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| 1 | Autoimmune pancreatitis in the context of IgG4-related disease:Review of imaging findings显示文摘Current understanding of autoimmune pancreatitis(AIP) recognizes a histopathological subtype of the disease to fall within the spectrum of IgG4-related disease.Along with clinical,laboratory,and histopathological data,imaging plays an important role in the diagnosis and management of AIP,and more broadly,within the spectrum of IgG4-related disease.In addition to the defined role of imaging in consensus diagnostic protocols,an array of imaging modalities can provide complementary data to address specific clinical concerns.These include contrast-enhanced computed tomography(CT) and magnetic resonance(MR) imaging for pancreatic parenchymal lesion localization and characterization,endoscopic retrograde and magnetic resonance cholangiopancreatography(ERCP and MRCP) to assess for duct involvement,and more recently,positron emission tomography(PET) imaging to assess for extra-pancreatic sites of involvement.While the imaging appearance of AIP varies widely,certain imaging features are more likely to represent AIP than alternate diagnoses,such as pancreatic cancer.While nonspecific,imaging findings which favor a diagnosis of AIP rather than pancreatic cancer include:delayed enhancement of affected pancreas,mild dilatation of the main pancreatic duct over a long segment,the 'capsule' and 'penetrating duct' signs,and responsiveness to corticosteroid therapy.Systemic,extra-pancreatic sites of involvement are also often seen in AIP and IgG4-related disease,and typically respond to corticosteroid therapy.Imaging by CT,MR,and PET also play a role in the diagnosis and monitoring after treatment of involved sites. | Leslie K Lee Dushyant V Sahani | 2014 | World Journal of Gastroenterology2014，20，41： | 23 |
| 2 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 3 | Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer显示文摘Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer(CRC),and the importance of angiogenesis in cancer progression has been established.Computed tomography(CT)perfusion(CTP)based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics.CTP has been reported to characterize tumor angiogenesis,and to be a sensitive marker for predicting recurrence or survival in CRC.In this review,we will discuss the biomarker value of CTP in the management of CRC patients. | Koichi Hayano Takeshi Fujishiro Dushyant V Sahani Asami Satoh Tomoyoshi Aoyagi Gaku Ohira Toru Tochigi Hisahiro Matsubara Kiyohiko Shuto | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 4 | New approaches for precise response evaluation in hepatocellular carcinoma显示文摘With the increasing clinical use of cytostatic and novel biologic targeted agents,conventional morphologic tumor burden assessments,including World Health Organization criteria and Response Evaluation Criteria in Solid Tumors,are confronting limitations because of their difficulties in distinguishing viable tumor from necrotic or fibrotic tissue.Therefore,the investigation for reliable quantitative biomarkers of therapeutic response such as metabolic imaging or functional imaging has been desired.In this review,we will discuss the conventional and new approaches to assess tumor burden.Since targeted therapy or locoregional therapies can induce biological changes much earlier than morphological changes,these functional tumor burden analyses are very promising.However,some of them have not gone thorough all steps for standardization and validation.Nevertheless,these new techniques and criteria will play an important role in the cancer management,and provide each patient more tailored therapy. | Koichi Hayano Jorge M Fuentes-Orrego Dushyant V Sahani | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 5 | Monitoring Response to Antiangiogenic Treatment and Predicting Outcomes in Advanced Hepatocellular Carcinoma Using Image Biomarkers, CT Perfusion, Tumor Density, and Tumor Size (RECIST)显示文摘 | Tao Jiang Avinash Kambadakone Naveen M. Kulkarni Andrew X. Zhu Dushyant V. Sahani | 2012 | Investigative Radiology2012，，1： | 3 |
| 6 | Mechanical properties and electrical conductivity of Cu–Cr and Cu–Cr–4% SiC nanocomposites for thermo-electric applications显示文摘 | Suhrit Mula Pankajini Sahani S.K. Pratihar Siddhartha Mal Carl C. Koch | 2011 | Materials Science & Engineering A2011，，13： | 2 |
| 7 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 8 | Radiation Dose Reduction at Multidetector CT with Adaptive Statistical Iterative Reconstruction for Evaluation of Urolithiasis: How Low Can We Go?显示文摘 | Naveen M. Kulkarni Raul N. Uppot Brian H. Eisner Dushyant V. Sahani | 2012 | Radiology2012，，： | 2 |
| 9 | Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue - - initial experience 显示文摘 | Sahani DV Holalkere NS Mueller PR | 2007 | Radiology2007，243，3： | 1 |
| 10 | Using multidetector CT for preoperative vascular evaluation of liver neoplasms:technique and results显示文摘 | Sahani D Saini S Pena C | 2002 | AJR2002，179，1： | 1 |
| 11 | Pancreatic cysts 3 em or smaller:how aggressive should treatment be? 显示文摘 | Sahani DV Saokar A Hahn PF | 2006 | Radiology2006，238，3： | 1 |
| 12 | Autoimmune pancreatitis显示文摘 | Finkelberg D L Sahani D Deshpande V | 2006 | N Engl J Med2006，355，25： | 1 |
| 13 | Low-dose CT of theabdomen: evaluation of image improvement with use of noisereduction filters pilot study显示文摘 | Kalra MK Maher MM Sahani DV | 2003 | Radiology2003，228，1： | 1 |
| 14 | Autoimmune panereatitis:imaging features显示文摘 | Sahani DV Kalva SP Farrell J | 2004 | Radiology2004，233，2： | 1 |
| 15 | Using multidetector CT for preoper ative vascular evaluation of liver neoplasms:technique and results显示文摘 | SAHANI D SAINI S PENA C | 2002 | AJR2002，179，1： | 1 |
| 16 | Low-dose CT of the ab-domen:evaluation of image improvement with use of noise reduc-tion filters-pilot study显示文摘 | Kalra MK Maher MM Sahani DV | 2003 | Radiology2003，228，1： | 1 |
| 17 | Using multidetector CTfor preoperative vascular evaluation of liver neoplasms:technique and results显示文摘 | Sahani D Saini S Pena C | 2002 | Am J Roentgenol2002，179，： | 1 |
| 18 | Preoperative hepatic vascular evaluation with CT and MR angiography:implications for surgery显示文摘 | Sahani D Blake M Prasad S | 2004 | Radiographics2004，24，5： | 1 |
| 19 | Efficacy,safety,and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma:a phase Ⅱ study显示文摘 | Zhu AX Sahani DV Duda DG | 2009 | J Clin Oncol2009，27，18： | 1 |
| 20 | Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue initial experience 显示文摘 | Sahani DV Holalkere NS Mueller PR | 2007 | Radiology2007，243，3： | 1 |
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