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    题名 作者 年代 出处 被引量
1Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo显示文摘This study investigated the humoral immunization of Astragalus polysaccharide(APS) against H9N2 avian influenza virus(H9N2 AIV) infection in chickens. The effects of APS treatment on H9N2 infection was evaluated by an MTT [3(4, 5-dimethylthiazol-2-yl)-2, 3-diphenyl tetrazolium bromide] assay and analysis of MHC and cytokine mRNA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to H9N2 AIV were enhanced in the first week after APS treatment. The results indicated that APS treatment reduces H9N2 AIV replication and promotes early humoral immune responses in young chickens.Sanpha Kallon Xiaorong Li Jun Ji Cuiying Chen Qianyun Xi Shuang Chang Chunyi Xue Jingyun Ma Qingmei Xie Youngliang Zhang 2013Journal of Animal Science and Biotechnology2013,4,4:48
2Mechanical Properties and Microstructure of Portland Cement Concrete Prepared with Coral Reef Sand显示文摘The feasibility of using coral reef sand(CRS) in Portland cement concrete is investigated by testing the mechanical property and microstructure of concrete. The composition, structure and properties of the CRS are analyzed. Mechanical properties and microstructure of concrete with CRS are studied and compared to concrete with natural river sand. The relationship between the microstructure and performance of CRS concrete is established. The CRS has a porous surface with high water intake capacity, which contributes to the mechanical properties of concrete. The interfacial transition zone between the cement paste and CRS is densified compared to normal concrete with river sand. Hydration products form in the pore space of CRS and interlock with the matrix of cement paste, which increases the strength. The total porosity of concrete prepared with CRS is higher than that with natural sand. The main difference in pore size distribution is the fraction of fine pores in the range of 100 nm.王乾坤 LI Peng 田亚坡 CHEN Wei SU Chunyi 2016Journal of Wuhan University of Technology(Materials Science)2016,31,5:19
3A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets.Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao 2018Virologica Sinica2018,33,2:16
4A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes显示文摘Thermal runaway has been a long-standing safety issue impeding the development of high-energydensity batteries. Physical safety designs such as employing circuit-breakers and fuses to batteries are limited by small operating voltage windows and no resumption of original working condition when it is cooled down. Here we report a smart thermoresponsive polymer electrolyte that can be incorporated inside batteries to prevent thermal runaway via a fast and reversible sol-gel transition, and successfully combine this smart electrolyte with a rechargeable Zn/a-MnO_2 battery system. At high temperature, battery operation is inhibited as a result of the increased internal resistance caused by the gelation of liquid electrolyte. After cooling down, the electrolyte is spontaneously reversed to sol state and the electrochemical performance of the battery is restored. More importantly, sol-gel transition enables the smart battery to experience different charge-discharge rates under various temperature levels, providing a smart and active strategy to achieve dynamic and reversible self-protection.Funian Mo Hongfei Li Zengxia Pei Guojin Liang Longtao Ma Qi Yang Donghong Wang Yan Huang Chunyi Zhi 2018Science Bulletin2018,63,16:13
5Effects of ammonium exchange and Si/Al ratio on the conversion of methanol to propylene over a novel and large partical size ZSM-5显示文摘One type of ZSM-5 zeolite with large partical size was prepared and characterized by XRD, SEM, N2 adsorption-desorption, XRF, Py-IR and NH3-TPD techniques. Effects of ammonium exchange and SiO2/Al2O3 molar ratios on the reaction of methanol to propylene (MTP) over Na-ZSM-5 and H-ZSM-5 zeolites have been studied in a fixed-bed flow reactor under the operating conditions of T = 500 °C, P = 1 atm, and WHSV = 6 h-1. Ammonium exchange led to a rapid decrease in Na content for Na-ZSM-5 zeolite. The reaction results indicated that Na-ZSM-5 and H-ZSM-5 with different SiO2/Al2O3 molar ratios all exhibited high activity for methanol conversion. Ammonium exchange and the decreased SiO2/Al2O3 molar ratio of ZSM-5 zeolite led to an increase both in strong acid sites and weak acid sites. Na-ZSM-5 with high SiO2/Al2O3 molar ratio was favorable for the formation of propylene. The highest propylene selectivity (45.9%) was obtained over Na-ZSM-5 zeolite catalyst with SiO2/Al2O3 molar ratio of 220.Ruchao Wei Chunyi Li Chaohe Yang Honghong Shan 2011Journal of Natural Gas Chemistry2011,20,3:12
6Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector显示文摘Anion starch nanoparticles (StNP) were prepared in water-in-oil microemulsion. Folate modi-fied with PEG was conjugated to the surface of StNP to obtain the folate-conjugated starch nanoparticles (FA-PEG/StNP). The average diameter of FA-PEG/ StNP determined by AFM and Zeta-Sizer apparatus was about 130 nm. Doxorubicin (DOX)-loaded FA- PEG/StNP was obtained via infiltrating combination. The result of UV spectrophotometer showed that the saturation concentration of DOX-loaded FA-PEG/ StNP was 28 μg/mg, which was effective for the con-trolled release of anticancer drug DOX. The cell ex-periments showed that the Lc50 of DOX-loaded FA-PEG/StNP and DOX-loaded StNP was higher than that of DOX, which indicates that FA-PEG/StNP and StNP can decrease the toxicity of DOX; while the lethal rate of DOX-loaded FA-PEG/StNP was 3 times that of DOX-loaded StNP with the same quantity of DOX, which indicates that FA in FA-PEG/StNP is ef-fective for improving the targeting function of nanoparticles, thus enhancing the inhibition effect of anticancer drug to cancer cell. This work demon-strates that the FA-PEG/StNP system is a potentially useful system for the targeted delivery of anticancer drug DOX.XlAO Suyao TONG Chunyi LIU Xuanming YU Danmi LIU Qiaoling XUE Changgang TANG Dongyin ZHAO Lijian 2006Chinese Science Bulletin2006,51,14:12
7Research on the control method for voltage-current source hybrid-HVDC system显示文摘The hybrid-HVDC topology,which consists of line-commutated-converter(LCC)and voltage source converter(VSC)and combines their advantages,has extensive application prospects.A hybrid-HVDC system,adopting VSC on rectifier side and LCC on inverter side,is investigated,and its mathematic model is deduced.The commutation failure issue of the LCC converter in the hybrid-HVDC system is considered,and a novel coordinated control method is proposed to enhance the system commutation failure immunity.A voltage dependent voltage order limiter(VDVOL)is designed based on the constant DC voltage control on the rectifier side,and constant extinction angle backup control is introduced based on the constant DC current control with voltage dependent current order limiter(VDCOL)on the inverter side.The hybrid-HVDC system performances under normal operation state and fault state are simulated in the PSCAD/EMTDC.Then,system transient state performances with or without the proposed control methods under fault condition are further compared and analyzed.It is concluded that the proposed control method has the ability to effectively reduce the probability of commutation failure and improve the fault recovery performance of the hybrid-HVDC system.GUO ChunYi LIU WenJing ZHAO ChengYong 2013Science China(Technological Sciences)2013,56,11:12
8Semi-active Sliding Mode Control of Vehicle Suspension with Magneto-rheological Damper显示文摘The vehicle semi-active suspension with magneto-rheological damper(MRD) has been a hot topic since this decade, in which the robust control synthesis considering load variation is a challenging task. In this paper, a new semi-active controller based upon the inverse model and sliding mode control(SMC) strategies is proposed for the quarter-vehicle suspension with the magneto-rheological(MR) damper, wherein an ideal skyhook suspension is employed as the control reference model and the vehicle sprung mass is considered as an uncertain parameter. According to the asymptotical stability of SMC, the dynamic errors between the plant and reference systems are used to derive the control damping force acquired by the MR quarter-vehicle suspension system. The proposed modified Bouc-wen hysteretic force-velocity(F-v) model and its inverse model of MR damper, as well as the proposed continuous modulation(CM) filtering algorithm without phase shift are employed to convert the control damping force into the direct drive current of the MR damper. Moreover, the proposed semi-active sliding mode controller(SSMC)-based MR quarter-vehicle suspension is systematically evaluated through comparing the time and frequency domain responses of the sprung and unsprung mass displacement accelerations, suspension travel and the tire dynamic force with those of the passive quarter-vehicle suspension, under three kinds of varied amplitude harmonic, rounded pulse and real-road measured random excitations. The evaluation results illustrate that the proposed SSMC can greatly suppress the vehicle suspension vibration due to uncertainty of the load, and thus improve the ride comfort and handling safety. The study establishes a solid theoretical foundation as the universal control scheme for the adaptive semi-active control of the MR full-vehicle suspension decoupled into four MR quarter-vehicle sub-suspension systems.ZHANG Hailong WANG Enrong ZHANG Ning MIN Fuhong SUBASH Rakheja SU Chunyi 2015Chinese Journal of Mechanical Engineering2015,28,1:12
9Skyhook-based Semi-active Control of Full-vehicle Suspension with Magneto-rheological Dampers显示文摘The control study of vehicle semi-active suspension with magneto-rheological (MR) dampers has been attracted much attention internationally. However, a simple, real time and easy implementing semi-active controller has not been proposed for the MR full-vehicle suspension system, and a systematic analysis method has not been established for evaluating the multi-objective suspension performances of MR full-vehicle vertical, pitch and roll motions. For this purpose, according to the 7-degree of freedom (DOF) fullvehicle dynamic system, a generalized 7-DOF MR and passive full-vehicle dynamic model is set up by employing the modified Boucwen hysteretic force-velocity (F-v) model of the MR damper. A semi-active controller is synthesized to realize independent control of the four MR quarter-vehicle sub-suspension systems in the full-vehicle, which is on the basis of the proposed modified skyhook damping scheme of MR quarter-vehicle sub-suspension system. The proposed controller can greatly simplify the controller design complexity of MR full-vehicle suspension and has merits of easy implementation in real application, wherein only absolute velocities of sprung and unsprung masses with reference to the road surface are required to measure in real time when the vehicle is moving. Furthermore, a systematic analysis method is established for evaluating the vertical, pitch and roll motion properties of both MR and passive full-vehicle suspensions in a more realistic road excitation manner, in which the harmonic, rounded pulse and real road measured random signals with delay time are employed as different road excitations inserted on the front and rear two wheels, by considering the distance between front and rear wheels in full-vehicle. The above excitations with different amplitudes are further employed as the road excitations inserted on left and right two wheels for evaluating the roll motion property. The multi-objective suspension performances of ride comfort and handling safety of the proposed MR full-vehicle suspension are thus thoroughly evaluated by comparing with those of the passive full-vehicle suspension. The results show that the proposed controller can ideally improve multiobjective suspension performances of the ride comfort and handling safety. The proposed harmonic, rounded pulse and real road measured random signals with delay time and asymmetric amplitudes are suitable for accurately analyzing the vertical, pitch and roll motion properties of MR full-vehicle suspension system in a more realistic road excitation manner. This research has important theoretical significance for improving application study on the intelligent MR semi-active suspension.ZHANG Hailong WANG Enrong MIN Fuhong SUBASH Rakheja SU Chunyi 2013Chinese Journal of Mechanical Engineering2013,26,3:11
10Hierarchical ZSM-11 with intergrowth structures:Synthesis,characterization and catalytic properties显示文摘Hierarchical ZSM-11 microspheres with intercrystalline mesoporous properties and rod-like crystals intergrowth morphology have been synthesized using a spot of tetrabutylammonium as a single template.XRD,FTIR,SEM,TEM and N2 adsorption analysis revealed that each individual particle was composed of nanosized rod crystals inserting each other and the intercrystalline voids existing among rods gave a significant mesopore size distribution.Steam treatment result demonstrated the excellent hydrothermal stability of samples.Various crystallization modes including constant temperature crystallization (one-stage crystallization) and two-stage temperature-varying crystallization with different 1st stage durations were investigated.The results suggested that the crystallization modes were mainly responsible for the adjustable particle size and textural properties of samples while the small amount of tetrabutylammonium bromide was mainly used to direct the formation of both ZSM-11 framework and its intergrowth morphology.Furthermore,the performance of optimal ZSM-11 as an active component for the catalytic pyrolysis of heavy oil was also investigated.Compared with the commercial pyrolysis catalyst,the hierarchical ZSM-11 catalyst exhibited a high selectivity to desired products(LPG+gasoline+diesel),as well as a much lower dry gas and coke yield,plus a high selectivity and yield of light olefins(C=3 C=4)and very poor selectivity to benzene.Therefore,fully open micropore-mesopore connectivity would make such hierarchically porous ZSM-11 zeolites very attractive for applications in clean petrochemical catalysis field.Qingjun Yu Chaoyue Cui Qiang Zhang Jing Chen Yang Li Jinpeng Sun Chunyi Li Qiukai Cui Chaohe Yang Honghong Shan 2013Journal of Energy Chemistry2013,22,5:10
11Toward Enhancing Wearability and Fashion of Wearable Supercapacitor with Modified Polyurethane Artificial Leather Electrolyte显示文摘Inspired by the sophisticated artificial leather garment industry and toward enhancing wearability of energy storage devices, we demonstrate a polyurethane artificial leather supercapacitor with large sheet electrodes embedded in theleather layer simultaneously working as a polyelectrolyte. This design totally reserves textiles underneath and thus addresses the well-known challenge of wearing comfortability. It provides a revolutionary configuration of wearable supercapacitors: the artificial leather on garment is also a supercapacitor.Unlike the polyvinyl alcohol-based acidic electrolytes, which are widely used, sodium chloride is used to modify the intrinsically fluorescent polyurethane leather for ionic transportation, which has no harm to human. The fluorescent leather supercapacitor is easily transferrable from any arbitrary substrates to form various patterns, enabling multifunctionalities of practical wearability, fashion, and energy storage.Yan Huang Zijie Tang Zhuoxin Liu Jun Wei Hong Hu Chunyi Zhi 2018Nano-Micro Letters2018,10,3:10
12Effects of Temperature and Catalyst to Oil Weight Ratio on the Catalytic Conversion of Heavy Oil to Propylene Using ZSM-5 and USY Catalysts显示文摘实际操作在 FCC 由重油的催化变换学习丙烯的生产的规则是有用的(液体催化裂开) 。产品的分发和丙烯的收益上的温度和 C/O 比率(给重量比率上油的催化剂) 的效果与二模型催化剂在一个微反应堆单位上被调查,也就是, ZSM-5/Al2O3 和 USY/Al2O3,和 Fushun 真空瓦斯油(VGO ) 被用作化工物品。在 ZSM-5 催化剂上的重油的变换能比得上在高温和高 C/O 比率的 USY 催化剂的。用 ZSM-5 平衡催化剂的重油的变换的率与在一般 FCC 条件下面的 USY 平衡催化剂相比是更低的,这能被归因于 ZSM-5 平衡催化剂的差的蒸气能力。在 USY 和 ZSM-5 的毛孔拓扑学的差别是为什么的原因为上述二催化剂的主要产品是不同的,也就是汽油和液体石油气体(LPG ) repspectively。那么 LPG 选择,特别丙烯选择,如果 USY 为最大化丙烯的生产被增加进 FCC 催化剂,可以衰退。增加 C/O 比率比二模型催化剂的温度的增加是为 LPG 产量的增加的最节俭的方法,因为轻油的损失是在以前的案例中的更少。在 HTC (氢转移系数) 和丙烯的收益之间有反的关联,并且限制氢转移反应是在增加 ZSM-5 催化剂的丙烯的收益的更重要的措施。ZSM-5/Al2O3 的乙烯收益更高,但是当 ZSM-5 催化剂被使用时,有低价值的气体的副产品没被提高。而且为 LPG 和结束产品,弄干气体和焦炭,他们他们的收益依赖的反应对条件的范围是不同的,并且结束产品的比 LPG 的更严重。最大化 LPG 和丙烯并且限制干燥气体和焦炭能是经由在产量对 LPG 敏感的反应条件的范围之中增加反应条件的严厉完成的两个,因此是清楚的。给词调音:液体催化裂开;重油;丙烯;温度;催化剂将给重量比率上油;ZSM-5;Xiaohong Li Chunyi Li Jianfang Zhang Chaohe Yang Honghong Shan 2007Journal of Natural Gas Chemistry2007,16,1:10
13Impact of Synchronous Condenser on the Dynamic Behavior of LCC-based UHVDC System Hierarchically Connected to AC System显示文摘Hierarchical connection(HC)is a very attractive mode for±800 kV line commutated converter based ultra high voltage direct current(LCC-UHVDC)system connected to different AC voltage levels because of its ability to reduce the scale factor of a converter transformer.Faults in the HC-UHVDC system can cause commutation failure(CF).In this paper,impact of synchronous condenser(SC)to mitigate CF in HC-UHVDC system is analyzed.A±800KV HC-UHVDC system along with synchronous condenser is built in PSCAD/EMTDC.Transient performance analysis of HC-UHVDC for single and three phase to ground faults is investigated.Commutation failure immunity index(CFII),commutation failure probability index(CFPI),fault recovery time(FRT),and transient overvoltage(TOV)are used as measures to evaluate the effects of SC at HC-UHVDC system design.The simulation results show that SC can make the HCUHVDC system less susceptible to CF,effectively improve fault recovery performances of the overall system,and reduce transient overvoltage when single or multiple converters are blocked.The results of this research can provide technical assistance in real world HC-UHVDC projects.Ali Aamir Li Qiao Chunyi Guo Atiq Ur Rehman Zhizhong Yang 2019CSEE Journal of Power and Energy Systems2019,5,2:9
14A high-surface-area silicoaluminophosphate material rich in Brnsted acid sites as a matrix in catalytic cracking显示文摘A transparent gel-like mesoporous silicoaluminophosphate material (SAP) with a Si/Al molar ratio of 20 was synthesized by hydrothermal method. The physicochemical features of SAP were characterized by XRD, XRF, BET, SEM and FT-IR spectroscopy of pyridine adsorption techniques. The results indicated that incorporation of phosphorus (P) into aluminasilica system altered the basic textural characteristics of aluminasilica. Especially after hydrothermal treatment, the material with large special surface area (up to 492 m 2 /g) exhibited a good performance on hydrothermal stability. Moreover, the phosphorus modifier can not only increase the amount of Bro¨nsted acidic sites (up to 48.44 μmol/g) and the percentage of weak acidic sites in total acidic sites, but also regulate the acid type, such as the ratio of B/L (Bro¨nsted acid/Lewis acid) increases to 1.15. The performances of samples as matrices for the catalytic cracking of heavy vacuum gas oil (VGO) were investigated. At 520 C, the catalysts showed much higher gasoline and diesel oil yields achieving to 45.59 wt% and 19.20 wt%, respectively, and lower coke selectivity (2.86%) than conventional FCC matrices, such as kaolin and amorphous silica-alumina.Shaoiun Xu Qiang Zhang Zhaoxuan Feng Xiaojing Meng Tongyu Zhao Chunyi Li Chaohe Yang Honghong Shan 2012Journal of Natural Gas Chemistry2012,21,6:8
15Numerical simulation of topography effects on the “00.7” severe rainfall in Beijing显示文摘In an effort to study the severe rainfall event of 4—5th July 2000 in Beijing (with 24h accumulated precipitation of 240 mm), we perform numerical simulations to investigate this event using the MM5v3.6 model. The model is initialized with the MM5/WRF 3DVAR analysis, which incorporates the ground-based GPS precipitable water vapor, automatic and conventional meteorological observations in its assimilation step. For 24 h accumulated precipitation forecast, the threat scores are 0.72, 0.76, 0.67 and 0.63, for thresholds of 1, 5, 10, and 20 mm, respectively. Holding other factors unchanged, sensitivity experiments were conducted with different topographic resolutions of 110, 50 and 3.7 km to investigate the topographic effects on precipitation over the Beijing area. In these sensitivity experiments, we attempt to preserve the realistic orographic distribution in the model topography under the condition of keeping the dynamic-thermodynamic consistency of the initial model atmosphere to the extent possible. Results indicate that the unique topographic distribution and variations in the Beijing area play an important role in determining the location, distribution and intensity of heavy precipitation.ZHANG Chaolin JI Chongping KUO Yinghwa FAN Shuiyong XUAN Chunyi CHEN Min 2005Progress in Natural Science:Materials International2005,15,9:8
16SEMI-ACTIVE CONTROL OF VEHICLE SUSPENSION WITH MAGNETO-RHEOLOGICAL DAMPERS:PART Ⅰ——CONTROLLER SYNTHESIS AND EVALUATION显示文摘A modified skyhook-based semi-active controller is proposed for implementing an asymmetric control suspension design with symmetric magneto-rheological (MR) dampers. The controller is formulated in current form,which is modulated by integrating a continuous modulation and an asymmetric damping force generation algorithms,so as to effectively minimize switching and hysteretic effects from the MR-damper. The proposed controller is implemented with a quarter-vehicle MR-suspension model,and its relative response characteristics are thus evaluated in terms of defined performance measures under varying amplitude harmonic,rounded pulse and random excitations. The sensitivity of the semi-active suspension performance to variations in controller parameters is thoroughly evaluated. The results illustrate that the proposed skyhook-based asymmetric semi-active MR-suspension controller has superior robustness on the system parameter variations,and can achieve desirable multi-objective suspension performance.WANG Enrong YING Liang WANG Wanjun RAKHEJASubhash SU Chunyi 2008Chinese Journal of Mechanical Engineering2008,21,1:8
17Changes of Accumulated Temperature, Growing Season and Precipitation in the North China Plain from 1961 to 2009显示文摘Using the high-quality observed meteorological data, changes of the thermal conditions and precipitation over the North China Plain from 1961 to 2009 were examined. Trends of accumulated temperature and negative temperature, growing season duration, as well as seasonal and annual rainfalls at 48 stations were analyzed. The results show that the accumulated temperature increased significantly by 348.5℃ day due to global warming during 1961-2009 while the absolute accumulated negative temperature decreased apparently by 175.3℃ day. The start of growing season displayed a significant negative trend of -14.3 days during 1961- 2009, but the end of growing season delayed insignificantly by 6.7 days. As a result, the length of growing season increased by 21.0 days. The annual and autumn rainfalls decreased slightly while summer rainfall and summer rainy days decreased significantly. In contrast, spring rainfall increased slightly without significant trends. All the results indicate that the thermal conditions were improved to benefit the crop growth over the North China Plain during 1961-2009, and the decreasing annual and summer rainfalls had no direct negative impact on the crop growth. But the decreasing summer rainfall was likely to influence the water resources in North China, especially the underground water, reservoir water, as well as river runoff, which would have influenced the irrigation of agriculture.SONG Yanling ZHAO Yanxia WANG Chunyi 2011Acta meteorologica Sinica2011,25,4:8
18Recent Progress of MXene-Based Nanomaterials in Flexible Energy Storage and Electronic Devices显示文摘The increasing demands for wearable electronics have stimulated the rapid development of flexible energy storage devices.MXenes are considered as promising flexible electrodes due to the ultrahigh volumetric specific capacitance,metallic conductivity,superior hydrophily,and rich surface chemistry.Qi Yang Yukun Wang Xinliang Li Hongfei Li Zifeng Wang Zijie Tang Longtao Ma Funian Mo Chunyi Zhi 2018Energy & Environmental Materials2018,1,4:8
19One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang 2020Nano-Micro Letters2020,12,10:8
20Nested-loop Mechanism Based Modular Multilevel Converter Topology and Optimal Design显示文摘普通模块化多电平换流器(modular multilevelconverter,MMC)拓扑中,因子模块数量较多,系统需采集和处理的信息量大,导致控制系统硬件构成复杂。提出一种基于循环嵌套机理的MMC拓扑,其电平输出能力得到显著提升。通过上下两组子模块的协调投切,相对于普通MMC拓扑,新型拓扑输出相同电平数所需的子模块及控制设备数量大幅减少。阐述该新型拓扑的构成方式及基本参数选取原则;针对循环嵌套结构,设计相应的模块协调控制策略;分别以模块用量最小化和换流器运行损耗最小化为目标,优化设计拓扑构成方案。在RTDS中搭建换流器模型,仿真结果表明,新型拓扑具备更强的电平输出能力,并达到大幅减少子模块数量、简化控制系统硬件构成的目标。LIU Xinghua ZHAO Chengyong PENG Maolan GUO Chunyi ZHANG Baoshun 2013中国电机工程学报2013,33,9:7
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