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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | 三级高血压单位5100例患者低血钾症与原发性醛固酮增多症的发病率显示文摘常伴有低血钾症的原发性醛固酮增多症(原醛)被认为是一个少见病。广泛筛查高血压患者发现正常血钾的原醛发生率增加。许多研究报道原醛低血钾症的发生率,相反,低血钾症患者中原醛的发生率并不明确。在该回顾性观察研究,研究者探讨了高血压患者中低钾的发生率以及低血钾症合并高血压患者中原醛的发生率。 | 赵狄(译) 刘莉(审校) Burrello J Monticone S Losano I Cavaglià G Buffolo F Tetti M Covella M Rabbia F Veglio F Pasini B Williams TA Mulatero P | 2020 | 中华高血压杂志2020，28，3： | 7 |
| 3 | Multiscale Mechanics and Optimization of Gastropod Shells显示文摘 | Mostafa Yourdkhani Damiano Pasini Francois Barthelat | 2011 | Journal of Bionic Engineering2011，8，4： | 6 |
| 4 | 环境许可制度:中国路径之建议显示文摘中国的环境许可立法虽有显著完善,但不改薄弱之现状。目前急需采取措施以帮助中国建立一项有效的环境许可制度。许可证在上世纪80年代后半期首次引入中国,但是在接下来的近三十年中,其主要充当排放报告制度的补充措施,而非一项污染治理政策。2014年至2015年间,中国两部环境保护和污染防治的基础法律被修订,尤其是在法律责任和公众参与方面进步明显。尽管如此,这两项法规并没有保障中国环境许可制度的有效实施。通过分析中国现行环境许可的法律和政策工具的优缺点,以及考查欧盟和美国许可制度的基本特征,本文旨在确定中国决策者为建立有效环境许可制度整体框架所应采取的重要措施。因此,在本文中,笔者认为应该制定并实施一个适应中国现状及需求的特别许可框架,并且可以从三个关键措施出发:整合现有政策工具出台专门法规;明确各级政府职责;加强企业责任追究。如果被适用,这些措施可能会大大有助于弥补中国环境许可立法的主要缺陷,从而为中国综合推行环境许可制度提供一个更加精简且兼具效率的框架。 | Federico PASINI 胡晶媚 | 2017 | 中国政法大学学报2017，，6： | 4 |
| 5 | How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center显示文摘Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.Methods: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.Results: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality risk.Conclusion: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients. | Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni Maria Letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 6 | Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis显示文摘AIM To identify the key epigenetically modulated genes and pathways in HCC by performing an integrative meta-analysis of all major, well-annotated and publicly available methylation datasets using tools of network analysis.METHODS Pub Med and Gene Expression Omnibus were searched for genome-wide DNA methylation datasets. Patient clinical and demographic characteristics were obtained. DNA methylation data were integrated using the Ingenuity Pathway Analysis, a software package for visualizing and analyzing biological networks. Pathway enrichment analysis was performed using IPA, which also provides literature-driven and computationallypredicted annotations for significant association of genes to curated molecular pathways.RESULTS From an initial 928 potential abstracts, we identified and analyzed 11 eligible high-throughput methylation datasets representing 354 patients. A significant proportion of studies did not provide concomitant clinical data. In the promoter region, HIST1H2AJ and SPDYA were the most commonly methylated, whereas HRNBP3 gene was the most commonly hypomethylated. ESR1 and ERK were central genes in the principal networks. The pathways most associated with the frequently methylated genes were G-protein coupled receptor and c AMP-mediated signalling. CONCLUSION Using an integrative network-based analysis approach of genome-wide DNA methylation data of both the promoter and body of genes, we identified G-protein coupled receptor signalling as the most highly associated with HCC. This encompasses a diverse range of cancer pathways, such as the PI3 K/Akt/m TOR and Ras/Raf/MAPK pathways, and is therefore supportive of previous literature on gene expression in HCC. However, there are novel targetable genes such as HIST1H2 AJ that are epigenetically modified, suggesting their potential as biomarkers and for therapeutic targeting of the HCC epigenome. | Venkat Bhat Sujitha Srinathan Elisa Pasini Marc Angeli Emily Chen Cristina Baciu Mamatha Bhat | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 7 | Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin显示文摘 | M.C. Guerra E. Speroni M. Broccoli M. Cangini P. Pasini A. Minghetti N. Crespi-Perellino M. Mirasoli G. Cantelli-Forti M. Paolini | 2000 | Life Sciences2000，，24： | 2 |
| 8 | Chronic hepatitis C virus (HCV) disease burden and cost in the United States显示文摘 | Homie Razavi Antoine C. ElKhoury Elamin Elbasha Chris Estes Ken Pasini Thierry Poynard Ritesh Kumar | 2013 | Hepatology2013，，6： | 2 |
| 9 | On - line preconcentration/determination of copper in parenteral solutions using activated carbon by inductively coupled plasma optical emission spectrometry 显示文摘 | TAKARA E A PASINI - CABELLO S D CERUTTI S | 2005 | J Pharmaceut Biomed2005，39，34： | 1 |
| 10 | Minocycline inhibits caspase activation and reactivation,increases the ratio of XIAP to smac/DIABLO,and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO显示文摘 | Stephanou A Pasini E | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 11 | High-dose chemotherapy in small-cell lung cancer显示文摘 | Pasini F Durante E De Manzoni D er al | 2002 | Anticancer Res2002，22，6： | 1 |
| 12 | Modelling practiceal combustion systems and predicting NOx emissions with an integrated CFD based approach显示文摘 | Falcitelli M Pasini S Tognotti L | 2002 | Computers & Chemical Engineering2002，26，9： | 1 |
| 13 | Determinants of short term recurrence rate of endometriosis显示文摘 | Parazzini F Bertulessi C Pasini A | 2005 | Eur J Obstet Gynecol Reprod Biol2005，121，2： | 1 |
| 14 | Minocycline inhibits caspase activation and reactivation and increases the ratio of XTAP to smac/DIABLO and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO显示文摘 | Scarabelli T M Stephanou A Pasini E | 2004 | J Am Cardiol2004，43，： | 1 |
| 15 | Immobilized laccase and tyrosinase: an approach for wine stabilization 显示文摘 | ZAMORANI A SPETTOLI P LANTE A CRAPISI A & PASINI G | 1993 | Italian Journal of Food Science1993，，4： | 1 |
| 16 | Results of surgical treatment of adenocarcinoma of the gastric cardia显示文摘 | De Manzoni G Pedrazzani C Pasini F | 2002 | Ann Thorac Surg2002，73，4： | 1 |
| 17 | Independent prognostic value of fascin immunoreactivity in stage Ⅰ non-small cell lung cancer显示文摘 | Pelosi G Pastorino U Pasini F | 2003 | British Journal of Cancer2003，24，88： | 1 |
| 18 | E -selectin plasma concentration is influenced by glycaemic control in NIDDM patients : possible role of oxidative stress显示文摘 | Cominacini L Fratta Pasini A Garbin U | 1997 | Diabetologia1997，40，4： | 1 |
| 19 | A simple operation of a plasmaelectrode pockel's cell for the laser megajoules 显示文摘 | J Gardelle E Pasini | 2002 | Journal of Applied Physics2002，191，5： | 1 |
| 20 | Ablation scaling in steady-state ablation dominated by inverse bremsstrahlung absorption显示文摘 | Pasini D Celliers P M Parfeniuk D | 1984 | Appl Phys Lett1984，45，10： | 1 |
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