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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 3 | Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology显示文摘 | Sibylle A. Kozek-Langenecker Arash Afshari Pierre Albaladejo Cesar Aldecoa Alvarez Santullano Edoardo De Robertis Daniela C. Filipescu Dietmar Fries Klaus G?rlinger Thorsten Haas Georgina Imberger Matthias Jacob Marcus Lancé Juan Llau Sue Mallett Jens Mei | 2013 | European Journal of Anaesthesiology2013，，6： | 3 |
| 4 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 5 | Antioxidant activities of sicilian prickly pear(opuntia ficus indica)fruit extracts and re ducing properties of its betalains: betanin and indicaxanthin显示文摘 | Daniela B Luisa T Francesca D G | 2002 | Agricultural and Food Chemistry2002，50，23： | 1 |
| 6 | Urologic Dysfunction and Neurologic Outcome in Coma Survivors After Severe Traumatic Brain Injury in the Postacute and Chronic Phase 显示文摘 | Antonella G Daniela S Salvatore S | 2011 | Archives of Physical Medicine and Rehabilitation2011，92，7： | 1 |
| 7 | Differential interactions of decorin mutants with type Ⅰ and type Ⅵ collagens显示文摘 | Gordon N Daniela G | 2004 | Eur J Biochem2004，271，16： | 1 |
| 8 | Influence of Neoadjuvant Therapy with Epirubicin and Docetaxel on the Expression of HER2/neu in Patients with Breast Cancer显示文摘 | Susanne Taucher Margaretha Rudas Robert M. Mader Michael Gnant Emanuel Sporn Peter Dubsky Sebastian Roka Thomas Bachleitner Florian Fitzal Daniela Kandioler Catharina Wenzel Günther G. Steger Martina Mittlb?ck Raimund Jakesz | 2003 | Breast Cancer Research and Treatment2003，，3： | 1 |
| 9 | Behavioral matchmaking for service retrieval:Application to conversation protocols显示文摘 | Daniela G Juan C C Mokrane B | 2008 | Information Systems2008，33，7： | 1 |
| 10 | Molecular investigation of lymph nodes in colon cancer patients using one‐step nucleic acid amplification (OSNA)显示文摘 | Ulrich Güller Andreas Zettl Mathias Worni Igor Langer Daniela Cabalzar‐Wondberg Carsten T. Viehl Nicolas Demartines Markus Zuber | 2012 | Cancer2012，，24： | 1 |
| 11 | The role C4 metabolism in the marine diatom Phaeodactylum tricornutum 显示文摘 | Maya H D Nitsan G Daniela E | 2013 | New Phytologist2013，197，： | 1 |
| 12 | Cytochrome 2C19*17 allelic vari-ant ,platelet aggregation,bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement显示文摘 | Sibbing D Werner K Daniela G | 2010 | Circulation2010，121，4： | 1 |
| 13 | The Effect of student aid on the duration of study显示文摘 | Daniela G | 2011 | Economics of Education Review2011，30，： | 1 |
| 14 | Adding a statin to a combination of ACE inhibitor and ARB normalizes proteinuria in experimental diabetes,which translates into full renoprotection显示文摘 | Carla Z Daniela C Elena G | 2010 | Am J Physiol Renal Physiol2010，299，5： | 1 |
| 15 | Lentiform fork sign: amagnetic resonance finding in a case of acute metabolic acidosis显示文摘 | Daniela G Carmela B Francesco P | 2014 | Neuroradiol J2014，27，3： | 1 |
| 16 | Overconfidence in absolute and relative performance: the regression hypothesis and bayesian updating显示文摘 | Daniela G Hogarth R M | 2009 | Journal of Economic Psychology2009，30，5： | 1 |
| 17 | Preparation of gelatin and enzymic hydrolysates from sheep skin scraps 显示文摘 | Peter T N Daniela K B Pentsho G D | 1995 | Bulgarian Chemical Communications1995，28，1： | 1 |
| 18 | Detection of Bordetella bronehiseptica by the polymerase chain reaction显示文摘 | Daniela Hozbor Frncose Fouque Nicole G uiso | 1999 | Gene1999，150，： | 1 |
| 19 | Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined in crease in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenie Arabidopsis plants 显示文摘 | Helene V Daniela H Peter G | 2011 | Plant Physiology2011，155，： | 1 |
| 20 | Distribution network design:New problems and related models显示文摘 | Daniela A Maria G S | 2005 | European Journal of Operation Research2005，165，： | 1 |
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