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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Gene Expression Profiling in Apoptotic K562 Cells Treated by Homoharringtonine显示文摘基因薄片技术被用来在 homoharringtonine 导致的 apoptotic K562 房间决定基因表达侧面。mRNAs 被发现显著地被换掉的 44 的表达式在与能够同时检测 14,218 不同人的 mRNA 种类的一块基因芯片屏蔽以后被识别。这些基因, 17 是起来调整的, 27 是下面调整的。他们中的大多数被发现与 apoptosis, oncogenes,或肿瘤抑制有关。有改变的基因表达的几基因,例如人的转变生长因素贝它可诱导的早蛋白质基因( TIEG ),在调整蛋白质上面的 维生素 D3 1 基因( VDUP1 ), RNA 有约束力的主题蛋白质 4 基因( RBM4 )和 v-myc myelocytomatosis 病毒的癌基因相当或相同的事物( C-MYC ),被RNA 印迹分析证实。根据在这些 apoptotic 房间的动态基因表达模式,激活的转变生长因素贝它和肿瘤坏死因素发信号小径在导致 homoharringtonine 的 apoptosis 起一个重要作用。TIEG 显著地在 apoptosis 正式就职以后被改变,它应该为 apoptosis 信号传播是批评的。 | Wei JINX Jiong WU Zhigang ZHUANG Junjie Li Fei FEI Genhong DI Ying CHEN Ming YAO Zhimin SHAO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 3 | Treatment patterns for adjuvant docetaxel-based chemotherapy in early-stage breast cancer in China:A pooled retrospective analysis of four observational studies显示文摘Objective:Adjuvant docetaxel-based chemotherapy is frequently used for operable early breast cancer(EBC).This study investigated patterns of use of docetaxel(T)in real-life clinical practice in China.Methods:This was a retrospective pooled analysis of the Asia-Pacific Breast Initiatives(APBI)Ⅰ(2006–2008)and Ⅱ(2009–2011)registries,and two Chinese observational studies;BC STATE(2011–2014)and BC Local Registry(2007–2010).Female Chinese adults(≥18 years)with operable breast cancer treated with docetaxel-based adjuvant chemotherapy were included in the analysis.Patients with metastatic disease were excluded.The primary endpoint was assessment of treatment patterns and patient profiles.A logistic regression analysis was conducted to identify factors associated with choice of adjuvant chemotherapy regimen.Results:Data from 3,020 patients were included.The most frequently used adjuvant regimen was docetaxel/anthracycline combination[n=1,421(47.1%);of whom 52.0%received T/epirubicin(E)/cyclophosphamide(C)],followed by docetaxel/other[n=705(23.3%);of whom 72.8%received TC],docetaxel/anthracycline sequential[n=447(14.8%);of whom 40.9%and 39.6%received 5-Fu/EC-T and EC-T,respectively],and'other'[n=447(14.8%);of whom 91.5%received T].A significant association was found between adjuvant therapy with docetaxel/anthracycline combination and patient weight,menopausal status and estrogen receptor status.Conclusions:Real-world data revealed that docetaxel/anthracycline combination is the most commonly used category of docetaxel-based adjuvant therapy for patients with operable breast cancer in China;of which TEC is the most frequently used regimen. | Binghe Xu Zhimin Shao Shui Wang Zefei Jiang Xichun Hu Xiaohua Zhang Xiru Li Jinping Liu Mengquan Li Shu Wang | 2018 | Chinese Journal of Cancer Research2018，30，3： | 5 |
| 4 | Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:a TCGA pan-cancer analysis显示文摘Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the clini-cal significance of PGK1 expression and function in cancer progression is unclear.Here,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism regulation.Methods:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas datasets.Using specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer types.Results:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,respectively.In breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor prognosis.Positively correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal cancers.PGK1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach cancer.Conclusions:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of cancer.PGK1 and PDHK1 phosphorylation may be potential prognostic biomarkers. | Fei Shao Xueying Yang Wei Wang Juhong Wang Wei Guo Xiaoli Feng Susheng Shi Qi Xue Shugeng Gao Yibo Gao Zhimin Lu Jie He | 2019 | Cancer Communications2019，39，1： | 4 |
| 5 | Bioinformatics study indicates possible microRNA-regulated pathways in the differentiation of breast cancer显示文摘microRNAs (miRNAs) have been reported to be associated with the pathogenesis and progression of breast cancer.However,little is known about the pathways through which miRNAs regulate these processes,e.g.,the interaction between miRNAs and their target genes with regard to different pathological status of breast cancer,such as histological grades.This study investigated the possible roles of miRNAs in the differentiation of histological grades of breast cancer with a computational approach.Based on a microarray dataset,15 candidate miRNAs were identified,whose predicted target genes are enriched as differentially expressed between grade I and grade III breast tumors.Among them,9 key miRNAs focalize their target genes on 6 central signaling pathways.The SMAD7 protein,the main inhibitory protein in the TGF-β pathway,is predicted as a target of several miRNAs and is also regulated by several other pathways that are possibly targeted by miRNAs.It was hypothesized that miRNAs participate in the differentiation of breast cancer and the TGF-β pathway acts as a major implementary pathway on which several miRNAs take effect through multiple channels.The prediction power of the predicted miRNA target genes was validated on three independent datasets.The differential expression of three miRNAs was validated by real-time PCR on breast carcinoma samples of 10 patients. | PEI YunFei WANG ZhiMin FEI Fei SHAO ZhiMing HUANG Wei ZHANG XueGong | 2010 | Chinese Science Bulletin2010，55，10： | 2 |
| 6 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 7 | A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability显示文摘Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor progression.As a key glycolytic enzyme,hexokinase 2(HK2)plays an instrumental role in aerobic glycolysis and tumor progression.However,whether HK2 directly contribute to CSC stemness maintenance in small cell lung cancer(SCLC)is largely unclear.In this study,we aimed to investgate whether HK2 independent of its glycolytic activity is directly involved in stemness maintenance of CSC in SCLC.Methods:Immunoblotting analyses were conducted to determine the expression of HK2 in SCLC CSCs and their differentiated counterparts.CSC-like properties and tumorigenesis of SCLC cells with or without HK2 depletion or overexpression were examined by sphere formation assay and xenograft mouse model.Immunoprecipitation and mass spectrometry analyses were performed to identify the binding proteins of CD133.The expression levels of CD133-associated and CSC-relevant proteins were evaluated by immunoblotting,immunoprecipitation,immunofluorescence,and immunohistochemistry assay.RNA expression levels of Nanog,POU5F1,Lin28,HK2,Prominin-1 were analyzed through quantitative reverse transcription PCR.Polyubiquitination of CD133 was examined by in vitro or in vivo ubiquitination assay.CD133+cells were sorted by flow cytometry using an anti-CD133 antibody.Results:We demonstrated that HK2 expression was much higher in CSCs of SCLC than in their differentiated counterparts.HK2 depletion inhibited CSC stemness and promoted CSC differentiation.Mechanistically,nonmitochondrial HK2 directly interacted with CD133 and enhanced CD133 expression without affecting CD133 mRNA levels.The interaction of HK2 and CD133 promoted the binding of the deubiquitinase ubiquitin-specific protease 11(USP11)to CD133,thereby inhibiting CD133 polyubiquitylation and degradation.HK2-mediated upregulation of CD133 expression enhanced the expression of cell renewal regulators,SCLC cell stemness,and tumor growth in mice.In addition,HK2 expression was positively correlated with CD133 expression in human SCLC specimens,and their expression levels were associated with poor prognosis of SCLC patients.Conclusions:These results revealed a critical non-metabolic function of HK2 in promotion of cancer cell stemness.Our findings provided new insights into the multifaceted roles of HK2 in tumor development. | Juhong Wang Fei Shao Yannan Yang Wei Wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu | 2022 | Cancer Communications2022，42，10： | 2 |
| 8 | An etwin support vector machine for regression显示文摘 | Shao Yuanhai Zhang Chunhua Yang Zhimin | 2013 | Neural Computing & Applications2013，23，： | 1 |
| 9 | Feasibility of sentinel lymph node biopsy omission after integration of ^(18)F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial显示文摘Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast cancer.The present study aimed to evaluate the negative predictive value(NPV)of 18F-FDG dedicated lymph node positron emission tomography(LymphPET)in cN0 patients.Methods:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by SLNB.In the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET.Here,we report the results of the first stage.The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports.Forty patients had LN-macro,and 16 patients had only lymph node micrometastasis.Of the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET. | Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang Feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 10 | Phosphorylated VEGFR2 and hypertension: potential biomarkers to indicate VEGF-dependency of advanced breast cancer in anti-angiogenic therapy显示文摘 | Minhao Fan Jian Zhang Zhonghua Wang Biyun Wang Qunlin Zhang Chunlei Zheng Ting Li Chen Ni Zhenhua Wu Zhimin Shao Xichun Hu | 2014 | Breast Cancer Research and Treatment2014，，1： | 1 |
| 11 | Ecto-5′-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells显示文摘 | Li Wang Xuerui Zhou Tingting Zhou Dong Ma Sifeng Chen Xiuling Zhi Lianhua Yin Zhimin Shao Zhouluo Ou Ping Zhou | 2008 | Journal of Cancer Research and Clinical Oncology2008，，3： | 1 |
| 12 | Cisplatin and gemcitabine as the first line therapy in metastatic triple negative breast cancer显示文摘 | Jian Zhang Zhonghua Wang Xichun Hu Biyun Wang Leiping Wang Wentao Yang Yang Liu Guangyu Liu Genhong Di Zhen Hu Jiong Wu Zhimin Shao | 2015 | Int. J. Cancer2015，，： | 1 |
| 13 | Platinum is essential in neoadjuvant treatment of triple-negative breast cancer: a network meta-analysis显示文摘Objective:This study aimed to assess the efficacy and safety of various neoadjuvant regimens for patients diagnosed with early-stage or locally advanced triple-negative breast cancer(TNBC).Methods:Medline,EMBASE,Cochrane Library,and Web of Science were searched in May 2020 to identify randomized controlled trials(RCTs).Bayesian network meta-analysis(NMA)was performed(Registration:PROSPERO CRD42020223012).Results:A total of 35 RCTs involving 8,424 participants were reviewed,of which 22 RCTs with 5,203 patients were included in this NMA focusing on pathologic complete response(pCR).An anthracycline-taxane-based(AT)regimen combined with a platinum(ATPt)[odds ratio(OR)=2.04,95%credible interval(CrI):1.69,2.48]regimen,and a docetaxel regimen combined with a carboplatin(TCb;OR=2.16,95%CrI:1.20,3.91)regimen improved pCR beyond that with AT only.AT and ATPt combined with targeted therapy[including bevacizumab(Bev),veliparib,atezolizumab,or pembrolizumab]also improved pCR.Five RCTs included in this NMA reported serious adverse events(SAEs)or grade≥3 AEs.TCb was associated with fewer grade≥3 AEs than was AT(OR=0.66,95%CrI:0.23,1.72)alone.In contrast,ATPt,AT+Bev,ATPt+Bev,ATPt+veliparib,and ATPt+pembrolizumab were associated with more SAEs than was AT alone.Conclusions:In patients with TNBC,platinum-based neoadjuvant regimens ATPt and TCb increase pCR beyond that with AT alone,but TCb appears to be better tolerated than either AT or ATPt.Platinum-based regimens combined with targeted therapies(Bev,PARPi,and PD-1/PD-L1 inhibitor)also improve the pCR rate beyond that with AT alone,but this benefit is accompanied by greater toxicity. | Junjie Li Li Chen Wei Tan Fang Qi Yang Zhang Zhonghua Wang Zhimin Shao | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 14 | Probabilistic outputs for twin support vector machines显示文摘 | Shao Yuanhai Deng Naiyang Yang Zhimin Chen Weijie Wang Zhen | 2012 | Knowledge-Based Systems2012，33，9： | 1 |
| 15 | Dynamic Microwave-Assisted Extraction of Arctigenin from Saussurea medusa Maxim.显示文摘 | Ruitao Yu Ruixue Yu Xingwang Zhang Zhimin Luo Huaigang Zhang Yun Shao Lijuan Mei Yanduo Tao | 2010 | Chromatographia . 2010 (3-4)2010，，3： | 1 |
| 16 | Probabilistic outputs for twin support vector machines显示文摘 | SHAO Yuanhai DENG Naiyang YANG Zhimin | 2012 | Knowledge-Based Systems2012，33，9： | 1 |
| 17 | The clinical significance of preoperative chemotherapy inducing cell's apoptosis in breast cancer显示文摘 | Li Jun Wu Ling | 2000 | Zhonghua Zhongliu Zazhi2000，22，4： | 1 |
| 18 | Geochemical and Nd isotopic variations in sediments of the South China Sea: A response to Cenozoic tectonism in SE Asia显示文摘 | Li Xianhua Wei Gangjian Shao Lei Liu Ying Liang Xirong Jian Zhimin Sun Min Wang Pinxian | 2003 | Earth Planet Sci Left2003，211，34： | 1 |
| 19 | Study of Characteristic LX-ray Spectra of Thick and Thin Au Target by Carbon Ions显示文摘 | Song Zhangyong Yang Zhihu Ruan Fangfang Cai Xiaohong Zhang Hongqiang Shao Jianxiong Cui Ying Xie Jiangshan Gao Zhimin Du Juan Liu Liewen | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 20 | Preparation of Quaternary FeCoMoCu Metal Oxides for Oxygen Evolution Reaction显示文摘Molybdenum doping is an effective way to improve the oxygen evolution reaction(OER)properties of catalysts,which can efficiently improve the electronic conductivity,mass transport process,and intrinsic activity of transition metal oxides or hydroxides,especially for those multi-component oxides with more abundant active sites.Herein,we have prepared a quaternary FeCoMoCu metal oxide on Cu foam(FeCoMoCuO_(x)@Cu)as an efficient OER catalyst.As expected,FeCoMoCuO_(x)@Cu could exhibit a low overpotential(252 mV at the current density of 10 mA/cm^(2))and exceptional stability(10000 cycles of CV scans or constant electrolysis for 48 h). | HAO Zhimin LIU Dapeng GE Huaiyun ZUO Xintao FENG Xilan SHAO Mingzhe YU Haohan YUAN Guobao ZHANG Yu | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
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