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| 1 | Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis显示文摘Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed. | Licia Polimeni Maria Del Ben Francesco Baratta Ludovica Perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico | 2015 | World Journal of Hepatology2015，7，10： | 23 |
| 2 | Modern approach to the clinical management of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common and emerging form of chronic liver disease worldwide.It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis,which may progress to cirrhosis,liver cancer,and liver mortality.Common metabolic diseases,which are well established cardiovascular risk factors,have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population.The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration.Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide.First-line management focuses on lifestyle modifications.Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended.Several therapeutic interventions have been proposed.These include insulin sensitizer agents,lipid lowering drugs,antioxidants such as vitamin E and supplementation of vitamin D3.However,therapeutic strategies have been largely empirical so far,and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes.Metabolic conditions such as diabetes mellitus,obesity,hypertension and hyperlipidemia,should be strongly considered and a multidisciplinary approach should be personalized for individual patients.Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients.The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease. | Maria Del Ben Licia Polimeni Francesco Baratta Daniele Pastori Lorenzo Loffredo Francesco Angelico | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 3 | Exaggerated morning blood pressure surge and cardiovascular events. A 5-year longitudinal study in normotensive and well-controlled hypertensive elderly显示文摘 | A. Amici P. Cicconetti C. Sagrafoli A. Baratta P. Passador T. Pecci G. Tassan W. Verrusio V. Marigliano M. Cacciafesta | 2008 | Archives of Gerontology and Geriatrics2008，，2： | 2 |
| 4 | Tobacco smoke in the development and therapy of periodondal disease:progress and questions显示文摘 | Rota MT Poggi P Baratta L | 1999 | Bull Group Int Rech Sci Stomatol Odontol1999，41，4： | 1 |
| 5 | Purification and characterization of a nitrous oxide reductase from thiosphaera pantotropha-lmplications for the mechanism of aerobic nitrous oxide reduction 显示文摘 | Berks BC Baratta D | 1993 | European Journal of Biochemistry1993，212，2： | 1 |
| 6 | Liposomal delivery of doxorubicin to hepatocytes in vivo by targeting heparan sulfate 显示文摘 | LONGMUIR K J HAYNES S M BARATTA J L | 2009 | lnt J Pharm2009，382，12： | 1 |
| 7 | Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphc nucleus显示文摘 | Amat J Baratta MV Paul E | 2005 | Nat Neurosci2005，8，3： | 1 |
| 8 | I,iposomal deliv- ery of doxorubicin to hepatocytes in vivo by targeting heparan sul- fate显示文摘 | Longmuir KJ Haynes SM Baratta JL | 2009 | Int J Pharm2009，382，12： | 1 |
| 9 | Fast and chemoselective transfer hydrogenation of aldehydes catalyzed by a terdentate CNN ruthenium complex显示文摘 | BARATTA W SIEGA K RIGO P | 2007 | Adv Synth Catal2007，349，： | 1 |
| 10 | Non-alcoholic fatty liverdisease and cardiovascular disease: epidemiological, clinical and pathophysiologieal evidences显示文摘 | Del Ben M Baratta F Polimeni L | 2012 | Intern Emerg Med2012，7，3： | 1 |
| 11 | Reciprocating gait orthoses:a muhieenter study of their use by spinal cord injurcd patients显示文摘 | Francesehni M Baratta S Zampolini M | 1997 | Arch Phys Med Rehabil1997，78，： | 1 |
| 12 | In vivo induction of massive proliferation,directed migration,and differentiation of neural cells in the adult mammalian brain显示文摘 | Fallon J Reid S Kinyamu R Opole I Opole R Baratta J Korc M Endo TL Duong A Nguyen G Karkehabadhi M Twardzik D Patel S Loughlin S | | 0，，： | 1 |
| 13 | IGF-1, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets 显示文摘 | Saleri R Baratta M Mainardi G L | 2001 | Reprod Nutr Dev2001，41，2： | 1 |
| 14 | The effect of divergent screw placement on the initial strength of plate-to-hone fixation显示文摘 | Robert KQ 3rd Chandler R Baratta RV | 2003 | J Trauma2003，55，6： | 1 |
| 15 | Chemical omposition, antimicrobial and antioxidative activity of laurel, sange, rosemary, oregano and coriander essential oils 显示文摘 | Baratta M T Dorman H J D Deans S G | 1998 | Journal of Essential Oil Pesearch1998，10，： | 1 |
| 16 | Antioxidant activity of extracts of the marine algal genus,Cystoseira in amicel-lar model system显示文摘 | RUBERTO G BARATTA M T BIONDI D M | 2001 | Journal of Applied Phycology2001，13，5： | 1 |
| 17 | Validity, reliability, feasibility and satisfaction of the mini-clinical evaluationexereise (mini-CEX) for cardiology residency training 显示文摘 | Alves de Lima A Barrero C Baratta S | 2007 | Med Teach2007，29，8： | 1 |
| 18 | A soluble PC-1 circulates in human plasma:relationship with insulin resistance and associated abnormalities 显示文摘 | Frittitta L Camastra S Baratta R | 1999 | J Clin Endocrinol Metab1999，84，： | 1 |
| 19 | Manipulation of muscle force with various firing rate and recruitment control strategies 显示文摘 | Zhou Binghe Baratta R Solomonow M | 1987 | IEEE Trans Biomed Eng1987，34，2： | 1 |
| 20 | Atypical Antipsychotics in the Treatment of Depressive and Psychotic Symptoms in Patients with Chronic Schizophrenia: A Naturalistic Study显示文摘 | Marco Innamorati Stefano Baratta Cristina Di Vittorio David Lester Paolo Girardi Maurizio Pompili Mario Amore Robin Emsley | 2013 | Schizophrenia Research and Treatment2013，，： | 1 |
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