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| 1 | Ovarian cancer standard of care: are there real alternatives?显示文摘Ovarian cancer remains a major issue for gynecological oncologists, and most patients are diagnosed when the disease is already advanced with a poor chance of survival. Debulking surgery followed by platinum-taxane chemotherapy is the current standard of care, but based on several different strategies currently under evaluation, some encouraging data have been published in the last 4 to 5 years. This review provides a state-of-the-art overview of the available alternatives to conventional treatment and the most promising new combinations. For example, neoadjuvant chemotherapy does not seem to be inferior to primary debulking. Despite its outcome improvements, intraperitoneal chemotherapy struggles for acceptance due to the heavy toxicity. Dose-dense chemotherapy, after showing an impressive efficacy in Asian populations, has not produced equal results in a European cohort, and the results of alternative platinum doublets are not superior to those of carboplatin and paclitaxel. In this setting, adherence to a maintenance therapy after first-line treatment and multiple(primarily antiangiogenic) agents appears to be effective. Although many questions, including the duration of maintenance treatment and the use of bevacizumab beyond progression, remain unanswered, new biologic agents, such as poly(ADP-ribose) polymerase(PARP) inhibitors, nintedanib, and mitogen-activated protein/extracellular signal-regulated kinase(MEK) inhibitors, have emerged as potential therapeutic options in the very near future. Based on the multiplicity of available strategies, the histological and molecular features of the tumor, in addition to patient's clinical condition and disease state, continue to gain importance in guiding treatment choices. | Chiara Della Pepa Giuseppe Tonini Carmela Pisano Marilena Di Napoli Sabrina Chiara Cecere Rosa Tambaro Gaetano Facchini Sando Pignata | 2015 | Chinese Journal of Cancer2015，34，1： | 5 |
| 2 | Holographic augmented reality display with conical holographic optical element for wide viewing zone显示文摘In this study, we propose a holographic augmented reality (AR) display with a wide viewing zone realized by using a special-designed reflective optical element. A conical holographic optical element (HOE) is used as such a reflective optical element. This conical HOE was implemented to reconstruct a diverging spherical wave with a wide spread angle. It has a sharp wavelength selectivity by recording it as a volume hologram, enabling augmented reality (AR) representation of real and virtual 3D objects. The quality of the generated spherical wave and the spectral reflectivity of the fabricated conical HOE were investigated. An optical superimposition between real and virtual 3D objects was demonstrated, thereby enhancing the validity of our proposed method. A horizontal viewing zone of 140° and a vertical viewing zone of 30° were experimentally confirmed. The fabrication procedure for the conical HOE is presented, and the calculation method of the computer-generated hologram (CGH) based on Fermat’s principle is explained in detail. | Yusuke Sando Kazuo Satoh Daisuke Barada Toyohiko Yatagai | 2022 | Light(Advanced Manufacturing)2022，3，1： | 4 |
| 3 | Incorporating travel time reliability in predicting the likelihood of severe crashes on arterial highways using non-parametric random-effect regression显示文摘Travel time reliability(TTR) modeling has gain attention among researchers’ due to its ability to represent road user satisfaction as well as providing a predictability of a trip travel time.Despite this significant effort,its impact on the severity of a crash is not well explored.This study analyzes the effect of TTR and other variables on the probability of the crash severity occurring on arterial roads.To address the unobserved heterogeneity problem,two random-effect regressions were applied;the Dirichlet random-effect(DRE)and the traditional random-effect(TRE) logistic regression.The difference between the two models is that the random-effect in the DRE is non-parametrically specified while in the TRE model is parametrically specified.The Markov Chain Monte Carlo simulations were adopted to infer the parameters’ posterior distributions of the two developed models.Using four-year police-reported crash data and travel speeds from Northeast Florida,the analysis of goodness-of-fit found the DRE model to best fit the data.Hence,it was used in studying the influence of TTR and other variables on crash severity.The DRE model findings suggest that TTR is statistically significant,at 95 percent credible intervals,influencing the severity level of a crash.A unit increases in TTR reduces the likelihood of a severe crash occurrence by 25 percent.Moreover,among the significant variables,alcohol/drug impairment was found to have the highest impact in influencing the occurrence of severe crashes.Other significant factors included traffic volume,weekends,speed,work-zone,land use,visibility,seatbelt usage,segment length,undivided/divided highway,and age. | Emmanuel Kidando Ren Moses Eren Erman Ozguven Thobias Sando | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，5： | 4 |
| 4 | Assessment of traffic performance measures and safety based on driver age and experience:A microsimulation based analysis for an unsignalized T-intersection显示文摘Traffic safety and performance measures such as crash risk and queue lengths or travel times are influenced by several important factors including those related to environment,human,and roadway design,especially at intersections.Previous research has studied different aspects related to these factors,yet these characteristics are not fully investigated with a focus on age and experience of drivers.In this paper,we investigate this issue by using a two-phase approach via a case study application on a critical T-intersection in the City of Tallahassee,Florida.The first phase includes a scenario-based microsimulation analysis through the use of a microscopic simulation software,namely VISSIM,to illustrate the variations in traffic performance measures with respect to driver compositions of different age groups in the traffic stream.A variety of scenarios is created where the driving characteristics are provided as inputs to these scenarios in terms of decision making and risk taking.This is also supported by a sensitivity analysis conducted based on the driver composition in the traffic.The second phase includes the analysis of microsimulation outputs via a tool developed by Federal Highway Administration tool,namely the Surrogate Safety Assessment Model(SSAM),in order to determine the traffic conflicts that occur in each scenario.These conflicts are also compared with real-life crash data for validation purposes.Results show that(a) the differences in risk perception that affect driving behavior might be significant in influencing traffic safety and performance measures,and(b) the proposed approach is considerably successful in simulating the actual crash conflict points. | Mehmet Baran Ulak Eren Erman Ozguven Ren Moses Thobias Sando Walter Boot Yassir AbdelRazig John Olusegun Sobanjo | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，5： | 2 |
| 5 | Role of cofacors in protein kinase C activation显示文摘 | Sando JJ Maurer MC Bolen EJ | 1992 | Cellular Singlling1992，4，： | 2 |
| 6 | Malignant adenomyoepithelioma of the breast with matrix production may be compatible with one variant form of matrix_producing carcinoma:a case report显示文摘 | Oka K Sando N Moriya T | 2007 | Pathol Res Pract2007，203，8： | 1 |
| 7 | Histopathologic features of a cochlear implant and otogenic meningitis in Mondini dysplasia显示文摘 | SUZUKI C SANDO I FAGAN J J | 1998 | Arch Otolaryngol Head Neck Surg1998，124，： | 1 |
| 8 | Localization of function in the eustachian tube:a hypothesis显示文摘 | Sando I Takahashi H Matsune S | 1994 | Ann Otol Rhinol Laryngol1994，103，4： | 1 |
| 9 | Infuence of intersection geometrics on the operation of triple left-turn lanes 显示文摘 | Thobias Sando Ren Moses | 2009 | Journal of Transportation Engineering2009，135，5： | 1 |
| 10 | Sensitive detection of circulating hepatocellalar carcinoma cells in peripheral venous blood 显示文摘 | Komeda F Fukuda Y Sando T | 1995 | Cancer1995，75，9： | 1 |
| 11 | Computer-aided 3-D temporal bone anatomy for cochlear implant surgery显示文摘 | TAKAHASHI H SANDO I | 1990 | Laryngoscope1990，100，： | 1 |
| 12 | Philosophical debate on the nature of well-being: Implications for animal welfare显示文摘 | Appleby M C Sandoe P | 2002 | Anita Well2002，11，： | 1 |
| 13 | Vertebral osteomyelitis caused by Enterocoecus nosus显示文摘 | Sandoe JAT Witherden IR Settle C | 2001 | J Clin Mierobiol2001，39，6： | 1 |
| 14 | Postnatal development of the vestibular aqueduct and endolymphatic sac显示文摘 | Kodama S Sando I | 1982 | Ann Otorhinol Laryngol1982，91，96： | 1 |
| 15 | Variation of Er3+ cross section for stimulated emission with glass composition显示文摘 | SANDOE J N SARKIES P H PARKE S | 1972 | J Phys D:App Phys1972，5，： | 1 |
| 16 | Portal vein thrombosis in patients with end stage liver disease awaiting liver transplantation: outcome of anticoagulation 显示文摘 | Wemer KT Sando S Carey E J | 2013 | Dig Dis Sci2013，58，6： | 1 |
| 17 | Functional anatomy of levator veli palatini muscle and tensor veli palatini muscle in association with eustachian tube cartilage显示文摘 | Ishijima K Sando I Balaban CD | 2002 | Ann Otol Rhinol Laryngol2002，111，6： | 1 |
| 18 | Linagliptin (Tradjenta) for the treat- ment of diabetes mellitus 显示文摘 | Karen W Sando KR | 2012 | Am Fam Physician2012，86，12： | 1 |
| 19 | Medial high jugular bulb显示文摘 | HAGINOMORI S SANDO I MIURA M | 2001 | Otol Neurotol2001，22，： | 1 |
| 20 | Color corn purer-generated holograms from projection images显示文摘 | Yusuke Sando Masahide ltoh Toyohiko Yatagai | 2004 | Optics Express2004，12，11： | 1 |
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