|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metal exposure and Alzheimer's pathogenesis.显示文摘 | Liu G Huang W Moir RD Vanderburg CR Lai B Peng Z Tanzi RE Rogers JT Huang X | 2006 | 中国生物学文摘2006，20，9： | 8 |
| 2 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 3 | Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter?显示文摘Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people worldwide.It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication.The ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic distribution.Genotypes A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and Alaska.This review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their subgenotypes.The lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely uncertain.It is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations. | Gianguglielmo Zehender Erika Ebranati Elena Gabanelli Chiara Sorrentino Alessra Lo Presti Elisabetta Tanzi Massimo Ciccozzi Massimo Galli | 2014 | World Journal of Gastroenterology2014，20，24： | 3 |
| 4 | Update on vascular endothelial Ca^(2+) signalling:A tale of ion channels,pumps and transporters显示文摘A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a multifunctional transducing organ that mediates a plethora of cardiovascular processes. The activation of ECs from as state of quiescence is, therefore, regarded among the early events leading to the onset and progression of potentially lethal diseases, such as hypertension, myocardial infarction, brain stroke, and tumor. Intracellular Ca2+ signals have long been know to play a central role in the complex network of signaling pathways regulating the endothelial functions. Notably, recent work has outlined how any change in the pattern of expression of endothelial channels, transporters and pumps involved in the modulation of intracellular Ca2+ levels may dramatically affect whole body homeostasis. Vascular ECs may react to both mechanical and chemical stimuli by generating a variety of intracellular Ca2+ signals, ranging from brief, localized Ca2+ pulses to prolonged Ca2+ oscillations engulfing the whole cytoplasm. The well-defined spatiotemporal profile of the subcellular Ca2+ signals elicited in ECs by specific extracellular inputs depends on the interaction between Ca2+ releasing channels, which arelocated both on the plasma membrane and in a number of intracellular organelles, and Ca2+ removing systems. The present article aims to summarize both the past and recent literature in the field to provide a clear-cut picture of our current knowledge on the molecular nature and the role played by the components of the Ca2+ machinery in vascular ECs under both physiological and pathological conditions. | Francesco Moccia Roberto Berra-Romani Franco Tanzi | 2012 | World Journal of Biological Chemistry2012，3，7： | 2 |
| 5 | Genetics of aging显示文摘 | Finch CE Tanzi RE | 1997 | Science1997，278，5337： | 1 |
| 6 | Side effects and complications of fractional laser photothermolysis: experience with 961 treatments显示文摘 | Graber EM Tanzi EL Alster TS | 2008 | Dermatol Surg2008，34，3： | 1 |
| 7 | The synaptic Abeta hypothesis of Alzheimer disease显示文摘 | Tanzi RE | 2005 | Nat Neurosci2005，8，8： | 1 |
| 8 | Preclinical predictionof AD using neuropsychological tests显示文摘 | Albert MS Moss MB Tanzi R | 2001 | J Int NeuropsycholSoc2001，7，： | 1 |
| 9 | Side effects and complications of variable-pulsed erbium: yttrium-aluminum-garnet laser laser skin resurfacing: extended experience with 50 patients 显示文摘 | Tanzi E Alster T | 2003 | Plast Reconstr Surg2003，111，： | 1 |
| 10 | Side effects and complications of fractional lriser photothermolysis:experience with 961 treatments 显示文摘 | Graber EM Tanzi EL Alster TS | 2008 | Dermatol Surg2008，34，3： | 1 |
| 11 | A prospective study on mother-to-infant transmission of hepatitis C virus显示文摘 | Zanetti AR Tanzi E Roman6 L | 1998 | Intervirology1998，41，45： | 1 |
| 12 | New frontiers in Alzheimer' s disease genetics 显示文摘 | Tanzi RE Bertram L | 2001 | Neuron2001，32，2： | 1 |
| 13 | Alzhei mer's disease andpostoperative cognitive dysfunction显示文摘 | Xie ZC Rudolph E Tanzi | 2006 | Exp Gerontol2006，41，2： | 1 |
| 14 | Determination of biogenic amines in fresh and processed meat by suppressed ion chromatography-mass spectrometry using a cation-exchange column显示文摘 | Saccani G Tanzi E Pastore P | | 0，，01： | 1 |
| 15 | Photopneumatic therapy for the treatment of acne显示文摘 | Wanitphakdeedecha R Tanzi EL Alster TS | 2009 | J Drugs Dermatol2009，8，3： | 1 |
| 16 | Alzheimer's disease and post-operative cognitive dysfunction显示文摘 | Xie Z Tanzi RE | 2006 | Exp Geronto2006，41，4： | 1 |
| 17 | Clearance of Alzheimer's Abeta peptide : the many roads to perdition 显示文摘 | TANZI R E MOIR R D WAGNER S L | 2004 | Neuron2004，43，5： | 1 |
| 18 | Medication noncompliance after kidney transplantation显示文摘 | Vasquez EM Tanzi M Benedetti E | 2003 | Am J Health-syst Pharm2003，60，： | 1 |
| 19 | Alzheimer' s disease:genetic studies and transgenic models 显示文摘 | Price DL Tanzi RE Borchelt DR | 1998 | Ann Rev Genet1998，32，5： | 1 |
| 20 | A genetic linkage map of human chromosome 21:analysis of recombination as a function of sex and age显示文摘 | Tanzi RE Watkins PC Stewart GD | 1992 | Am J Hum Genet1992，50，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员