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| 1 | 大豆抗胞囊线虫病种质rhg_1和Rhg_4位点的单核苷酸多态性(SNPs)显示文摘研究以 5 7份中美大豆抗胞囊线虫病种质资源为实验材料 ,利用基于检测微珠的单碱基延伸方法 ,对与大豆胞囊线虫病 (SCN)抗性基因rhg1和Rhg4紧密连锁的SNPs进行分析 ,目的是阐明我国大豆抗性种质在这两个位点的SNPs等位变异分布频率 ,为中国大豆种质抗SCN资源的利用奠定基础。分析结果表明 ,SNPs的抗性等位基因与中国大豆种质综合抗性的关系比不同生理小种的抗性关系更为密切。在rhg1和Rhg4位点 ,美国的 9份抗性种质中 ,有 7份抗性种质的SNPs均为纯合抗病基因型 ,而中国 4 8份抗性种质中有 32份 ,分别占鉴定总数的 77 8%和 6 6 7% ,推测大豆抗SCN种质中 ,以rhg1和Rhg4这两个基因协同作用表现出的抗性可能占多数 ,但还存在其他的抗性机制。 | 邱丽娟 常汝镇 王文辉 Perry Cregan Dechun Wang Yiwu Chen 马凤鸣 | 2003 | 植物遗传资源学报2003，4，2： | 19 |
| 2 | Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway显示文摘Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory cytokines.Punicalagin(PUN)is an active substance extracted from pomegranate peel.We found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA mice.PUN effectively alleviated the high expression of inflammatory cytokines in synovial tissue in vivo.PUN treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment group.However,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was increased.In addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand IL-18.Mechanistically,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of macrophages.We concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA. | Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng | 2022 | Science China(Life Sciences)2022，65，3： | 14 |
| 3 | Direct low-temperature synthesis of graphene on various glasses by plasma-enhanced chemical vapor deposition for versatile, cost-effective electrodes显示文摘在低温度的各种各样的玻璃底层上的 graphene 的没有催化剂、可伸缩的合成具有到象便宜透明电子学和最先进的显示器那样的众多的应用程序的首要的意义。然而,在这个有希望的研究领域以内的系统的学习远这样仍然保持少见。此处,我们用一个低温度的提高血浆的化学蒸汽免职方法在各种各样的眼镜上报导 graphene 的直接生长。如此的一条灵巧、可伸缩的途径在 400600 的一个生长温度范围在各种各样的玻璃底层上保证一致、没有转移的 graphene | Jingyu Sun Yubin Chen Xin Cai Bangjun Ma Zhaolong Chen Manish Kr. Priydarshi Ke Chen Teng Gao Xiuju Song Qingqing Ji Xuefeng Guo Dechun Zou Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，11： | 12 |
| 4 | Assessing the numbers of SNPs needed to establish molecular IDs and characterize the genetic diversityof soybean cultivars derived from Tokachi nagaha显示文摘The development of a core set of SNP molecular markers that could be widely used in soybean genetic research would greatly facilitate research into the genetic diversity of soybean.We conducted an analysis of Tokachi nagaha and 137 of its descendant soybean cultivars using 4044 SNP markers with the goal of determining the appropriate number of single-nucleotide polymorphisms(SNPs)needed to construct unambiguous molecular IDs and characterize genetic diversity based on a genetic distance matrix correlation method.When the number of SNPs was held constant,the number of accession pairs that could be distinguished increased as the polymorphism informative content(PIC)value of the SNPs increased.A core panel of 20 selected SNPs from 11 linkage groups with a mean PIC value of 0.3703 and a range of 0.3640–0.3749 was able to identify almost all of the accession pairs in our study[9445 pairs(99.92%)].The eight accession pairs that could not be identified with this core SNP set all originated from the same province and some of them had the same parental cultivars.The molecular IDs of the 138 accessions were constructed using the core 20 SNPs.It is known that both the number of SNPs and PIC values should be considered when SNPs are selected for use in the analysis of genetic diversity.In this study,when the PIC value was 0.3460,the correlation coefficient between the genetic distance matrices associated with a panel of 200 SNPs and the total population was>0.800,indicating satisfactory correlation.Our high-accuracy,high-resolution core SNP panel for germplasm fingerprinting and our findings about assessing genetic diversity will likely markedly improve the management and utilization efficiency of soybean germplasm resources. | Zhangxiong Liu Jun Li Xuhong Fan Nang Myint Phyu Sin Htwe Shuming Wang Wen Huang Jiyu Yang Lili Xing Lijun Chen Yinghui Li Rongxia Guan Ruzhen Chang Dechun Wang Lijuan Qiu | 2017 | The Crop Journal2017，5，4： | 10 |
| 5 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 6 | The nonresonant perturbation theory based field measurement and tuning of a linac accelerating structure显示文摘Assisted by the bead pull technique,nonresonant perturbation theory is applied for measuring and tuning the field of the linac accelerating structure.The method is capable of making non-touching amplitude and phase measurements,real time mismatch feedback and field tuning.Some key considerations of the measurement system and of a C-band traveling-wave structure are discussed,and the bead pull measurement and the tuning of the C-band traveling-wave linac accelerating structure are presented at last. | FANG WenCheng TONG DeChun GU Qiang ZHAO ZhenTang SHENG Xing CHEN LiFang WANG Lin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 3 |
| 7 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 8 | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy显示文摘Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance.However,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a dilemma.Inspired by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido terminal.The peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of biofunctionalizations.In this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair.Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone regeneration.In a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements. | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng | 2022 | Bioactive Materials2022，7，2： | 2 |
| 9 | Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism显示文摘Copper(Cu)is an essential trace mineral element for all forms of life,and is an important structural component and co-factor for a variety of metalloenzymes(Pen^a et al.,1999;Bertinato and L'Abbe,2004).In humans,Cu deficiency is not common because of the ubiquitous occurrence of Cu and ease of gastrointestinal absorption(Zidar et al.,1977;Uauy et al.,1998).However,because of the low Cu content in most sources of feed,the use of Cu as a growth promoter to maximize animal production has been well documented in animal feeding(Braude,1945;Lu et al.,2010).Pre- | Mingfeng Tang Chuanshe Zhou Lu Meng Donghai Mao Can Peng Yuxing Zhu Daoyou Huang Zhiliang Tan Caiyan Chen Chengbing Liu Dechun Zhang | 2016 | Journal of Genetics and Genomics2016，43，11： | 2 |
| 10 | Targeting strategies for bone diseases:signaling pathways and clinical studies显示文摘Since the proposal of Paul Ehrlich’s magic bullet concept over 100 years ago,tremendous advances have occurred in targeted therapy.From the initial selective antibody,antitoxin to targeted drug delivery that emerged in the past decades,more precise therapeutic efficacy is realized in specific pathological sites of clinical diseases.As a highly pyknotic mineralized tissue with lessened blood flow,bone is characterized by a complex remodeling and homeostatic regulation mechanism,which makes drug therapy for skeletal diseases more challenging than other tissues.Bone-targeted therapy has been considered a promising therapeutic approach for handling such drawbacks.With the deepening understanding of bone biology,improvements in some established bone-targeted drugs and novel therapeutic targets for drugs and deliveries have emerged on the horizon.In this review,we provide a panoramic summary of recent advances in therapeutic strategies based on bone targeting.We highlight targeting strategies based on bone structure and remodeling biology.For bone-targeted therapeutic agents,in addition to improvements of the classic denosumab,romosozumab,and PTH1R ligands,potential regulation of the remodeling process targeting other key membrane expressions,cellular crosstalk,and gene expression,of all bone cells has been exploited.For bone-targeted drug delivery,different delivery strategies targeting bone matrix,bone marrow,and specific bone cells are summarized with a comparison between different targeting ligands.Ultimately,this review will summarize recent advances in the clinical translation of bone-targeted therapies and provide a perspective on the challenges for the application of bone-targeted therapy in the clinic and future trends in this area. | Hao Xu Wentao Wang Xin Liu Wei Huang Chen Zhu Yaozeng Xu Huilin Yang Jiaxiang Bai Dechun Geng | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 2 |
| 11 | Modal Analysis of Thread off Failure of Oil Round Thread Casing Connection显示文摘The dynamic modal model analysis of the oil casing connection is done by finite element method (FEM), and the first nature frequency, the second nature frequency, the vibration mode shape and the time domain of the node displacement and the element stress variation in the thread connection are gotten. The Von.Mises stresses of the connection in the static and dynamic state are also studied. The results of calculation and analysis show: (1) because the maximum of static stress is at the coupling thread end of connection, the connection begins to thread off at the coupling thread end, which is in accord with the results of the thread off experiment in laboratory; (2) because the first nature frequency is very high, the probability of casing connection to be damaged from vibration is little; (3) the sho- ck dynamic load makes casing connection begin to thread off at the tube thread end. | LiWang, Yong Zang, Zhaoneng Chen, Dechun Tong, Jiaxiang Zou 1) Shanahai Jiaotong University Shanghai 200030 China 2) Mechanical Engineering School. University of Science and Technology Beijing. Beijing 100083. China | 2001 | Journal of University of Science and Technology Beijing2001，8，4： | 1 |
| 12 | On mechanism of the effect of rare earth on wear-ability of nickel base self-fluxing alloy 显示文摘 | Li Muqin Ma Chen Shao Dechun | 1991 | Journal of Rare Earths1991，9，3： | 1 |
| 13 | Construction of an intra-specific sweet cherry (Prunus avium L.) genetic linkage map and synteny analysis with the Prunus reference map显示文摘 | James W. Olmstead Audrey M. Sebolt Antonio Cabrera Suneth S. Sooriyapathirana Sue Hammar Gloria Iriarte Dechun Wang Charles Y. Chen Esther Knaap Amy F. Iezzoni | 2008 | Tree Genetics & Genomes2008，，4： | 1 |
| 14 | Research on the photoluminescence of spectral broadening by rapid thermal annealing on InAs/GaAs quantum dots显示文摘Photoluminescence (PL) test was conducted to investigate the effect of rapid thermal annealing (RTA) on the opticalperformance of self-assembled InAs/GaAs quantum dots (QDs) at the temperatures of 16 and 300 K. It was found that after RTAtreatment, the PL spectrum of the QDs sample had a large blue-shift and significantly broadened at 300 K. Compared with theas-grown InAs QDs sample, the PL spectral width has increased by 44.68 meV in the InAs QDs sample RTA-treated at800 ℃. The excitation power-dependent PL measurements showed that the broadening of the PL peaks of the RTA-treatedInAs QDs should be related to the emission of the ground state (GS) of different-sized InAs QDs, the InAs wetting layer (WL)and the In0.15Ga0.85As strain reduction layer (SRL) in the epitaxial InAs/GaAs layers. | Dandan Ning Yanan Chen Xinkun Li Dechun Liang Shufang Ma Peng Jin Zhanguo Wang | 2020 | Journal of Semiconductors2020，41，12： | 1 |
| 15 | Organolead trihalide perovskite materials for efficient light emitting diodes显示文摘Organolead trihalide perovskite materials have been attracting increasing attention due to their promising role in solid solar cells. Several advantages make them potential candidates for optoelectronics:(1) solution- or/and vapor-processed preparation at low temperature;(2) tunable optical bandgap, wide absorption spectrum but narrow photoluminescence peaks;(3) long car-rier life time, large diffusion length and high charge mobility;(4) various nanostructures via tuning capping agents and sol-vents. In this review, we summarize recent attempts toward efficient LEDs based on organolead trihalide perovskite materials. The strategies of materials science, device design and interface engineering are highlighted. Recent development and future perspectives are summarized for practical perovskite light technologies. | Ming Peng Wen Wen Si Chen Buxin Chen Kai Yan Hsienwei Hu Bin Dong Xue Gao Xiao Yu Xiaoming Jiang Dechun Zou | 2016 | Science China Chemistry2016，59，6： | 1 |
| 16 | Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma显示文摘 | Yinying Lu Wanping Xu Junfang Ji Dechun Feng Carole Sourbier Youfeng Yang Jianhui Qu Zhen Zeng Chunping Wang Xiujuan Chang Yan Chen Alok Mishra Max Xu Min‐Jung Lee Sunmin Lee Jane Trepel W. Marston Linehan Xinwei Wang Yongping Yang Len Neckers | 2015 | Hepatology2015，，： | 1 |
| 17 | Dissolved oxygen in aeration-driven piezo-catalytic for antibiotics pollutants removal in water显示文摘The misuse of antibiotics and oxygen-lacking in aquaculture causes serious water environmental problems.Herein,a piezoelectic odd-layered MoS_(2)is prepared and applied to piezo-catalytic remove tinidazole(TNZ)and other antibiotic pollutants with aeration as a piezo-driving force.About 89.6%of TNZ can be degraded by MoS_(2)under aeration in the presence of dissolved oxygen with a reaction rate constant of0.15 min^(-1),which is 2.4 times higher than that under N2atmosphere and quiescence conditions.Quenching experiments and electron paramagnetic resonance(EPR)tests identify that singlet oxygen(^(1)O_(2))and superoxide radical(O_(2)^(·-))are dominant reactive oxygen species in MoS_(2)/aeration system.These results demonstrate that MoS2can trigger a piezoelectric effect and produce charge carriers to generate reactive oxygen species with dissolved oxygen(DO)for contaminant degradation with the turbulence and water bubbles rupture driven by aeration. | Minxian Zhang Wanqian Guo Yingyin Chen Dechun He Abdulgalim B.Isaev Mingshan Zhu | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 18 | An Intelligent Diagnosis Method of the Working Conditions in Sucker-Rod Pump Wells Based on Convolutional Neural Networks and Transfer Learning显示文摘In recent years,deep learning models represented by convolutional neural networks have shown incomparable advantages in image recognition and have been widely used in various fields.In the diagnosis of sucker-rod pump working conditions,due to the lack of a large-scale dynamometer card data set,the advantages of a deep convolutional neural network are not well reflected,and its application is limited.Therefore,this paper proposes an intelligent diagnosis method of the working conditions in sucker-rod pump wells based on transfer learning,which is used to solve the problem of too few samples in a dynamometer card data set.Based on the dynamometer cards measured in oilfields,image classification and preprocessing are conducted,and a dynamometer card data set including 10 typical working conditions is created.On this basis,using a trained deep convolutional neural network learning model,model training and parameter optimization are conducted,and the learned deep dynamometer card features are transferred and applied so as to realize the intelligent diagnosis of dynamometer cards.The experimental results show that transfer learning is feasible,and the performance of the deep convolutional neural network is better than that of the shallow convolutional neural network and general fully connected neural network.The deep convolutional neural network can effectively and accurately diagnose the working conditions of sucker-rod pump wells and provide an effective method to solve the problem of few samples in dynamometer card data sets. | Ruichao Zhang Liqiang Wang Dechun Chen | 2021 | Energy Engineering2021，118，4： | 0 |
| 19 | A novel sea-land segmentation based on integral image reconstruction in MWIR images显示文摘Dear editor,Middle wave infrared remote(MWIR)technology is the main approach in remote sensing applications,because thermal infrared can work all-time.The MWIR technology can provide valid object information in remote sensing technology than optical and synthetic aperture radar(SAR) | Yin ZHUANG Dechun GUO He CHEN Fukun BI Long MA Nouman Q.SOOMRO | 2017 | Science China(Information Sciences)2017，60，6： | 0 |
| 20 | A BRIEF INTRODUCTION TO THE WEST CHINA BRANCH OF CAMS——WEST CHINA UNIVERSITY OF MEDICAL SCIENCES显示文摘The West China University of MedicalSciences (WCUMS),founded in 1910 and form-erly named West China Union University,wasdesignated as a branch of CAMS in a ceremonyheld on the 29th of November,1989.WCUMS.one of the key medical universities directed bythe Ministry of Public Health (MPH),incor-porates eight schools,namely:Schools of BasicMedical Sciences,Medicine,Stomatology,PublicHealth,Pharmacy,Forensic Medicine,ForeignLanguages,and Social Sciences.The Universityoffers 12 special programs on medicine。 | (Luo Dechun Chen Huaiqing) | 1990 | Chinese Medical Sciences Journal1990，8，2： | 0 |
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