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| 1 | The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury显示文摘称为 autophagy 品质上的一个生理的序列由移开蛋白质总数和损坏细胞质的成分决定细胞的生存能力,并且显著地作出贡献到心肌的 ischemia-reperfusion (I/R ) 的度损害。这紧安排的分解代谢的细胞的 ‘ housekeeping’过程向房间提供精力的新来源适应紧张的条件。当支持幸存的机制,而是增加的证据建议它能也导致房间的遗赠,这个过程首先被描述。Autophagy 包括心肌的 I/R 损害在多重心脏的条件的致病被含有。然而,争论至于 autophagy 是否充当保护的机制或在心贡献 I/R 损害的有害效果坚持。这争吵可以在试验性的模型和种包括可变性源自几个因素,并且方法论过去常估计 autophagy。这评论在向操作 autophagy 显著地在压力大多数的条件下面增加心脏的 myocytes 的幸存受到 I/R,和成长兴趣的孤立的心脏的房间在 autophagy 的调整和角色上提供更新的知识是 I/R 损害。这的不安 evolutionarily 保存了细胞内部的清洁的 autophagy 机制,由指向的调整通过在其它之中, rapamycin ( mTOR )的哺乳动物的目标禁止者,腺苷 激活monophosphate 的蛋白质 kinase ( AMPK )调节的人,钙降低代理人, resveratrol , longevinex , sirtuin 使活跃之物, proapoptotic 基因 Bnip3 , IP3 和 lysosome 禁止者,可以对 I/R 授与抵抗到心房间导致的房间死亡。因此,在质问心肌层的 autophagy 的治疗学的操作可以有益于梗塞以后的心脏的愈合并且改变。 | Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat Narula Tiziano M. Scarabelli Richard Knight | 2014 | Journal of Geriatric Cardiology2014，11，4： | 37 |
| 2 | Autophagy in mammalian cells显示文摘Autophagy is a regulated process for the degradation of cellular components that has been well conserved in eukaryotic cells. The discovery of autophagy-regulating proteins in yeast has been important in understanding this process. Although many parallels exist between fungi and mammals in the regulation and execution of autophagy, there are some important differences. The preautophagosomal structure found in yeast has not been identified in mammals, and it seems that there may be multiple origins for autophagosomes, including endoplasmic reticulum, plasma membrane and mitochondrial outer membrane. The maturation of the phagophore is largely dependent on 5'-AMP activated protein kinase and other factors that lead to the dephosphorylation of mammalian target of rapamycin. Once the process is initiated, the mammalian phagophore elongates and matures into an autophagosome by processes that are similar to those in yeast. Cargo selection is dependent on the ubiquitin conjugation of protein aggregates and organelles and recognition of these conjugates by autophagosomal receptors. Lysosomal degradation of cargo produces metabolites that can be recycled during stress. Autophagy is an impor-tant cellular safeguard during starvation in all eukaryotes; however, it may have more complicated, tissue specific roles in mammals. With certain exceptions, autophagy seems to be cytoprotective, and defects in the process have been associated with human disease. | Kadija Abounit Tiziano M Scarabelli Roy B McCauley | 2012 | World Journal of Biological Chemistry2012，3，1： | 18 |
| 3 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 4 | Dilemmas in end-stage heart failure显示文摘心失败(HF ) ,复杂临床的症候群由于结构或心的机能紊乱,是一个主要全球健康问题,与在 USA 的超过 580 万的流行独自,并且过去 2300 万世界范围。作为在 65 岁以上的病人之中的住院的一个领先的原因, HF 是保健资源的一个主要消费者,创造保健系统上的实质的紧张。这份报纸在结束阶段 HF 照顾讨论 HF,金融影响,和 multifaceted 困境的传染病学。搜索用象结束阶段心失败那样的关键词在药网站(www.pubmed.gov ) 的美国国家图书馆上被进行,辩解的照顾,道德的窘境。尽管有 HF 的差的预后(比那更坏为许多癌症) ,许多 HF 病人, caregivers,和临床医生不知道差的预后。另外, HF 的无法预言的临床的轨道复杂化计划 end-of-life 照顾,例如辩解的照顾和供旅客休息的招待所,导致如此的资源的 underutilization。在结论,在结束阶段 HF 的道德的窘境是众多的,使不仅病人,而且 caregiver 卷入,保健队,和社会。 | Carol Chen-Scarabelli Louis Saravolatz Benjamin Hirsh Pratik Agrawal Tiziano M. Scarabelli | 2015 | Journal of Geriatric Cardiology2015，12，1： | 4 |
| 5 | Minocycline inhibits caspase activation and reactivation,increases the ratio of XIAP to smac/DIABLO,and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO显示文摘 | Stephanou A Pasini E | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 6 | Induction of Apoptosisand Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusionin Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcrip-tion Factor but Not Tyrosine显示文摘 | Stephanou A Scarabelli TM Brar BK et a1 | 2007 | J Bid Chem2007，276，28： | 1 |
| 7 | Peimany cytoreductive surgery with rectosigmoid colon for patient with advanced epithelial ovarian carcinoma显示文摘 | Scarabelli C Gallo A Franceschi S | 2000 | Cancer2000，88，2： | 1 |
| 8 | Minocycline inhibits caspase activation and reactivation and increases the ratio of XTAP to smac/DIABLO and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO显示文摘 | Scarabelli T M Stephanou A Pasini E | 2004 | J Am Cardiol2004，43，： | 1 |
| 9 | STAT-1 interacts with p53 to enhance DNA damage induced apoptosis显示文摘 | Townsend PA Scarabelli TM Davidson SM | 2004 | J Biol Chem2004，279，7： | 1 |
| 10 | Primary cytoreductive surgery with rectosigmoid colon resectionfor patients with advanced epithelial ovarian carcinoma 显示文摘 | Scarabelli C Gallo A Franceschi S | 2000 | Cancer2000，88，2： | 1 |
| 11 | Clinical implications of apoptosis in ischemic myocardium显示文摘 | Scarabelli TM Knight R Stephanou A | 2006 | Curr Probl Cadiol2006，31，3： | 1 |
| 12 | STAT-1interacts with p53 to enhance DNA damage-inducedapoptosis显示文摘 | Townsend PA Scarabelli TM Davidson SM | 2004 | J Biol Chem2004，279，7： | 1 |
| 13 | Apoptosis ofendothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury显示文摘 | Scarabelli T Stephanou A Rayment N | 2001 | Circulation2001，104，3： | 1 |
| 14 | Apoptosis of endothelial cells precede myocyte cell apoptosis in ischemia/reperfusion injury 显示文摘 | SCARABELLI T STEPHANOU A RAYMENT N | 2001 | Circulation2001，104，： | 1 |
| 15 | Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO 显示文摘 | Scarabelli TM Stephanou A Pasini E | 2004 | J Am Coil Cardiol2004，43，5： | 1 |
| 16 | Periparbum Cardiomyopathy : a Comprehensive review显示文摘 | Abboud J Murad Y Cheir Scarabelli C | 2007 | Int J Caridol2007，118，3： | 1 |
| 17 | Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701显示文摘 | Stephanou A Scarabelli TM Brar BK | 2001 | J Biol Chem2001，276，28： | 1 |
| 18 | Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury显示文摘 | Stephanou A Rayment N | 2001 | Circulation2001，104，3： | 1 |
| 19 | Primary cytoreductive surgery with rectosigmoid colon resection for patients with advanced epithelial ovarian显示文摘 | Scarabelli C Gallo A Franceschi S | 2000 | Cancer2000，88，2： | 1 |
| 20 | K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect显示文摘 | Lawrence K M Chanalaris A Scarabelli T | 2002 | Circulation2002，106，12： | 1 |
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