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| 1 | Non-coding landscapes of colorectal cancer显示文摘For two decades Vogelstein's model has been theparadigm for describing the sequence of molecular changes within protein-coding genes that would lead to overt colorectal cancer(CRC). This model is now too simplistic in the light of recent studies, which have shown that our genome is pervasively transcribed in RNAs other than m RNAs, denominated non-coding RNAs(nc RNAs). The discovery that mutations in genes encoding these RNAs [i.e., micro RNAs(mi RNAs), long non-coding RNAs, and circular RNAs] are causally involved in cancer phenotypes has profoundly modified our vision of tumour molecular genetics and pathobiology. By exploiting a wide range of different mechanisms, nc RNAs control fundamental cellular processes, such as proliferation, differentiation, migration, angiogenesis and apoptosis: these data have also confirmed their role as oncogenes or tumor suppressors in cancer development and progression. The existence of a sophisticated RNA-based regulatory system, which dictates the correct functioning of protein-coding networks, has relevant biological and biomedical consequences. Different mi RNAs involved in neoplastic and degenerative diseases exhibit potential predictive and prognostic properties. Furthermore, the key roles of nc RNAs make them very attractive targets for innovative therapeutic approaches. Several recent reports have shown that nc RNAs can be secreted by cells into the extracellular environment(i.e., blood and other body fluids): this suggests the existence of extracellular signalling mechanisms, which may be exploited by cells in physiology and pathology. In this review, we will summarize the most relevant issues on the involvement of cellular and extracellular nc RNAs in disease. We will then specifically describe their involvement in CRC pathobiology and their translational applications to CRC diagnosis, prognosis and therapy. | Marco Ragusa Cristina Barbagallo Luisa Statello Angelo Giuseppe Condorelli Rosalia Battaglia Lucia Tamburello Davide Barbagallo Cinzia Di Pietro Michele Purrello | 2015 | World Journal of Gastroenterology2015，21，41： | 6 |
| 2 | Survival of lactic acid bacteria from fermented milks in an in vitro digestion model exploiting sequential incubation in human gastric and duodenum juice显示文摘 | FAYE T TAMBURELLO A BEGARUD G E | | 0，，2： | 1 |
| 3 | Diversion to the Mental Health Sys- tem:Emergency Psychiatric Evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psychiatry Law2006，34，3： | 1 |
| 4 | Diversion to the Mental Health System: Emergency Psychiatric Evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psychiatry Law2006，34，3： | 1 |
| 5 | Diversion to the mental health system :emergency psychiatric evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psychiatry Law2006，34，3： | 1 |
| 6 | Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression显示文摘 | Maurizio Pompili Marco Innamorati J. John Mann Maria A. Oquendo David Lester Antonio Del Casale Gianluca Serafini Silvia Rigucci Andrea Romano Antonino Tamburello Giovanni Manfredi Eleonora De Pisa Stefan Ehrlich Giancarlo Giupponi Mario Amore Roberto Tat | 2008 | Progress in Neuropsychopharmacology & Biological Psychiatry2008，，6： | 1 |
| 7 | Diversion to the Mental Heahh System: Emergency Psychiatric Evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psy chiatry Law2006，34，3： | 1 |
| 8 | Active manipulation of a particle-laden jet 显示文摘 | Tamburello D A Amitay M | 2008 | International Journal of Multiphase Flow2008，34，： | 1 |
| 9 | Diversion to the mental health system:emergency psychiatric evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psychiatry Law2006，34，3： | 1 |
| 10 | Diversion to the Mental Health System:Emergency Psychiatric Evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psychiatry Law2006，34，3： | 1 |
| 11 | Diversion to the Mental Health System: Emergency Psychiatric Evaluations显示文摘 | Janofsky JS Tamburello AC | 2006 | J Am Acad Psychiatry Law2006，34，3： | 1 |
| 12 | 上地幔碳含量随熔融深度增加而增加显示文摘上地幔中的碳含量对于理解地球内部运行机制和全球碳循环至关重要。地幔矿物中的熔体包裹体是获取碳含量的主要途径,但由于它们在上升至地表的过程中大多经历了强烈的去气作用,因此测定的碳含量能否代表地幔仍存在争议。从包裹体逃逸出的CO_(2)大多经火山作用释放到地表。因此,可以通过研究火山喷发的气体对地幔碳含量进行定量研究。来自意大利巴勒莫大学的Alessandro Aiuppa及其合作者通过搜集12个与地幔柱相关或大陆裂谷背景的火山的高温火山气体、熔体包裹体及岩浆岩等相关数据,对上地幔中的碳含量进行了模拟计算。 | 夏群科(编译) Aiuppa A Casetta F Coltorti M Stagno V Tamburello G | 2021 | 矿物岩石地球化学通报2021，40，6： | 0 |
| 13 | 上地幔碳含量随熔融深度增加而增加显示文摘上地幔中的碳含量对于理解地球内部运行机制和全球碳循环至关重要。地幔矿物中的熔体包裹体是获取碳含量的主要途径,但由于它们在上升至地表的过程中大多经历了强烈的去气作用,因此测定的碳含量能否代表地幔仍存在争议。从包裹体逃逸出的CO_(2)大多经火山作用释放到地表。因此,可以通过研究火山喷发的气体对地幔碳含量进行定量研究。来自意大利巴勒莫大学的Alessandro Aiuppa及其合作者通过搜集12个与地幔柱相关或大陆裂谷背景的火山的高温火山气体、熔体包裹体及岩浆岩等相关数据,对上地幔中的碳含量进行了模拟计算。 | Aiuppa A Casetta F Coltorti M Stagno V Tamburello G. 夏群科(编译) | 2022 | 矿物岩石地球化学通报2022，41，1： | 0 |
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