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| 1 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | Ultrasound Doppler system for two-dimensional flow mapping in liquid metals显示文摘 | Sven Franke Lars Büttner Jürgen Czarske Dirk R?biger Sven Eckert | 2010 | Flow Measurement and Instrumentation2010，，3： | 3 |
| 4 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 5 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 6 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 7 | Click chemistry as an efficient synthetic tool for the preparation of novel conjugated polymers显示文摘 | Dirk J V C David O R P Strijdonck G P E | 2005 | Chemistry Common2005，，34： | 1 |
| 8 | Terpenoid indole alkaloid profile changes in Catharanthus pusillus during development显示文摘 | Zarate R Dirks C van der Heijden R Verpoorte R | 2001 | Plant Sci2001，160，5： | 1 |
| 9 | Cryptochromes and neuronal-activity markers colocalize in the retina of migratory birds during magnetic orientation显示文摘 | Mouritsen H Janssen-Bienhold J Liedvogel M Feenders G Stalleicken J Dirks P Weiler R | | 0，，： | 1 |
| 10 | Determination of 2-methylimidazole, 4-methylimidazole and 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in caramel colours and cola using LC/MS/MS显示文摘 | Claudia Schlee Mariya Markova Julia Schrank Fanette Laplagne Rüdiger Schneider Dirk W. Lachenmeier | 2012 | Journal of Chromatography B2012，，： | 1 |
| 11 | Fish and immunoeytoehemistry: towards visualising single target molecules in living ceils 显示文摘 | Tanke H J Dirks R W | 2005 | Current Opinion in Biotechnology2005，16，1： | 1 |
| 12 | The complete nucleotide sequence and development of a diferential detection assay for a Pepper mild mottle virus(PMMoV) isolate that overcomes L3 resistance in pepper显示文摘 | LEONARDO V DIRK J LETICIA R G | 2002 | Journal of Virological Methods2002，106，： | 1 |
| 13 | Strain FAcl2, a dissimilatory iron-reducing member of the Anaeromyxobacter subgroup of Myxo- coccales显示文摘 | Nicole T Dirk R Werner L | 2003 | FEMS Microbiology Ecology2003，44，2： | 1 |
| 14 | Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer显示文摘 | Claus R?del Dirk Arnold Matthias Hipp Torsten Liersch Kathrin Dellas Igors Iesalnieks Robert Michael Hermann Florian Lordick Axel Hinke Werner Hohenberger Rolf Sauer | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
| 15 | prospective proof of concept study of the efficacy of tacrolimus ointment onuraemicpruritus (UP) in patients on chronic dialysis therapy显示文摘 | Dirk R Kuypers Kathleen Claes Pieter Eveneplel | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 16 | Doppler echocardiographic assessment of left ventricular filling in dilated cardiomyopathy during a one-year follow-up:relation to the clinical course of the disease显示文摘 | Werner GS Schaefer C Dirks R | 1993 | Am Heart J1993，126，： | 1 |
| 17 | Adhesion enhancement in waterborne acrylic latex binders synthesized with phosphate methacrylate monomers 显示文摘 | INIGO G A DIRK M JOSE R L | 2008 | Progress in Organic Coatings2008，61，： | 1 |
| 18 | Dynamic electric behavior and open-cir- cuit-voltage modeling of LiFePO4-based lithium ion secondarybattefies显示文摘 | Michael A R Dirk U S | 2011 | J Power Sources2011，196，1： | 1 |
| 19 | Supramolecular architecture of cyanobacterial thylakoid membranes: How is the phycobilisome connected with the photosystems?显示文摘 | Dirk Bald Jochen Kruip Matthias R?gner | 1996 | Photosynthesis Research1996，，2： | 1 |
| 20 | Cancer stem cells: an evolving concept显示文摘 | Nguyen L V Vanner R Dirks P | 2012 | Nature Reviews Cancer2012，12，2： | 1 |
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