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| 1 | Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis显示文摘Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone sclerosis.However,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain unclear.In knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte function.Suppression of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular matrix.As a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 promoter.Not only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised cartilage.Even in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early OA.Thus,in humans and mice,defects in PLR coincide with cartilage defects.Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on PLR.Together,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis. | Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston | 2019 | Bone Research2019，7，4： | 10 |
| 2 | 原油掺混、处理和脱盐技术的最新进展显示文摘原油加工能力的增长以及原油来源多样化、劣质化导致人们对原油掺混、处理和脱盐技术更加重视,而重质原油和高酸'机会'原油的使用将会影响这些工艺操作。解决方案包括改进掺混计划和调度、相容性测试、原料油配置、脱盐设备和化学添加剂等。软件开发是改进原油掺混的关键,多家公司为原油掺混调度的优化、掺混过程监测和掺混性能预测提供了解决方案。原油相容性预测与测试是广受关注的另一个原油掺混领域。脱盐方面的研究重点是处理重质原油和机会油。精确测量油/水界面位置的新技术也在不断出现,包括放射技术、微波技术、基于压力的技术和声纳技术。目前越来越流行在静电脱盐装置的上游安装静态混合器,研究人员还提出在混合过程中使用超声辐照技术。减少清洗水消耗量和处理脱盐废水的方法已引起各方关注,研究重点是用来净化浓盐废水的超滤膜。逆向破乳剂用于在废水处理厂上游对含油浓盐废水进行处理,提供更多品种的多功能添加剂产品可能会获得丰厚的利润。 | Brett P.Goldhammer Claire H.Weber Thomas W.Yeung | 2010 | 中外能源2010，15，10： | 4 |
| 3 | Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders显示文摘AIM:To evaluate the feasibility and utility of confocal laser endomicroscopy(CLE) in the description of normal gastrointestinal(GI) mucosa and in the diagnosis of GI disorders in children,in comparison to histology.METHODS:Forty-four patients(19 female) median age 10.9 years(range 0.7-16.6 years) with suspected or known GI pathology underwent esophago-gastro-duodenoscopy(OGD)(n = 36) and/or ileocolonoscopy(IC)(n = 31) with CLE using sodium fluorescein and acriflavine as contrast agents.Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists,respectively.RESULTS:Duodenum and ileum were intubated in all but one patient undergoing OGD and IC.The median procedure time was 16.4 min(range 7-25 min) for OGD and 27.9 min(range 15-45 min) for IC.A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures,and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 procedures.Confocal images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis,Helicobacter pylori gastritis,celiac disease,inflammatory bowel disease,colonic heterotopia,and graft versus host disease.CONCLUSION:CLE offers the prospect of targeting biopsies to abnormal mucosa,thereby increasing diagnostic yield,reducing the number of biopsies,decreasing the burden on the histopathological services,and reducing costs. | Krishnappa Venkatesh Marta Cohen Clair Evans Peter Delaney Steven Thomas Christopher Taylor Ashraf Abou-Taleb Ralf Kiesslich Mike Thomson | 2009 | World Journal of Gastroenterology2009，15，18： | 2 |
| 4 | Immersedmembrane filtration for the production of drinking water:combination with PAC for NOM and SOCs removal显示文摘 | Thomas Lebeau Claire Lelie vre | 1998 | Desalination1998，117，13： | 1 |
| 5 | The effects of temperature on the local structure of metakaolin-based geopolymer binder: A neutron pair distribution function investigation显示文摘 | WHITE CLAIRE E PROVIS JOHN L PROFFEN THOMAS | 2010 | JAm Cerarn Soc2010，93，10： | 1 |
| 6 | Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury显示文摘 | Jace W. Jones Alexander Bennett Claire L. Carter Gregory Tudor Kim G. Hankey Ann M. Farese Catherine Booth Thomas J. MacVittie Maureen A. Kane | 2015 | Health Physics2015，，5： | 1 |
| 7 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 8 | Myocardial matrix metalloproteinase activity and abundance with congestive heart failure显示文摘 | Thomas CV Clair MJ | 1998 | Am J Physiol1998，274，52： | 1 |
| 9 | The iterative time reversal process:Analysis of the convergence显示文摘 | Claire Prada Jean-Louis Thomas Mathias Fink | | 0，，01： | 1 |
| 10 | Enhanced Neocortical Neural Sprouting, Synaptogenesis, and Behavioral Recovery With D-Amphetamine Therapy After Neocortical Infarction in Rats显示文摘 | R. Paul Stroemer Thomas A. Kent Claire E. Hulsebosch | 1998 | Stroke: A Journal of Cerebral Circulation1998，，11： | 1 |
| 11 | Vibrational spectroscopy of solid state molecular dimmers显示文摘 | Thomas J K Claire L S Dana D D | 1983 | Chemical Physics Letters1983，96，1： | 1 |
| 12 | Image-Guided Robotic Stereotactic Body Radiation Therapy for Liver Metastases: Is There a Dose Response Relationship?显示文摘 | Claire Vautravers-Dewas Sylvain Dewas Fran?ois Bonodeau Antoine Adenis Thomas Lacornerie Nicolas Penel Eric Lartigau Xavier Mirabel | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 13 | Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use显示文摘 | Loren Laine Laurine G. Connors Alise Reicin Christopher J. Hawkey Ruben Burgos–Vargas Thomas J. Schnitzer Qinfen Yu Claire Bombardier | 2003 | Gastroenterology2003，，2： | 1 |
| 14 | Beta-blockers cause paracentesis-induced circulatory dysfunction in patients with cirrhosis and refractory ascites: A cross-over study显示文摘 | Thomas Sersté Claire Francoz Fran?ois Durand Pierre-Emmanuel Rautou Christian Melot Dominique Valla Richard Moreau Didier Lebrec | 2011 | Journal of Hepatology2011，，4： | 1 |
| 15 | Beta-blockers cause paracentesis-induced circulatory dysfunction in patients with cirrhosis and refractory ascites: A cross-over study显示文摘 | Thomas Sersté Claire Francoz Fran?ois Durand Pierre-Emmanuel Rautou Christian Melot Dominique Valla Richard Moreau Didier Lebrec | 2011 | Journal of Hepatology2011，，4： | 1 |
| 16 | Myocardial matrix metalloproteinase activity and abundance with congestive heart failure显示文摘 | Coker ML Thomas CV Clair MJ | 1998 | Am J Physiol1998，274，52： | 1 |
| 17 | Percutaneous lum- bar and thoracic pedicle screws: a trauma experience显示文摘 | Park DK Thomas AO St Clair S | 2012 | J Spinal Disord Tech2012，，： | 1 |
| 18 | Determination of the oxidation states of manganese in brain,liver,and heart mitochondria显示文摘 | Thomas E G Lisa M M Claire E G | 2004 | Journal of Neurochemistry2004，88，： | 1 |
| 19 | Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria显示文摘 | Christophe Duvoux Fran?oise Roudot–Thoraval Thomas Decaens Fabienne Pessione Hanaa Badran Tullio Piardi Claire Francoz Philippe Compagnon Claire Vanlemmens Jérome Dumortier Sébastien Dharancy Jean Gugenheim Pierre–Henri Bernard René Adam Sylvie Radenne Fa | 2012 | Gastroenterology2012，，4： | 1 |
| 20 | Synthesis of multispectral images to high spatial resolution: a critical review of fusion methods based on remote sensing physics显示文摘 | Thomas Claire Ranchin Thierry Wald Lucien | 2008 | IEEE Transactions on Geoscience and Remote Sensing2008，46，2： | 1 |
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