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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 3 | Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates显示文摘Dear Editor,Omicron(B.1.1.529),is a heavily mutated and highly contagious SARS-CoV-2 variant,which is currently causing large outbreaks in many countries.Protection provided by current vaccines is substantially reduced against Omicron.1,2 Moreover,many immunocompromised individuals cannot effectively be protected by vaccines.3 Hence,antiviral therapies will be essential to protect the most vulnerable individuals from severe COVID-19. | Denisa Bojkova Marek Widera Sandra Ciesek Mark N.Wass Martin Michaelis Jindrich Cinatl Jr | 2022 | Cell Research2022，32，3： | 10 |
| 4 | Therapies targeting cancer stem cells: Current trends and future challenges显示文摘Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers. | Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2015 | World Journal of Stem Cells2015，7，9： | 10 |
| 5 | Building an Earth Observations Data Cube: lessons learned from the Swiss Data Cube (SDC) on generating Analysis Ready Data (ARD)显示文摘Pressures on natural resources are increasing and a number of challenges need to be overcome to meet the needs of a growing population in a period of environmental variability.Some of these environmental issues can be monitored using remotely sensed Earth Observations(EO)data that are increasingly available from a number of freely and openly accessible repositories.However,the full information potential of EO data has not been yet realized.They remain still underutilized mainly because of their complexity,increasing volume,and the lack of efficient processing capabilities.EO Data Cubes(DC)are a new paradigm aiming to realize the full potential of EO data by lowering the barriers caused by these Big data challenges and providing access to large spatio-temporal data in an analysis ready form.Systematic and regular provision of Analysis Ready Data(ARD)will significantly reduce the burden on EO data users.Nevertheless,ARD are not commonly produced by data providers and therefore getting uniform and consistent ARD remains a challenging task.This paper presents an approach to enable rapid data access and pre-processing to generate ARD using interoperable services chains.The approach has been tested and validated generating Landsat ARD while building the Swiss Data Cube. | Gregory Giuliani Bruno Chatenoux Andrea De Bono Denisa Rodila Jean-Philippe Richard Karin Allenbach Hy Dao Pascal Peduzzi | 2017 | Big Earth Data2017，1，1： | 7 |
| 6 | Heteroatom-doped graphene for electrochemical energy storage显示文摘The increasing energy consumption and environmental concerns due to burning fossil fuel are key drivers for the development of effective energy storage systems based on innovative materials.Among these materials,graphene has emerged as one of the most promising due to its chemical,electrical,and mechanical properties.Heteroatom doping has been proven as an effective way to tailor the properties of graphene and render its potential use for energy storage devices.In this view,we review the recent developments in the synthesis and applications of heteroatom-doped graphene in supercapacitors and lithium ion batteries. | Yangyang Wen Congcong Huang Lianzhou Wang Denisa Hulicova-Jurcakova | 2014 | Chinese Science Bulletin2014，59，18： | 5 |
| 7 | Ni-induced stepwise capacity increase in Ni-poor Li-rich cathode materials for high performance lithium ion batteries显示文摘Li 富有的阴极材料为高精力的锂离子电池(解放) 被认为候选人同样有希望。在这研究,我们报导Li富有的材料的一个新系列(李[李<潜水艇class=“ a-plus-plus ”> 1/32x/3 Mn <潜水艇class=“ a-plus-plus ”> 2/3x/3 Ni <潜水艇class=“ a-plus-plus ”> x ]O 2 ( 0.09 x 0.2 ))在解放作为阴极材料与 Ni 的小数量做了,它由于李的连续激活展出了能力增加的不平常的现象直到十个周期<潜水艇class=“ a-plus-plus ”> 2 MnO <潜水艇class= a-plus-plus > 3 阶段。试验性、计算的结果显示不同于通常学习的做 Ni 的 Li 富有的阴极材料,做的 Ni 的更小的数量能提拔逐步的李 < 潜水艇 class= “ a-plus-plus ” > 2 MnO < 潜水艇 class= “ a-plus-plus ” > 获得的 3 激活增加了特定的能力和更好骑车的能力。相反,过多的 Ni 愿望在激活上李 < 潜水艇 class= “ a-plus-plus ” > 2 MnO < 潜水艇 class= “ a-plus-plus ” > 在在第一的大能力损失的 3 和结果骑车。李<潜水艇class=“ a-plus-plus ”> 1.25 Mn <潜水艇class=“ a-plus-plus ”> 0.625 Ni <潜水艇class=“ a-plus-plus ”> 0.125 O <潜水艇class=“ a-plus-plus ”>有 Ni 的一个优化内容的 2 材料高交付了上级能力 280 mAh ?瀠汯??瑳特湥?潣洭污楥??€ ????????????????????楢慬敹?????搠獩潣摩污?慮潮慰瑲捩敬?? | Delai Ye Chenghua Sun Yu Chen Kiyoshi Ozawa Denisa Hulicova-JurcakovaI Jin Zou Lianzhou Wang | 2015 | Nano Research2015，8，3： | 4 |
| 8 | Menzerath-Altmann定律:理论贡献与局限显示文摘Menzerath–Altmann定律是20世纪世界上重要的基础性语言定律。本文主要在介绍该计量语言学定律的基础上,探讨该定律的理论贡献,并指出其理论局限。首先,本文聚焦于计量语言学的介绍。其次,我们介绍该定律的理论背景和主要内容。接下来,我们论述了Menzerath–Altmann定律的研究现状。最后,本文揭示其主要的理论贡献和理论局限性。 | Denisa Schusterova Tereza Motalova 王馥芳 | 2017 | 语言学研究2017，，1： | 2 |
| 9 | Murine models based on acute myeloid leukemia-initiating stem cells xenografting显示文摘Acute myeloid leukemia(AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells(LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells. Animal models provides the means to investigate the factors responsible for leukemic transformation, the intrinsic differences between secondary post-myeloproliferative neoplasm AML and de novo AML, especially the signaling pathways involved in inflammation and hematopoiesis. However, AML proved to be one of the hematological malignancies that is difficult to engraft even in the most immunodeficient mice strains, and numerous ongoing attempts are focused to develop 'humanized mice' that can support the engraftment of LSC. This present review is aiming to in-troduce the field of AML pathogenesis and the concept of LSC, to present the current knowledge on leukemic blasts surface markers and recent attempts to develop best AML animal models. | Cristina Mambet Mihaela Chivu-Economescu Lilia Matei Laura Georgiana Necula Denisa Laura Dragu Coralia Bleotu Carmen Cristina Diaconu | 2018 | World Journal of Stem Cells2018，10，6： | 2 |
| 10 | Tumor Necrosis Factor-α-Converting Enzyme (ADAM17) Mediates GPIbα Shedding From Platelets In Vitro and In Vivo显示文摘 | Wolfgang Bergmeier Crystal L. Piffath Guiying Cheng Vandana S. Dole Yuhua Zhang Ulrich H. von Andrian Denisa D. Wagner | 2004 | Circulation Research2004，，7： | 2 |
| 11 | GEOEssential–mainstreaming workflows from data sources to environment policy indicators with essential variables显示文摘When defining indicators on the environment,the use of existing initiatives should be a priority rather than redefining indicators each time.From an Information,Communication and Technology perspective,data interoperability and standardization are critical to improve data access and exchange as promoted by the Group on Earth Observations.GEOEssential is following an end-user driven approach by defining Essential Variables(EVs),as an intermediate value between environmental policy indicators and their appropriate data sources.From international to local scales,environmental policies and indicators are increasingly percolating down from the global to the local agendas.The scientific business processes for the generation of EVs and related indicators can be formalized in workflows specifying the necessary logical steps.To this aim,GEOEssential is developing a Virtual Laboratory the main objective of which is to instantiate conceptual workflows,which are stored in a dedicated knowledge base,generating executable workflows.To interpret and present the relevant outputs/results carried out by the different thematic workflows considered in GEOEssential(i.e.biodiversity,ecosystems,extractives,night light,and food-water-energy nexus),a Dashboard is built as a visual front-end.This is a valuable instrument to track progresses towards environmental policies. | Anthony Lehmann Stefano Nativi Paolo Mazzetti Joan Maso Ivette Serral Daniel Spengler Aidin Niamir Ian McCallum Pierre Lacroix Petros Patias Denisa Rodila Nicolas Ray Grégory Giuliani | 2020 | International Journal of Digital Earth2020，13，2： | 1 |
| 12 | Surgical approaches for the correction of unstable thoracolumbar burst fractures:a retrospective analysis of treatment outcomes 显示文摘 | Denisa OA Shaffrey CI Jane JA | 1995 | J Neurosurg1995，6，： | 1 |
| 13 | Double-layer capacitance of waste coffee ground activated carbons in an organic electrolyte 显示文摘 | THOMAS E R DENISA H J FISET E | 2009 | Electrochem Commun2009，11，5： | 1 |
| 14 | Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet显示文摘 | Gabriella L Denisa M Wu MH | 2006 | Pathobiology2006，73，5： | 1 |
| 15 | The role of resistin in obesity-induced insulin resistance显示文摘 | Martin H Denisa H | 2006 | Curr OPin Investig Drugs2006，7，4： | 1 |
| 16 | Fe3 O4/SiO2/APTMS Nanoparticles with Core-Shell Structure as Potential Materials for Cooper Removal显示文摘 | Denisa Fi Antion Fi Mihaela A | 2011 | Chem Rev2011，6，： | 1 |
| 17 | Avian reovirus major-class outer capsid protein influences efficiency of productive macrophage infection in a virus strain-specific manner 显示文摘 | DAVID O MEGAN P DENISA C | 2001 | J of Virology2001，75，11： | 1 |
| 18 | Expression of TAp73 and ΔNp73 isoform transcripts in thyroid tumouts显示文摘 | Ferrua A Denisa S Guilhotc J | 2006 | European Journal of Surgical Oncology2006，32，2： | 1 |
| 19 | Defensin-mRNA Expression in the Upper Gastrointestinal Tract Is Modulated in Children With Celiac Disease and Helicobacter pylori–positive Gastritis显示文摘 | Stefan Vordenb?umen Denisa Pilic Jan-Michel Otte Frank Schmitz Anjona Schmidt-Choudhury | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，6： | 1 |
| 20 | Pro-Inflammatory Cytokine Genes Influence the Clinical Features of Frontotemporal Lobar Degeneration显示文摘 | Rainero Innocenzo Rubino Elisa Cappa Giorgetta Rota Eugenia Valfrè Walter Ferrero Patrizia Fenoglio Pierpaola Baci Denisa D’amico Giuseppina Vaula Giovanna Gallone Salvatore Pinessi Lorenzo | 2009 | Dementia and Geriatric Cognitive Disorders2009，，6： | 1 |
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