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| 1 | Metabolic analyses reveal different mechanisms of leaf color change in two purple-leaf tea plant (Camellia sinensis L.) cultivars显示文摘Purple-leaf tea plants,as anthocyanin-rich cultivars,are valuable materials for manufacturing teas with unique colors or flavors.In this study,a new purple-leaf cultivar“Zixin”(“ZX”)was examined,and its biochemical variation and mechanism of leaf color change were elucidated.The metabolomes of leaves of“ZX”at completely purple,intermediately purple,and completely green stages were analyzed using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry(UPLC-QTOF-MS).Metabolites in the flavonoid biosynthetic pathway remained at high levels in purple leaves,whereas intermediates of porphyrin and chlorophyll metabolism and carotenoid biosynthesis exhibited high levels in green leaves.In addition,fatty acid metabolism was more active in purple leaves,and steroids maintained higher levels in green leaves.Saponin,alcohol,organic acid,and terpenoid-related metabolites also changed significantly during the leaf color change process.Furthermore,the substance changes between“ZX”and“Zijuan”(a thoroughly studied purple-leaf cultivar)were also compared.The leaf color change in“Zijuan”was mainly caused by a decrease in flavonoids/anthocyanins.However,a decrease in flavonoids/anthocyanins,an enhancement of porphyrin,chlorophyll metabolism,carotenoid biosynthesis,and steroids,and a decrease in fatty acids synergistically caused the leaf color change in“ZX”.These findings will facilitate comprehensive research on the regulatory mechanisms of leaf color change in purple-leaf tea cultivars. | Jiazhi Shen Zhongwei Zou Xuzhou Zhang Lin Zhou Yuhua Wang Wanping Fang Xujun Zhu | 2018 | Horticulture Research2018，5，1： | 22 |
| 2 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 3 | 中国城乡家庭结构变动分析:基于2010年人口普查数据(英文)显示文摘2000年以来中国家庭结构变动表现为:核心家庭比例明显下降,单人户显著上升,直系家庭没有降低反而略有增加。城乡家庭结构变动有别:城市核心家庭构成缩小,单人户明显增加,直系家庭稍有降低;农村核心家庭构成降幅较大,单人户提高,直系家庭上升。城乡二级家庭结构变动也不尽相同。人口流动、子女数量、人口老龄化、婚姻和住房情况对家庭结构及其变动有显著影响。在家庭结构小型化为主导的时代,政府及社会组织应加强以家庭为目标的公共服务建设;改进户籍制度,减少劳动者与其家庭成员的地域分割;为增进和改善家庭代际关系创造条件。 | 王跃生 Lin Wanping | 2014 | Social Sciences in China2014，35，4： | 16 |
| 4 | Exogenous abscisic acid significantly affects proteome in teaplant (Camellia sinensis) exposed to drought stress显示文摘Tea[Camellia sinensis(L.)O.Kuntze]is an important economic crop,and drought is the most important abiotic stress affecting yield and quality.Abscisic acid(ABA)is an important phytohormone responsible for activating drought resistance.Increased understanding of ABA effects on tea plant under drought stress is essential to develop drought-tolerant tea genotypes,along with crop management practices that can mitigate drought stress.The objective of the present investigation is evaluation of effects of exogenous ABA on the leaf proteome in tea plant exposed to drought stress.Leaf protein patterns of tea plants under simulated drought stress[(polyethylene glycol(PEG)-treated]and exogenous ABA treatment were analyzed in a time-course experiment using two-dimensional electrophoresis(2-DE),followed by matrix-assisted laser desorption/ionization time-of-flight(MALDI-TOF)mass spectrometry(MS).Among the 72 protein spots identified by MALDI-TOF MS,16 proteins were downregulated and two were upregulated by exogenous ABA.The upregulated proteins have roles in glycolysis and photosystem II stabilization.Twenty-one protein spots were responsive to drought stress and most participate in carbohydrate and nitrogen metabolism,control of reactive oxygen species(ROS),defense,signaling or nucleic acid metabolism.The combined treatments of exogenous ABA and drought showed upregulation of 10 protein spots at 12 h and upregulation of 11 proteins at 72 h after initiation of drought stress.The results support the importance of the role that ABA plays in the tea plant during drought stress,by improving protein transport,carbon metabolism and expression of resistance proteins. | Lin Zhou Hui Xu Sue Mischke Lyndel W Meinhardt Dapeng Zhang Xujun Zhu Xinghui Li Wanping Fang | 2014 | Horticulture Research2014，1，1： | 12 |
| 5 | High Strength Silicon Carbide Foams and Their Deformation Behavior显示文摘碳化矽(原文如此) 有连续地连接的开房间的结构的泡沫为他们的机械表演作好准备并且描绘。SiCfoams 的表观虎度在大约 0.4 和 1.3 g/cm^3 之间被控制,与相应压缩强度从从大约 8 ~ 30 MPa 的大约 13 ~ 60 MPa 和曲折力量。压缩测试原文如此,泡沫与仅仅一个线性橡皮的区域产出压力紧张曲线,它与在文学在陶器的泡沫上报导的那些不同。这能可能与好、稠密、高的力量微观结构被归因于细丝的存在。原文如此并且细丝对装载使用同类地作出回应。 | Chong TIAN Jinsong ZHANG Xiaoming CAO Qiang LIU Wanping HU | 2006 | Journal of Materials Science & Technology2006，22，2： | 11 |
| 6 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 7 | Developing single nucleotide polymorphism(SNP)markers from transcriptome sequences for identification of longan(Dimocarpus longan)germplasm显示文摘Longan(Dimocarpus longan Lour.)is an important tropical fruit tree crop.Accurate varietal identification is essential for germplasm management and breeding.Using longan transcriptome sequences from public databases,we developed single nucleotide polymorphism(SNP)markers;validated 60 SNPs in 50 longan germplasm accessions,including cultivated varieties and wild germplasm;and designated 25 SNP markers that unambiguously identified all tested longan varieties with high statistical rigor(P<0.0001).Multiple trees from the same clone were verified and off-type trees were identified.Diversity analysis revealed genetic relationships among analyzed accessions.Cultivated varieties differed significantly from wild populations(Fst=0.300;P<0.001),demonstrating untapped genetic diversity for germplasm conservation and utilization.Within cultivated varieties,apparent differences between varieties from China and those from Thailand and Hawaii indicated geographic patterns of genetic differentiation.These SNP markers provide a powerful tool to manage longan genetic resources and breeding,with accurate and efficient genotype identification. | Boyi Wang Hua-Wei Tan Wanping Fang Lyndel W Meinhardt Sue Mischke Tracie Matsumoto Dapeng Zhang | 2015 | Horticulture Research2015，2，1： | 6 |
| 8 | 发展战略、城市化与中国城乡收入差距(英文)显示文摘本文从政府发展战略的视角,研究中国城市化滞后、城乡收入差距持续扩大的原因。结果发现,旨在鼓励资本密集型部门优先发展的政府战略,造成城市部门就业需求的相对下降,进而延缓城市化进程,农村居民不能有效地向城市转移,城乡收入差距扩大。以技术选择指数作为政府对资本密集性部门政策倾斜程度的度量指标,利用1978-2008年中国省级面板数据,对理论假说进行了实证检验。研究还发现,中国城乡收入差距在经济发展过程中呈现出先下降、后上升的U型规律。 | 陈斌开 林毅夫 Lin Wanping | 2014 | Social Sciences in China2014，35，1： | 5 |
| 9 | Great Diversity in Stability of Perovskite-Type Oxides Studied by Electrochemical Hydrogen Charging显示文摘Single crystals of 0.91Pb(Zn1/3Nb2/3)O3-0.09PbTiO3,SrTiO3 and BaTiO3,and ceramic pellets of CaCu3Ti4O12 and BiFeO3 have been studied and compared through electrochemical hydrogen charging,in which the oxides were coated with silver electrodes to electrolyze water as the cathode.Great diversity has been observed in the stability of the oxides:0.91Pb(Zn1/3Nb2/3)O3-0.09PbTiO3 was quickly decomposed;hydrogen could enter the lattice of the other four oxides,but their properties were influenced at extremely different speeds.Such a great diversity in stability against hydrogen among perovskite-type oxides highlights the importance of reliability study over functional oxides materials. | PEI Yuchong CHEN Wanping | 2011 | Wuhan University Journal of Natural Sciences2011，16，3： | 4 |
| 10 | Metabolic and molecular analysis of nonuniform anthocyanin pigmentation in tomato fruit under high light显示文摘Pigment intensity and patterns are important factors that determine the nutritional and market values of tomato fruits.The acropetal manner of light-dependent anthocyanin accumulation with the highest levels at the stem end of the fruit makes Pro35S:BrTT8 tomato plants an ideal system for investigating the effects of light intensity on anthocyanin biosynthesis.Extensive transcript analyses indicate that anthocyanin pigmentation in Pro35S:BrTT8 plants under high light might be coordinately regulated by the exogenous protein BrTT8 and endogenous proteins SlAN2 and SlMYBL2.Furthermore,yeast two-hybrid assays showed that BrTT8 could interact efficiently with SlAN2,SlMYBL2,and SlAN11.Moreover,the physical interaction between BrTT8 and SlAN2 was validated by FRET.Simultaneous overexpression of SlAN2 and BrTT8 activated significant anthocyanin biosynthesis in infiltrated tobacco leaves.In addition,the ability of SlMYBL2 to suppress anthocyanin accumulation was also demonstrated in infiltrated tobacco leaves.Altogether,these results prove that tissue-specific assemblage of the heterogeneous MYB-bHLH-WD40 complex consisting of SlAN2,BrTT8 and SlAN11 triggers nonuniform anthocyanin accumulation in tomato fruit under high light.Additionally,it is proposed that a negative-feedback loop fulfilled by SlMYBL2 also participates in the regulation of anthocyanin production. | Yanjie Zhang Yan Li Wanping Li Zongli Hu Xiaohui Yu Yun Tu Min Zhang Jinyong Huang Guoping Chen | 2019 | Horticulture Research2019，6，1： | 4 |
| 11 | Identification of the varietal origin of processed loose-leaf tea based on analysis of a single leaf by SNP nanofluidic array显示文摘Tea is an important cash crop, representing a $40 billion-a-year global market. Differentiation of the tea market has resulted in increasing demand for tea products that are sustainably and responsibly produced. Tea authentication is important because of growing concerns about fraud involving premium tea products. Analytical technologies are needed for protection and value enhancement of high-quality brands. For loose-leaf teas, the challenge is that the authentication needs to be established on the basis of a single leaf, so that the products can be traced back to the original varieties. A new generation of molecular markers offers an ideal solution for authentication of processed agricultural products. Using a nanofluidic array to identify variant SNP sequences, we tested genetic identities using DNA extracted from single leaves of 14 processed commercial tea products. Based on the profiles of 60 SNP markers, the genetic identity of each tea sample was unambiguously identified by multilocus matching and ordination analysis. Results for repeated samples of multiple tea leaves from the same products(using three independent DNA extractions) showed 100% concordance, showing that the nanofluidic system is a reliable platform for generating tea DNA fingerprints with high accuracy. The method worked well on green, oolong, and black teas, and can handle a large number of samples in a short period of time. It is robust and cost-effective, thus showing high potential for practical application in the value chain of the tea industry. | Wanping Fang Lyndel W.Meinhardt Huawei Tan Lin Zhou Sue Mischke Xinghua Wang Dapeng Zhang | 2016 | The Crop Journal2016，4，4： | 4 |
| 12 | The tea plant CsLHT1 and CsLHT6 transporters take up amino acids, as a nitrogen source, from the soil of organic tea plantations显示文摘Organic tea is more popular than conventional tea that originates from fertilized plants.Amino acids inorganic soils constitute a substantial pool nitrogen(N)available for plants.However,the amino-acid contents in soils of tea plantations and how tea plants take up these amino acids remain largely unknown.In this study,we show that the amino-acid content in the soil of an organic tea plantation is significantly higher than that of a conventional tea plantation.Glutamate,alanine,valine,and leucine were the most abundant amino acids in the soil of this tea plantation.When 15 N-glutamate was fed to tea plants,it was efficiently absorbed and significantly increased the contents of other amino acids in the roots.We cloned seven CsLHT genes encoding amino-acid transporters and found that the expression of CsLHT1,CsLHT2,and CsLHT6 in the roots significantly increased upon glutamate feeding.Moreover,the expression of CsLHT1 or CsLHT6 in a yeast amino-acid uptake-defective mutant,22Δ10α,enabled growth on media with amino acids constituting the sole N source.Amino-acid uptake assays indicated that CsLHT1 and CsLHT6 are H^(+)-dependent high-and low-affinity amino-acid transporters,respectively.We further demonstrated that CsLHT1 and CsLHT6 are highly expressed in the roots and are localized to the plasma membrane.Moreover,overexpression of CsLHT1 and CsLHT6 in Arabidopsis significantly improved the uptake of exogenously supplied 15 N-glutamate and 15 N-glutamine.Taken together,our findings are consistent with the involvement of CsLHT1 and CsLHT6 in amino-acid uptake from the soil,which is particularly important for tea plants grown inorganic tea plantations. | Fang Li Chunxia Dong Tianyuan Yang Shilai Bao Wanping Fang William J.Lucas Zhaoliang Zhang | 2021 | Horticulture Research2021，8，1： | 3 |
| 13 | Gas sensing capabilities of TiO_(2) porous nanoceramics prepared through premature sintering显示文摘Pure and noble metal(Pt,Pd,and Au)doped TiO_(2)nanoceramics have been prepared from TiO_(2)nanoparticles through traditional pressing and sintering.For those samples sintered at 550℃,a typical premature sintering occurred,which led to the formation of a highly porous microstructure with a Brunauer-Emmett-Teller(BET)specific surface area of 23 m^(2)/g.At room temperature,only Pt-doped samples showed obvious response to hydrogen,with sensitivities as high as~500 for 1000 ppm H_(2)in N_(2);at 300℃,all samples showed obvious responses to CO,while the responses of noble metal doped samples were much higher than that of the undoped ones.The mechanism for the observed sensing capabilities has been discussed,in which the catalytic effect of Pt for hydrogen is believed responsible for the room-temperature hydrogen sensing capabilities,and the absence of glass frit as commonly used in commercial thick-film metal oxide gas sensors is related to the high sensitivities.It is proposed that much attention should be paid to metal oxide porous nanoceramics in developing gas sensors with high sensitivities and low working temperatures. | Yao XIONG Zilong TANG Yu WANG Yongming HU Haoshuang GU Yuanzhi LI Helen Lai Wah CHAN Wanping CHEN | 2015 | Journal of Advanced Ceramics2015，4，2： | 3 |
| 14 | 户籍改革、劳动力流动与城市层级体系优化(英文)显示文摘合理的'等级-规模'分布层级结构,是城市层级体系优化的必要条件。根据我国城市常住人口人数,利用'等级-规模'法则检验和核密度估计,并基于空间经济学框架,建立劳动力区位选择模型,且进行数值模拟,结果发现:我国城市层级结构与幂律为1对应的金字塔结构存在差异,户籍制度阻碍了劳动力自由流动,使城市规模分布偏离了帕累托最优。户籍改革有助于优化我国城市层级体系。优化城市层级体系,应该成为当前新型城镇化与城市群、都市圈建设的一致目标。 | 梁琦 陈强远 王如玉 Lin Wanping | 2015 | Social Sciences in China2015，36，2： | 2 |
| 15 | Contrasting room-temperature hydrogen sensing capabilities of Pt-SnO2 and Pt-TiO2 composite nanoceramics显示文摘察觉到行为的形成对照的房间温度氢为 Pt-TiO 2 和 Pt-SnO 2 被揭示了合成 nanoceramics。在 Pt-TiO 2 nanoceramics 的情况中,超离频当在周围的空气的氧 / 氢集中比率到达批评价值时,氢敏感突然地被失去。在 Pt-SnO 2 nanoceramics 的情况中,然而,如此的现象不发生,并且察觉到能力的非凡的房间温度氢在空中面对氧被观察。我们的联合了试验性、理论的调查为系统建立统一机制,它在表面和 SnO 2 和 TiO 2 的空隙的格子地点上根植于氢化学吸着;在 SnO 2 和 TiO 2 上的使用化学方法吸附的氢的稳定性的差别为察觉到能力的形成对照的氢被认为负责。中央调查结果在在改变混合气体的集中在房间温度充实我们和各种各样的金属氧化物半导体(苔藓) 的氢相互作用的显微镜的理解是有用的,并且他们能在基于体积苔藓开发可靠房间温度氢传感器是有帮助的。 | Yao Xiong Wanping Chen Yesheng Li Ping Cui Shishang Guo Wei Chen Zilong Tang Zijie Yan Zhenyu Zhang | 2016 | Nano Research2016，9，11： | 1 |
| 16 | Reinforcement learning based parameter optimization of active disturbance rejection control for autonomous underwater vehicle显示文摘This paper proposes a liner active disturbance rejection control(LADRC) method based on the Q-Learning algorithm of reinforcement learning(RL) to control the six-degree-of-freedom motion of an autonomous underwater vehicle(AUV).The number of controllers is increased to realize AUV motion decoupling.At the same time, in order to avoid the oversize of the algorithm, combined with the controlled content, a simplified Q-learning algorithm is constructed to realize the parameter adaptation of the LADRC controller.Finally, through the simulation experiment of the controller with fixed parameters and the controller based on the Q-learning algorithm, the rationality of the simplified algorithm, the effectiveness of parameter adaptation, and the unique advantages of the LADRC controller are verified. | SONG Wanping CHEN Zengqiang SUN Mingwei SUN Qinglin | 2022 | Journal of Systems Engineering and Electronics2022，33，1： | 1 |
| 17 | Insulator contamination forecasting based on fractal analysis of leakage current显示文摘 | Weigen C Wanping W Qing X | 2012 | Energies2012，5，7： | 1 |
| 18 | Investigation of Synthesizing MCM-41/ZSM-5 Composites 显示文摘 | Huang Limin Guo Wanping Deng Peng | 2000 | JPhys Chem B2000，104，13： | 1 |
| 19 | Coupled electro-thermal-flow model for very long electric arcs显示文摘 | Wanping H Lavers J D | 1997 | IEEE Transactions on Magnetics1997，33，2： | 1 |
| 20 | Dihydrophenanthrenes from Bletilla Iormosana 显示文摘 | Lin YunLian Chen WanPing Abdulgafor D M | 2005 | Chem Pharm Bull2005，53，9： | 1 |
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