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| 1 | 时间分辨红外光谱对丝蛋白膜构象转变动力学的研究──再生蚕丝蛋白膜在高浓度醇溶液中的构象转变显示文摘运用时间分辨红外光谱研究再生蚕丝蛋白膜在高浓度醇溶液中 (醇含量≥ 90 % )的构象转变过程 .研究结果表明 ,丝蛋白膜在纯甲醇中可以发生构象转变 ,但是在纯乙醇和纯异丙醇中却几乎不能发生构象转变 .进一步研究发现 ,当乙醇和异丙醇溶液中的水含量达到 7%~ 8%时 ,丝蛋白开始发生构象转变 .在研究的醇溶液浓度范围中 ,丝蛋白发生构象转变的速率随醇溶液中水含量的增加而增大 .根据实验结果 ,认为丝蛋白膜在溶液体系中 (无论是有机溶剂溶液还是离子溶液 )发生构象转变 ,膜的溶胀是一个前提因素 ,其原因在于溶胀可使分子链获得运动的空间 ,从而通过氢键重组而发生构象转变 . | 陈新 周丽 邵正中 周平 KNIGHT David P VOLLRATH Fritz | 2003 | 化学学报2003,61,4: | 22 |
| 2 | 时间分辨红外光谱对丝蛋白膜构象转变动力学的研究:不同碱金属离子对蜘蛛丝蛋白膜构象转变的影响显示文摘运用时间分辨红外光谱对碱金属盐溶液诱导发生的蜘蛛丝蛋白膜的构象转变过程进行跟踪研究.结果表明虽然构象转变速率为NaCl>KCl>LiCl,但是在最终完成构象转变的丝蛋白膜中 β 折叠结构的比例却是KCl>LiCl>NaCl.综合膜的构象转变速率和程度,可以认为在三种碱金属盐中,KCl最有利于丝蛋白的构象转变,这与钾在蜘蛛吐丝过程中起重要作用的观点(即发现在丝腺体中的丝蛋白胶状物,越靠近吐丝口,钾离子含量越高)相吻合.同时根据对构象转变动力学数据的分析,认为蜘蛛丝蛋白膜的构象转变由快慢两相组成,其中较快相(相应时间常数为5min左右)对应于链段运动引起的构象转变,而较慢相(相应时间常数为 5 0min左右) | 陈新 邵正中 KNIGHT David P. VOLLRATH Fritz | 2002 | 化学学报2002,60,12: | 20 |
| 3 | 神农架国家公园居民可持续旅游感知空间分异及影响机理研究显示文摘在我国生态文明建设的背景下,国家公园已成为我国自然保护地管理体系改革的重中之重。居民作为国家公园的核心利益相关者,是自然生态系统保护的主体,也是可持续旅游发展的关键。通过引入可持续旅游棱镜模型,构建居民可持续感知与支持度的结构关系模型。以神农架国家公园3个典型社区(木鱼、红坪、下谷坪土家族乡)为研究对象,对不同空间区位社区居民的可持续感知差异及影响机理进行探讨。研究发现:(1)相较于旅游经济影响感知在过渡及边缘社区发挥主导作用,政策制度影响感知在核心社区成为影响居民满意度的关键因素;(2)国家公园建设对居民的生活质量和环境认知产生显著影响,并表现出明显的地域分异;(3)旅游发展满意度对支持度有显著正向影响,且满意度的中介效用随距离增加而衰减;(4)国家公园社区居民可持续评价的空间分异呈现出独特规律。即核心区和边缘区的经济和社会文化影响感知均高于过渡区;而环境和制度影响感知则由核心区向边缘区递增。为此,在神农架国家公园建设过程中,应全面衡量旅游发展效果,注重居民核心诉求,健全社区参与机制。要完善利益分配制度,将发展成果惠及所有居民。同时通过差异化社区发展路径,提高所有居民对旅游发展的认可和支持。 | 龚箭 刘畅 David Knight | 2021 | 长江流域资源与环境2021,30,12: | 7 |
| 4 | 以系统为导向的反转课堂教学在MBBS心脏诊断学教学中的运用评价显示文摘目的评价以系统为导向的反转课堂教学在MBBS心脏诊断学教学中的运用效果。方法对昆明医科大学2014年9月进入诊断学学习阶段的80名东南亚医学留学生采用'以系统为导向'的'反转课堂'教学方法教授心脏诊断学部分。结果 73.80%的学生认为采用的一个病例串联与临床工作很吻合,23.81%的学生认为比较吻合;91.67%的学生认为授课过程中师资有引导学生讨论,其中69.05%认为非常有用;95.24%的学生认为教师的讲课有使用多元化教学方式,其中78.57%认为很有效;96.43%的学生认为教师有进行小结和总结,其中67.86%认为很有效;86.90%的学生认为所讲内容没有超负荷;95.24%的学生认为师资有寻求学生反馈;96.43%的学生认为教学课件设计清晰;96.43%的学生认为教师对课题内容掌握透彻;97.62%的学生认为教师有充分时间给学生提问答疑。结论以系统为导向的反转课堂教学方法能很好地发挥学生的积极主动性,更好地从纵向扩充MBBS留学生对心脏诊断学部分的学习,并且是有效的和容易被接受的。该教学方法更符合外国留学生的医学教学,更好地优化了教学时间和教学资源,从而提高了医学教学质量和学生对知识的运用能力。 | 周娜 林玥 林秋果 James D.Smith Loh Cheng David KNIGHT 张红珊 陈江 周晓鸿 李炯明 | 2015 | 中国继续医学教育2015,7,7: | 7 |
| 5 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021,9,2: | 5 |
| 6 | Memory intensive statistical slgorithms for multibeam bathymetric data显示文摘 | Colin Ware William Knight David Well | 1991 | Computers & Geosciences1991,17,7: | 2 |
| 7 | Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors显示文摘 | Edward Sausville Patricia LoRusso Michael Carducci Judith Carter Mary F. Quinn Lisa Malburg Nilofer Azad David Cosgrove Richard Knight Peter Barker Sonya Zabludoff Felix Agbo Patricia Oakes Adrian Senderowicz | 2014 | Cancer Chemotherapy and Pharmacology2014,,3: | 1 |
| 8 | Rubidium- and caesium-doped silicotungstic acid catalysts supported on alumina for the catalytic dehydration of glycerol to acrolein显示文摘 | Muhammad H. Haider Nicholas F. Dummer Dazhi Zhang Peter Miedziak Thomas E. Davies Stuart H. Taylor David J. Willock David W. Knight David Chadwick Graham J. Hutchings | 2011 | Journal of Catalysis2011,,: | 1 |
| 9 | Stress and coping among gay men: age and ethnic differences显示文摘 | David S Knight BG | 2008 | Psychol Aging2008,23,1: | 1 |
| 10 | A comparison of trajectory and air mass approaches to examine ozone variability显示文摘 | Robert E. Davis Caroline P. Normile Luke Sitka David M. Hondula David B. Knight Stephen P. Gawtry Philip J. Stenger | 2009 | Atmospheric Environment2009,,1: | 1 |
| 11 | Adaptive dy- namic relaxation algorithm for non-linear hyperelastic structures ( Ⅰ) : formulation 显示文摘 | DAVID R Oakley NORMAN F Knight Jr | 1995 | Computer Methods in Applied Mechanics and Engineering1995,126,12: | 1 |
| 12 | Short-term physiological hyperleptinemia decreases arterial blood pressure 显示文摘 | W DAVID KNIGHT R SETH J BORON et at | 2009 | Regulatory Peptides2009,154,: | 1 |
| 13 | Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury显示文摘 | Tiziano Scarabelli Anastasis Stephanou Neil Rayment Evasio Pasini Laura Comini Salvatore Curello Roberto Ferrari Richard Knight David Latchman | 2001 | Circulation: Journal of the American Heart Association2001,,3: | 1 |
| 14 | Frontal interaction with mesoscal topography显示文摘 | Michael J Dickinson J David Knight | 1999 | Amcr Meteor Soe1999,6,: | 1 |
| 15 | Frontal interaction with mesoscal topography显示文摘 | Michael J Dickinson J David Knight | 1999 | Amer Meteor Soc1999,6,: | 1 |
| 16 | Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota显示文摘 | Purna C. Kashyap Angela Marcobal Luke K. Ursell Samuel A. Smits Erica D. Sonnenburg Elizabeth K. Costello Steven K. Higginbottom Steven E. Domino Susan P. Holmes David A. Relman Rob Knight Jeffrey I. Gordon Justin L. Sonnenburg | 2013 | Proceedings of the National Academy of Sciences2013,,42: | 1 |
| 17 | Human papillomavirus not detected in esophageal adenocarcinoma tumor specimens显示文摘 | Annika Antonsson Lani Knight David C. Whiteman | 2016 | Cancer Epidemiology2016,,: | 1 |
| 18 | Interactions of prolactin and growth hormone (GH) in the regulation of mammary gland function and epithelial cell survival显示文摘 | David J Flint Christopher H Knight | 1997 | Journal of mammary gland biology and neoplasia1997,2,: | 1 |
| 19 | Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL^sup +^ leukemia cells显示文摘 | Kharas Michael G Janes Matthew R Scarfone Vanessa M Lilly Michael B Knight Zachary A Shokat Kevan M Fruman David A | 2008 | Journal of Clinical Investigation2008,,9: | 1 |
| 20 | Solvent-free oxidation of benzyl alcohol with oxygen using zeolite-supported Au and Au–Pd catalysts显示文摘 | Gang Li Dan I. Enache Jennifer Edwards Albert F. Carley David W. Knight Graham J. Hutchings | 2006 | Catalysis Letters (-)2006,,12: | 1 |