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| 1 | Ecological-hydrological processes in arid environment: Past, present and future显示文摘Ecohydrology, aiming to study the interactions between terrestrial ecological systems and hydrological cycles as well as their impacts on water management, has been an emerging interdisciplinary research field since the 20 th century. It hosts both natural and human regulated processes that are potentially coupled in complex ways. Understanding the ecological-hydrological processes, the fundamental mechanisms and the connections between them is critical since these processes are not isolated but integrated to impact basin-scale hydrological and biogeochemical functioning of a larger river system, especially in arid environment where water resources are considered to be the source of life. Thus, research on ecological-hydrological processes in arid environment is not only a scientific focus area but also important to sustainable development. Research projects and initiatives involved in observation, measurement, modeling and data assimilation have been well-developed for those purposes over the past 20 years. This review summarizes the historical development of ecohydrology science in China and the state-of-the-art tools available in the research framework. Five grand scientific challenges are listed as prospects and exciting opportunities for the scientific community. To advance the current ecological-hydrological processes research, scientists from multidisciplinary backgrounds(such as geography, geology, geomorphology, hydrology, geochemistry and ecology), need to unite to tackle the many open problems in new dimensions. | SONG Changqing YUAN Lihua YANG Xiaofan FU Bojie | 2017 | Journal of Geographical Sciences2017，27，12： | 13 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Drinking water treatment using a submerged internal-circulation membrane coagulation reactor coupled with permanganate oxidation显示文摘A submerged internal circulating membrane coagulation reactor(MCR) was used to treat surface water to produce drinking water. Polyaluminum chloride(PACl) was used as coagulant,and a hydrophilic polyvinylidene fluoride(PVDF) submerged hollow fiber microfiltration membrane was employed. The influences of trans-membrane pressure(TMP), zeta potential(ZP) of the suspended particles in raw water, and KMnO_4 dosing on water flux and the removal of turbidity and organic matter were systematically investigated. Continuous bench-scale experiments showed that the permeate quality of the MCR satisfied the requirement for a centralized water supply, according to the Standards for Drinking Water Quality of China(GB 5749-2006), as evaluated by turbidity(<1 NTU) and total organic carbon(TOC)(<5 mg/L)measurements. Besides water flux, the removal of turbidity, TOC and dissolved organic carbon(DOC) in the raw water also increased with increasing TMP in the range of 0.01–0.05 MPa. High ZP induced by PACl, such as 5–9 mV, led to an increase in the number of fine and total particles in the MCR, and consequently caused serious membrane fouling and high permeate turbidity.However, the removal of TOC and DOC increased with increasing ZP. A slightly positive ZP, such as 1–2 mV, corresponding to charge neutralization coagulation, was favorable for membrane fouling control. Moreover, dosing with KMnO_4 could further improve the removal of turbidity and DOC, thereby mitigating membrane fouling. The results are helpful for the application of the MCR in producing drinking water and also beneficial to the research and application of other coagulation and membrane separation hybrid processes. | Zhongguo Zhang Dan Liu Yu Qian Yue Wu Peiran He Shuang Liang Xiaozheng Fu Jiding Li Changqing Ye | 2017 | Journal of Environmental Sciences2017，29，6： | 3 |
| 4 | High-performance flexural fatigue of carbon nanotube yarns显示文摘Carbon nanotube yarns(CNTY)possess good specific strength and specific conductivity.As such,their potential for commercial applications is significant.Fatigue performance is a significant consideration in yarn/wire applications.In this study,the flexural fatigue performance of CNTY spun from super-aligned carbon nanotube arrays was investigated using a reversed bending test.The results showed that CNTY exhibited excellent resistance to pure flexural fatigue,significantly outperforming stainless steel wire;CNTY failed where a combination of flexural fatigue and tension–tension fatigue had special hollow fracture morphology,and CNTY resistance remained fundamentally unchanged in the combination fatigue process. | Fu Xu Xiaolong Mo Sen Wan Changqing Jiang Hongwei Hao Luming Li | 2014 | Chinese Science Bulletin2014，59，29： | 2 |
| 5 | Mineralogy of Chang’e-4 landing site:preliminary results of visible and near-infrared imaging spectrometer显示文摘The exploration of mafic anomaly in South Pole-Aitken(SPA,the largest confirmed)basin on the Moon provides important insights into lunar interior.The landing of Chang’e-4(CE-4)and deployment of Yutu-2 rover on the discontinuous ejecta from Finsen crater enabled in-situ measurements of the unusual mineralogy in the central portion of SPA basin with visible and near-infrared imaging spectrometer(VNIS).Here we present detailed processing procedures based on the level 2B data of CE-4 VNIS and preliminary mineralogical results at the exploration area of Yutu-2 rover.A systematic processing pipeline is developed to derive credible reflectance spectra,based on which several spectral and mineral indices are calculated to constrain the mafic mineralogy.The mafic components in the soils and boulder around CE-4 landing site are concluded as clinopyroxene-bearing with intermediate composition and probably dominated by pigeonite although the possibility of mixing orthopyroxen(OPX)and calcic clinopyroxene(CPX)also exists.These mineralogical results are more consistent with a petrogenesis that the CE-4 regolith and rock fragment are derived from rapid-cooling magmatic systems and we interpret that the materials at the CE-4 landing site ejected from Finsen crater are probably recrystallized from impact melt settings. | Jian CHEN Zongcheng LING Le QIAO Zhiping HE Rui XU Lingzhi SUN Jiang ZHANG Bo LI Xiaohui FU Changqing LIU Xiaobin QI | 2020 | Science China(Information Sciences)2020，63，4： | 2 |
| 6 | Verteporfin synergizes the efflcacy of anti-PD-1 in cholangiocarcinoma显示文摘Background:Cholangiocarcinoma(CCA)is one of the primary hepatobiliary malignant neoplasms with only 10%of 5-year survival rate.Promising immunotherapy with the blockade of immune checkpoints has no clear benefit in CCA.The inhibition of YAP1 signaling by verteporfin has shown encouraging results by inhibiting cell proliferation and inducing apoptosis.This study aimed to evaluate the potential benefit of the combination of verteporfin and anti-programmed cell death 1(PD-1)in CCA mouse model.Methods:We assessed the cytotoxicity of verteporfin in human CCA cell lines in vitro,including both intrahepatic CCA and extrahepatic CCA cells.We examined the in vitro effect of verteporfin on cell proliferation,apoptosis,and stemness.We evaluated the in vivo efflcacy of verteporfin,anti-PD-1,and a combination of both in subcutaneous CCA mouse model.Results:Our study showed that verteporfin reduced tumor cell growth and enhanced apoptosis of human CCA tumor cells in vitro in a dose-dependent fashion.Nevertheless,verteporfin impaired stemness evidenced by reduced spheroid formation and colony formation,decreased numbers of cells with aldehyde dehydrogenase activity and positive cancer stem cell markers(all P<0.05).The combination of verteporfin and anti-PD-1 reduced tumor burden in CCA subcutaneous SB1 tumor model compared to either agent alone.Conclusions:Verteporfin exhibits antitumor effects in both intrahepatic and extrahepatic CCA cell lines and the combination with anti-PD-1 inhibited tumor growth. | Jianyang Fu Nicole A McGrath Jihye Lee Xin Wang Gagandeep Brar Changqing Xie | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 1 |
| 7 | Bioactive borate glass scaffolds: in vitro and in vivo evaluation for use as a drug delivery system in the treatment of bone infection显示文摘 | Xin Liu Zongping Xie Changqing Zhang Haobo Pan Mohamed N. Rahaman Xin Zhang Qiang Fu Wenhai Huang | 2010 | Journal of Materials Science: Materials in Medicine2010，，2： | 1 |
| 8 | A fully bio-based waterborne polyurethane dis- persion from vegetable oils: From synthesis of precursors by thiol-ene reaction to study of final material显示文摘 | Fu Changqing Zheng Zitong Yang Zhe | 2014 | Progress in Organic Coatings2014，77，1： | 1 |
| 9 | Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobinand MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patientsreceiving platinum-based chemotherapy显示文摘 | Haijiao Jiang He Wang Shiyu Wang Zhengtong Pei Zhimin Fu Changqing Fang Jian Wang Qingjie Lu Enhua Wang Jianhua Li | 2015 | Molecular Medicine Reports2015，，： | 1 |
| 10 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 11 | Immunotherapy of hepatocellular carcinoma with infection of hepatitis B or C virus显示文摘Hepatocellular carcinoma(HCC)has one of highest mortalities globally amongst cancers,but has limited therapeutic options once in the advanced stage.Hepatitis B or C virus infection are the most common drivers for HCC carcinogenesis,triggering chronic liver inflammation and adding to the complexity of the immune microecosystem of HCC.The emergence of immunotherapy has afforded a new avenue of therapeutic options for patients with advanced HCC with a history of hepatitis B or C virus infection.This article reviews the change of immunity elicited by hepatitis B or C virus infection,the immune feature of HCC,and the clinical evidence for immunotherapy in advanced HCC and discusses future directions in this field. | Cecilia Monge Bonilla Nicole A.McGrath Jianyang Fu Changqing Xie | 2020 | Hepatoma Research2020，6，10： | 1 |
| 12 | Preparation and properties of waterborne bio - based polyurethane/siloxane cross - linked films by an in situ sol - gel process 显示文摘 | Fu Changqing Hu Xiuzheng | 2015 | Progress in Organic Coatings2015，，84： | 1 |
| 13 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 14 | Causes of progressive stamping die damage and retooling measures to reduce carbide punch fracture显示文摘We investigated the reasons for frequently appearing early failure of carbide punches in a progressive stamping die when they were used to produce magnetic shielding steel parts.The failure modes of the carbide punches were statistically classified.Edge chipping and shoulder fracturing were the two types of failure modes that were found.The composition,hardness,and microstructure of the punches were analyzed.The cobalt content was found to be too low to ensure sufficient toughness.The brittle phase of tungsten carbide(WC) was prone to breaking off during the shear cutting process,and resulted in edge chipping.In addition,the material chips were easily bonded to the punch edge when there was a lack of press oil lubricity.It resulted in an uneven blanking clearance,which caused a lateral force and finally resulted in shoulder fracturing of the punches.Improvement measures were introduced to address the abovementioned issues.By using the carbide punches with greater toughness and shear cutting oil with high lubricity,the early damage problems of the punches are effectively solved,which ensures normal production of the magnetic shielding steel parts. | LIANG Gaofei YAN Yuanyuan LUO Xiaoliang LIN Changqing FU Yan'an SHAO Zongqiang | 2016 | Baosteel Technical Research2016，10，4： | 0 |
| 15 | Synthesis of a Fully Biobased Polyfunctional Vinyl Oligomer and Their UV Cured Films Prepared via Thiol-ene Coupling显示文摘In this paper,a fully bio-based vinyl oligomer with high functionalities was successfully prepared from rapeseed oil by three modification steps:epoxidation of rapeseed oil,solvent-free and catalyst-free ring opening by 10-undecylenic acid followed by esterification with 10-undecenoyl chloride.Then,the renewable polymers were prepared by photo-polymerization of these modified vegetable oils with typical thiol monomers:pentaerythritol tetrakis(3-mercaptopropionate),pentaerythritol tris(3-mercaptopropionate)and 1,2-ethanedithiol.The synthesis of the vinyl oligomer was monitored by nuclear magnetic resonance and Fourier-transform infrared spectroscopy.The average number of the carbon-carbon double bonds of the resulting vinyl oligomer is high to be 7.2.The kinetic of thiol-ene photo-polymerization of vegetable oil-based vinyl oligomer was studied by FTIR-ATR analyses.In addition,the thermo-physical properties,thermal stability and solvent resistance of these UV cured films were characterized.The polymers from 1,2-ethanedithiol exhibit higher gel content,storage modulus and glass transition temperature than those from other thiol monomers due to the high crosslinking densities of the resulting polymers.All polymers show excellent thermal stability up to 290oC.The resulting polymers exhibit thermo-physical properties,excellent water resistance and thermals stability,which is promising to find application in coatings and adhesives. | Changqing Fu Jiahui Wang Lie Chen Liang Shen | 2019 | Journal of Renewable Materials2019，7，8： | 0 |
| 16 | Legionella sainthelensi Pneumonia with Abdominal Symptoms as Prominent Manifestations:A Case Report显示文摘Fewstudies have reported Legionella sainthelensi infection.This infection primarily presents with respiratorymanifestations.Here,we report an immunocompromised patient with cavitary pneumonia caused by L.sainthelensi who mainly had abdominal symptoms.The timely administration of moxifloxacin provided clinical improvement and resolution of symptoms.To our knowledge,this is one of the rare cases of L.sainthelensi infection presenting uniquelywith abdominal distension and liver function impairment butwithout obvious respiratory symptoms. | Xin Yuan Fanglin Meng Xinting Yu Changqing Bai Rui Jia Fanping Meng Fu-sheng Wang Junliang Fu | 2022 | Infectious Diseases & Immunity2022，2，4： | 0 |
| 17 | Epidemiological Analysis of Foodborne Botulism Outbreaks-China,2004-2020显示文摘Introduction:Foodborne botulism is a rare,potentially fatal illness resulting from the ingestion of foods contaminated with preformed botulinum neurotoxin types A,B,E,or F,produced by Clostridium botulinum.The descriptive epidemiology of foodborne botulism outbreaks in China during 2004−2020 was performed to inform public health response strategies.Methods:Data from 22 of 31 provincial-level administrative divisions(PLADs)of the National Foodborne Disease Outbreaks Surveillance System during 2004−2020 and Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,and Chinese Science and Technique Journals(CQVIP)from January 2004 to December 2020 to identify indexed publications in the Chinese literature using the following search terms“botulism,”or“botulinum toxin,”or“Clostridium botulinum.”The number and proportion of outbreaks,illnesses,and deaths by PLAD,food types,and contributing factors were calculated.Results:During 2004−2020,a total of 80 foodborne botulism outbreaks occurred in China,involving 386 illnesses and 55 deaths;most outbreaks were reported between June and August,with a sharp peak in January;22 out of 31 PLADs reported foodborne botulism outbreaks,Xinjiang reported the largest number of outbreaks(20),followed by Qinghai(13);the most commonly implicated foods were homeprepared traditional processed stinky tofu and dried beef,accounting for 51.25%events.Improper processing and improper storage in contributing factors accounted for 77.50%outbreaks.Initial misdiagnosis occurred in 27.50%of cases.Conclusions:Outbreaks of foodborne botulism had a high case-fatality rate.Targeted food safety and popularization education to farmers and herdsmen in Xinjiang and Qinghai related to botulism prevention should be carried out,and timely outbreak investigation and hospital surge capacity should be improved. | Hongqiu Li Yunchang Guo Tian Tian Wanhua Guo Changqing Liu Xiaocheng Liang Jikai Liu Weiwei Li Ping Fu | 2022 | China CDC weekly2022，4，35： | 0 |
| 18 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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