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| 1 | BRAF突变提示转移性结直肠癌患者转移灶切除术后预后不良显示文摘BRAF突变发生于5%~11%的转移性结直肠癌患者。该研究分析了BRAF突变患者转移灶切除术后的临床病理因素、PIK3CA突变频率以及预后情况。研究通过回顾性的对2009年至2012年单中心1941例转移性结直肠癌患者行KRAS/BRAF突变检测,共检出92例患者含BRAF突变。2011年423例BRAF野生型转移性肠癌患者作为对照组。 研究发现在转移性大肠癌中,与BRAF野生型组相比,BRAF突变型与确诊时高龄、女性、肿瘤位于右侧以及低分化、粘液组织形态更加相关。 BRAF突变更多出现于肠癌分期III期、T4期患者。 PIK3C与5%的BRAF突变共存,与17%的KRAS突变共存,与4%的BRAF/KRAS共突变共存。 BRAF突变的患者一般不只局限于肝转移,更容易出现腹膜转移。研究人员进一步研究发现合并BRAF突变的转移性肠癌患者转移灶相对不容易切除,即使切除后总生存期也较短。 | Yaeger R Cercek A Chou JF | 2014 | 中华结直肠疾病电子杂志2014，3，2： | 13 |
| 2 | Biparental behavior in the burying beetle Nicrophorus orbicollis: a role for dopamine?显示文摘 | S. Carmen PANAITOF Jazmine D. W. YAEGER Jarod P. SPEER Kenneth J. RENNER | 2016 | Current Zoology2016，62，3： | 3 |
| 3 | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer显示文摘 | Misale S Yaeger R Hobor S | 2012 | Nature2012，486，7404： | 1 |
| 4 | Cytologyadds value ito imaging studies for risk assessment ofmalignancy in pancreatic mucinous cysts 显示文摘 | Genevay M Mino - Kenudson M Yaeger K | 2011 | Ann Surg2011，254，6： | 1 |
| 5 | Synergistic action of transforming growth factor-beta and insuliu-like growth factor-1 induces expression of type Ⅱ collagen and aggrecan genes in adult human articular chondrocytes显示文摘 | Masi TL Ortiz JL | 1997 | Exp Cell Res1997，15，： | 1 |
| 6 | A comparison of virus isolation,immunohistochemistry,fetal serology,and reverse-transcription polymerase chain reaction assay for the identification of porcine reproductive and respiratory syndrome virus transplacental infection in the fetus显示文摘 | Benson J E Yaeger M J Christopher-Hennings J | 2002 | J Vet Diagn Invest2002，14，： | 1 |
| 7 | Designing piezoelectric films for micro electromechanical system显示文摘 | Trolier-McKinstry S Griggio F Yaeger C | | 0，，： | 1 |
| 8 | Atypical antipsychotics in the treatment of schizophrenia during pregnancy and the postpartum显示文摘 | Yaeger D Smith HC Altshuler LL | | 0，，12： | 1 |
| 9 | Laboratory investigation of PRRS virus infection in three swine herds显示文摘 | Zemen D Neiger R Yaeger M | 1993 | Vet Diagn Invest1993，5，： | 1 |
| 10 | Immunohistochemical evalu- ation of substance P and calcitonin gene-related peptide in skin and peri- osteum after extracorporeal shock wave therapy and radial pressure wave therapy in sheep显示文摘 | Abed J M McClure S R Yaeger M J | 2007 | Am J Vet Res2007，68，3： | 1 |
| 11 | Microradiography of the effect of acute and chronic administration of fluoride on human and rat dentine and enamel显示文摘 | Fejerskov O Yaeger JA Thylstrup A | 1979 | Arch Oral Biol1979，24，2： | 1 |
| 12 | Cloning and characterization of human gin- gival and periodontal ligament fibroblasts 显示文摘 | Hou LT Yaeger JA | 1993 | J Periodontol1993，64，12： | 1 |
| 13 | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer显示文摘 | Misale S Yaeger R Hobor S | 2012 | Nature2012，486，7404： | 1 |
| 14 | Immunohistoshenical evalua - tion of substance P and caicitonin gene - related peptide in skin and pe - riosteum after extracorporeal shock wave therapy and radial pressure wave therapy in sheep 显示文摘 | Abed JM McClure SR Yaeger M J | 2007 | Am J Vet Res2007，68，3： | 1 |
| 15 | Emergence of KRASmutations and acquired resistance to anti 一 EGFR therapy in color-ectal cancer显示文摘 | MISALE S YAEGER R HOBOR S | 2012 | Nature2012，486，7404： | 1 |
| 16 | Immunohistochemical evaluation of substance and calcitonin gene-related peptide in skinand periosteum after extracorporeal shock wave therapy and radialpressurewave therapy in sheep显示文摘 | Abed JM McClure SR Yaeger MJ | 2007 | Am J Vet Res2007，68，3： | 1 |
| 17 | Emergence of KRASmutations and acquired resistance to anti-EGFR therapy in color-ectal cancer显示文摘 | MISALE S YAEGER R HOBOR S | 2012 | Nature2012，486，7404： | 1 |
| 18 | Evidence for transmission of porcine reproductive and respiratory syndrome (PRRS) virus inboar semen显示文摘 | Yaeger M J Prieve T Collins J | 1993 | Swine Health Prod1993，1，5： | 1 |
| 19 | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer显示文摘 | Misale S Yaeger R Hobor S | 2012 | Nature2012，486，7404： | 1 |
| 20 | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer 显示文摘 | Misale S Yaeger R Hobor S | 2012 | Nature2012，486，7404： | 1 |
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