年略有增加,但到2070年有所减少。在更大的尺度上考虑,2050年适宜栖息地的净损失为5%,2070年为7.17%(RCP4.5)。相似的,在RCP8.5下,2050年适宜栖息地的净损失为6%,2070年为7.3%。研究结果可用于制定秃鹫的保护规划和管理,从而保护其免受未来的气候变化等威胁。 | Kaushalendra K.JHA Radhika JHA | 2021 | Journal of Resources and Ecology2021，12，1： | 2 |
| 17 | Estrogen Receptor Beta ( ERβ ) in endometrial simple hyperplasia and endometrioid carcinoma 显示文摘 | Dimple C Radhika S Sujata G | 2008 | Appl Immunohistochem Mol Morphol2008，16，6： | 1 |
| 18 | Increased cyclooxygenase- 2 levels in carcinopen -induced rat colomic tumors 显示文摘 | Dubois RN Radhika A Reddy BS | 1996 | Gastroenterology1996，110，4： | 1 |
| 19 | A Retrospective Review of Enteroclysis in Patients with Obscure Gastrointestinal Bleeding and Chronic Abdominal Pain of Undetermined Etiology显示文摘 | Aslam Malik MD Kathleen Lukaszewski MD Dina Caroline MD Henry Parkman MD Joshua DeSipio MD Felice Banson MD Khalid Bazir MD Lakshmi Reddy MD Radhika Srinivasan MD Robert Fisher MD Larry Miller MD | 2005 | Digestive Diseases and Sciences2005，，4： | 1 |
| 20 | Elevated cyclooxygenase-2 levels in Min mouse adenomas显示文摘 | Williams CS Luongo C Radhika A | 1996 | Gastroenterology1996，111，： | 1 |
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