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34篇 您的检索式:作者名="Cheng Jingyi"
    题名 作者 年代 出处 被引量
1Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue显示文摘Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes,fatty liver and cardiovascular diseases.The lipid droplet(LD)is an important subcellular organelle responsible for lipid storage.We previously observed that Fsp27,a member of the CIDE family proteins,is localized to LD-contact sites and promotes atypical LD fusion and growth.Cidea,a close homolog of Fsp27,is expressed at high levels in brown adipose tissue.However,the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains unknown.Here,we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and growth.Next,we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean phenotype.In addition,Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to cold.Furthermore,we observed that the brown and white adipose tissues of Cidea/Fsp27double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27single deficient mice.Overall,these data reveal an important role of Cidea in controlling lipid droplet fusion,lipid storage in brown and white adipose tissue,and the development of obesity.WU LiZhen ZHOU LinKang CHEN Cheng GONG JingYi XU Li YE Jing LI De LI Peng 2014Science China(Life Sciences)2014,57,1:11
2The construction of a genetic linkage map of non-heading Chinese cabbage (Brassica campestris ssp.chinensis Makino)显示文摘Non-heading Chinese cabbage(Brassica campestris ssp.chinensis Makino) is one of the most important vegetables in eastern China.A genetic linkage map was constructed using 127 doubled haploid(DH) lines,and the DH population was derived from a commercial hybrid 'Hanxiao'(lines SW-13 × L-118).Out of the 614 polymorphic markers,43.49% were not assigned to any of the linkage groups(LGs).Chi-square tests showed that 42.67% markers were distorted from expected Mendelian segregation ratios,and the direction of distorted segregation was mainly toward the paternal parent L-118.After sequentially removing the markers that had an interval distance smaller than 1 cM from the upper marker,the overall quality of the linkage map was increased.Two hundred and sixty-eight molecular markers were mapped into 10 LGs,which were anchored to the corresponding chromosome of the B.rapa reference map based on common simple sequence repeat(SSR) markers.The map covers 973.38 cM of the genome and the average interval distance between markers was 3.63 cM.The number of markers on each LG ranged from 18(R08) to 64(R07),with an average interval distance within a single LG from 1.70 cM(R07) to 6.71 cM(R06).Among these mapped markers,169 were sequence-related amplified polymorphism(SRAP) mo-lecular markers,50 were SSR markers and 49 were random amplification polymorphic DNA(RAPD) markers.With further saturation to the LG,the current map offers a genetic tool for loci analysis for important agronomic traits.Yan Cheng Jianfeng Geng Jingyi Zhang Qian Wang Qingyu Ban Xilin Hou 2009Journal of Genetics and Genomics2009,36,8:9
3Effects of RapidEye Imagery's Red-edge Band and Vegetation Indices on Land Cover Classification in an Arid Region显示文摘Land cover classification(LCC) in arid regions is of great significance to the assessment, prediction, and management of land desertification. Some studies have shown that the red-edge band of RapidE ye images was effective for vegetation identification and could improve LCC accuracy. However, there has been no investigation of the effects of RapidE ye images' red-edge band and vegetation indices on LCC in arid regions where there are spectrally similar land covers mixed with very high or low vegetation coverage information and bare land. This study focused on a typical inland arid desert region located in Dunhuang Basin of northwestern China. First, five feature sets including or excluding the red-edge band and vegetation indices were constructed. Then, a land cover classification system involving plant communities was developed. Finally, random forest algorithm-based models with different feature sets were utilized for LCC. The conclusions drawn were as follows: 1) the red-edge band showed slight contribution to LCC accuracy; 2) vegetation indices had a significant positive effect on LCC; 3) simultaneous addition of the red-edge band and vegetation indices achieved a significant overall accuracy improvement(3.46% from 86.67%). In general, vegetation indices had larger effect than the red-edge band, and simultaneous addition of them significantly increased the accuracy of LCC in arid regions.LI Xianju CHEN Gang LIU Jingyi CHEN Weitao CHENG Xinwen LIAO Yiwei 2017Chinese Geographical Science2017,27,5:8
4Automation in U.S. longwall coal mining: A state-of-the-art review显示文摘This paper reviews the development of U.S. longwall mining from an unknown to became the world standard in the past five decades with emphasis on automation. Large scale longwall face equipment were imported from Germany and United Kingdom to increase production in the 1970 s and great effort was made to improve them to suit U.S. conditions, rather than domestic market. Automation began with the development of electrohydraulic shields in 1984 and continue to present. Introduction of first generation semi-automated longwall system occurred in 1995 and step-to-step improvement continues to present following the development of sensor technology and internet of things(IOT). Since then, emphasis on new development has been concentrated on the improvement of equipment reliability, miner's health and safety as well as production, including dust control techniques, proximity sensor, anti-collision and remote control. Automation is classified into two categories: automation of individual face equipment and automation of longwall system. The automation development of longwall system is divided into three stages: shearer-initiated-shield-advance(SISA), semi-automated longwall system, and remote control shearer.Syd S.Peng Feng Du Jingyi Cheng Yang Li 2019International Journal of Mining Science and Technology2019,29,2:7
5Underground ground control monitoring and interpretation,and numerical modeling, and shield capacity design显示文摘Mine or longwall panel layout is a 3D structure with highly non-uniform stress distribution. Recognition of such fact will facilitate underground problem identification/investigation and solving by numerical modeling through proper model construction. Due to its versatility, numerical modeling is the most popular method for ground control design and problem solving. However numerical modeling results require highly experienced professionals to interpret its validity/applicability to actual mining operations due to complicated mining and geological conditions. Underground ground control monitoring is routinely performed to predict roof behavior such as weighting and weighting interval without matching observation of face mining condition while the mining pressures are being monitored, resulting in unrealistic interpretation of the obtained data on mining pressure. The importance of ground control pressure monitoring and simultaneous observation of mining and geological conditions is illustrated by an example of shield leg pressure monitoring and interpretation in an U.S. longwall coal mine: it was found that the roof strata act like a plate, not an individual block of the size of a shield dimension, as commonly assumed by all researchers and shield capacity is not a fixed property for a longwall panel or a mine or a coal seam. A new mechanism on the interaction between shield's hydraulic leg pressure and roof strata for shield loading is proposed.Syd S.Peng Jingyi Cheng Feng Du Yuting Xue 2019International Journal of Mining Science and Technology2019,29,1:7
6Oxidation Behavior of C/C-SiC Gradient Matrix Composites显示文摘Oxidation behavior of C/C-SiC gradient matrix composites and C/C composites were compared in stationary air. The results show that oxidation threshold of C-SiC materials increases with the amount of SiC particles in the codeposition matrix. Oxidation rate of C/C-SiC gradient matrix composites is significantly lower than that of C/C material. The micro-oxidation process was observed by SEM.Jingyi DENG, Wenchuan LIU, Haifeng DU, Huiming CHENG and Yiyi LI Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China 2001Journal of Materials Science & Technology2001,17,5:6
7What can the changes in shield resistance tell us during the period of shearer's cutting and neighboring shields' advance?显示文摘In order to determine the influence of shearer's cutting and neighboring shields' advance on the support resistance variation, leg pressure data of all 235 shields in the panel LW61 of Cumberland coal mine were analyzed. The results show that the relationship between the leg pressure increment and the distance from shield to front drum of shearer is a quadratic function and that the higher leg pressure increment before shield advance tends to be related to adverse roof conditions. In addition, the three proposed leg pressure increment-related parameters and the three traditional parameters(time-weighted average pressure, setting pressure, and final pressure) of approximately 32000 shield supporting cycles were calculated by a self-developed software package to analyze the correlation between them. The results show that there is a powerful connection between them, and that the three proposed leg pressure increment-related parameters could be used as the indexes to evaluate the interaction between shields and the roof, and to identify the periodic weighting.Cheng Jingyi Wan Zhijun Peng Syd S. Liu Sifei Ji Yinlin 2015International Journal of Mining Science and Technology2015,25,3:5
8Abutment pressure distribution for longwall face mining through abandoned roadways显示文摘Abutment pressure distribution is different when a longwall panel is passing through the abandoned gate roads in a damaged coal seam. According to the geological condition of panel E13103 in Cuijiazhai Coal Mine in China, theoretical analysis and finite element numerical simulation were used to determine the front pressure distribution characteristics when the longwall face is 70, 50, 30, 20, 10, and 5 m from the abandoned roadways. The research results show that the influence range of abutment pressure is 40 to 45 m outby the face, and the peak value of front abutment pressure is related to the distance between the face and abandoned roadways. When the distance between the longwall face and abandoned roadways is reduced from 50 to 10 m, the front abutment pressure peak value kept increasing. When the distance is 10 m, it has reached the maximum. The peak value is located in 5 to 6 m outby the faceline. When the distance between the longwall face and abandoned roadways is reduced from 10 to 5 m, the front abutment pressure sharply decreases, the intact coal yields and is even in plastic state. The peak value transfers to the other side of the abandoned roadways. The research results provide a theoretical basis for determining the advance support distance of two roadways in the panel and the reinforcement for face stability when the longwall face is passing through the abandoned roadways.Yang Li Mingxing Lei Haosen Wang Cheng Li Weiwei Li Yang Tao Jingyi Wang 2019International Journal of Mining Science and Technology2019,29,1:4
9Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy显示文摘Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia(AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor(G-CSF)(low-dose chemotherapy(LDC)/G-CSF). Complete response(CR) after two induction courses was attained in 87.0%(40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy(SDC) for induction(80/94(85.1%) of the patients attained CR after induction Ⅱ, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free(67.4 vs. 70.7%;P = 0.99)and overall(70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell(WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC(11.5 vs. 18.5 d for WBCs(P < 0.001);15.5 vs. 22.0 d for platelets(P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF(n = 9) or SDC(n = 11), all of the mutations were below the reference value(variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML.Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C. Ribeiro Shaoyan Hu Qian-fei Wang 2019National Science Review2019,6,3:3
10An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma显示文摘Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016.Clinical characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal cytology.Predictive factors were assessed with Cox univariate and multivariate analyses.Factors selected from multivariate analysis results were used to build a predictive model.Results:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study.Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium level.Multivariate analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium level.We also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery.Xingchen Li Yuan Cheng Yangyang Dong Boqiang Shen Xiao Yang Jiaqi Wang Jingyi Zhou Jianliu Wang 2019Chinese Journal of Cancer Research2019,31,6:3
11CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis显示文摘躲避 TGF -- 调停的生长抑制经常在肝与 tumorigenesis 被联系,包括 hepatocellular 癌(HCC ) 。更好在 HCC 开始和前进理解功能和 TGF- 的内在的分子的机制,我们执行了定序的 transcriptome (RNA-Seq ) 识别 TGF- 的目标基因。CXXC5, CXXC 类型锌手指的一个成员包含域的蛋白质家庭,在 Hep3B HCC 房间作为新奇 TGF- 目标基因被识别。稀释的 CXXC5 击倒 TGF- 目标基因和改善 TGF 的实质的部分的表示 -- 导致的生长抑制或 Hep3B 细胞的 apoptosis,建议那 CXXC5 为 TGF 被要求 -- HCC 的调停的抑制前进。TCGA 数据库的分析显示那 CXXC5 表情在正常纸巾与那相比在 HCC 织物样品的多数被减少。而且, CXXC5 与 histone deacetylase HDAC1 联系并且竞争它和 Smad2/3 的相互作用,从而在 TGF- 发信号上废除 HDAC1 的禁止的效果。这些观察一起建议 CXXC5 可以由支持经由一个积极反馈环发信号的 TGF- 充当肿瘤 suppressor,并且揭示策略让 HCC 绕过 TGF -- 由破坏积极反馈规定的调停的 cytostasis。我们的调查结果在表明规定的 TGF- 上打开新灯并且在 HCC 开发表明 CXXC5 的函数。Xiaohua Yan Jingyi Wu Quanlong Jiang Hao Cheng Jing-Dong J. Han Ye-Guang Chen 2018Journal of Molecular Cell Biology2018,10,1:3
12A novel Z-scheme CeO_(2)/g-C_(3)N_(4)heterojunction photocatalyst for degradation of Bisphenol A and hydrogen evolution and insight of the photocatalysis mechanism显示文摘CeO_(2)/g-C_(3)N_(4)heterojunction photocatalyst had been successfully fabricated through a one-step in-situ pyrolysis formation of 3D hollow CeO_(2)mesoporous nanospheres and 2D g-C_(3)N_(4)nanosheets together with simultaneous removal of carbon sphere templates after heat treatment.The sample shows high catalytic performances for photocatalytic hydrogen generation and photocatalytic oxidation of Bisphenol A(BPA)under visible light irradiation,and the catalytic degradation route of BPA was suggested by the degradation products determined by GC-MS.The enhancing catalytic activity was attributed to the effective interfacial charge migration and separation.Finally,it was proposed that the CeO_(2)/g-C_(3)N_(4)heterojunction photocatalyst could follow a more appropriate Z-scheme charge transfer mechanism,which was confirmed by the analysis of experiment and theoretical calculation results.Wei Zhao Tiantian She Jingyi Zhang Guoxiang Wang Sujuan Zhang Wei Wei Gang Yang Lili Zhang Dehua Xia Zhipeng Cheng Haibao Huang Dennis Y.C.Leung 2021Journal of Materials Science & Technology2021,,26:3
13The Helicobacter pylori Protein CagM is Located in the Transmembrane Channel That is Required for CagA Translocation显示文摘Feng Ling Xiaochun Wang DongFang Dai Min Yu Cheng Chen Jingyi Qian Chang Liu Yuanyuan Zhang Jie Ding Xian Wei Guan Shihe Shao 2013Current Microbiology2013,,5:2
14Reconsideration of the taxonomy of the marine ciliate Neobakuella aenigmatica Moon et al.,2019(Protozoa,Ciliophora,Hypotrichia)显示文摘The morphology and divisional morphogenesis in a Chinese population of Neobakuella aenigmatica Moon et al.,2019 are reinvestigated.The body size,number and arrangement of parabuccal cirri and development of nuclear nodules in this population are discussed in comparison with closely related genera.The 18S rRNA gene sequence of the Chinese population is identical to that of a Korean population,supporting a distant relationship between N.aenigmatica and the cluster of N.flava and Apobakuella fuse a.We deduce that this may be caused by the differences in the pattern of the parabuccal cirri and the number of parabuccal rows which are important for the phylogeny of Bakuella-like,species.Tengyue Zhang Jingyi Dong Ting Cheng Lili Duan Chen Shao 2020Marine Life Science & Technology2020,2,2:1
15Research on power-supply cost of regional power system under carbon-peak target显示文摘With the establishment of the carbon-peak target by 2030,the direction of carbon emission reduction in China’s energy system has been further clarified.As the industry with the largest proportion of carbon emissions in China,the lowcarbon transformation of the electric power industry is critical to realize the carbon-peak target.Current research mostly focuses on technical analysis or system cost accounting of the carbon-peak realization path at the national level.There is a lack of targeted research on regional power systems with complex inter-regional power flow exchange and limited energy resource development.Simultaneously,the calculation of the system cost lacks the perspective of the life cycle and ignores the inertia of the stock and change inertia of incremental disturbance.From the perspective of the life cycle,this study proposes a calculation model of power supply cost for regional power systems according to the carbon-peak target,analyzes the realization path of the carbon target from an economic perspective,and provides references for the path selection and policy formulation of system transformation.Jingyi Wang Min Cang Xiaomeng Zhai Shuang Wu Xi Cheng Lei Zhu 2022Global Energy Interconnection2022,5,1:1
16Feasibility of sentinel lymph node biopsy omission after integration of ^(18)F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial显示文摘Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast cancer.The present study aimed to evaluate the negative predictive value(NPV)of 18F-FDG dedicated lymph node positron emission tomography(LymphPET)in cN0 patients.Methods:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by SLNB.In the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET.Here,we report the results of the first stage.The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports.Forty patients had LN-macro,and 16 patients had only lymph node micrometastasis.Of the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET.Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang Feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao 2022Cancer Biology & Medicine2022,19,7:1
17Source apportionment of PM 2.5 nitrate and sulfate in China using a source-oriented chemical transport model显示文摘Hongliang Zhang Jingyi Li Qi Ying Jian Zhen Yu Dui Wu Yuan Cheng Kebin He Jingkun Jiang 2012Atmospheric Environment2012,,:1
18Unravelling the critical role of surface Nafion adsorption in Ptcatalyzed oxygen reduction reaction by in situ electrical transport spectroscopy显示文摘Solid-state ionic conductor is a vital part in all electrochemical energy conversion devices. As a widely-applied protonconducting polymer and stabilizer for electrode preparation, Nafion has key applications in electrochemical devices operated under acidic conditions. Specific adsorption of Nafion on the catalyst surface is considered to result in partial loss of intrinsic activity in reactions such as oxygen reduction reaction(ORR), due to its comprehensive occupation of active sites. Many in situ characterization methods such as voltammetric fingerprinting and spectroscopic approaches have been used to explore the dynamic adsorption of Nafion on the electrode surface. However, most of current efforts have been focused on the behaviors of Nafion itself, with little attention paid to its effects on the adsorption of surface intermediates. Here, we employed the in situ electrical transport spectroscopy(ETS) to investigate Nafion adsorption on Pt catalysts and its effects on the ORR intermediates.Our findings suggest that specific adsorption of Nafion results in the increased coverage of oxygen intermediates with weaker adsorption strength, which in turn plays a critical role in the reaction selectivity. The successful application of ETS on the dynamic characterization of reaction intermediates provides a novel perspective for catalyst design in ORR-related applications in future sustainable chemistry.Yamei Sun Jingyi Tian Zhangyan Mu Bailin Tian Qiulan Zhou Cheng Liu Shengtang Liu Qiang Wu Mengning Ding 2022Science China Chemistry2022,65,11:1
19Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer.Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen 2022Science China(Life Sciences)2022,65,1:1
20The SU- Vmax(maximum standardized uptake value for F-18 fluo- rodeoxyglucose) and serum squamous cell carcinoma anti- gen(SCC-ag) function as prognostic biomarkers in patients with primary cervical cancer显示文摘Lingling Pan Jingyi Cheng Min Zhou 2012Journal of Cancer Research and Clinical Oncology2012,,2:1
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