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| 1 | Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle显示文摘Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed 'myokines'. The purpose of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA expression of several myokines, including the prototypical myokine interleukin-6(IL-6), and recently identified myokines fibronectin type III domain-containing protein 5(FNDC5)(irisin) and meteorin-like protein(METRNL).Methods: Both before and after a 20-day period of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years performed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% pretraining peak power output) with skeletal muscle biopsy samples(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h recovery.Results: Before training, a single bout of HIIE increased IL-6(p < 0.05) and METRNL(p < 0.05) mRNA expression measured at 3 h recovery when compared to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when compared to rest(both p < 0.05). Resting METRNL and FNDC5 mRNA expression were higher following training(p < 0.05), and there was an overall increase in FNDC5 mRNA post-training(main effect of training, p < 0.05).Conclusion: In human skeletal muscle(1) an acute bout of HIIE can induce upregulation of skeletal muscle IL-6 mRNA both before and after a period of intensified HIIT;(2) Resting and overall FNDC5 mRNA expression is increased by 20 days of HIIT; and(3) METRNL mRNA expression is responsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the protein and secretion level in humans. | Malcolm Eaton Cesare Granata Julianne Barry Adeel Safdar David Bishop Jonathan P.Little | 2018 | Journal of Sport and Health Science2018，7，2： | 15 |
| 2 | Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA显示文摘AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of Gd-DOTA or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOTA).RESULTS: The normalized SI and ER of the pancreas using Gd-DOTA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P < 0.05). The area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOTA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOTA injection(Gadofluorine P vs Gd-DOTA, 7.37 vs 0.00, P < 0.01). A significant difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-induced diabetes rat model,Gadofluorine P-enhanced MRI of the pancreas showed high accuracy in the diagnosis of diabetes. | Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 3 | Water reuse systems analysis显示文摘 | Bruce Bishop A David W Hendrichs | | 0，，01： | 1 |
| 4 | Spatial-tmporal model for demand and allocation of waste landfills in growing urban regions显示文摘 | Ian Bishop David Evans | 2004 | Computer Enviroment and Urban System2004，28，： | 1 |
| 5 | Physiological predictors of flat-water kayak performance in women 显示文摘 | David Bishop | 2000 | European Journal of Applied Physiology2000，82，1： | 1 |
| 6 | Physiological predictors of fiat-water kayak performance in women 显示文摘 | David Bishop | 2000 | European Journal of Applied Physiology2000，82，1： | 1 |
| 7 | Physiological predictors of fiat - water kayak performance in women 显示文摘 | David Bishop | 2000 | Eur J Appl Physiol2000，82，1： | 1 |
| 8 | Physical and chemical properties of flax fibres from stand-retted crops desiccated at different stages of maturity显示文摘 | Sandra Sampaio David Bishop Jinsong Shen | | 0，，： | 1 |
| 9 | A prespective study of monitoring practices for metabolic disease in antipsychotic treated community psychiatric patient显示文摘 | Paul Mackin David R Bishop Helen MoWatkinson | 2007 | BMC Psychiatric2007，7，： | 1 |
| 10 | Effects of high intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogenions in women显示文摘 | DAVID BISHOP JOHANN EDGE CLAIRE THOMAS | 2008 | Am J Physiol2008，295，6： | 1 |
| 11 | Disproportionate Language Impairment in Children Using Cochlear Implants显示文摘 | Kelvin Hawker Jayne Ramirez-Inscoe Dorothy V. M. Bishop Tracey Twomey Gerard M. O’Donoghue David R. Moore | 2008 | Ear and Hearing2008，，3： | 1 |
| 12 | Physiological predictors of flat-water kayak per- formance in women显示文摘 | Bishop David | 2000 | Eur J Appl Physiol2000，2，1： | 1 |
| 13 | Human Papillomavirus-related Carcinomas of the Sinonasal Tract显示文摘 | Justin A. Bishop Theresa W. Guo David F. Smith Hao Wang Takenori Ogawa Sara I. Pai William H. Westra | 2013 | The American Journal of Surgical Pathology2013，，2： | 1 |
| 14 | Effects of laundering on the sensory and mechanical properties of 1 × 1 rib knitwear fabrics显示文摘 | Colina Mackay Subhash C Anand David P Bishop | 1999 | Textile Res J1999，69，4： | 1 |
| 15 | Activity patterns, blood lactate concentrations and ratings of perceived exertionduring a professional singles tennis tournament 显示文摘 | Alberto Mendez Villanueva Jaime Fernandez Fernandez David Bishop | 2007 | British Journal Sports Medicine2007，，41： | 1 |
| 16 | Emergencies Related to Cancer Chemotherapy and Hematopoietic Stem Cell Transplantation显示文摘 | David E. Adelberg Michael R. Bishop | 2009 | Emergency Medicine Clinics of North America2009，，2： | 1 |
| 17 | Activity pattems, blood lactate concentrations and ratings of perceived exertion during a professional singles tennis tournament显示文摘 | Alberto Mendez-Villanueva Jaime Femandez-Femandez David Bishop | 2007 | British Journal Sports Medicine2007，，41： | 1 |
| 18 | Comparison of the Sequences and Coding of La Crosse and Snowshoe Hare Bunyavirus S RNA Species显示文摘 | Hiroomi Akashi David HL Bishop | 1983 | Journal of Virology1983，45，3： | 1 |
| 19 | Effects of laundering on the sensory and mechanical properties of 1×1 rib knitwear fabrics显示文摘 | Colina Mackay Subhash C Ansnd David P Bishop | 1999 | Textile Res J1999，69，4： | 1 |
| 20 | Cytology Adds Value to Imaging Studies for Risk Assessment of Malignancy in Pancreatic Mucinous Cysts显示文摘 | Muriel Genevay Mari Mino-Kenudson Kurt Yaeger Ioannis T. Konstantinidis Cristina R. Ferrone Sarah Thayer Carlos Fernandez-del Castillo Dushyant Sahani Brenna Bounds David Forcione William R. Brugge Martha Bishop Pitman | 2011 | Annals of Surgery2011，，6： | 1 |
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