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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Photodynamic inactivation of Escherichia coli by methylene blue incorporated in ZSM-5 zeolite channels under red LED light 显示文摘 | Miroslava S Petra O Daniela H | 2010 | Acta Chimica Slovaca2010，3，1： | 1 |
| 3 | Laparoscopic Approach to Colorectal Procedures in the Obese Patient: Risk Factor or Benefit?显示文摘 | Hubert Scheidbach Frank Benedix Omar Hügel Daniela Kose Ferdinand K?ckerling Hans Lippert | 2007 | Obesity Surgery2007，，1： | 1 |
| 4 | Crystallization of gahnite in CMAS glass forming system - mechanism and process kinetics 显示文摘 | DANIELA H TOMASZ O WIESLAW W | 2010 | Adv Sci Tech2010，68，： | 1 |
| 5 | The Effect of Mn and Si on the Properties of Advanced High Strength Steels Processed by Quenching and Partitioning 显示文摘 | Bohuslav M Hana J Daniela H | 2010 | Materials Science Forum2010，65，： | 1 |
| 6 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 7 | Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice显示文摘Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory diseases.While TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects.In this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced arthritis.Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second day.Two days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were analyzed.Mice were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by histology.Treatment with TNCscTNF80 increased arthritis-induced myelopoiesis.Little effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid organs.Upon treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph nodes.In addition,the expression of TNFR2 on Treg cells was enhanced.The clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of therapy.The histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control mice.Activation of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis. | Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel | 2019 | Cellular & Molecular Immunology2019，16，1： | 1 |
| 8 | Functional assay for BRCA1:mutagenesis of the COOH-terminal region reveals critical residues for transcription activation显示文摘 | Finbarr H Charmagne C Daniela B | 2000 | Cancer Res2000，60，5： | 1 |
| 9 | The role C4 metabolism in the marine diatom Phaeodactylum tricornutum 显示文摘 | Maya H D Nitsan G Daniela E | 2013 | New Phytologist2013，197，： | 1 |
| 10 | Oncoids from the river Alz (southern Germany): Tiny ecosystems in a phosphorus-limited environment显示文摘 | Daniela H?gele Reinhold Leinfelder Jürke Grau Ernst-Gerhard Burmeister Ulrich Struck | 2006 | Palaeogeography Palaeoclimatology Palaeoecology2006，，2： | 1 |
| 11 | Ganglioneuroma of the adrenal gland 显示文摘 | Daniela S A Donna E H | 2009 | J Urology2009，，182： | 1 |
| 12 | Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined in crease in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenie Arabidopsis plants 显示文摘 | Helene V Daniela H Peter G | 2011 | Plant Physiology2011，155，： | 1 |
| 13 | Development of an aggrega- tion assay to screenFimH antagonists显示文摘 | Daniela A Gina R Lucie H eta! | 2010 | J Microbiol Meth2010，，82： | 1 |
| 14 | 14-3-3 Proteins in the nervous system显示文摘 | Daniela B Carsten H Olaf R | 2003 | Nature2003，4，： | 1 |
| 15 | Poor responder-high responder:the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols显示文摘 | Joseph N Daniela W Carster H | 2001 | Hum Reprod2001，16，4： | 1 |
| 16 | Protective efficacy against tuberculosis of ESAT-6 secreted by a live salmonella typhimurium vaccine carrier strain and expressed by naked DNA显示文摘 | Mollenkolpf H J Daniela G T Andersen P | 2001 | Vaccine2001，19，： | 1 |
| 17 | Mammalian type Ⅰ interferon receptors consists of two subunits:IFNaR1 and IFNaR2显示文摘 | Soo H K Batya C Daniela N | 1997 | Gene1997，196，： | 1 |
| 18 | Preoperative Education in Cholecystectomy in the Context of a Multimodal Protocol of Perioperative Care: A Randomized, Controlled Trial显示文摘 | de Aguilar-Nascimento Jos 6 E Leal Fernando S Dantas Daniela C S Anabuki Nadia T de Souza Amanda M C Silva E Lima Ver6nica P Tanajura Guilherme H Canevari Mariana | 2013 | World journal of surgery2013，34，23： | 1 |
| 19 | Oncoids from the river Alz southern Germany :Tiny ecosystems in a phosphorus limitedenvironment 显示文摘 | Daniela H Reinhold L | 2006 | Palaeogeography Palaeoclimatology Palaeoecology2006，237，： | 1 |
| 20 | Quality of Life, Psychosocial Well-Being, and Sexual Satisfaction in Women with Polycystic Ovary Syndrome显示文摘 | Sigrid E Susanne H Daniela K | 2003 | J Clin Endocrinol Metab2003，88，12： | 1 |
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