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| 1 | 抗氧化剂一、二级预防随机试验中的死亡率系统回顾及汇总分析显示文摘背景:抗氧化剂正用于多种疾病的预防。
目的:评估补充抗氧化剂对一、二级预防随机临床试验参试者死亡率的影响。数据来源及试验选择:检索2005年10月前的电子数据库以及发表的文献目录。所有于成人中进行的、比较单独或联合使用β胡萝卜素、维生素A、维生素C(抗坏血酸)、维生素E及硒剂的安慰剂或空白治疗对照随机试验均纳入分析。使用随机、盲法及随访作为评估入选试验偏倚的指标。采用随机效应分析法分析抗氧化剂对全因死亡率的影响,结果以相对危险度(relative risk,RR)及其95%可信区间(confidence interval,CI)表示。采用汇总回归评估试验协变量的影响。
数据提取:共入选68项随即试验,包括232606例参试者(385篇文章)。
数据整合:将所有低和高偏倚风险抗氧化剂试验汇总后发现,抗氧化剂对死亡率无显著影响(RR,1.02;95%CI,0.98~1.06)。多变量汇总回归分析表明,低偏倚风险试验(RR,1.16;95%CI,1.05~1.29)和硒剂(RR,0.998;95%CI,0.997~0.9995)与死亡率显著相关。在包括180938例参试者在内的47项低偏倚试验中,补充抗氧化剂显著增加死亡率(RR,1.05;95%CI,1.02~1.08)。排除硒剂试验后,在低偏倚风险试验中,β胡萝卜素(RR,1.07;95%CI,1.02~1,11)、维生素A(RR,1.16;95%CI,1.10~1.24)以及维生素E(RR,1.04;95%CI,1.01~1.07)单独或联合使用均显著增加死亡率。维生素C及硒剂对死亡率无显著影响。
结论:β胡萝卜素、维生素A及维生素E治疗可能增加死亡率。维生素C和硒剂对死亡率的影响需要进一步研究。 | Goran Bjelakovic Dimitrinka Nikolova Lise Lotte Gluud Rose G. Simonetti Christian Gluud 顾佳(译) | 2007 | 美国医学会杂志(中文版)2007，26，5： | 35 |
| 2 | Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres transcatheter arterial chemo-embolization显示文摘AIM: To evaluate the downstaging rates in hepatitis C virus-patients with hepatocellular carcinoma(HCC), treated with degradable starch microspheres transcatheter arterial chemoembolization(DSM-TACE), to reach new-Milan-criteria(nM C) for transplantation. METHODS: This study was approved by the Ethics Committee of our institution. From September 2013 to March 2014 eight patients(5 men and 3 women) with liver cirrhosis and multinodular HCC, that did not meet n MC at baseline, were enrolled in this study. Patients who received any other type of treatment such as termal ablation or percutaneous ethanol injection were excluded. DSM-TACE was performed in all patients using Embo Cept? S and doxorubicin. Baseline and follow-up computed tomography or magnetic resonance imaging was assessed measuring the longest enhancing axial dimension of each tumor according to the modified Response Evaluation Criteria In Solid Tumors measure-ments, and medical records were reviewed.RESULTS: DSM-TACE was successfully performed in all patients without major complication. We treated 35 lesions(mean 4.3 per patient). Six of eight patients(75%) had their HCC downstaged to meet nM C. Every patient whose disease was downstaged eventually underwent transplantation. The six patients who received transplant were still living at the time of this writing, without recurrence of HCC. Baseline age(P = 0.25), Model for End-stage Liver Disease score(P = 0. 77), and α-fetoprotein level(P = 1.00) were similar between patients with and without downstaged HCC. CONCLUSION: DSM-TACE represents a safely and effective treatment option with similar safety and efficacy of conventional chemoembolization and could be successfully performed also for downstaging disease in patients without n MC, allowing them to reach liver transplantation. | Antonio Orlacchio Fabrizio Chegai Stefano Merolla Simona Francioso Costantino Del Giudice Mario Angelico Giuseppe Tisone Giovanni Simonetti | 2015 | World Journal of Hepatology2015，7，12： | 23 |
| 3 | Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease显示文摘AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold standard.METHODS:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively enrolled.All patients were under follow-up.The study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed consent.SICUS and CTE were performed ≤ 3 mo before surgery,followed by surgical pathology.The following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel dilation.Comparison between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold standard.RESULTS:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal tube.The analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients enrolled.Differently from CTE,SICUS was feasible in all the 15 patients enrolled.No complications were observed when using SICUS or CTE.Surgical pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 patients.In order to compare findings by using SICUS,CTE,histology and surgery,characteristics of the small bowel lesions observed in CD each patient were blindly reported in the same form by one gastroenterologistsonologist,radiologist,surgeon and anatomopathologist.At surgery,lesions related to CD were detected in the distal ileum in all 13 patients,also visualized by both SICUS and CTE in all 13 patients.Ileal lesions > 10 cm length were detected at surgery in all the 13 CD patients,confirmed by SICUS and CTE in the same 12 out of the 13 patients.When using surgical findings as a gold standard,SICUS and CTE showed the exactly same sensitivity,specificity and accuracy for detecting the presence of small bowel fistulae(accuracy 77% for both) and abscesses(accuracy 85% for both).In the tested CD population,SICUS and CTE were also quite comparable in terms of accuracy for detecting the presence of small bowel strictures(92% vs 100%),small bowel fistulae(77% for both) and small bowel dilation(85% vs 82%).CONCLUSION:In our study population,CTE and the non-invasive and radiation-free SICUS showed a comparable high accuracy for assessing small bowel lesions in CD. | Sara Onali Emma Calabrese Carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri Giovanni Simonetti Francesco Pallone Livia Biancone | 2012 | World Journal of Gastroenterology2012，18，42： | 5 |
| 4 | Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials显示文摘 | R. G. Simonetti A. Liberati C. Angiolini L. Pagliaro | 1997 | Annals of Oncology1997，，2： | 3 |
| 5 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 6 | Mineral Chemistry of Melanite from Calcitic Ijolite, the Oka Carbonatite Complex, Canada: Implications for Multi-Pulse Magma Mixing显示文摘Ti-rich garnet is found within calcitic ijolite from the Oka carbonatite complex in Canada, which is characterized by 58%–73% andradite component(2.12 wt.%–4.18 wt.% TiO_2) and classified as melanite. The garnet displays complex zoning and contains abundant high field strength elements(HFSEs) and rare earth elements(REEs). Three groups(Ⅰ, Ⅱ, Ⅲ) have been identified based on their petrographic nature. Compared to groups Ⅱ and Ⅲ, Group Ⅰ garnet cores contain higher TiO_2, Mg O, HFSE, and REE and lower SiO_2 abundances. The distinct chemical and petrographic signatures of the investigated garnets cannot be attributed to simple closed system crystallization, but they are consistent with the multi-pulse magma mixing. Combined with previously reported U-Pb ages for apatite from the calcitic ijolite, at least three stages of magma evolution and subsequent mixing have been involved in the generation of calcitic ijolite at Oka. The early-formed melt that generated Group I garnet core was later mixed with at least two small-volume, more evolved melts. The intermediate stage melt formed the remaining garnet along with some pyroxene, calcite, nepheline, and apatite at 127±3.6 Ma. The youngest, most evolved melt generated the majority of pyroxene, calcite, nepheline, and apatite within the calcitic ijolite at 115±3.1 Ma. | Wei Chen Weiqi Zhang Antonio Simonetti Shaoyong Jiang | 2016 | Journal of Earth Science2016，27，4： | 2 |
| 7 | Minimally invasive oxygen-ozone therapy for lumbar disk herniation显示文摘 | Andreula CF Simonetti L De Santis F | | 0，，： | 1 |
| 8 | Volatile compound and organic acid productions by mixed wheat sour dough starters: influence of fermentation parameters and dynamics during baking显示文摘 | GOBBETTI M SIMONETTI M S CORSETTI A | 1995 | Food Microbiology1995，，12： | 1 |
| 9 | Mechanism of pain in disc disease显示文摘 | Simonetti L Agati R Cenni P | 2001 | Riv Neuroradiol2001，14，： | 1 |
| 10 | Procyanidins from vitis vinifera seeds:in vivo effects on oxidative stress显示文摘 | Simonetti P Ciappellano S Gardana C | 2002 | J Agric Food Chem2002，50，21： | 1 |
| 11 | The variation of the reflection coefficient of extensional guided waves in pipes from defects as a function of defect depth,axial extent,circumferential extent and frequency显示文摘 | Cawley P Lowe M Simonetti F | 2002 | Journal of Mechanical Engineering Science2002，216，11： | 1 |
| 12 | Neurophysiological and ultrasound findings in sural nerve lesions following stripping of the small saphenous vein显示文摘 | SIMONETTI S BIANCHI S MARTINOLI C | 1999 | Muscle Nerve1999，22，12： | 1 |
| 13 | Cine MR angiography of the heart with segmented true fast imaging with steady state precession显示文摘 | Carr JC Simonetti O Bundy J | 2001 | Radiology2001，219，3： | 1 |
| 14 | Minimally invasive oxygen-ozone therapy for lumbar disk herniation 显示文摘 | Andreula C F Simonetti L De Santis F | 2003 | AJNR Am J Neuroradiol2003，24，5： | 1 |
| 15 | Minimally invasive oxygen-ozone therapy for Iumbar disk herniation显示文摘 | Andreula CF Simonetti L De-Santis F ct al | 2003 | AJNR Am J Neuroradiol2003，24，5： | 1 |
| 16 | Bone augmentation with bioactive glass in three cases of dental implant placement 显示文摘 | Gatti AM Simonetti LA Monari E | 2006 | J Biomater2006，20，4： | 1 |
| 17 | Mechanisms mediating the enhanced gene transcription of P2X3receptor by calcitonin gene-related peptide in trigeminal sensory neurons显示文摘 | Simonetti M Giniatullin R Fabbretti E | 2008 | J Biol Chem2008，283，18： | 1 |
| 18 | Immunological' s host profile for HPV and Chlamydia trachomatis, a cervical cancer cofactor 显示文摘 | Simonetti AC Melo JH de Souza PR | 2009 | Microbes Infect2009，11，4： | 1 |
| 19 | Macrocephaly in neurofibromatosis type 1:a sign post for optic pathway gliomas显示文摘 | Schindera C Wingeier K Goeggel Simonetti B | | 0，，12： | 1 |
| 20 | Clinical Performance of fiber post restorations in endodontically treated teeth:2-year results显示文摘 | Cagidiaco MC Radovic I Simonetti M | | 0，，03： | 1 |
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