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| 1 | Identification of key tissue type for antler regeneration through pedicle periosteum deletion显示文摘 | Chunyi Li Colin G. Mackintosh Shirley K. Martin Dawn E. Clark | 2007 | Cell and Tissue Research2007，，1： | 1 |
| 2 | hnproved naturalrubber processing and physical properties by use of selected compounding additives显示文摘 | Colin Clarke Manfred Hensel | 2009 | Rubber world2009，241，11： | 1 |
| 3 | Finance and Income Inequality:Test of Aherative Theories显示文摘 | Clarke George Xu Lixin Colin Zou Hengfu | 2002 | World Bank PoHcy Research Working2002，，： | 1 |
| 4 | Evaluation of the thermodynamic functions for aqueous sodium chloride from equilibrium and calorimetric measurements below 154 ℃显示文摘 | Colin E Clarke W Glew D N | | 0，，02： | 1 |
| 5 | Implementation of enhanced recovery programme after pancreatoduodenectomy: A single-centre UK pilot study显示文摘 | Mohammed Abu Hilal Francesco Di Fabio AbdAllah Badran Hani Alsaati Hannah Clarke Imogen Fecher Thomas H. Armstrong Colin D. Johnson Neil W. Pearce | 2013 | Pancreatology2013，，1： | 1 |
| 6 | The optimal exploitation of renewable resource stocks:problems of irreversible investment显示文摘 | Clark Colin W Clarke Frank H MunRo Gordon R | 1979 | Econometrica1979，147，1： | 1 |
| 7 | Finanee and Income Inequality: Test of Alterna- tiveTheories 显示文摘 | Clark Goerge Xu Lixin Colin and Heng- fu | 2006 | World Bank Policy Research Working Pa- per29842006，，03： | 1 |
| 8 | Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis显示文摘 | Jamieson Thomas Clarke Mairi Steele Colin W Samuel Michael S Neumann Jens Jung Andreas Huels David Olson Michael F Das Sudipto Nibbs Robert J B Sansom Owen J | 2012 | EN2012，，： | 1 |
| 9 | New Tools for Studying Network Industry Reforms in Developing Countries: The Telecommunications and Electricity Regulation Database显示文摘 | Wallsten Scott George Clarke Luke Haggarty Rosario Kaneshiro Roger Noll Mary Shirleyand Lixin Colin Xu | 2004 | Review of Network Economics2004，33，： | 1 |
| 10 | Profit Maximization and the Extinction of AnimalsSpecies显示文摘 | Colin clark | 1973 | Journal of Political Economy1973，81，4： | 1 |
| 11 | Fi- nance and Income Inequality: What Do the Data Tell Us? 显示文摘 | Clarke George R G XuLixin Colin Heng-fu Zou | 2006 | Southern Economic Journal2006，72，3： | 1 |
| 12 | International Comparisons of Productivity Trends显示文摘 | Clark Colin | 1958 | The Journal of Business1958，31，4： | 1 |
| 13 | The Economics of Overexploitation显示文摘 | Clark Colin W | 1973 | Science[J]1973，181，： | 1 |
| 14 | Computation fluid dynamics study of flow around floating-roof oil storage tanks显示文摘 | Humphrey Pasley Colin Clark | 2000 | Journal of Wind Engineering and and Industrial Aerodynamics2000，86，1： | 1 |
| 15 | Finance and Income Inequality: Test of Alternative Theories 显示文摘 | George Clarke Lixin Colin Xu Heng-fu Zou | 2003 | World Bank Policy Research Working Paper 29842003，2003，： | 1 |
| 16 | Early diagnosis of cardiac implantable electronic device generator pocket infection using 18F-FDG-PET/CT显示文摘 | Fozia Zahir Ahmed Jacqueline James Colin Cunnington Manish Motwani Catherine Fullwood Jacquelyn Hooper Phillipa Burns Ahmed Qamruddin Ghada Al-Bahrani Ian Armstrong Deborah Tout Bernard Clarke Jonathan A.T. Sandoe Parthiban Arumugam Mamas A. Mamas Amir M. | 2015 | European Heart Journal - Cardiovascular Imaging2015，，5： | 1 |
| 17 | An Introduction to Phonetics and Phonology 显示文摘 | John CLark and Colin Yallop | 2000 | Foreign Language Teaching and Research2000，，8： | 1 |
| 18 | Finance and Income Inequality: Test of Alternative Theories 显示文摘 | George Clarke Lixin Colin Xu Zou Heng-fu | 2003 | World Bank Policy Research Working Paper2003，，： | 1 |
| 19 | Critical Role of Macrophage 12/15-Lipoxygenase for Atherosclerosis in Apolipoprotein E–Deficient Mice显示文摘 | Yuqing Huo Lei Zhao Matthew Craig Hyman Pavel Shashkin Brian L. Harry Tracy Burcin S Bradley Forlow Matthew A. Stark David F. Smith Sean Clarke Suseela Srinivasan Catherine C. Hedrick Domenico Praticò Joseph L. Witztum Jerry L. Nadler Colin D. Funk Klaus | 2004 | Circulation2004，，14： | 1 |
| 20 | Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine显示文摘AIM To identify mi RNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the intestine.METHODS Exponentially growing Caco-2 and HT-29 cells were harvested and prepared for m RNA, mi RNA and proteomic profiling. m RNA microarray profiling analysis was carried out using the Affymetrix Gene Chip Human Gene 1.0 ST array. mi RNA microarray profiling analysis was carried out using the Affymetrix Genechip mi RNA 3.0 array. Quantitative Label-free LC-MS/MS proteomic analysis was performed using a Dionex Ultimate 3000 RSLCnano system coupled to a hybrid linear iontrap/Orbitrap mass spectrometer. Peptide identities were validated in Proteome Discoverer 2.1 and were subsequently imported into Progenesis QI software for further analysis. Hierarchical cluster analysis for all three parallel datasets(mi RNA, proteomics, m RNA) was conducted in the R software environment using the Euclidean distance measure and Ward's clustering algorithm. The prediction of mi RNA and oppositely correlated protein/m RNA interactions was performed using Target Scan 6.1. GO biological process, molecular function and cellular component enrichment analysis was carried out for the DE mi RNA, protein and m RNA lists via the Pathway Studio 11.3 Web interface using their Mammalian database.RESULTS Differential expression(DE) profiling comparing the intestinal cell lines HT-29 and Caco-2 identified 1795 Genes, 168 Proteins and 160 mi RNAs as DE between the two cell lines. At the gene level, 1084 genes were upregulated and 711 were downregulated in the Caco-2 cell line relative to the HT-29 cell line. At the protein level, 57 proteins were found to be upregulated and 111 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Finally, at the mi RNAs level, 104 were upregulated and 56 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Gene ontology(GO) analysis of the DE m RNA identified cell adhesion, migration and ECM organization, cellular lipid and cholesterol metabolic processes, small molecule transport and a range of responses to external stimuli, while similar analysis of the DE protein list identified gene expression/transcription, epigenetic mechanisms, DNA replication, differentiation and translation ontology categories. The DE protein and gene lists were found to share 15 biological processes including for example epithelial cell differentiation [P value ≤ 1.81613 E-08(protein list); P ≤ 0.000434311(gene list)] and actin filament bundle assembly [P value ≤ 0.001582797(protein list); P ≤ 0.002733714(gene list)]. Analysis was conducted on the three data streams acquired in parallel to identify targets undergoing potential mi RNA translational repression identified 34 proteins, whose respective m RNAs were detected but no change in expression was observed. Of these 34 proteins, 27 proteins downregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 19 unique anti-correlated/upregulated micro RNAs and 7 proteins upregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 15 unique anti-correlated/downregulated micro RNAs.CONCLUSION This first study providing 'tri-omics' analysis of the principal intestinal cell line models Caco-2 and HT-29 has identified 34 proteins potentially undergoing mi RNA translational repression. | Finbarr O’Sullivan Joanne Keenan Sinead Aherne Fiona O’Neill Colin Clarke Michael Henry Paula Meleady Laura Breen Niall Barron Martin Clynes Karina Horgan Padraig Doolan Richard Murphy | 2017 | World Journal of Gastroenterology2017，23，41： | 1 |
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