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| 1 | 载脂蛋白E、5-羟色胺转运体基因多态性与阿尔茨海默病的关联分析显示文摘目的 探索载脂蛋白E (apoE)基因及 5 羟色胺 (5 HT)转运体基因多态性在阿尔茨海默病 (AD)发病中的作用。方法 应用聚合酶链反应 (PCR)和限制性片段长度多态性方法 ,观察 10 2例AD和 10 5名正常对照者 (对照组 )的apoE基因多态性及 2个 5 HT转运体基因多态性的分布。结果中、重度AD患者含apoEε4 基因型频率 (2 4% )高于对照组 (12 % ) ,但差异无显著性 (χ2 =3 17,P >0 0 5 ) ;携带apoEε4 等位基因频率 (16 % )高于正常对照 [(7% ) ,χ2 =6 43,P <0 0 5 ,RR =2 6 0 ,95 %CI =1 14~ 5 95 ]和轻度AD[(6 % ) ,χ2 =5 0 9,P <0 0 5 ;RR =2 98,95 %CI=1 0 3~ 8 96 ]。AD患者中携带的apoEε4 等位基因数多者的发病年龄低 ,不含ε4 、含 1个ε4 、含 2个ε4 等位基因者发病年龄分别为 (78± 8)岁、(75± 8)岁、(71± 8)岁 (F =1 85 ,P >0 0 5 )。AD患者 5 HT转运体基因启动子区缺失 /插入多态性 (χ2 =1 0 3,P >0 0 5 )及可变数重复序列多态性 (χ2 =0 0 3,P >0 0 5 )与对照组的差异无显著性。结论 apoEε4 等位基因与中、重度AD相关联 ,是中、重度AD的易感因素 ;不支持 5 | 唐牟尼 李涛 刘协和 韩海英 唐铭民 David A Collier | 2000 | 中华精神科杂志2000，33，3： | 14 |
| 2 | 不同发病年龄强迫症患者6种功能基因的分子遗传学研究显示文摘目的探讨与5-羟色胺和多巴胺递质系统有关的基因在强迫症发病中的作用。方法收集120个强迫症的核心家系,按患者的发病年龄分为≤16岁组和>16岁组,应用基因扩增的限制性片段长度多态和数目可变的顺向重复多态技术对强迫症核心家系在5-羟色胺2A受体基因、5-羟色胺转运体(5-HTT)基因、多巴胺D2受体(DRD2)基因、多巴胺D4受体(DRD4)基因、儿茶酚氧位甲基转移酶(C0MT)基因、单胺氧化酶A(MAO-A)基因等6个基因的7个位点进行传递不平衡检测和数量性状的传递不平衡检测以及DRD4基因的单体型分析。结果 (1)未发现6个功能基因与强迫症存在传递不平衡;(2)DRIY2-141C Del/Ins多态性与≤16岁组存在传递不平衡(X2=3.98,P=0.04),COMT-Val/Met多态性与>16岁组存在传递不平衡(X2=3.65,P=0.05),经相关分析,这两个位点与强迫症的发病年龄相关(DRD2:r=-0.29,P=0.002;COMT:r=-0.19,P=0.04)。结论DRD2基因和COMT基因可能与不同发病年龄的强迫症病因相关。 | 张岚 刘协和 李涛 杨彦春 胡迅 David Collier | 2004 | 中华精神科杂志2004，37，4： | 4 |
| 3 | Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease显示文摘 | Rajarshi Banerjee Michael Pavlides Elizabeth M. Tunnicliffe Stefan K. Piechnik Nikita Sarania Rachel Philips Jane D. Collier Jonathan C. Booth Jurgen E. Schneider Lai Mun Wang David W. Delaney Ken A. Fleming Matthew D. Robson Eleanor Barnes Stefan Neubaue | 2014 | Journal of Hepatology2014，，1： | 2 |
| 4 | Sources of sedimentary lipids deduced from stable carbon isotope analyses of individual compounds 显示文摘 | Gareth Rieley Robert J Collier David M Jones Geoffrey Eglinton Paul A Eakin Anthony E Fallick | 1991 | Nature1991，352，： | 1 |
| 5 | Agonistic Autoantibodies as Vasodilators in Orthostatic Hypotension: A New Mechanism显示文摘 | Hongliang Li David C. Kem Sean Reim Muneer Khan Megan Vanderlinde-Wood Caitlin Zillner Daniel Collier Campbell Liles Michael A. Hill Madeleine W. Cunningham Christopher E. Aston Xichun Yu | 2012 | 2012 (2 Su)2012，，2： | 1 |
| 6 | Chemerin Is Associated with Metabolic Syndrome Phenotypes in a Mexican-American Population显示文摘 | Kiymet Bozaoglu David Segal Katherine A. Shields Nik Cummings Joanne E. Curran Anthony G. Comuzzie Michael C. Mahaney David L. Rainwater John L. VandeBerg Jean W. MacCluer Greg Collier John Blangero Ken Walder Jeremy B.M. Jowett | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，8： | 1 |
| 7 | Painful pseudarthrosis following lumbar spinal fusion: detection by combined SPECT and planar bone scintigraphy显示文摘 | Walter J. Slizofski M.D. B. David Collier M.D. Thomas J. Flatley M.D. Guillermo F. Carrera M.D. Robert S. Hellman M.D. Ali T. Isitman M.D | 1987 | Skeletal Radiology1987，，2： | 1 |
| 8 | Agonistic Autoantibodies as Vasodilators in Orthostatic Hypotension: A New Mechanism显示文摘 | Hongliang Li David C. Kem Sean Reim Muneer Khan Megan Vanderlinde-Wood Caitlin Zillner Daniel Collier Campbell Liles Michael A. Hill Madeleine W. Cunningham Christopher E. Aston Xichun Yu | 2012 | Hypertension . 2012 (2 Su)2012，，2： | 1 |
| 9 | Sources of sedimentary lipids deduced from stable carbon-isotope analyses of individual compounds 显示文摘 | Rieley Gareth Collier Robert J Jones David M | 1991 | Nature1991，352，： | 1 |
| 10 | The frequency of peptic ulcer as a cause of upper-GI bleeding is exaggerated显示文摘 | Somprak Boonpongmanee David E Fleischer John C Pezzullo Kevin Collier William Mayoral Firas Al-Kawas Robynne Chutkan James H Lewis Thian L Tio Stanley B Benjamin | 2004 | Gastrointestinal Endoscopy2004，，7： | 1 |
| 11 | A comparative revenue analysis of hotel yield management heuristics显示文摘 | Timothy K Baker David A Collier | 1999 | Decision Sciences1999，30，1： | 1 |
| 12 | Research opportunities in service process design显示文摘 | Arthur V Hill David A Collier Craig M Froehle John C Goodale Richard D Metters Rohit Verma | 2002 | Journal of Operations Management2002，20，189： | 1 |
| 13 | Inducements versus Constraints: Disaggregating “Corporatism”显示文摘 | Ruth Berins Collier David Collier | 1979 | American Political Science Review1979，，： | 1 |
| 14 | Supply management orientation and supplier/buyer performance显示文摘 | Hojung Shin David A Collier Darryl D Wilson | 2000 | Journal of Operations Management2000，，3： | 1 |
| 15 | Measurement Validity: A Shared Standard for Qualitative and Quantitative Research 显示文摘 | Adcock Robert David Collier | 2001 | The American Political Science Review2001，95，3： | 1 |
| 16 | The frequency of peptic ulcer as a cause of upper-GI bleeding is exaggerated显示文摘 | Somprak Boonpongmanee David E Fleischer John C Pezzullo Kevin Collier William Mayoral Firas Al-Kawas Robynne Chutkan James H Lewis Thian L Tio Stanley B Benjamin | 2004 | Gastrointestinal Endoscopy2004，，7： | 1 |
| 17 | Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter显示文摘The Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind conditions.To suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray images.In this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is maximized.Two assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause curvature.We create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson noise.We then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea ks.From the filte red images,we calculate RS and its accuracy for different LEXI locations,look directions,and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground truth.Our method estimates RS with an accuracy of<0.3 RE when the solar wind density exceeds>10 cm-3.The accuracy improves for greater solar wind densities and during southward interplanetary magnetic fields.The method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field turnings.Consequently,the technique will enable quantitative analysis of the magnetopause motion and help reveal the dayside reconnection modes for dynamic solar wind conditions.This technique will suppo rt the LEXI and SMILE missions in achieving their scientific o bjectives. | Hyangpyo Kim Hyunju K.Connor Jaewoong Jung Brian M.Walsh David Sibeck Kip D.Kuntz Frederick S.Porter Catriana K.Paw U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael Collier | 2024 | Earth and Planetary Physics2024，8，1： | 1 |
| 18 | The relationship of strategic business alignment and enterprise information management in achieving better business performance显示文摘 | Honggeng Zhou David A Collier Darryl D Wilson | 2008 | Enterprise Information Systems2008，2，2： | 1 |
| 19 | Democracy and Dichotomies: A Pragmatic Approach to Choices about Concept显示文摘 | David Collier and Robert Adcock | 1999 | Annual Review of Political Sci- ence1999，，2： | 1 |
| 20 | An empirical comparison of service matrices显示文摘 | David A Collier Susan M Meyer | | 0，，： | 1 |
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