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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Radiometric correction of visible and infrared remote sensing data at the Canada Centre for Remote Sensing显示文摘 | AHERN F J Brown R J Cihlar J Gauthier R Murphy J Neville R A and Teillet P M | 1984 | International Journal of Remote Sensing1984，8，： | 2 |
| 3 | Volatility and chemistry of trace elements in a coal combustor 显示文摘 | Yan R Gauthier D Flamant G | 2001 | Fuel2001，80，： | 1 |
| 4 | SDF-1 c and IL- 7 treatment improves homeostatic proliferation of naive CD4 ( + ) T cells after allogeneic stem cell transplantation显示文摘 | Gauthier SD Leboeuf D Manuguerra-Gagn6 R | 2015 | Biol Blood Marrow Transplant2015，21，10： | 1 |
| 5 | Nitric-oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia显示文摘 | Gauthier TW Scalia R Murohara T | 1995 | Arterioscler Thromb Vasc Biol1995，15，10： | 1 |
| 6 | Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia:a pilot randomized controlled trial显示文摘 | Rey E Garneau P David M Gauthier R Leduc L Michon N | 2009 | J Thromb Haemost2009，7，1： | 1 |
| 7 | Genetic diversity among a complex of cereal cyst nematode inferred from RFLP analysis of the ribosomal internal transcribed spacer region显示文摘 | Bekal S Gauthier J P Rivoal R | 1997 | Genome1997，40，： | 1 |
| 8 | Optical trapping a tool to assist optical machining显示文摘 | Gauthier R C | 1997 | Optics & Laser Technology1997，9，7： | 1 |
| 9 | Optical trapping a tool to assist optical machining显示文摘 | GAUTHIER R C | 1997 | Optics & Laser Technology1997，9，7： | 1 |
| 10 | Neuroprotective and neurorescuing effect of isoform-specific nitric oxide synthase inhitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity显示文摘 | Law A Gauthier S Quirion R | 2001 | Br J Pharmacol2001，133，： | 1 |
| 11 | Analyt- ical modeling of the transient response of a coil encircling a ferro- magnetic conducting rod in pulsed eddy current testing显示文摘 | DESJARDINS D P R KRAUSE T W GAUTHIER N | 2013 | NDT E International2013，60，12： | 1 |
| 12 | Apoptosis related to telomere instability and cell cycle alteration in human glioma cells treated by new highly selective G-quadruplex ligands显示文摘 | PENNARUN G GRANOTIER C GAUTHIER L R | 2005 | Oncogene2005，24，18： | 1 |
| 13 | Apeptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands显示文摘 | PENNARUN G GRANOTIER C GAUTHIER L R | 2005 | Oncogene2005，24，18： | 1 |
| 14 | Influence of the β crystalline phase on the mechanical properties of unfilled and CaCO3-filled polypropylene(Ⅰ):Structural and mechanical characterization 显示文摘 | Labour T Gauthier C Seguela R | 2001 | Polym2001，42，16： | 1 |
| 15 | Role of nitric oxide in antibacterial non-specific immunity:in vivo and in vitro study显示文摘 | Gauthier Y P Burckhart M F Vidal D R | 1994 | Trav Sci Chercheurs Serv Sante Armees1994，15，： | 1 |
| 16 | The Contribution of Social Rank and Attachment Theory to Depression in a Non Clinical Sample of Adolescents显示文摘 | Puissant S P Gauthier J M Oirbeek R V | 2011 | The Spanish Journal of Psychology2011，14，2： | 1 |
| 17 | RFLP diversity and relationships among traditional European maize populations显示文摘 | Gauthier P Gouesnard B DallardJ Redaelli R Rebourg C Charcosset A Boyat A | 2002 | Theoretical and Applied Genetics2002，105，1： | 1 |
| 18 | Molecular detection of telomerase -positive circulating epithelial cells in metastatic breast cancer patients显示文摘 | Jean-Charles Soria Laurent R Gauthier | 1999 | Clinical Cancer Research1999，5，5： | 1 |
| 19 | Micro- structural aspects in a polymer-modified cement 显示文摘 | Ollitrault-Fichet R Gauthier C Clamen G | 1998 | Ce- ment and Concrete Research1998，28，12： | 1 |
| 20 | Adsorption of copper(Ⅱ) and chromium (Ⅲ) ions onto amidoximated cellulose显示文摘 | KUBOTA H SHIGEHISA Y GAUTHIER R | | 0，，13： | 1 |
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