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| 1 | Prunus genetics and applications after de novo genome sequencing:achievements and prospects显示文摘Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST resources.With public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits ensued.In this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome sequences.Within the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs worldwide.Functionally,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus traits.These include phenology,fruit quality,allergens,disease resistance,tree architecture,and self-incompatibility.Translationally,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop improvement.Finally,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry. | Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan Gao Ksenija Gasic Amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao Ignazio Verde Albert G.Abbott Pere Arús | 2019 | Horticulture Research2019，6，1： | 8 |
| 2 | QTL analysis and candidate gene mapping for skin and flesh color in sweet cherry fruit ( Prunus avium L.)显示文摘 | Suneth S. Sooriyapathirana Amjad Khan Audrey M. Sebolt Dechun Wang Jill M. Bushakra Kui Lin-Wang Andrew C. Allan Susan E. Gardiner David Chagné Amy F. Iezzoni | 2010 | Tree Genetics & Genomes2010，，6： | 2 |
| 3 | Crytogenic cirrhosis: clinical characterization and risk factors for tmderlying disease 显示文摘 | CALDWELL S H OELSNER D H IEZZONI J C | 1999 | Hepatology1999，29，： | 1 |
| 4 | Sarcomatoid carcinomas (carcinosarcomas) of the gastrointestinal tract:a review显示文摘 | Iezzoni JC Mills SE | 1993 | Semin Diagn Pathol1993，10，2： | 1 |
| 5 | Formoterol and Tiotropium Compared With Tiotropium Alone for Treatment of COPD显示文摘 | Tashkin DP Pearle J Iezzoni D | 2009 | COPD2009，6，1： | 1 |
| 6 | CBF1 orthologs in sour cherry and strawberry and the heterologous expression of CBF1 in strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F IEZZONI A F | 2002 | Am Soc Hortic Sci2002，127，4： | 1 |
| 7 | A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis显示文摘 | Stephen H Caldwell Elizabeth E Hespenheide Jan A Redick Julia C Iezzoni Emily H Battle Bonnie L Sheppard | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 8 | Applications of principal component analysis to horticultural research显示文摘 | Iezzoni A Pritts M | 1991 | Hortscience1991，26，： | 1 |
| 9 | Measuring hospital efficiency with frontier eost funetions显示文摘 | Zuckerman S Hadley J Iezzoni L | 1994 | Journal of Health Economies1994，13，10： | 1 |
| 10 | Aggressive angiomyxoma in males, a report of four cases显示文摘 | Iezzoni JC Fechner RE Wang LS | 1995 | Am J Clin Pathol1995，104，： | 1 |
| 11 | Using Severity measures to predict the likelihood of death from pneumonia in patients 显示文摘 | Iezzoni L1 Shwartz M Ash AS | 1996 | J Gen Intern Med1996，11，1： | 1 |
| 12 | Primary structural features of the S haplotype-specific F-box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIJIMA K YAMANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sexual Plant Reproduction2004，16，5： | 1 |
| 13 | Disahility and the training of health professionals显示文摘 | Shakespeare T Iezzoni LI Groce NE | 2009 | Lancet2009，374，9704： | 1 |
| 14 | Formoterol and tiotropium compared with titropium alone for treatment of COPD 显示文摘 | Tashkin DP Pearle J Iezzoni D | 2009 | COPD2009，6，： | 1 |
| 15 | Using Severity measures to predict the likelihood of death from pneumoniain patients显示文摘 | Iezzoni L I Shwartz M Ash A S | | 0，，01： | 1 |
| 16 | Measuring hospital efficiency with frontier cost functions显示文摘 | ZUCKERMAN S J HADLEY L IEZZONI | 1994 | Journal of Health Economics1994，13，3： | 1 |
| 17 | Primary structural features of the S haplotype -specific F -box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIJIMA K YAMANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sex Plant Reprod2004，16，： | 1 |
| 18 | Aggressive angiomyxoma in males:a report of four cases显示文摘 | Iezzoni JC Fechner RE Wong LS | 1995 | Am J Clin Pathol1995，104，： | 1 |
| 19 | Pri- mary structural features of the S hyplotype-specifie F-box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIIJIMA K YANANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sex Plant Repord2004，16，： | 1 |
| 20 | Measuring hospital effi- ciency with frontier cost functions显示文摘 | ZUCKERMAN S HADLEY J IEZZONI L | 1994 | Journal of Health Economics1994，13，3： | 1 |
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