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| 1 | A Study of the Structural, Optical and Electrical Properties of SnS Thin Films Modified by Plasma显示文摘 | Aar6n Gomez Horacio Martinez Manuela Calixto-Rodriguez David Avellaneda Pedro Guillermo Reyes Osvaldo Flores | 2013 | 材料科学与工程(中英文B版)2013，3，6： | 3 |
| 2 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 3 | Need for infliximab dose intensification in Crohn's disease and ulcerative colitis显示文摘AIM: To compare the need for infliximab dose intensification in two cohorts of patients with Crohn's disease(CD) or ulcerative colitis(UC).METHODS: Single centre, uncontrolled, observational study. Consecutive patients with CD and UC who responded to infliximab induction doses were included. Data collected in a prospectively maintained database were retrospectively analysed. Differences in the rates of dose intensification per patient-month and the intensification-free survival time were compared. We also evaluated the interval between the first infliximab induction dose and the first infliximab escalated dose. The weight-adjusted infliximab administration costs were also calculated.RESULTS: Fifty nine patients with CD and 38 patients with UC were enrolled. The rate of intensification per patient-month was 3.9% for UC and 1.4% for CD(P = 0.005). The median time from baseline to intensification was significantly shorter in UC compared to CD [6.6 mo(IQR: 4.2-9.5 mo) vs 10.7 mo(IQR: 8.9-11.7 mo), P = 0.005]. In the survival analysis, the cumulative probability of avoiding infliximab dose intensification was significantly higher in CD(P = 0.002). In the multivariate analysis, disease(UC vs CD) was the only factor significantly associated with dose intensification. The infiximab administration costs during the first year were significantly higher for UC compared to CD(mean ± SD 234.9 ± 53.3 Euros/kg vs 212.3 ± 15.1 Euros/kg, P = 0.03).CONCLUSION: The rate of infliximab dose intensification per patient-month is significantly higher in UC patients. The infliximab administration costs are also significantly higher in patients with UC. | Carlos Taxonera David Olivares Juan L Mendoza Manuel Díaz-Rubio Enrique Rey | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 4 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 5 | Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia:a pilot randomized controlled trial显示文摘 | Rey E Garneau P David M Gauthier R Leduc L Michon N | 2009 | J Thromb Haemost2009，7，1： | 1 |
| 6 | Thrombophilic disorders and fetal loss:a meta-analysis显示文摘 | Rey E Kahn SR David M | | 0，，9361： | 1 |
| 7 | Thrombophilic disorders and fetal loss:a meta-analysis显示文摘 | Rey E Kahn SR David M | | 0，，： | 1 |
| 8 | Thrombophilic disordersand fetal loss: a meta-analysis 显示文摘 | Rey E Kahn SR David M | 2003 | Lancet2003，361，9361： | 1 |
| 9 | The Role of Functional MR Imaging in the Assessment of Tumor Response after Chemoembolization in Patients with Hepatocellular Carcinoma显示文摘 | Ihab R. Kamel David A. Bluemke John Eng Eleni Liapi Wells Messersmith Diane K. Reyes Jean-Francois H. Geschwind | 2006 | Journal of Vascular and Interventional Radiology2006，，： | 1 |
| 10 | Thrombophilic disorders and fetal loss:a meta - analysis显示文摘 | Rey E Kahn SR David M | 2003 | Lancet2003，361，9361： | 1 |
| 11 | Thrombophilic disorders and fetal loss:a meta-analysis显示文摘 | Rey E Kahn SR David M | | 0，，9361： | 1 |
| 12 | Thrombophilic disorders and fetal 1 ss :ameta-analysis显示文摘 | Rey E Kahn SR David M | 2003 | Lancet2003，361，9361： | 1 |
| 13 | Thrombophilia disorders and fetal loss:a meta-analysis显示文摘 | Rey E Kahn SR David M | 2003 | Lancet2003，361，9361： | 1 |
| 14 | Thrombophilic disorders and fetal loss: a meta-analysls 显示文摘 | Rey E Kahn SR David M | 2003 | Lancet2003，361，9： | 1 |
| 15 | Thrombophilic disorders and fetal loss: a meta-analysis显示文摘 | Evelyne Rey Susan R Kahn Michèle David Ian Shrier | 2003 | The Lancet . 2003 (9361)2003，，： | 1 |
| 16 | CagA-Dependent Downregulation of B7-H2 Expression on Gastric Mucosa and Inhibition of Th17 Responses during Helicobacter pylori Infection显示文摘 | Taslima T. Lina Irina V. Pinchuk Jennifer House Yoshio Yamaoka David Y. Graham Ellen J. Beswick Victor E. Reyes | 2013 | The Journal of Immunology2013，，7： | 1 |
| 17 | Thrombophilic disorders and fetal loss:a meta-analysis显示文摘 | Rey E Kahn SR David M | 2003 | Lancet2003，361，9361： | 1 |
| 18 | Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular cancer in childhood and adolescence显示文摘 | Jorge D. Reyes Brian Carr Igor Dvorchik Samuel Kocoshis Ronald Jaffe David Gerber George V. Mazariegos Javier Bueno Rick Selby | 2000 | The Journal of Pediatrics2000，，6： | 1 |
| 19 | Increasing the number of hepatitis B vaccine injections augments anti-HBs response rate in HIV-infected patients. Effects on HIV-1 viral load显示文摘 | David Rey Véronique Krantz Marialuisa Partisani Marie-Paule Schmitt Pierre Meyer Eric Libbrecht Marie-Josée Wendling Denis Vetter Margreet Nicolle Georgette Kempf-Durepaire Jean-Marie Lang | 2000 | Vaccine2000，，： | 1 |
| 20 | Study of Peptide Mimetics of Hepatitis A Virus Conjugated to Keyhole Limpet Hemocyanin and as Multiple Antigen Peptide System显示文摘 | Alicia Aguilar Frank Camacho Raiza Martínez Vivian Huerta Hilda E. Garay Nevis Amin Arturo Talavera Mildrey Fari?as Osvaldo Reyes David I. Stott Armando Acosta Ela M. Pérez | 2014 | International Journal of Peptide Research and Therapeutics2014，，： | 1 |
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