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| 1 | microRNAs and ceRNAs: RNA networks in pathogenesis of cancer显示文摘microRNAs (miRNAs) are a class of endogenous, single-stranded non-coding RNAs of 2023 nucleotides in length, functioning as negative regulators of gene expression at the post-transcriptional level. The dysregulation of miRNAs has been demonstrated to play critical roles in tumorigenesis, either through inhibiting tumor suppressor genes or activating oncogenes inappropriately. Besides their promising clinical applications in cancer diagnosis and treatment, recent studies have uncovered that miRNAs could act as a regulatory language, through which messenger RNAs, transcribed pseudogenes, and long noncoding RNAs crosstalk with each other and form a novel regulatory network. RNA transcripts involved in this network have been termed as competing endogenous RNAs (ceRNAs), since they influence each other's level by competing for the same pool of miRNAs through miRNA response elements (MREs) on their target transcripts. The discovery of miRNA-ceRNA network not only provides the possibility of an additional level of post-transcriptional regulation, but also dictates a reassessment of the existing regulatory pathways involved in cancer initiation and progression. | Xiangqian Su Jiadi Xing Zaozao Wang Lei Chen Ming Cui Beihai Jiang | 2013 | Chinese Journal of Cancer Research2013，25，2： | 13 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Laparoscopic vs.open lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction:An exploratory,observational,prospective,IDEAL stage2b cohort study(CLASS-10 study)显示文摘Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observational,prospective,cohort study will be carried out under the Idea,Development,Exploration,Assessment and Long-term Follow-up(IDEAL)framework(stage 2 b).Paritcipants:The study will recruit 1,036 patients with cases of locally advanced AEG(Siewert typeⅡ/Ⅲ,clinical stage cT2-4 aN0-3 M0),and 518 will be assigned to either the laparoscopy group or the open group.Interventions:Patients will receive lower mediastinal lymphadenectomy along with either total or proximal gastrectomy.Primary and secondary outcome measures:The primary endpoint is the number of lower mediastinal lymph nodes retrieved,and the secondary endpoints are the surgical safety and prognosis,including intraoperative and postoperative lower-mediastinal-lymphadenectomy-related morbidity and mortality,rate of rehospitalization,R0 resection rate,3-year local recurrence rate,and 3-year overall survival.Conclusions:The study will provide data for the guidance and development of surgical treatment strategies for AEG.Trial registration number:The study has been registered in ClinicalTrials.gov(No.NCT04443478). | Shuangxi Li Xiangji Ying Fei Shan Yongning Jia Zhemin Li Kan Xue Rulin Miao Yinkui Wang Zhaode Bu Xiangqian Su Ziyu Li Jiafu Ji | 2022 | Chinese Journal of Cancer Research2022，34，4： | 3 |
| 4 | Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface显示文摘 | Jing Yang Feng Wang Linlin Tian Jing Su Xiangqian Zhu Li Lin Xiaoran Ding Xuejun Wang Shengqi Wang | 2010 | Archives of Virology2010，，6： | 1 |
| 5 | OShnscc:a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information显示文摘Head and neck squamous cell carcinoma(HNSCC),as the most common type(>90%)of head and neck cancer,includes various epithelial malignancies that arise in the nasal cavity,oral cavity,pharynx,and larynx.In 2020,approximately 878000 new cases and 444000 deaths linked to HNSCC occurred worldwide(Sung et al.,2021).Due to the associated frequent recurrence and metastasis. | Guosen ZHANG Qiang WANG Xinlei QI Huimin YANG Xiaodong SU Manman YANG Chao JIANG Yang AN Hong Zheng LU Zhang Wan ZHU Jiancheng GUO Xiangqian GUO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 1 |
| 6 | 3-Thiomorpholin-8-oxo-8 H -acenaphtho [1,2- b ] pyrrole-9-carbonitrile ( S1 ) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-x L and Mcl-1显示文摘 | Ting Song Xiangqian Li Xilong Chang Xiaomeng Liang Yan Zhao Guiye Wu Shenghui Xie Pengchen Su Zhiyong Wu Yingang Feng Zhichao Zhang | 2013 | Bioorganic & Medicinal Chemistry2013，，1： | 1 |
| 7 | New Upper Limit ofγ-Rays Emitted by Tritium Nucleus显示文摘Using a strong tritium source and a low background HPGe spectrometer a new upper limit of γ-rays emitted by tritium nucleus,less than 3.4X10^(-13),is obtained. | TANG Xiaowei WU Yigen ZHANG Su CHEN Qingwang XIE Xiangqian | 1992 | Chinese Physics Letters1992，9，10： | 0 |
| 8 | An In-Situ Formed Tunneling Layer Enriches the Options of Anode for Efficient and Stable Regular Perovskite Solar Cells显示文摘Perovskite solar cells(PSCs)are taking steps to commercialization.However,the halogen-reactive anode with high cost becomes a stumbling block.Here,the halogen migration in PSCs is utilized to in situ generate a uniform tunneling layer between the hole transport materials and anodes,which enriches the options of anodes by breaking the Schottky barrier,enabling the regular PSCs with both high efficiency and stability.Specifically,the regular PSC that uses silver iodide as the tunneling layer and copper as the anode obtains a champion power conversion efficiency of 23.24%(certified 22.74%)with an aperture area of 1.04 cm^(2).The devices are stable,maintaining 98.6%of the initial effi-ciency after 500 h of operation at the maximum power point with continuous 1 sun illumination.PSCs with different tunneling layers and anodes are fabricated,which confirm the generality of the strategy. | Xuesong Lin Yanbo Wang Hongzhen Su Zhenzhen Qin Ziyang Zhang Mengjiong Chen Min Yang Yan Zhao Xiao Liu Xiangqian Shen Liyuan Han | 2023 | Nano-Micro Letters2023，15，1： | 0 |
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