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| 1 | Risk factors for colonoscopic perforation: A population-based study of 80118 cases显示文摘AIM: To assess the incidence and risk factors associated with colonic perforation due to colonoscopy. METHODS: This was a retrospective cross-sectional study. Patients were retrospectively eligible for inclusion if they were 18 years and older and had an inpatient or outpatient colonoscopy procedure code in any facility within the Geisinger Health System during the period from January 1, 2002 to August 25, 2010. Data are presented as median and inter-quartile range, for continuous variables, and as frequency and percentage for categorical variables. Baseline comparisons across those with and without a perforation were made using the two-sample t -test and Pearson's χ2 test, as appropriate.RESULTS: A total of 50 perforations were diagnosed out of 80118 colonoscopies, which corresponded to an incidence of 0.06% (95%CI: 0.05-0.08) or a rate of 6.2 per 10000 colonoscopies. All possible risk factors associated with colonic perforation with a P -value < 0.1 were checked for inclusion in a multivariable logbinomial regression model predicting 7-d colonic perforation. The final model resulted in the following risk factors which were significantly associated with risk of colonic perforation: age, gender, body mass index, albumin level, intensive care unit (ICU) patients, inpatient setting, and abdominal pain and Crohn's disease as indications for colonoscopy. CONCLUSION: The cumulative 7 d incidence of colonic perforation in this cohort was 0.06%. Advanced age and female gender were significantly more likely to have perforation. Increasing albumin and BMI resulted in decreased risk of colonic perforation. Having a colonoscopy indication of abdominal pain or Crohn's disease resulted in a higher risk of colonic perforation. Colonoscopies performed in inpatients and particularly the ICU setting had substantially greater odds of perforation. Biopsy and polypectomy did not increase the risk of perforation and only three perforations occurred with screening colonoscopy. | Uzair Hamdani Raza Naeem Fyeza Haider Pardeep Bansal Michael Komar David L Diehl H Lester Kirchner | 2013 | World Journal of Gastroenterology2013，19，23： | 9 |
| 2 | The exploitation of epichloae endophytes for agricultural benefit显示文摘Epichloae endophytes of family Clavicipitaceae(comprising genera Epichloëand Neotyphodium)are fungal symbionts of Pooideae grasses.The associations formed,range from mutually beneficial to antagonistic and the nature of this relationship is dependent upon the importance of vertical(via host seeds)versus horizontal(ascospore mediated)transmission of the fungus.These endophytes can enhance their hosts’survival through protection from abiotic and biotic stresses and can thus be utilized in an agricultural context.Animal-safe grass-endophyte associations that confer bio-protective properties for increased pasture persistence and productivity have been developed and commercialized.One of the crucial drivers underpinning the selection of epichloae strains for commercial development is endophyte derived bioactivity.The potential of next generation endophytes is determined by testing a number of attributes such as agronomic fitness,animal and food safety as well as compatibility with host plants of interest.Strategic research supports these activities by focusing on elucidating mechanisms of compatibility between host and fungal symbiont,as well as investigating other molecular drivers of symbiosis such as siderophore mediated iron-uptake,fungal signalling,fungal growth in host plants and fungal secondary metabolism.This review weaves together the different strands of multidisciplinary research aimed at ultimately exploiting epichloae endophytes for increased pasture performance. | Linda J.Johnson Anouck C.M.de Bonth Lyn R.Briggs John R.Caradus Sarah C.Finch Damien J.Fleetwood Lester R.Fletcher David E.Hume Richard D.Johnson Alison J.Popay Brian A.Tapper Wayne R.Simpson Christine R.Voisey Stuart D.Card | 2013 | Fungal Diversity2013，，3： | 5 |
| 3 | Diagnosis and Management of Partial Small Bowel Obstruction after Laparoscopic Antecolic Antegastric Roux-en-Y Gastric Bypass for Morbid Obesity显示文摘 | Minyoung Cho Lester Carrodeguas David Pinto Charles Lascano Flavia Soto Oliver Whipple Richard Gordon Conrad Simpfendorfer John Paul Gonzalvo Samuel Szomstein Raul J. Rosenthal | 2006 | Journal of the American College of Surgeons2006，，2： | 1 |
| 4 | Neutrophil and Nonneutrophil-Mediated Injury in Intestinal Ischemia-Reperfusion显示文摘 | Ruth Simpson Rafael Alon Lester Kobzik C. Robert Valeri David Shepro Herbert B. Hechtman | 1993 | Annals of Surgery1993，，4： | 1 |
| 5 | Atypical Antipsychotics in the Treatment of Depressive and Psychotic Symptoms in Patients with Chronic Schizophrenia: A Naturalistic Study显示文摘 | Marco Innamorati Stefano Baratta Cristina Di Vittorio David Lester Paolo Girardi Maurizio Pompili Mario Amore Robin Emsley | 2013 | Schizophrenia Research and Treatment2013，，： | 1 |
| 6 | Constructions of religlosity,subjective well-being,anxiety,and depression in two cultures:Kuwait and USA显示文摘 | Ahmed David Lester | 2010 | Intema- tional Journal of Social Psychiatry2010，11，： | 1 |
| 7 | Factors affecting student attitudes toward war显示文摘 | David Lester | 1993 | TheJournalof Psychology1993，134，4： | 1 |
| 8 | Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells显示文摘 | Lester M. Davids Britta Kleemann Denisa Kacerovská Karl Pizinger Susan H. Kidson | 2008 | Journal of Photochemistry & Photobiology, B: Biology2008，，2： | 1 |
| 9 | Genome mapping of postzygotic hybrid necrosis in an interspecific pear population显示文摘Deleterious epistatic interactions in plant inter-and intraspecific hybrids can cause a phenomenon known as hybrid necrosis,characterized by a typical seedling phenotype whose main distinguishing features are dwarfism,tissue necrosis and in some cases lethality.Identification of the chromosome regions associated with this type of incompatibility is important not only to increase our understanding of the evolutionary diversification that led to speciation but also for breeding purposes.Development of molecular markers linked to the lethal genes will allow breeders to avoid incompatible inbred combinations that could affect the expression of important agronomic tratis co-segregating with these genes.Although hybrid necrosis has been reported in several plant taxa,including Rosaceae species,this phenomenon has not been described previously in pear.In the interspecific pear population resulting from a cross between PEAR3(Pyrus bretschneideri×Pyrus communis)and‘Moonglow’(P.communis),we observed two types of hybrid necrosis,expressed at different stages of plant development.Using a combination of previously mapped and newly developed genetic markers,we identified three chromosome regions associated with these two types of lethality,which were genetically independent.One type resulted from a negative epistatic interaction between a locus on linkage group 5(LG5)of PEAR3 and a locus on LG1 of‘Moonglow’,while the second type was due to a gene that maps to LG2 of PEAR3 and which either acts alone or more probably interacts with another gene of unknown location inherited from‘Moonglow’. | Sara Montanari Lester Brewer Robert Lamberts Riccardo Velasco Mickael Malnoy Laure Perchepied Philippe Guérif Charles-Eric Durel Vincent G M Bus Susan E Gardiner David Chagné | 2016 | Horticulture Research2016，3，1： | 1 |
| 10 | An exploratory investigation of the ethical Values of American and Australian Consumers显示文摘 | Rawwas Mohammed Y A David Strutton Lester W Johnson | 1996 | Journal of Direct-marketing1996，，10： | 1 |
| 11 | Validation of the Farsi version of the Death Obsession Scale among nurses显示文摘Objectives:Obsession is one of the important aspects in death distress.The objective of this study was to estimate the reliability,validity,and factorial structure of the Farsi version of the Death Obsession Scale(DOS).Methods:A convenience sample of 106 Iranian nurses from two hospitals at Tehran city,Iran was recruited.They completed the DOS,Death Concern Scale,Collett-Lester Fear of Death Scale,Death Anxiety Scale,Reasons for Death Fear Scale,and Death Depression Scale.Results:Cronbach's a for the DOS was 0.95,and 2-week test-retest reliability was 0.74.The DOS correlated 0.48,0.46,0.47,0.39 and 0.44 with the last mentioned scales,respectively(P<0.01),indicating good construct and criterion-related validity.Principle components analysis of the DOS identified three factors accounted for 74.82%of the variance.Factor 1 labeled“Death rumination”(34.78%of the variance),Factor 2 labeled“Death dominance”(29.65%of the variance),and Factor 3 labeled“Death idea repetition”(10.38%of the variance).Conclusions:The DOS has good validity and reliability,and it could be recommended for use in clinical and research settings to assess the death obsession in Iranian nurses. | Mahboubeh Dadfar Ahmed M.Abdel-Khalek David Lester | 2018 | International Journal of Nursing Sciences2018，5，2： | 1 |
| 12 | Noninvasive Assessment of Pulmonary Vascular Resistance by Doppler Echocardiography显示文摘 | Amr E. Abbas Laura M. Franey Thomas Marwick Micha T. Maeder David M. Kaye Antonios P. Vlahos Walter Serra Karim Al-Azizi Nelson B. Schiller Steven J. Lester | 2013 | Journal of the American Society of Echocardiography2013，，： | 1 |
| 13 | Electrocardiographic findings in Emergency Department patients with pulmonary embolism显示文摘 | Peter B Richman Hassan Loutfi Steven J Lester Patricia Cambell Jessica Matthews Jeremy Friese Joseph Wood David Kasper Frederick Chen Mark Mandell | 2004 | Journal of Emergency Medicine2004，，2： | 1 |
| 14 | Suicide prevention on campus-what direction? 显示文摘 | David Lester | 2013 | Crisis2013，34，6： | 1 |
| 15 | Mast cell involvement in fibrodysplasia ossificans progressiva显示文摘 | Francis H Gannon David Glaser Robert Caron Lester D.R Thompson Eileen M Shore Frederick S Kaplan | 2001 | Human Pathology2001，，8： | 1 |
| 16 | A novel automated image analysis method for maceral analysis显示文摘 | Edward Lester David Watts Michael Cloke | 2002 | Fuel2002，81，： | 1 |
| 17 | Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders显示文摘 | Gianluca Serafini Maurizio Pompili Marco Innamorati Paolo Fusar-Poli Hagop S. Akiskal Zoltan Rihmer David Lester Andrea Romano Irismar Reis de Oliveira Leonardo Strusi Stefano Ferracuti Paolo Girardi Roberto Tatarelli | 2010 | Journal of Affective Disorders2010，，1： | 1 |
| 18 | Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression显示文摘 | Maurizio Pompili Marco Innamorati J. John Mann Maria A. Oquendo David Lester Antonio Del Casale Gianluca Serafini Silvia Rigucci Andrea Romano Antonino Tamburello Giovanni Manfredi Eleonora De Pisa Stefan Ehrlich Giancarlo Giupponi Mario Amore Roberto Tat | 2008 | Progress in Neuropsychopharmacology & Biological Psychiatry2008，，6： | 1 |
| 19 | Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent显示文摘 | Rodney J. Hicks Danny Rischin Richard Fisher David Binns Andrew M. Scott Lester J. Peters | 2005 | European Journal of Nuclear Medicine and Molecular Imaging2005，，12： | 1 |
| 20 | Near-infrared spectral imaging for quality assurance of pharmaceutical products: Analysis of tablets to assess powder blend homogeneity显示文摘 | Robbe C. Lyon David S. Lester E. Neil Lewis Eunah Lee Lawrence X. Yu Everett H. Jefferson Ajaz S. Hussain | 2002 | AAPS PharmSciTech2002，，3： | 1 |
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